Motif ID: Foxo6

Z-value: 0.422


Transcription factors associated with Foxo6:

Gene SymbolEntrez IDGene Name
Foxo6 ENSMUSG00000052135.8 Foxo6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_120287349-0.142.3e-01Click!


Activity profile for motif Foxo6.

activity profile for motif Foxo6


Sorted Z-values histogram for motif Foxo6

Sorted Z-values for motif Foxo6



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_75111684 3.309 ENSMUST00000100542.3
 Ly6c2
lymphocyte antigen 6 complex, locus C2
chrY_-_6681243 2.055 ENSMUST00000115940.1
 Gm21719
predicted gene, 21719
chr1_-_184883218 2.025 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr11_-_12027958 2.001 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr10_-_93310963 1.909 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr6_-_23248264 1.681 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_-_84425258 1.664 ENSMUST00000074262.2
 Calcrl
calcitonin receptor-like
chr16_+_10812915 1.592 ENSMUST00000115822.1
 Gm11172
predicted gene 11172
chr10_-_93311073 1.520 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr4_+_134510999 1.454 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr1_-_162898665 1.432 ENSMUST00000111510.1
ENSMUST00000045902.6
 Fmo2

flavin containing monooxygenase 2

chr12_-_113260217 1.370 ENSMUST00000178282.1
 Igha
immunoglobulin heavy constant alpha
chr1_+_74391479 1.316 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr3_-_106167564 1.298 ENSMUST00000063062.8
 Chi3l3
chitinase 3-like 3
chr2_-_67194695 1.206 ENSMUST00000147939.1
 Gm13598
predicted gene 13598
chr15_+_3270767 1.183 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chrX_-_163761323 1.173 ENSMUST00000059320.2
 Rnf138rt1
ring finger protein 138, retrogene 1
chr14_-_47418407 0.892 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr6_+_88724667 0.885 ENSMUST00000163271.1
 Mgll
monoglyceride lipase
chr9_+_25089422 0.781 ENSMUST00000086238.2
 Gm10181
predicted gene 10181
chr17_-_31277327 0.721 ENSMUST00000024832.7
 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chrX_-_8193387 0.688 ENSMUST00000143223.1
ENSMUST00000033509.8
 Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr3_-_51408925 0.677 ENSMUST00000038108.6
 Ndufc1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1
chr13_-_71963713 0.669 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr17_-_57839233 0.660 ENSMUST00000095218.3
 Rpl7a-ps5
ribosomal protein L7A, pseudogene 5
chr17_-_24696147 0.636 ENSMUST00000046839.8
 Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr5_+_110330697 0.633 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr5_-_65391408 0.620 ENSMUST00000057885.6
 Rpl9
ribosomal protein L9
chr9_+_6168638 0.610 ENSMUST00000058692.7
 Pdgfd
platelet-derived growth factor, D polypeptide
chr5_-_65391380 0.606 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
 Rpl9


ribosomal protein L9


chr5_-_117389029 0.543 ENSMUST00000111953.1
ENSMUST00000086461.6
 Rfc5

replication factor C (activator 1) 5

chr12_-_102423741 0.526 ENSMUST00000110020.1
 Lgmn
legumain
chr15_-_81843699 0.500 ENSMUST00000092020.2
 Gm8444
predicted gene 8444
chrX_+_134585644 0.494 ENSMUST00000113211.1
 Rpl36a
ribosomal protein L36A
chr18_-_60648290 0.474 ENSMUST00000143275.2
 Synpo
synaptopodin
chr5_+_7179299 0.472 ENSMUST00000179460.1
 Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chrX_+_106920618 0.448 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr14_-_50924626 0.422 ENSMUST00000160375.1
ENSMUST00000162177.1
ENSMUST00000159292.1
 Osgep


O-sialoglycoprotein endopeptidase


chr2_-_155357392 0.401 ENSMUST00000165234.1
ENSMUST00000077626.6
 Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chr14_+_34170640 0.400 ENSMUST00000104925.3
 Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr7_+_28808795 0.387 ENSMUST00000172529.1
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr7_+_140881898 0.385 ENSMUST00000026560.7
 Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr16_+_44943737 0.364 ENSMUST00000114622.3
ENSMUST00000166731.1
 Cd200r3

CD200 receptor 3

chr11_+_46235460 0.360 ENSMUST00000060185.2
 Fndc9
fibronectin type III domain containing 9
chr1_-_180245927 0.333 ENSMUST00000010753.7
 Psen2
presenilin 2
chr1_+_171270321 0.324 ENSMUST00000064272.3
ENSMUST00000141999.1
ENSMUST00000111313.3
 B4galt3


UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3


chr7_+_19368498 0.307 ENSMUST00000132655.1
 Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr7_+_28440927 0.306 ENSMUST00000078845.6
 Gmfg
glia maturation factor, gamma
chr19_+_8892987 0.294 ENSMUST00000096249.5
 Ints5
integrator complex subunit 5
chr11_-_89639631 0.255 ENSMUST00000128717.1
 Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr7_+_62476306 0.254 ENSMUST00000097132.3
 Atp5l-ps1
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g, pseudogene 1
chr7_-_123369870 0.250 ENSMUST00000106442.2
ENSMUST00000098060.3
ENSMUST00000167309.1
 Arhgap17


Rho GTPase activating protein 17


chr4_-_139131058 0.250 ENSMUST00000143971.1
 Minos1
mitochondrial inner membrane organizing system 1
chr3_-_34351685 0.238 ENSMUST00000174114.1
 Gm20514
predicted gene 20514
chr10_+_79879614 0.228 ENSMUST00000006679.8
 Prtn3
proteinase 3
chr11_+_87853207 0.228 ENSMUST00000038196.6
 Mks1
Meckel syndrome, type 1
chr12_-_84617326 0.224 ENSMUST00000021666.4
 Abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr1_-_180245757 0.224 ENSMUST00000111104.1
 Psen2
presenilin 2
chr5_-_99037035 0.222 ENSMUST00000031277.6
 Prkg2
protein kinase, cGMP-dependent, type II
chr1_+_110099295 0.217 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr1_+_51987139 0.215 ENSMUST00000168302.1
 Stat4
signal transducer and activator of transcription 4
chr8_+_83566671 0.212 ENSMUST00000036996.5
 Ndufb7
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
chr8_+_46986913 0.211 ENSMUST00000039840.7
ENSMUST00000119686.1
 Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr2_+_4718145 0.208 ENSMUST00000056914.6
 Bend7
BEN domain containing 7
chr15_+_103453782 0.201 ENSMUST00000047405.7
 Nckap1l
NCK associated protein 1 like
chr5_+_65391497 0.183 ENSMUST00000031101.3
ENSMUST00000122026.1
 Lias

lipoic acid synthetase

chr7_+_143052739 0.177 ENSMUST00000037941.9
 Cd81
CD81 antigen
chr4_-_149099802 0.170 ENSMUST00000103217.4
 Pex14
peroxisomal biogenesis factor 14
chr17_+_25471564 0.151 ENSMUST00000025002.1
 Tekt4
tektin 4
chr18_+_60212080 0.146 ENSMUST00000031549.5
 Gm4951
predicted gene 4951
chr9_-_22071345 0.136 ENSMUST00000179605.1
ENSMUST00000043922.6
 Zfp653

zinc finger protein 653

chr2_+_129593195 0.134 ENSMUST00000099113.3
ENSMUST00000103202.3
 Sirpa

signal-regulatory protein alpha

chr11_+_85832551 0.134 ENSMUST00000000095.6
 Tbx2
T-box 2
chr5_+_115605642 0.115 ENSMUST00000094427.3
 Gcn1l1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
chr2_-_30194112 0.102 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr5_+_21186267 0.068 ENSMUST00000036031.8
 Gsap
gamma-secretase activating protein
chr5_+_115279666 0.068 ENSMUST00000040421.4
 Coq5
coenzyme Q5 homolog, methyltransferase (yeast)
chr19_-_45742873 0.061 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr1_-_160077918 0.045 ENSMUST00000028061.3
 4930562F07Rik
RIKEN cDNA 4930562F07 gene
chr18_+_5593566 0.013 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr2_+_129592914 0.005 ENSMUST00000103203.1
 Sirpa
signal-regulatory protein alpha
chr7_+_64287665 0.000 ENSMUST00000032736.4
 Mtmr10
myotubularin related protein 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.4 1.4 GO:0072592 oxygen metabolic process(GO:0072592)
0.3 1.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 2.0 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 0.6 GO:0045004 DNA replication proofreading(GO:0045004)
0.2 0.6 GO:0035696 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.2 0.7 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.2 0.5 GO:0098886 modification of dendritic spine(GO:0098886)
0.1 0.5 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 0.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.4 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 1.4 GO:0002385 mucosal immune response(GO:0002385)
0.1 0.2 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.1 0.2 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.4 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 0.5 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.6 GO:0097421 liver regeneration(GO:0097421)
0.1 0.2 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.1 GO:0007521 muscle cell fate determination(GO:0007521) mammary placode formation(GO:0060596)
0.0 0.3 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.6 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.4 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.2 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.2 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.2 GO:2001225 hypotonic response(GO:0006971) cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.0 0.3 GO:0050957 equilibrioception(GO:0050957)
0.0 0.2 GO:0061009 common bile duct development(GO:0061009)
0.0 0.2 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 1.3 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.1 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 1.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.3 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 0.7 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.3 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.0 0.7 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 1.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 1.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.5 GO:0097444 spine apparatus(GO:0097444)
0.1 0.5 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 0.7 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.4 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.4 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 0.9 GO:0043196 varicosity(GO:0043196)
0.0 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.4 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 3.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.6 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.4 GO:0045120 pronucleus(GO:0045120)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.4 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.3 1.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 0.7 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.2 0.6 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.2 1.7 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.2 0.6 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 1.3 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.4 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.1 1.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.4 GO:0034235 GPI anchor binding(GO:0034235)
0.1 0.6 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.3 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.1 0.4 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.2 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.1 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 2.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.4 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.6 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 1.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.3 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 1.2 GO:0019843 rRNA binding(GO:0019843)
0.0 0.2 GO:1990459 virus receptor activity(GO:0001618) transferrin receptor binding(GO:1990459)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 2.0 PID_IGF1_PATHWAY IGF1 pathway
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.5 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.2 PID_IL23_PATHWAY IL23-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 1.2 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 0.5 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.4 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.6 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.9 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.7 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.7 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.2 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.1 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.1 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions