Motif ID: Foxp2_Foxp3
Z-value: 0.669


Transcription factors associated with Foxp2_Foxp3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Foxp2 | ENSMUSG00000029563.10 | Foxp2 |
Foxp3 | ENSMUSG00000039521.6 | Foxp3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Foxp2 | mm10_v2_chr6_+_14901440_14901497 | -0.16 | 1.7e-01 | Click! |
Foxp3 | mm10_v2_chrX_+_7579666_7579693 | -0.03 | 7.8e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 212 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.4 | 15.3 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.4 | 14.1 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
0.6 | 11.1 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
2.0 | 9.8 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
0.6 | 8.4 | GO:0070842 | aggresome assembly(GO:0070842) |
2.2 | 6.5 | GO:0099547 | regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254) |
0.6 | 6.3 | GO:0042118 | endothelial cell activation(GO:0042118) |
0.5 | 5.8 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
0.7 | 5.1 | GO:0019532 | oxalate transport(GO:0019532) |
0.3 | 5.1 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
0.5 | 5.0 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
1.0 | 4.1 | GO:0002069 | columnar/cuboidal epithelial cell maturation(GO:0002069) |
1.3 | 4.0 | GO:0032915 | positive regulation of transforming growth factor beta2 production(GO:0032915) |
0.1 | 4.0 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
0.2 | 3.7 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
0.4 | 3.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
0.0 | 3.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.3 | 3.4 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
0.2 | 3.2 | GO:0001967 | suckling behavior(GO:0001967) |
0.8 | 3.1 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 103 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 15.3 | GO:0016605 | PML body(GO:0016605) |
0.3 | 11.2 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.0 | 7.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
1.6 | 6.5 | GO:1902737 | viral replication complex(GO:0019034) dendritic filopodium(GO:1902737) |
0.1 | 5.0 | GO:0009925 | basal plasma membrane(GO:0009925) |
0.9 | 4.6 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
0.0 | 4.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.1 | 3.9 | GO:0035861 | site of double-strand break(GO:0035861) |
0.0 | 3.8 | GO:0016363 | nuclear matrix(GO:0016363) |
0.0 | 3.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
0.0 | 3.6 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
0.3 | 3.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.6 | 2.5 | GO:0044307 | dendritic branch(GO:0044307) |
0.2 | 2.5 | GO:1990635 | proximal dendrite(GO:1990635) |
0.0 | 2.4 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
0.0 | 2.4 | GO:0045171 | intercellular bridge(GO:0045171) |
0.1 | 2.3 | GO:0071564 | npBAF complex(GO:0071564) |
0.7 | 2.2 | GO:0098855 | HCN channel complex(GO:0098855) |
0.0 | 2.1 | GO:0032993 | protein-DNA complex(GO:0032993) |
0.2 | 1.9 | GO:0032300 | mismatch repair complex(GO:0032300) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 146 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.2 | 15.3 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
0.1 | 11.0 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
0.4 | 10.6 | GO:0042287 | MHC protein binding(GO:0042287) |
0.9 | 6.5 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
1.6 | 6.3 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
0.3 | 5.2 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.5 | 5.1 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
1.2 | 4.8 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
0.0 | 4.4 | GO:0005509 | calcium ion binding(GO:0005509) |
0.1 | 4.0 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
0.0 | 4.0 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
0.4 | 3.9 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.1 | 3.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
0.1 | 3.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.1 | 2.9 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
0.0 | 2.9 | GO:0003823 | antigen binding(GO:0003823) |
0.9 | 2.8 | GO:0003796 | lysozyme activity(GO:0003796) |
0.1 | 2.8 | GO:0001223 | transcription coactivator binding(GO:0001223) |
0.7 | 2.6 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
0.1 | 2.6 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 38 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 12.9 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.3 | 10.2 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
0.1 | 7.2 | PID_FOXO_PATHWAY | FoxO family signaling |
0.1 | 6.0 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
0.0 | 5.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
0.2 | 5.6 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.1 | 5.5 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
0.1 | 4.2 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
0.2 | 3.9 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
0.1 | 3.8 | PID_IL3_PATHWAY | IL3-mediated signaling events |
0.1 | 3.3 | PID_SHP2_PATHWAY | SHP2 signaling |
0.0 | 3.2 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
0.1 | 2.9 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
0.0 | 2.8 | PID_LKB1_PATHWAY | LKB1 signaling events |
0.1 | 2.4 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
0.0 | 2.3 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
0.0 | 2.0 | PID_ENDOTHELIN_PATHWAY | Endothelins |
0.1 | 1.8 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
0.1 | 1.8 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
0.0 | 1.7 | PID_P53_REGULATION_PATHWAY | p53 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 60 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 4.9 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
0.6 | 4.8 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
0.2 | 4.5 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
0.0 | 4.5 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.2 | 4.3 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
0.1 | 2.6 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
0.1 | 2.5 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.1 | 2.5 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
0.1 | 2.1 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.1 | 2.0 | REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE | Genes involved in Early Phase of HIV Life Cycle |
0.0 | 2.0 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
0.1 | 1.9 | REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE | Genes involved in GPVI-mediated activation cascade |
0.4 | 1.8 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
0.1 | 1.8 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
0.1 | 1.8 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
0.1 | 1.8 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
0.1 | 1.8 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
0.0 | 1.8 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
0.0 | 1.7 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
0.0 | 1.7 | REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |