Motif ID: Foxp2_Foxp3

Z-value: 0.669

Transcription factors associated with Foxp2_Foxp3:

Gene SymbolEntrez IDGene Name
Foxp2 ENSMUSG00000029563.10 Foxp2
Foxp3 ENSMUSG00000039521.6 Foxp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxp2mm10_v2_chr6_+_14901440_14901497-0.161.7e-01Click!
Foxp3mm10_v2_chrX_+_7579666_7579693-0.037.8e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Foxp2_Foxp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_66386292 11.099 ENSMUST00000039540.5
ENSMUST00000110253.2
March1

membrane-associated ring finger (C3HC4) 1

chr15_+_3270767 6.870 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
Sepp1



selenoprotein P, plasma, 1



chr4_+_144892813 6.081 ENSMUST00000105744.1
ENSMUST00000171001.1
Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr16_-_22439719 6.059 ENSMUST00000079601.6
Etv5
ets variant gene 5
chr6_+_30541582 5.236 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr4_+_144893077 4.874 ENSMUST00000154208.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr6_+_141524379 4.846 ENSMUST00000032362.9
Slco1c1
solute carrier organic anion transporter family, member 1c1
chr18_+_69344503 4.828 ENSMUST00000114985.3
Tcf4
transcription factor 4
chr4_+_144893127 4.387 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr16_-_22439570 3.712 ENSMUST00000170393.1
Etv5
ets variant gene 5
chr4_-_14621805 3.614 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr10_+_60106452 3.488 ENSMUST00000165024.2
Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr1_+_51289106 3.486 ENSMUST00000051572.6
Sdpr
serum deprivation response
chr9_-_77251829 3.473 ENSMUST00000184322.1
ENSMUST00000184316.1
Mlip

muscular LMNA-interacting protein

chr6_-_148444336 3.258 ENSMUST00000060095.8
ENSMUST00000100772.3
Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr8_-_46294592 3.156 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr9_-_77347816 3.122 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
Mlip



muscular LMNA-interacting protein



chr17_+_70522083 3.051 ENSMUST00000148486.1
ENSMUST00000133717.1
Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr19_+_23141183 3.040 ENSMUST00000036884.1
Klf9
Kruppel-like factor 9
chr17_+_70561739 3.011 ENSMUST00000097288.2
Dlgap1
discs, large (Drosophila) homolog-associated protein 1

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 212 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 15.3 GO:0042572 retinol metabolic process(GO:0042572)
0.4 14.1 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.6 11.1 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
2.0 9.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.6 8.4 GO:0070842 aggresome assembly(GO:0070842)
2.2 6.5 GO:0099547 regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254)
0.6 6.3 GO:0042118 endothelial cell activation(GO:0042118)
0.5 5.8 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.7 5.1 GO:0019532 oxalate transport(GO:0019532)
0.3 5.1 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.5 5.0 GO:0015721 bile acid and bile salt transport(GO:0015721)
1.0 4.1 GO:0002069 columnar/cuboidal epithelial cell maturation(GO:0002069)
1.3 4.0 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 4.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 3.7 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.4 3.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 3.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 3.4 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.2 3.2 GO:0001967 suckling behavior(GO:0001967)
0.8 3.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.3 GO:0016605 PML body(GO:0016605)
0.3 11.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 7.1 GO:0045211 postsynaptic membrane(GO:0045211)
1.6 6.5 GO:1902737 viral replication complex(GO:0019034) dendritic filopodium(GO:1902737)
0.1 5.0 GO:0009925 basal plasma membrane(GO:0009925)
0.9 4.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 4.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 3.9 GO:0035861 site of double-strand break(GO:0035861)
0.0 3.8 GO:0016363 nuclear matrix(GO:0016363)
0.0 3.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.6 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.3 3.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.6 2.5 GO:0044307 dendritic branch(GO:0044307)
0.2 2.5 GO:1990635 proximal dendrite(GO:1990635)
0.0 2.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 2.4 GO:0045171 intercellular bridge(GO:0045171)
0.1 2.3 GO:0071564 npBAF complex(GO:0071564)
0.7 2.2 GO:0098855 HCN channel complex(GO:0098855)
0.0 2.1 GO:0032993 protein-DNA complex(GO:0032993)
0.2 1.9 GO:0032300 mismatch repair complex(GO:0032300)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 15.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 11.0 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.4 10.6 GO:0042287 MHC protein binding(GO:0042287)
0.9 6.5 GO:0033592 RNA strand annealing activity(GO:0033592)
1.6 6.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 5.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.5 5.1 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
1.2 4.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 4.4 GO:0005509 calcium ion binding(GO:0005509)
0.1 4.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 4.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 3.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 3.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 3.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 2.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 2.9 GO:0003823 antigen binding(GO:0003823)
0.9 2.8 GO:0003796 lysozyme activity(GO:0003796)
0.1 2.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.7 2.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 2.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 12.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 10.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 7.2 PID_FOXO_PATHWAY FoxO family signaling
0.1 6.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 5.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 5.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 5.5 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 4.2 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 3.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 3.8 PID_IL3_PATHWAY IL3-mediated signaling events
0.1 3.3 PID_SHP2_PATHWAY SHP2 signaling
0.0 3.2 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.9 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 2.8 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 2.3 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 2.0 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 1.8 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 1.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.7 PID_P53_REGULATION_PATHWAY p53 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.6 4.8 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.2 4.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 4.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 4.3 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 2.6 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 2.5 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 2.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 2.1 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.0 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle
0.0 2.0 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 1.9 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.4 1.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.8 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 1.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 1.8 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 1.8 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 1.8 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.7 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription