Motif ID: Foxp2_Foxp3
Z-value: 0.669
Transcription factors associated with Foxp2_Foxp3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Foxp2 | ENSMUSG00000029563.10 | Foxp2 |
| Foxp3 | ENSMUSG00000039521.6 | Foxp3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxp2 | mm10_v2_chr6_+_14901440_14901497 | -0.16 | 1.7e-01 | Click! |
| Foxp3 | mm10_v2_chrX_+_7579666_7579693 | -0.03 | 7.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.5 | GO:0099547 | regulation of translation at synapse, modulating synaptic transmission(GO:0099547) regulation of translation at postsynapse, modulating synaptic transmission(GO:0099578) positive regulation of intracellular transport of viral material(GO:1901254) |
| 2.0 | 9.8 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 1.4 | 15.3 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 1.3 | 4.0 | GO:0032915 | positive regulation of transforming growth factor beta2 production(GO:0032915) |
| 1.0 | 4.1 | GO:0002069 | columnar/cuboidal epithelial cell maturation(GO:0002069) |
| 0.9 | 2.8 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.8 | 2.5 | GO:0070343 | white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) |
| 0.8 | 3.1 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.8 | 1.5 | GO:0032650 | regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) |
| 0.7 | 5.1 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.7 | 2.8 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 0.6 | 8.4 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.6 | 3.0 | GO:0050847 | progesterone receptor signaling pathway(GO:0050847) |
| 0.6 | 1.8 | GO:0090425 | hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
| 0.6 | 1.8 | GO:0090403 | oxidative stress-induced premature senescence(GO:0090403) |
| 0.6 | 11.1 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.6 | 6.3 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.5 | 1.6 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.5 | 5.8 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.5 | 1.6 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.5 | 2.0 | GO:0035470 | positive regulation of vascular wound healing(GO:0035470) |
| 0.5 | 1.5 | GO:0043379 | rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) |
| 0.5 | 5.0 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.4 | 2.2 | GO:0070305 | response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321) |
| 0.4 | 2.1 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.4 | 1.3 | GO:0002159 | desmosome assembly(GO:0002159) |
| 0.4 | 1.2 | GO:0014877 | response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.4 | 3.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.4 | 3.1 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.4 | 1.9 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.4 | 1.1 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.4 | 14.1 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.4 | 1.8 | GO:0042636 | negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279) |
| 0.3 | 5.1 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
| 0.3 | 1.7 | GO:0046684 | response to pyrethroid(GO:0046684) |
| 0.3 | 1.3 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155) |
| 0.3 | 1.3 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
| 0.3 | 1.6 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.3 | 3.4 | GO:1901621 | negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621) |
| 0.3 | 0.9 | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape(GO:0071963) |
| 0.3 | 1.8 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.3 | 1.7 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.3 | 0.9 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.3 | 2.2 | GO:2000973 | regulation of pro-B cell differentiation(GO:2000973) |
| 0.3 | 0.8 | GO:1902524 | interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 0.3 | 2.2 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.3 | 1.9 | GO:0007144 | female meiosis I(GO:0007144) |
| 0.3 | 2.7 | GO:0097421 | liver regeneration(GO:0097421) |
| 0.3 | 0.8 | GO:0090327 | negative regulation of locomotion involved in locomotory behavior(GO:0090327) |
| 0.3 | 0.8 | GO:0050925 | negative regulation of negative chemotaxis(GO:0050925) |
| 0.3 | 1.8 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.3 | 1.3 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.3 | 2.3 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.2 | 2.7 | GO:0071455 | cellular response to hyperoxia(GO:0071455) |
| 0.2 | 3.7 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.2 | 1.7 | GO:0060137 | maternal process involved in parturition(GO:0060137) |
| 0.2 | 1.2 | GO:0032346 | positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) |
| 0.2 | 0.2 | GO:0010616 | negative regulation of cardiac muscle adaptation(GO:0010616) |
| 0.2 | 0.5 | GO:0010838 | positive regulation of keratinocyte proliferation(GO:0010838) |
| 0.2 | 0.4 | GO:1902263 | apoptotic process involved in embryonic digit morphogenesis(GO:1902263) |
| 0.2 | 1.1 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 0.2 | 1.7 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.2 | 1.7 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
| 0.2 | 2.5 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.2 | 0.6 | GO:1903244 | regulation of cardiac muscle adaptation(GO:0010612) positive regulation of cardiac muscle adaptation(GO:0010615) regulation of cardiac muscle hypertrophy in response to stress(GO:1903242) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203) |
| 0.2 | 1.6 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.2 | 1.2 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.2 | 1.2 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.2 | 0.4 | GO:0060913 | cardiac cell fate determination(GO:0060913) regulation of cardiac cell fate specification(GO:2000043) |
| 0.2 | 1.1 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.2 | 0.7 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis(GO:0051088) |
| 0.2 | 0.4 | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity(GO:2000481) |
| 0.2 | 1.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.2 | 0.5 | GO:0021972 | cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) corticospinal neuron axon guidance(GO:0021966) corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
| 0.2 | 0.7 | GO:0050904 | diapedesis(GO:0050904) |
| 0.2 | 0.7 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
| 0.2 | 0.9 | GO:0008355 | olfactory learning(GO:0008355) |
| 0.2 | 1.4 | GO:0098967 | exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967) |
| 0.2 | 1.0 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.2 | 0.5 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.2 | 1.3 | GO:0002681 | somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153) |
| 0.2 | 3.2 | GO:0001967 | suckling behavior(GO:0001967) |
| 0.2 | 0.5 | GO:1903054 | negative regulation of extracellular matrix organization(GO:1903054) |
| 0.2 | 0.5 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 0.1 | 2.5 | GO:0007194 | negative regulation of adenylate cyclase activity(GO:0007194) |
| 0.1 | 0.4 | GO:0070543 | response to linoleic acid(GO:0070543) |
| 0.1 | 0.7 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.1 | 0.7 | GO:2001015 | negative regulation of skeletal muscle cell differentiation(GO:2001015) |
| 0.1 | 4.0 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 0.4 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.1 | 2.4 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.1 | 2.6 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.1 | 0.5 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.1 | 0.9 | GO:1903025 | regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025) |
| 0.1 | 1.6 | GO:2001014 | regulation of skeletal muscle cell differentiation(GO:2001014) |
| 0.1 | 0.6 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.1 | 1.0 | GO:0098707 | ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
| 0.1 | 0.4 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.1 | 1.0 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.1 | 0.6 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.1 | 1.2 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.1 | 2.6 | GO:0019835 | cytolysis(GO:0019835) |
| 0.1 | 1.1 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.1 | 1.7 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.1 | 0.8 | GO:0007343 | egg activation(GO:0007343) |
| 0.1 | 0.8 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.1 | 0.2 | GO:0009826 | unidimensional cell growth(GO:0009826) |
| 0.1 | 1.2 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.1 | 1.8 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
| 0.1 | 0.8 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 1.1 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.1 | 0.4 | GO:0033580 | protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125) |
| 0.1 | 1.8 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.1 | 0.8 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.1 | 0.4 | GO:0010957 | negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) regulation of cell differentiation involved in embryonic placenta development(GO:0060800) Notch signaling involved in heart development(GO:0061314) |
| 0.1 | 1.0 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.1 | 1.9 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.1 | 0.9 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.1 | 0.3 | GO:2000858 | mineralocorticoid secretion(GO:0035931) aldosterone secretion(GO:0035932) regulation of mineralocorticoid secretion(GO:2000855) positive regulation of mineralocorticoid secretion(GO:2000857) regulation of aldosterone secretion(GO:2000858) positive regulation of aldosterone secretion(GO:2000860) |
| 0.1 | 0.3 | GO:1902310 | positive regulation of peptidyl-serine dephosphorylation(GO:1902310) |
| 0.1 | 0.1 | GO:0090194 | negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) negative regulation of cell proliferation involved in kidney development(GO:1901723) |
| 0.1 | 0.3 | GO:1903538 | meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
| 0.1 | 0.5 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.1 | 0.5 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.1 | 0.4 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.1 | 0.5 | GO:0071630 | nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630) |
| 0.1 | 2.7 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.1 | 0.1 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
| 0.1 | 0.9 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 0.2 | GO:0045575 | basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575) |
| 0.1 | 3.0 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.1 | 1.5 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.1 | 0.3 | GO:0035461 | vitamin transmembrane transport(GO:0035461) |
| 0.1 | 0.4 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.1 | 0.3 | GO:0006048 | glucosamine metabolic process(GO:0006041) UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.1 | 0.6 | GO:0072498 | embryonic skeletal joint development(GO:0072498) |
| 0.1 | 0.5 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.1 | 0.9 | GO:0015809 | arginine transport(GO:0015809) |
| 0.1 | 0.7 | GO:0060136 | embryonic process involved in female pregnancy(GO:0060136) |
| 0.1 | 1.4 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.1 | 0.6 | GO:0003214 | cardiac left ventricle morphogenesis(GO:0003214) |
| 0.1 | 0.4 | GO:0090267 | positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) |
| 0.1 | 1.4 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.1 | 0.2 | GO:0071034 | CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051) |
| 0.1 | 0.5 | GO:0034776 | response to histamine(GO:0034776) cellular response to histamine(GO:0071420) |
| 0.1 | 0.2 | GO:0010920 | negative regulation of inositol phosphate biosynthetic process(GO:0010920) |
| 0.1 | 0.3 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 0.1 | 1.0 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.1 | 2.6 | GO:0046326 | positive regulation of glucose import(GO:0046326) |
| 0.1 | 0.8 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.1 | 0.2 | GO:0015886 | heme transport(GO:0015886) |
| 0.1 | 0.6 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 0.2 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.0 | 1.8 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.0 | 0.8 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 1.8 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 1.0 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 0.4 | GO:0070664 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of T cell proliferation(GO:0042130) negative regulation of lymphocyte proliferation(GO:0050672) negative regulation of leukocyte proliferation(GO:0070664) |
| 0.0 | 0.4 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.0 | 0.2 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.0 | 2.1 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.5 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.0 | 1.2 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 0.4 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.0 | 3.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.2 | GO:0031022 | nuclear migration along microfilament(GO:0031022) |
| 0.0 | 0.1 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 0.0 | 1.2 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 0.0 | 0.3 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.0 | 0.1 | GO:0035526 | retrograde transport, plasma membrane to Golgi(GO:0035526) |
| 0.0 | 1.0 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.0 | 0.6 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.0 | 0.1 | GO:0030449 | regulation of complement activation(GO:0030449) negative regulation of complement activation(GO:0045916) regulation of protein activation cascade(GO:2000257) negative regulation of protein activation cascade(GO:2000258) |
| 0.0 | 0.1 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.0 | 0.7 | GO:0002931 | response to ischemia(GO:0002931) |
| 0.0 | 0.2 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.0 | 0.2 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.0 | 0.3 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
| 0.0 | 0.3 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.0 | 0.6 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.0 | 0.1 | GO:0045915 | positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964) |
| 0.0 | 0.9 | GO:0007129 | synapsis(GO:0007129) |
| 0.0 | 0.1 | GO:0016188 | synaptic vesicle maturation(GO:0016188) |
| 0.0 | 0.4 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
| 0.0 | 0.2 | GO:0016560 | protein import into peroxisome matrix, docking(GO:0016560) |
| 0.0 | 0.4 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.0 | 0.4 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.0 | 0.2 | GO:0072321 | chaperone-mediated protein transport(GO:0072321) |
| 0.0 | 1.6 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.0 | 0.2 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 0.0 | 0.3 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.0 | 0.2 | GO:0002693 | positive regulation of cellular extravasation(GO:0002693) |
| 0.0 | 0.1 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.0 | 0.1 | GO:0045925 | positive regulation of female receptivity(GO:0045925) |
| 0.0 | 0.1 | GO:0042126 | nitrate metabolic process(GO:0042126) |
| 0.0 | 0.6 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.7 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.2 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.0 | 1.2 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 0.0 | 0.0 | GO:0060854 | patterning of lymph vessels(GO:0060854) |
| 0.0 | 0.1 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 0.0 | 0.2 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.0 | 0.9 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.0 | 0.3 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.0 | 0.1 | GO:0071472 | hypotonic response(GO:0006971) cellular response to salt stress(GO:0071472) cellular hypotonic response(GO:0071476) |
| 0.0 | 0.1 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.0 | 0.0 | GO:0046101 | hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101) |
| 0.0 | 0.2 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.0 | 0.4 | GO:0060612 | adipose tissue development(GO:0060612) |
| 0.0 | 0.0 | GO:1902219 | regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
| 0.0 | 0.3 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.0 | 0.1 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.5 | GO:1902737 | viral replication complex(GO:0019034) dendritic filopodium(GO:1902737) |
| 0.9 | 4.6 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.7 | 2.2 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.6 | 2.5 | GO:0044307 | dendritic branch(GO:0044307) |
| 0.6 | 1.8 | GO:0043512 | inhibin A complex(GO:0043512) |
| 0.5 | 1.5 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.5 | 1.4 | GO:0098835 | presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) |
| 0.4 | 1.4 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.3 | 11.2 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.3 | 0.9 | GO:0097135 | cyclin E2-CDK2 complex(GO:0097135) |
| 0.3 | 1.2 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.3 | 0.9 | GO:0016939 | kinesin II complex(GO:0016939) |
| 0.3 | 1.1 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.3 | 3.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 1.0 | GO:0031673 | H zone(GO:0031673) |
| 0.2 | 1.8 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.2 | 1.9 | GO:0032300 | mismatch repair complex(GO:0032300) |
| 0.2 | 1.8 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.2 | 2.5 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.2 | 1.1 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.2 | 1.0 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
| 0.2 | 0.5 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.2 | 0.8 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.1 | 1.3 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.1 | 3.9 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 15.3 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 1.4 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.1 | 1.5 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.1 | 1.3 | GO:0071664 | catenin-TCF7L2 complex(GO:0071664) |
| 0.1 | 1.0 | GO:0097433 | dense body(GO:0097433) |
| 0.1 | 0.4 | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) |
| 0.1 | 2.3 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 1.8 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.7 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 1.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 0.6 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 1.5 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.1 | 0.7 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 1.6 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 0.4 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 0.2 | GO:0034657 | GID complex(GO:0034657) |
| 0.1 | 0.4 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.1 | 5.0 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 1.3 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 1.1 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 0.6 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.1 | 0.9 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.1 | 0.7 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 0.4 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.0 | 0.2 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.0 | 0.8 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 2.4 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 2.4 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.7 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.0 | 0.5 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.0 | 3.6 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 1.0 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 0.3 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.0 | 0.2 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.0 | 0.4 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 3.8 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.2 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 0.2 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.0 | 1.7 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.0 | 1.7 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 0.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.3 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.0 | 0.5 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 0.7 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.1 | GO:0030314 | junctional membrane complex(GO:0030314) |
| 0.0 | 0.2 | GO:0051286 | cell tip(GO:0051286) |
| 0.0 | 0.3 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.0 | 0.7 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 4.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.6 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 1.1 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.0 | 0.4 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
| 0.0 | 7.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 0.4 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.7 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 0.2 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.0 | 3.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.2 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.0 | 0.1 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.0 | 0.5 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.3 | GO:0098878 | ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878) |
| 0.0 | 1.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.6 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.0 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.0 | 1.9 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 1.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 0.3 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 0.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 0.3 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.5 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 2.1 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 0.7 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.7 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 0.1 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.0 | 1.7 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.0 | 1.0 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 0.4 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 15.3 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 1.6 | 6.3 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.2 | 4.8 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.9 | 2.8 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.9 | 6.5 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.7 | 2.0 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.7 | 2.6 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.6 | 2.2 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.5 | 2.4 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.5 | 1.9 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.5 | 5.1 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 0.4 | 1.3 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.4 | 1.8 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 0.4 | 10.6 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.4 | 1.7 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.4 | 3.9 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.3 | 2.0 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.3 | 1.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.3 | 5.2 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.3 | 1.4 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.3 | 1.1 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.3 | 0.8 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.3 | 1.8 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.3 | 1.5 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.2 | 0.7 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.2 | 1.4 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.2 | 1.8 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.2 | 2.2 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 1.6 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.2 | 0.6 | GO:0035500 | MH2 domain binding(GO:0035500) |
| 0.2 | 1.6 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.2 | 1.6 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.2 | 0.6 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.2 | 1.7 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.2 | 1.1 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.2 | 1.8 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.2 | 1.6 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.2 | 1.1 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.2 | 1.3 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
| 0.2 | 2.0 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.2 | 1.5 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.2 | 0.5 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.2 | 0.5 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.2 | 0.5 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.1 | 0.9 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.1 | 0.4 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.1 | 0.9 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.1 | 1.0 | GO:0015091 | ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510) |
| 0.1 | 0.5 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 0.1 | 2.9 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.1 | 1.6 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 0.9 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.1 | 2.4 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 1.6 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 3.5 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 1.7 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 0.6 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.1 | 0.5 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 0.4 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.1 | 1.1 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 4.0 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.1 | 1.3 | GO:0004300 | enoyl-CoA hydratase activity(GO:0004300) |
| 0.1 | 1.3 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.1 | 0.3 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
| 0.1 | 2.6 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.1 | 1.2 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 11.0 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.1 | 1.8 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.1 | 0.6 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.1 | 2.8 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 0.4 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.1 | 0.2 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.1 | 0.2 | GO:0035651 | AP-3 adaptor complex binding(GO:0035651) |
| 0.1 | 0.4 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.1 | 1.5 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 0.4 | GO:0047276 | N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276) |
| 0.1 | 3.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 0.5 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.1 | 0.9 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.1 | 0.6 | GO:0001846 | opsonin binding(GO:0001846) |
| 0.1 | 0.4 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995) |
| 0.1 | 0.6 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 2.0 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.1 | 1.1 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 2.6 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.1 | 0.5 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 0.2 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.1 | 0.8 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.1 | 0.6 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.0 | 0.4 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 0.0 | 1.2 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 4.0 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 2.3 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 0.6 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 2.9 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 0.4 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.0 | 0.2 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 0.3 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 1.3 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.5 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.3 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.0 | 1.0 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.8 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.6 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 1.4 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 0.5 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 1.4 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 0.2 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.0 | 0.8 | GO:0031690 | adrenergic receptor binding(GO:0031690) |
| 0.0 | 0.4 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 2.4 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 0.5 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 0.3 | GO:0090482 | vitamin transmembrane transporter activity(GO:0090482) |
| 0.0 | 1.6 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 0.2 | GO:0016428 | tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) |
| 0.0 | 0.1 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 0.4 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 0.1 | GO:0003963 | RNA-3'-phosphate cyclase activity(GO:0003963) |
| 0.0 | 0.9 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 1.4 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.2 | GO:0008376 | acetylgalactosaminyltransferase activity(GO:0008376) |
| 0.0 | 0.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.2 | GO:0015093 | ferrous iron transmembrane transporter activity(GO:0015093) |
| 0.0 | 0.1 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.0 | 0.7 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.7 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.0 | 0.4 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.0 | 1.3 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.6 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.4 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.7 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062) |
| 0.0 | 1.3 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 2.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.1 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.0 | 0.3 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.0 | 0.1 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 0.1 | GO:0038049 | glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.0 | 0.1 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 1.3 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.1 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.0 | 2.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 0.1 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 4.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.2 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.2 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 0.5 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 12.9 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 3.9 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.2 | 5.6 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 7.2 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.1 | 2.4 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.1 | 5.5 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 1.8 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.1 | 3.8 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.1 | 1.8 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 2.9 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.1 | 3.3 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.1 | 4.2 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 1.5 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.1 | 6.0 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 3.2 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 2.8 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 2.0 | PID_ENDOTHELIN_PATHWAY | Endothelins |
| 0.0 | 1.0 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.6 | PID_ILK_PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 5.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.7 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 1.7 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.5 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.2 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 2.3 | PID_CMYB_PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.8 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.2 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.7 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.0 | 1.3 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 0.9 | PID_P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.5 | PID_INTEGRIN1_PATHWAY | Beta1 integrin cell surface interactions |
| 0.0 | 0.3 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.2 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.2 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.0 | 0.3 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
| 0.0 | 0.5 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.8 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
| 0.4 | 1.8 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.2 | 4.5 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 1.4 | REACTOME_THE_NLRP3_INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 4.3 | REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 4.9 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.6 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 1.1 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.1 | 1.8 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.1 | 2.5 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.1 | 0.5 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 2.1 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 0.6 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.1 | 2.0 | REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE | Genes involved in Early Phase of HIV Life Cycle |
| 0.1 | 1.2 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.1 | 2.5 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 1.2 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 1.8 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 1.2 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 1.1 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.1 | 0.5 | REACTOME_IL_7_SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 1.9 | REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.1 | 1.8 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.1 | 1.1 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 0.7 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.1 | 1.0 | REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN | Genes involved in Signalling to p38 via RIT and RIN |
| 0.1 | 0.6 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 2.6 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 1.0 | REACTOME_SIGNALING_BY_NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.1 | 1.2 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 1.6 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 1.3 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 1.8 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 0.7 | REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.0 | 0.5 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.0 | 0.7 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 4.5 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.4 | REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.0 | 0.8 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 1.7 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.2 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.4 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.5 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 2.0 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.5 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.3 | REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH | Genes involved in NCAM signaling for neurite out-growth |
| 0.0 | 0.5 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.3 | REACTOME_GAP_JUNCTION_TRAFFICKING | Genes involved in Gap junction trafficking |
| 0.0 | 1.8 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.7 | REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.4 | REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 1.4 | REACTOME_NEURONAL_SYSTEM | Genes involved in Neuronal System |
| 0.0 | 0.4 | REACTOME_REGULATORY_RNA_PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.0 | 0.7 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 0.1 | REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ | Genes involved in Cyclin E associated events during G1/S transition |
| 0.0 | 0.2 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 0.9 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.9 | REACTOME_DNA_REPAIR | Genes involved in DNA Repair |
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