Motif ID: Foxq1

Z-value: 1.114


Transcription factors associated with Foxq1:

Gene SymbolEntrez IDGene Name
Foxq1 ENSMUSG00000038415.8 Foxq1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxq1mm10_v2_chr13_+_31558157_315581760.243.4e-02Click!


Activity profile for motif Foxq1.

activity profile for motif Foxq1


Sorted Z-values histogram for motif Foxq1

Sorted Z-values for motif Foxq1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxq1

PNG image of the network

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Top targets:


Showing 1 to 20 of 136 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_103483205 18.764 ENSMUST00000127786.2
 Xist
inactive X specific transcripts
chr2_-_77519565 17.867 ENSMUST00000111830.2
 Zfp385b
zinc finger protein 385B
chr14_-_30353468 15.332 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr16_+_43363855 12.079 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr2_+_76406529 11.190 ENSMUST00000111929.1
ENSMUST00000077972.4
ENSMUST00000111930.2
 Osbpl6


oxysterol binding protein-like 6


chr18_+_51117754 10.258 ENSMUST00000116639.2
 Prr16
proline rich 16
chr16_+_43364145 9.784 ENSMUST00000148775.1
 Zbtb20
zinc finger and BTB domain containing 20
chr8_-_84773381 9.783 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr5_+_122643878 9.365 ENSMUST00000100737.3
ENSMUST00000121489.1
ENSMUST00000031425.8
ENSMUST00000086247.5
 P2rx7



purinergic receptor P2X, ligand-gated ion channel, 7



chr18_-_89769479 9.174 ENSMUST00000097495.3
 Dok6
docking protein 6
chr18_+_37442517 9.041 ENSMUST00000056915.1
 Pcdhb13
protocadherin beta 13
chr11_+_16257706 8.892 ENSMUST00000109645.2
ENSMUST00000109647.2
 Vstm2a

V-set and transmembrane domain containing 2A

chr17_+_35076902 8.843 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr18_+_37496997 8.780 ENSMUST00000059571.5
 Pcdhb19
protocadherin beta 19
chr1_+_51289106 7.818 ENSMUST00000051572.6
 Sdpr
serum deprivation response
chr18_+_69344503 7.711 ENSMUST00000114985.3
 Tcf4
transcription factor 4
chr5_-_122002340 7.435 ENSMUST00000134326.1
 Cux2
cut-like homeobox 2
chr18_+_37518341 7.082 ENSMUST00000097609.1
 Pcdhb22
protocadherin beta 22
chr10_+_60106452 7.056 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr18_+_37489465 6.941 ENSMUST00000055949.2
 Pcdhb18
protocadherin beta 18

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 37.8 GO:0007416 synapse assembly(GO:0007416)
0.5 21.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
6.3 18.8 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.2 17.9 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.5 15.7 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
3.8 15.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
1.3 11.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 11.7 GO:0006869 lipid transport(GO:0006869)
0.7 10.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.4 10.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.7 9.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 9.5 GO:0007614 short-term memory(GO:0007614)
3.1 9.4 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) interleukin-1 alpha secretion(GO:0050703) regulation of bleb assembly(GO:1904170)
3.0 8.9 GO:0070343 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.7 7.7 GO:0042118 endothelial cell activation(GO:0042118)
1.0 6.7 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.8 6.7 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 6.5 GO:0043087 regulation of GTPase activity(GO:0043087)
2.0 6.0 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 5.5 GO:0008210 estrogen metabolic process(GO:0008210)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 43.9 GO:0005887 integral component of plasma membrane(GO:0005887)
1.9 18.8 GO:0000805 X chromosome(GO:0000805)
0.1 18.0 GO:0001650 fibrillar center(GO:0001650)
1.5 15.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 13.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.4 11.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 10.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.5 10.0 GO:0098644 complex of collagen trimers(GO:0098644)
0.6 9.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 7.7 GO:0032993 protein-DNA complex(GO:0032993)
0.1 6.7 GO:0072686 mitotic spindle(GO:0072686)
0.0 6.4 GO:0031965 nuclear membrane(GO:0031965)
0.5 6.0 GO:0044327 dendritic spine head(GO:0044327)
0.1 5.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 4.9 GO:0031012 extracellular matrix(GO:0031012)
0.3 3.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 3.7 GO:1990635 proximal dendrite(GO:1990635)
0.0 3.0 GO:0055037 recycling endosome(GO:0055037)
0.1 2.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 2.3 GO:0009897 external side of plasma membrane(GO:0009897)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 30.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 18.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.2 16.9 GO:0002039 p53 binding(GO:0002039)
1.9 15.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
4.6 13.8 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.0 13.0 GO:0005509 calcium ion binding(GO:0005509)
0.2 11.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 10.4 GO:0008289 lipid binding(GO:0008289)
1.6 9.4 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
1.9 7.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.7 6.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 6.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.4 5.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 5.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 5.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 4.4 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
1.4 4.3 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 4.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 4.2 GO:0003823 antigen binding(GO:0003823)
0.4 3.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 11.4 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 6.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 5.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 5.0 PID_FOXO_PATHWAY FoxO family signaling
0.1 3.9 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 1.9 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 1.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.3 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 9.4 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 7.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.5 7.5 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 5.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 3.9 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 3.7 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.1 3.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 3.0 REACTOME_SIGNALLING_BY_NGF Genes involved in Signalling by NGF
0.2 2.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 2.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 2.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.9 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.9 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 1.7 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.1 1.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 1.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.9 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type