Motif ID: Foxq1

Z-value: 1.114


Transcription factors associated with Foxq1:

Gene SymbolEntrez IDGene Name
Foxq1 ENSMUSG00000038415.8 Foxq1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxq1mm10_v2_chr13_+_31558157_315581760.243.4e-02Click!


Activity profile for motif Foxq1.

activity profile for motif Foxq1


Sorted Z-values histogram for motif Foxq1

Sorted Z-values for motif Foxq1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxq1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_103483205 18.764 ENSMUST00000127786.2
Xist
inactive X specific transcripts
chr2_-_77519565 17.867 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr14_-_30353468 15.332 ENSMUST00000112249.1
Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr16_+_43363855 12.079 ENSMUST00000156367.1
Zbtb20
zinc finger and BTB domain containing 20
chr2_+_76406529 11.190 ENSMUST00000111929.1
ENSMUST00000077972.4
ENSMUST00000111930.2
Osbpl6


oxysterol binding protein-like 6


chr18_+_51117754 10.258 ENSMUST00000116639.2
Prr16
proline rich 16
chr16_+_43364145 9.784 ENSMUST00000148775.1
Zbtb20
zinc finger and BTB domain containing 20
chr8_-_84773381 9.783 ENSMUST00000109764.1
Nfix
nuclear factor I/X
chr5_+_122643878 9.365 ENSMUST00000100737.3
ENSMUST00000121489.1
ENSMUST00000031425.8
ENSMUST00000086247.5
P2rx7



purinergic receptor P2X, ligand-gated ion channel, 7



chr18_-_89769479 9.174 ENSMUST00000097495.3
Dok6
docking protein 6
chr18_+_37442517 9.041 ENSMUST00000056915.1
Pcdhb13
protocadherin beta 13
chr11_+_16257706 8.892 ENSMUST00000109645.2
ENSMUST00000109647.2
Vstm2a

V-set and transmembrane domain containing 2A

chr17_+_35076902 8.843 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr18_+_37496997 8.780 ENSMUST00000059571.5
Pcdhb19
protocadherin beta 19
chr1_+_51289106 7.818 ENSMUST00000051572.6
Sdpr
serum deprivation response
chr18_+_69344503 7.711 ENSMUST00000114985.3
Tcf4
transcription factor 4
chr5_-_122002340 7.435 ENSMUST00000134326.1
Cux2
cut-like homeobox 2
chr18_+_37518341 7.082 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chr10_+_60106452 7.056 ENSMUST00000165024.2
Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr18_+_37489465 6.941 ENSMUST00000055949.2
Pcdhb18
protocadherin beta 18
chr7_+_19176416 6.680 ENSMUST00000117338.1
Eml2
echinoderm microtubule associated protein like 2
chr1_-_170110491 6.667 ENSMUST00000027985.2
Ddr2
discoidin domain receptor family, member 2
chr18_+_37477768 6.138 ENSMUST00000051442.5
Pcdhb16
protocadherin beta 16
chr18_+_37447641 6.041 ENSMUST00000052387.3
Pcdhb14
protocadherin beta 14
chr4_-_129121889 6.023 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
Hpca


hippocalcin


chr3_+_68584154 5.540 ENSMUST00000182997.1
Schip1
schwannomin interacting protein 1
chr1_+_45311538 5.326 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chr4_-_87806276 5.295 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr3_+_7366598 5.234 ENSMUST00000028999.6
Pkia
protein kinase inhibitor, alpha
chr4_-_87806296 5.121 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr15_-_58214882 4.992 ENSMUST00000022986.6
Fbxo32
F-box protein 32
chr18_+_57468478 4.977 ENSMUST00000091892.2
Ctxn3
cortexin 3
chr17_+_35077080 4.953 ENSMUST00000172959.1
Ly6g6e
lymphocyte antigen 6 complex, locus G6E
chr10_+_97479470 4.710 ENSMUST00000105287.3
Dcn
decorin
chr19_-_43674844 4.398 ENSMUST00000046038.7
Slc25a28
solute carrier family 25, member 28
chr19_-_28963863 4.390 ENSMUST00000161813.1
4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr14_-_103844173 4.312 ENSMUST00000022718.3
Ednrb
endothelin receptor type B
chr7_+_141476374 4.232 ENSMUST00000117634.1
Tspan4
tetraspanin 4
chr3_-_146781351 3.924 ENSMUST00000005164.7
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr2_+_120977017 3.771 ENSMUST00000067582.7
Tmem62
transmembrane protein 62
chr11_-_54860564 3.736 ENSMUST00000144164.1
Lyrm7
LYR motif containing 7
chr7_+_110772604 3.677 ENSMUST00000005829.6
Ampd3
adenosine monophosphate deaminase 3
chr3_+_129532386 3.594 ENSMUST00000071402.2
Elovl6
ELOVL family member 6, elongation of long chain fatty acids (yeast)
chr15_-_89196457 3.361 ENSMUST00000078953.7
Dennd6b
DENN/MADD domain containing 6B
chr3_+_145987835 3.095 ENSMUST00000039517.6
Syde2
synapse defective 1, Rho GTPase, homolog 2 (C. elegans)
chr13_-_21453714 3.091 ENSMUST00000032820.7
ENSMUST00000110485.1
Zscan26

zinc finger and SCAN domain containing 26

chr9_-_112187766 3.062 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr19_-_17837620 3.038 ENSMUST00000025618.8
ENSMUST00000050715.8
Pcsk5

proprotein convertase subtilisin/kexin type 5

chr16_+_91391721 2.996 ENSMUST00000160764.1
Gm21970
predicted gene 21970
chr7_+_24134148 2.847 ENSMUST00000056549.7
Zfp235
zinc finger protein 235
chr15_-_97247287 2.846 ENSMUST00000053106.5
Amigo2
adhesion molecule with Ig like domain 2
chrX_-_70365052 2.814 ENSMUST00000101509.2
Ids
iduronate 2-sulfatase
chr19_-_36919606 2.793 ENSMUST00000057337.7
Fgfbp3
fibroblast growth factor binding protein 3
chr5_-_123140135 2.772 ENSMUST00000160099.1
AI480526
expressed sequence AI480526
chr2_+_91256144 2.719 ENSMUST00000154959.1
ENSMUST00000059566.4
Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr7_+_45783883 2.682 ENSMUST00000072580.5
Lmtk3
lemur tyrosine kinase 3
chr13_-_67637776 2.628 ENSMUST00000012314.8
A530054K11Rik
RIKEN cDNA A530054K11 gene
chr3_+_135825648 2.480 ENSMUST00000180196.1
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr19_-_56822161 2.430 ENSMUST00000118592.1
A630007B06Rik
RIKEN cDNA A630007B06 gene
chr10_+_34297421 2.405 ENSMUST00000047935.6
Tspyl4
TSPY-like 4
chr7_+_120917744 2.388 ENSMUST00000033173.7
ENSMUST00000106483.2
Polr3e

polymerase (RNA) III (DNA directed) polypeptide E

chr7_-_100932140 2.345 ENSMUST00000107032.1
Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr14_-_36935560 2.328 ENSMUST00000183038.1
Ccser2
coiled-coil serine rich 2
chr13_-_67061131 2.324 ENSMUST00000167565.1
Zfp712
zinc finger protein 712
chr1_-_195131536 2.323 ENSMUST00000075451.6
Cr1l
complement component (3b/4b) receptor 1-like
chr1_-_6215292 2.307 ENSMUST00000097832.1
4732440D04Rik
RIKEN cDNA 4732440D04 gene
chr3_+_53488677 2.276 ENSMUST00000029307.3
Stoml3
stomatin (Epb7.2)-like 3
chr2_-_6722187 2.140 ENSMUST00000182657.1
Celf2
CUGBP, Elav-like family member 2
chr5_-_146220901 2.121 ENSMUST00000169407.2
ENSMUST00000161331.1
ENSMUST00000159074.2
ENSMUST00000067837.3
Rnf6



ring finger protein (C3H2C3 type) 6



chr2_-_7395879 2.085 ENSMUST00000182404.1
Celf2
CUGBP, Elav-like family member 2
chr12_-_104865076 2.078 ENSMUST00000109937.1
ENSMUST00000109936.1
Clmn

calmin

chr16_-_92400067 2.017 ENSMUST00000023672.8
Rcan1
regulator of calcineurin 1
chr3_+_136670076 1.988 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr6_+_36388055 1.881 ENSMUST00000172278.1
Chrm2
cholinergic receptor, muscarinic 2, cardiac
chr6_-_39725448 1.861 ENSMUST00000002487.8
Braf
Braf transforming gene
chr8_+_25911670 1.784 ENSMUST00000120653.1
ENSMUST00000126226.1
Kcnu1

potassium channel, subfamily U, member 1

chr3_+_122419772 1.753 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr9_-_110375430 1.743 ENSMUST00000168137.1
5830462I19Rik
RIKEN cDNA 5830462I19 gene
chr17_-_32822200 1.733 ENSMUST00000179695.1
Zfp799
zinc finger protein 799
chr8_+_93810832 1.727 ENSMUST00000034198.8
ENSMUST00000125716.1
Gnao1

guanine nucleotide binding protein, alpha O

chr2_+_112284561 1.593 ENSMUST00000053666.7
Slc12a6
solute carrier family 12, member 6
chr12_+_77238093 1.585 ENSMUST00000177595.1
ENSMUST00000171770.2
Fut8

fucosyltransferase 8

chr10_-_53638269 1.563 ENSMUST00000164393.1
Fam184a
family with sequence similarity 184, member A
chr10_+_90576252 1.561 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr4_+_139622842 1.557 ENSMUST00000039818.9
Aldh4a1
aldehyde dehydrogenase 4 family, member A1
chr15_+_97247011 1.525 ENSMUST00000059433.6
Pced1b
PC-esterase domain containing 1B
chr15_-_102189032 1.468 ENSMUST00000023805.1
Csad
cysteine sulfinic acid decarboxylase
chr11_-_107348130 1.458 ENSMUST00000134763.1
Pitpnc1
phosphatidylinositol transfer protein, cytoplasmic 1
chr12_+_33314277 1.448 ENSMUST00000133549.1
Atxn7l1
ataxin 7-like 1
chr1_-_43098622 1.399 ENSMUST00000095014.1
Tgfbrap1
transforming growth factor, beta receptor associated protein 1
chr1_+_89454769 1.385 ENSMUST00000027521.8
ENSMUST00000074945.5
Agap1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr18_-_3281036 1.277 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
Crem


cAMP responsive element modulator


chr13_+_40917626 1.207 ENSMUST00000067778.6
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr3_-_57301919 1.203 ENSMUST00000029376.8
Tm4sf1
transmembrane 4 superfamily member 1
chr12_-_101958148 1.200 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
Atxn3



ataxin 3



chr7_-_38019505 1.197 ENSMUST00000085513.4
Uri1
URI1, prefoldin-like chaperone
chr6_-_48086530 1.077 ENSMUST00000073124.6
Zfp746
zinc finger protein 746
chr7_+_120677579 1.013 ENSMUST00000060175.6
BC030336
cDNA sequence BC030336
chrX_+_38600626 1.009 ENSMUST00000000365.2
Mcts1
malignant T cell amplified sequence 1
chr6_+_38918969 0.902 ENSMUST00000003017.6
Tbxas1
thromboxane A synthase 1, platelet
chr1_+_33719863 0.864 ENSMUST00000088287.3
Rab23
RAB23, member RAS oncogene family
chr1_+_43098710 0.816 ENSMUST00000010434.7
AI597479
expressed sequence AI597479
chr3_+_19957037 0.813 ENSMUST00000091309.5
ENSMUST00000108329.1
ENSMUST00000003714.6
Cp


ceruloplasmin


chr4_+_108847827 0.702 ENSMUST00000102738.2
Kti12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr16_-_85550417 0.700 ENSMUST00000175700.1
ENSMUST00000114174.2
Cyyr1

cysteine and tyrosine-rich protein 1

chr2_+_91255954 0.688 ENSMUST00000134699.1
Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr2_-_37703275 0.669 ENSMUST00000072186.5
Strbp
spermatid perinuclear RNA binding protein
chr6_+_39592569 0.642 ENSMUST00000135671.1
ENSMUST00000119379.1
Ndufb2

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2

chr1_+_87404916 0.630 ENSMUST00000173152.1
ENSMUST00000173663.1
Gigyf2

GRB10 interacting GYF protein 2

chr9_+_15239045 0.584 ENSMUST00000034413.6
Vstm5
V-set and transmembrane domain containing 5
chr2_-_181581996 0.582 ENSMUST00000057816.8
Uckl1
uridine-cytidine kinase 1-like 1
chr1_-_132707304 0.558 ENSMUST00000043189.7
Nfasc
neurofascin
chr7_+_24270420 0.557 ENSMUST00000108438.3
Zfp93
zinc finger protein 93
chr2_-_176917518 0.548 ENSMUST00000108931.2
Gm14296
predicted gene 14296
chr9_+_108560422 0.528 ENSMUST00000081111.8
Impdh2
inosine 5'-phosphate dehydrogenase 2
chr12_-_110840905 0.512 ENSMUST00000177224.1
ENSMUST00000084974.4
ENSMUST00000070565.8
Stk30


serine/threonine kinase 30


chr3_-_36053512 0.510 ENSMUST00000166644.2
ENSMUST00000062056.8
Ccdc144b

coiled-coil domain containing 144B

chr10_-_116549101 0.409 ENSMUST00000164088.1
Cnot2
CCR4-NOT transcription complex, subunit 2
chr4_+_109343029 0.405 ENSMUST00000030281.5
Eps15
epidermal growth factor receptor pathway substrate 15
chr5_+_25247344 0.376 ENSMUST00000114950.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr2_+_60209887 0.366 ENSMUST00000102748.4
ENSMUST00000102747.1
March7

membrane-associated ring finger (C3HC4) 7

chr4_+_32243733 0.336 ENSMUST00000165661.1
D130062J21Rik
RIKEN cDNA D130062J21 gene
chr9_+_70678950 0.321 ENSMUST00000067880.6
Adam10
a disintegrin and metallopeptidase domain 10
chr8_+_86745679 0.284 ENSMUST00000098532.2
Gm10638
predicted gene 10638
chr9_+_50494516 0.233 ENSMUST00000114474.1
1600029D21Rik
RIKEN cDNA 1600029D21 gene
chr3_+_79884496 0.205 ENSMUST00000118853.1
Fam198b
family with sequence similarity 198, member B
chr2_-_37647199 0.197 ENSMUST00000028279.3
Strbp
spermatid perinuclear RNA binding protein
chr16_+_13358375 0.193 ENSMUST00000149359.1
Mkl2
MKL/myocardin-like 2
chr14_+_124005355 0.154 ENSMUST00000166105.1
Gm17615
predicted gene, 17615
chr4_+_108479081 0.129 ENSMUST00000155068.1
Zcchc11
zinc finger, CCHC domain containing 11
chr8_-_67515606 0.128 ENSMUST00000032981.5
Gm9755
predicted pseudogene 9755
chr5_-_31108218 0.102 ENSMUST00000182776.1
ENSMUST00000182444.1
Slc30a3

solute carrier family 30 (zinc transporter), member 3

chr10_-_80900749 0.088 ENSMUST00000020440.6
Timm13
translocase of inner mitochondrial membrane 13
chr7_-_133782721 0.072 ENSMUST00000063669.1
Dhx32
DEAH (Asp-Glu-Ala-His) box polypeptide 32
chr10_+_69925954 0.050 ENSMUST00000181974.1
ENSMUST00000182795.1
ENSMUST00000182437.1
Ank3


ankyrin 3, epithelial


chr11_+_62551676 0.000 ENSMUST00000136938.1
Ubb
ubiquitin B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 18.8 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
3.8 15.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
3.1 9.4 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) interleukin-1 alpha secretion(GO:0050703) regulation of bleb assembly(GO:1904170)
3.0 8.9 GO:0070343 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
2.5 5.0 GO:0014877 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
2.0 6.0 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
1.4 4.3 GO:0014826 vein smooth muscle contraction(GO:0014826)
1.3 11.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.1 5.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
1.0 6.7 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.8 6.7 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.7 7.7 GO:0042118 endothelial cell activation(GO:0042118)
0.7 2.0 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.7 9.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.7 10.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.5 21.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.5 3.7 GO:0032264 IMP salvage(GO:0032264)
0.5 15.7 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.4 10.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.4 5.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.4 2.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.4 9.5 GO:0007614 short-term memory(GO:0007614)
0.4 1.6 GO:0046368 GDP-L-fucose metabolic process(GO:0046368)
0.4 3.0 GO:0033625 positive regulation of integrin activation(GO:0033625)
0.4 3.9 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.3 2.8 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.3 3.7 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.3 3.6 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.3 2.3 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.3 1.6 GO:0071476 cellular hypotonic response(GO:0071476)
0.3 1.0 GO:0002188 translation reinitiation(GO:0002188)
0.3 5.5 GO:0008210 estrogen metabolic process(GO:0008210)
0.2 2.5 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.2 1.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.2 1.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.2 1.9 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 37.8 GO:0007416 synapse assembly(GO:0007416)
0.2 0.9 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.2 1.4 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.2 1.6 GO:0006560 proline metabolic process(GO:0006560)
0.2 17.9 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.1 3.4 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.6 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 1.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 4.4 GO:0006826 iron ion transport(GO:0006826)
0.1 0.6 GO:0008655 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.1 1.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.1 0.3 GO:0042117 monocyte activation(GO:0042117)
0.1 0.5 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 4.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.9 GO:0006968 cellular defense response(GO:0006968)
0.1 0.8 GO:0006825 copper ion transport(GO:0006825)
0.1 1.8 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 3.1 GO:0034605 cellular response to heat(GO:0034605)
0.1 0.4 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.1 0.4 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0 0.9 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 1.7 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.4 GO:0033147 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 11.7 GO:0006869 lipid transport(GO:0006869)
0.0 0.4 GO:0002643 regulation of tolerance induction(GO:0002643)
0.0 0.6 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 1.3 GO:0051591 response to cAMP(GO:0051591)
0.0 1.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 6.5 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 2.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 1.8 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.1 GO:0097501 stress response to metal ion(GO:0097501)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 1.8 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 1.1 GO:1901216 positive regulation of neuron death(GO:1901216)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 18.8 GO:0000805 X chromosome(GO:0000805)
1.5 15.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.6 9.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.5 10.0 GO:0098644 complex of collagen trimers(GO:0098644)
0.5 6.0 GO:0044327 dendritic spine head(GO:0044327)
0.4 11.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 13.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.3 2.0 GO:0005955 calcineurin complex(GO:0005955)
0.3 3.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 3.7 GO:1990635 proximal dendrite(GO:1990635)
0.2 10.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 1.4 GO:0033263 CORVET complex(GO:0033263)
0.1 0.6 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 2.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 1.6 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 18.0 GO:0001650 fibrillar center(GO:0001650)
0.1 1.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 1.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 6.7 GO:0072686 mitotic spindle(GO:0072686)
0.1 5.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 7.7 GO:0032993 protein-DNA complex(GO:0032993)
0.0 43.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 1.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 6.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 3.0 GO:0055037 recycling endosome(GO:0055037)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.9 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 2.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.7 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.9 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.5 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.8 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
1.9 7.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.9 15.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
1.6 9.4 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
1.4 4.3 GO:0004962 endothelin receptor activity(GO:0004962)
0.7 6.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.6 1.8 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.5 3.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.5 3.0 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.4 1.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.4 4.4 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.4 3.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.4 1.9 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.4 5.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 5.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.3 2.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3 2.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.3 3.6 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 1.7 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.3 3.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 1.6 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 11.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 2.8 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.2 1.6 GO:0008417 fucosyltransferase activity(GO:0008417)
0.2 16.9 GO:0002039 p53 binding(GO:0002039)
0.2 1.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 0.8 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 30.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 0.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 2.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.6 GO:0004849 uridine kinase activity(GO:0004849)
0.1 0.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 18.5 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.1 2.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 2.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 4.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 1.6 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 1.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 3.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.1 GO:0050681 androgen receptor binding(GO:0050681)
0.1 0.4 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 4.2 GO:0003823 antigen binding(GO:0003823)
0.0 3.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.6 GO:0070064 proline-rich region binding(GO:0070064)
0.0 13.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 6.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 2.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.9 GO:0016860 intramolecular oxidoreductase activity(GO:0016860)
0.0 3.1 GO:0005516 calmodulin binding(GO:0005516)
0.0 10.4 GO:0008289 lipid binding(GO:0008289)
0.0 0.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.3 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 2.3 GO:0008017 microtubule binding(GO:0008017)
0.0 5.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 11.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 1.9 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 5.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 11.4 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 3.9 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 5.0 PID_FOXO_PATHWAY FoxO family signaling
0.1 6.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.3 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 3.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 9.4 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.5 7.5 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 3.7 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.2 7.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 3.9 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 2.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.9 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 3.6 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 2.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 5.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.9 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 0.8 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.7 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.1 2.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 0.9 REACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 1.5 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.5 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 5.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.4 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.0 3.0 REACTOME_SIGNALLING_BY_NGF Genes involved in Signalling by NGF
0.0 1.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.4 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 2.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins