Motif ID: Gata2_Gata1

Z-value: 0.608

Transcription factors associated with Gata2_Gata1:

Gene SymbolEntrez IDGene Name
Gata1 ENSMUSG00000031162.8 Gata1
Gata2 ENSMUSG00000015053.8 Gata2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata2mm10_v2_chr6_+_88198656_881986750.412.0e-04Click!
Gata1mm10_v2_chrX_-_7967817_7967910-0.019.0e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gata2_Gata1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_+_84701430 6.762 ENSMUST00000037165.4
Lyl1
lymphoblastomic leukemia 1
chr6_+_30541582 5.755 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr16_+_45093611 5.105 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80
chr1_-_162866502 5.059 ENSMUST00000046049.7
Fmo1
flavin containing monooxygenase 1
chr16_+_45094036 4.550 ENSMUST00000061050.5
Ccdc80
coiled-coil domain containing 80
chr4_-_14621805 4.296 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr13_-_91388079 4.090 ENSMUST00000181054.1
A830009L08Rik
RIKEN cDNA A830009L08 gene
chr9_-_77251829 3.968 ENSMUST00000184322.1
ENSMUST00000184316.1
Mlip

muscular LMNA-interacting protein

chr6_+_125552948 3.950 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chrX_+_150547375 3.834 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chr7_+_119900099 3.823 ENSMUST00000106516.1
Lyrm1
LYR motif containing 1
chr10_-_62342674 3.805 ENSMUST00000143179.1
ENSMUST00000130422.1
Hk1

hexokinase 1

chr16_-_95459245 3.733 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr3_+_135825788 3.638 ENSMUST00000167390.1
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr11_+_90030295 3.528 ENSMUST00000092788.3
Tmem100
transmembrane protein 100
chr7_-_139582790 3.289 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr13_+_38345716 3.073 ENSMUST00000171970.1
Bmp6
bone morphogenetic protein 6
chr7_-_4522427 3.066 ENSMUST00000098859.3
Tnni3
troponin I, cardiac 3
chr17_-_45593626 3.012 ENSMUST00000163905.1
ENSMUST00000167692.1
Slc29a1

solute carrier family 29 (nucleoside transporters), member 1

chr9_-_32541589 2.973 ENSMUST00000016231.7
Fli1
Friend leukemia integration 1
chr3_+_7366598 2.866 ENSMUST00000028999.6
Pkia
protein kinase inhibitor, alpha
chr9_-_77251871 2.825 ENSMUST00000183955.1
Mlip
muscular LMNA-interacting protein
chr6_+_17306335 2.684 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
Cav1



caveolin 1, caveolae protein



chr1_+_45311538 2.653 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chrX_-_107403295 2.613 ENSMUST00000033591.5
Itm2a
integral membrane protein 2A
chr3_-_84479418 2.494 ENSMUST00000091002.1
Fhdc1
FH2 domain containing 1
chr10_-_115185015 2.366 ENSMUST00000006949.8
Tph2
tryptophan hydroxylase 2
chr3_-_20242173 2.351 ENSMUST00000001921.1
Cpa3
carboxypeptidase A3, mast cell
chr1_+_75507077 2.350 ENSMUST00000037330.4
Inha
inhibin alpha
chr2_+_169633517 2.203 ENSMUST00000109157.1
Tshz2
teashirt zinc finger family member 2
chr13_-_116309639 2.126 ENSMUST00000036060.6
Isl1
ISL1 transcription factor, LIM/homeodomain
chr3_+_135826075 2.075 ENSMUST00000029810.5
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr4_-_14621669 2.037 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr2_-_33086366 2.027 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr5_-_125294107 2.025 ENSMUST00000127148.1
Scarb1
scavenger receptor class B, member 1
chr2_-_33087169 2.023 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr6_+_17463927 1.978 ENSMUST00000115442.1
Met
met proto-oncogene
chr14_-_52279238 1.968 ENSMUST00000167116.1
ENSMUST00000100631.4
Rab2b

RAB2B, member RAS oncogene family

chr7_-_4522794 1.953 ENSMUST00000140424.1
Tnni3
troponin I, cardiac 3
chr6_-_122856151 1.783 ENSMUST00000042081.8
C3ar1
complement component 3a receptor 1
chr7_+_110627650 1.737 ENSMUST00000033054.8
Adm
adrenomedullin
chr4_-_14621494 1.682 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr2_+_70474923 1.680 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr2_-_36104060 1.640 ENSMUST00000112961.3
ENSMUST00000112966.3
Lhx6

LIM homeobox protein 6

chr14_-_64455903 1.600 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr5_-_121836810 1.598 ENSMUST00000118580.1
ENSMUST00000040308.7
Sh2b3

SH2B adaptor protein 3

chr3_-_88000350 1.588 ENSMUST00000090971.5
Bcan
brevican
chr2_+_26583858 1.480 ENSMUST00000100290.5
ENSMUST00000102907.5
Egfl7

EGF-like domain 7

chr13_-_18031616 1.401 ENSMUST00000099736.2
Vdac3-ps1
voltage-dependent anion channel 3, pseudogene 1
chr6_+_17743582 1.392 ENSMUST00000000674.6
ENSMUST00000077080.2
St7

suppression of tumorigenicity 7

chr7_+_28833975 1.391 ENSMUST00000066723.8
Lgals4
lectin, galactose binding, soluble 4
chr3_-_59262825 1.351 ENSMUST00000050360.7
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr2_+_32621750 1.348 ENSMUST00000113278.2
Ak1
adenylate kinase 1
chr10_+_116177351 1.325 ENSMUST00000155606.1
ENSMUST00000128399.1
Ptprr

protein tyrosine phosphatase, receptor type, R

chrX_+_99975570 1.323 ENSMUST00000113779.1
ENSMUST00000113776.1
ENSMUST00000113775.1
ENSMUST00000113780.1
ENSMUST00000113778.1
ENSMUST00000113781.1
ENSMUST00000113783.1
ENSMUST00000071453.2
ENSMUST00000113777.1
Eda








ectodysplasin-A








chr1_-_132367879 1.323 ENSMUST00000142609.1
Tmcc2
transmembrane and coiled-coil domains 2
chr6_-_136941887 1.265 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr5_-_121836852 1.243 ENSMUST00000086310.1
Sh2b3
SH2B adaptor protein 3
chr13_+_42709482 1.208 ENSMUST00000066928.5
ENSMUST00000148891.1
Phactr1

phosphatase and actin regulator 1

chr12_-_25096080 1.205 ENSMUST00000020974.6
Id2
inhibitor of DNA binding 2
chr2_+_169632996 1.204 ENSMUST00000109159.2
Tshz2
teashirt zinc finger family member 2
chr18_+_76059458 1.198 ENSMUST00000167921.1
Zbtb7c
zinc finger and BTB domain containing 7C
chrX_+_73757069 1.178 ENSMUST00000002079.6
Plxnb3
plexin B3
chr11_+_87760533 1.173 ENSMUST00000039627.5
ENSMUST00000100644.3
Bzrap1

benzodiazepine receptor associated protein 1

chr2_-_77170592 1.122 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chr11_+_67586520 1.118 ENSMUST00000108682.2
Gas7
growth arrest specific 7
chr1_+_172341197 1.112 ENSMUST00000056136.3
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr19_-_7019423 1.109 ENSMUST00000040772.8
Fermt3
fermitin family homolog 3 (Drosophila)
chr13_+_42681513 1.095 ENSMUST00000149235.1
Phactr1
phosphatase and actin regulator 1
chr5_+_24364804 1.085 ENSMUST00000030834.4
ENSMUST00000115090.1
Nos3

nitric oxide synthase 3, endothelial cell

chr10_+_80019621 1.083 ENSMUST00000043311.6
Hmha1
histocompatibility (minor) HA-1
chrX_+_10485121 1.053 ENSMUST00000076354.6
ENSMUST00000115526.1
Tspan7

tetraspanin 7

chr4_-_59438633 1.028 ENSMUST00000040166.7
ENSMUST00000107544.1
Susd1

sushi domain containing 1

chr11_-_102469839 0.999 ENSMUST00000103086.3
Itga2b
integrin alpha 2b
chr4_-_138326234 0.993 ENSMUST00000105817.3
ENSMUST00000030536.6
Pink1

PTEN induced putative kinase 1

chr6_-_136941494 0.986 ENSMUST00000111892.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr8_+_46490968 0.976 ENSMUST00000110372.1
ENSMUST00000130563.1
Acsl1

acyl-CoA synthetase long-chain family member 1

chr2_+_103957976 0.966 ENSMUST00000156813.1
ENSMUST00000170926.1
Lmo2

LIM domain only 2

chr6_-_136941694 0.941 ENSMUST00000032344.5
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr3_-_154330543 0.931 ENSMUST00000184966.1
ENSMUST00000177846.2
Lhx8

LIM homeobox protein 8

chr14_-_55560340 0.929 ENSMUST00000066106.3
A730061H03Rik
RIKEN cDNA A730061H03 gene
chr6_+_15185203 0.915 ENSMUST00000154448.1
Foxp2
forkhead box P2
chr11_-_61453992 0.885 ENSMUST00000060255.7
ENSMUST00000054927.7
ENSMUST00000102661.3
Rnf112


ring finger protein 112


chr7_-_80403315 0.862 ENSMUST00000147150.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr19_+_38264761 0.857 ENSMUST00000087252.5
Lgi1
leucine-rich repeat LGI family, member 1
chr14_+_55560904 0.780 ENSMUST00000072530.4
ENSMUST00000128490.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr10_-_62327757 0.753 ENSMUST00000139228.1
Hk1
hexokinase 1
chr11_+_5009515 0.735 ENSMUST00000101613.2
Ap1b1
adaptor protein complex AP-1, beta 1 subunit
chr10_+_90576708 0.730 ENSMUST00000182430.1
ENSMUST00000182960.1
ENSMUST00000182045.1
ENSMUST00000182083.1
Anks1b



ankyrin repeat and sterile alpha motif domain containing 1B



chr19_-_37176055 0.720 ENSMUST00000142973.1
ENSMUST00000154376.1
Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr10_+_90576570 0.719 ENSMUST00000182786.1
ENSMUST00000182600.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr6_+_17306415 0.719 ENSMUST00000150901.1
Cav1
caveolin 1, caveolae protein
chr3_+_106113229 0.717 ENSMUST00000079132.5
ENSMUST00000139086.1
Chia

chitinase, acidic

chr10_+_90576252 0.663 ENSMUST00000182427.1
ENSMUST00000182053.1
ENSMUST00000182113.1
Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr19_-_42202150 0.650 ENSMUST00000018966.7
Sfrp5
secreted frizzled-related sequence protein 5
chr9_-_21963568 0.647 ENSMUST00000006397.5
Epor
erythropoietin receptor
chr10_+_90576777 0.643 ENSMUST00000183136.1
ENSMUST00000182595.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr14_+_55561060 0.608 ENSMUST00000117701.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr2_-_25224653 0.593 ENSMUST00000043584.4
Tubb4b
tubulin, beta 4B class IVB
chr1_+_75549581 0.569 ENSMUST00000154101.1
Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr11_+_4986824 0.567 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr16_-_44016387 0.547 ENSMUST00000036174.3
Gramd1c
GRAM domain containing 1C
chr10_+_90576678 0.516 ENSMUST00000182284.1
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr14_+_55560480 0.514 ENSMUST00000121622.1
ENSMUST00000143431.1
ENSMUST00000150481.1
Dcaf11


DDB1 and CUL4 associated factor 11


chr7_-_100662315 0.512 ENSMUST00000151123.1
ENSMUST00000107047.2
Plekhb1

pleckstrin homology domain containing, family B (evectins) member 1

chr4_+_43493345 0.511 ENSMUST00000030181.5
ENSMUST00000107922.2
Ccdc107

coiled-coil domain containing 107

chr18_-_78123324 0.449 ENSMUST00000160292.1
ENSMUST00000091813.5
Slc14a1

solute carrier family 14 (urea transporter), member 1

chr2_+_112284561 0.429 ENSMUST00000053666.7
Slc12a6
solute carrier family 12, member 6
chr1_+_75450699 0.415 ENSMUST00000037708.9
Asic4
acid-sensing (proton-gated) ion channel family member 4
chr3_+_133338936 0.414 ENSMUST00000150386.1
ENSMUST00000125858.1
Ppa2

pyrophosphatase (inorganic) 2

chr2_-_52558539 0.413 ENSMUST00000102760.3
ENSMUST00000102761.2
Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr10_+_61648552 0.412 ENSMUST00000020286.6
Ppa1
pyrophosphatase (inorganic) 1
chr13_+_98263242 0.397 ENSMUST00000022164.8
ENSMUST00000150352.1
Ankra2

ankyrin repeat, family A (RFXANK-like), 2

chr19_+_58670358 0.392 ENSMUST00000057270.7
Pnlip
pancreatic lipase
chr11_+_118428493 0.377 ENSMUST00000017590.2
C1qtnf1
C1q and tumor necrosis factor related protein 1
chr17_+_46650328 0.370 ENSMUST00000043464.7
Cul7
cullin 7
chrX_-_134111852 0.366 ENSMUST00000033610.6
Nox1
NADPH oxidase 1
chr10_+_5593718 0.353 ENSMUST00000051809.8
Myct1
myc target 1
chr6_-_122609964 0.327 ENSMUST00000032211.4
Gdf3
growth differentiation factor 3
chr10_+_90576872 0.325 ENSMUST00000182550.1
ENSMUST00000099364.5
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr15_-_77153772 0.318 ENSMUST00000166610.1
ENSMUST00000111581.2
Rbfox2

RNA binding protein, fox-1 homolog (C. elegans) 2

chr7_+_110773658 0.310 ENSMUST00000143786.1
Ampd3
adenosine monophosphate deaminase 3
chr7_-_44892358 0.297 ENSMUST00000003049.6
Med25
mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)
chr10_+_53337686 0.293 ENSMUST00000046221.6
ENSMUST00000163319.1
Pln

phospholamban

chr5_+_42067960 0.277 ENSMUST00000087332.4
Gm16223
predicted gene 16223
chr3_+_79884496 0.251 ENSMUST00000118853.1
Fam198b
family with sequence similarity 198, member B
chr11_+_32276400 0.250 ENSMUST00000020531.2
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr4_-_46404224 0.245 ENSMUST00000107764.2
Hemgn
hemogen
chrX_-_18461371 0.241 ENSMUST00000044188.4
4930578C19Rik
RIKEN cDNA 4930578C19 gene
chr1_+_75450436 0.217 ENSMUST00000113577.1
Asic4
acid-sensing (proton-gated) ion channel family member 4
chr3_+_79885930 0.214 ENSMUST00000029567.8
Fam198b
family with sequence similarity 198, member B
chr11_+_70639118 0.196 ENSMUST00000055184.6
ENSMUST00000108551.2
Gp1ba

glycoprotein 1b, alpha polypeptide

chr2_+_97467657 0.175 ENSMUST00000059049.7
Lrrc4c
leucine rich repeat containing 4C
chr6_+_86078070 0.175 ENSMUST00000032069.5
Add2
adducin 2 (beta)
chr17_-_85688252 0.165 ENSMUST00000024947.7
ENSMUST00000163568.2
Six2

sine oculis-related homeobox 2

chr8_+_34115030 0.140 ENSMUST00000095345.3
Mboat4
membrane bound O-acyltransferase domain containing 4
chr3_-_94886945 0.138 ENSMUST00000005923.6
Psmb4
proteasome (prosome, macropain) subunit, beta type 4
chr3_+_79884576 0.115 ENSMUST00000145992.1
Fam198b
family with sequence similarity 198, member B
chr8_+_105636509 0.111 ENSMUST00000005841.9
Ctcf
CCCTC-binding factor
chr9_+_44069421 0.110 ENSMUST00000114830.2
Usp2
ubiquitin specific peptidase 2
chr18_-_43477764 0.107 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chrM_+_5319 0.105 ENSMUST00000082402.1
mt-Co1
mitochondrially encoded cytochrome c oxidase I
chr15_-_83170498 0.104 ENSMUST00000162178.1
Cyb5r3
cytochrome b5 reductase 3
chr7_-_100662414 0.103 ENSMUST00000079176.6
Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chrX_-_7572843 0.101 ENSMUST00000132788.1
Ppp1r3f
protein phosphatase 1, regulatory (inhibitor) subunit 3F
chr16_+_43503607 0.101 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
Zbtb20


zinc finger and BTB domain containing 20


chr10_-_83648631 0.085 ENSMUST00000146876.2
ENSMUST00000176294.1
Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr2_+_3704787 0.076 ENSMUST00000115054.2
Fam107b
family with sequence similarity 107, member B
chr7_-_99238564 0.074 ENSMUST00000064231.7
Mogat2
monoacylglycerol O-acyltransferase 2
chr8_+_107436355 0.063 ENSMUST00000166615.1
Wwp2
WW domain containing E3 ubiquitin protein ligase 2
chr9_-_44713196 0.054 ENSMUST00000144251.1
ENSMUST00000156918.1
Phldb1

pleckstrin homology-like domain, family B, member 1

chr10_-_13388830 0.028 ENSMUST00000079698.5
Phactr2
phosphatase and actin regulator 2
chr9_+_109832998 0.006 ENSMUST00000119376.1
ENSMUST00000122343.1
Nme6

NME/NM23 nucleoside diphosphate kinase 6


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 8.0 GO:0019532 oxalate transport(GO:0019532)
1.0 6.8 GO:0001955 blood vessel maturation(GO:0001955)
0.8 5.0 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.7 3.7 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.7 2.1 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.7 3.4 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.7 2.0 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.7 4.6 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.6 1.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.6 3.5 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.6 5.7 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.5 3.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.5 2.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.5 3.1 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.5 3.3 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.5 1.4 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 1.3 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.4 2.6 GO:0002317 plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.4 3.0 GO:0015862 uridine transport(GO:0015862)
0.4 5.1 GO:0070995 toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995)
0.4 1.2 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.4 2.3 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.4 1.1 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100) regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.3 2.4 GO:0006586 tryptophan metabolic process(GO:0006568) indolalkylamine metabolic process(GO:0006586)
0.3 2.4 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.3 1.3 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 3.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.3 1.7 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.3 2.0 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.3 1.1 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.3 3.8 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.3 1.6 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 1.0 GO:0036482 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.2 0.7 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.2 2.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 1.2 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.2 1.3 GO:0006172 ADP biosynthetic process(GO:0006172)
0.2 0.7 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.2 0.9 GO:0090472 dibasic protein processing(GO:0090472)
0.2 1.1 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.2 6.8 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 0.3 GO:0048859 formation of anatomical boundary(GO:0048859)
0.1 0.4 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 1.2 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.1 3.0 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.4 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 1.0 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.2 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 1.0 GO:0044539 long-chain fatty acid import(GO:0044539)
0.1 1.7 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 9.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 0.4 GO:0071476 cellular hypotonic response(GO:0071476)
0.1 0.4 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.1 0.6 GO:0061032 visceral serous pericardium development(GO:0061032)
0.1 1.5 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.1 5.3 GO:0030168 platelet activation(GO:0030168)
0.1 1.3 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.4 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.3 GO:0032261 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.0 1.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.3 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0 1.2 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.0 1.1 GO:0051642 centrosome localization(GO:0051642)
0.0 1.3 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 0.4 GO:0043254 regulation of protein complex assembly(GO:0043254)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
0.0 2.0 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.0 0.2 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 1.3 GO:0021766 hippocampus development(GO:0021766)
0.0 0.1 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0 0.8 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.1 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.0 GO:1990584 cardiac Troponin complex(GO:1990584)
0.8 4.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.8 2.3 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.4 6.9 GO:0005614 interstitial matrix(GO:0005614)
0.3 3.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 4.6 GO:0097228 sperm principal piece(GO:0097228)
0.2 2.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 1.3 GO:0001520 outer dense fiber(GO:0001520)
0.2 0.9 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 2.1 GO:0097449 astrocyte projection(GO:0097449)
0.1 0.8 GO:1990393 3M complex(GO:1990393)
0.1 0.4 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.4 GO:0031528 microvillus membrane(GO:0031528)
0.1 6.8 GO:0016605 PML body(GO:0016605)
0.1 0.6 GO:0045298 tubulin complex(GO:0045298)
0.1 1.0 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 0.9 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 1.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 13.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.3 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 3.5 GO:0043204 perikaryon(GO:0043204)
0.0 3.8 GO:0030496 midbody(GO:0030496)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 19.0 GO:0005615 extracellular space(GO:0005615)
0.0 0.1 GO:0045178 basal part of cell(GO:0045178)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 1.1 GO:0042383 sarcolemma(GO:0042383)
0.0 3.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 8.5 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 GO:0030172 troponin C binding(GO:0030172)
1.3 3.8 GO:0016748 succinyltransferase activity(GO:0016748)
1.0 5.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
1.0 1.0 GO:0070051 fibrinogen binding(GO:0070051)
0.9 4.6 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.8 2.4 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.7 8.0 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.7 3.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.7 2.0 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.6 1.8 GO:0004875 complement receptor activity(GO:0004875)
0.5 1.6 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.5 2.0 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.5 3.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.5 8.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.4 4.0 GO:0019865 immunoglobulin binding(GO:0019865)
0.4 1.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.4 1.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.3 9.7 GO:0001968 fibronectin binding(GO:0001968)
0.3 1.0 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.3 3.1 GO:0070700 BMP receptor binding(GO:0070700)
0.3 2.3 GO:0034711 inhibin binding(GO:0034711)
0.2 1.4 GO:0016936 galactoside binding(GO:0016936)
0.2 5.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 0.8 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.2 1.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 2.9 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 2.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 1.2 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1 1.0 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 0.4 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 3.0 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 1.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.4 GO:0015265 urea channel activity(GO:0015265)
0.1 1.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.9 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 2.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 3.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 2.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 2.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 2.8 GO:0035591 signaling adaptor activity(GO:0035591)
0.0 3.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 1.7 GO:0005179 hormone activity(GO:0005179)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:2001069 glycogen binding(GO:2001069)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.7 GO:0005112 Notch binding(GO:0005112)
0.0 0.6 GO:0005272 sodium channel activity(GO:0005272)
0.0 0.4 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 1.8 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 2.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.4 GO:0003924 GTPase activity(GO:0003924)
0.0 3.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.3 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.3 GO:0046965 retinoid X receptor binding(GO:0046965)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 8.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.0 PID_ARF6_PATHWAY Arf6 signaling events
0.1 2.6 PID_EPO_PATHWAY EPO signaling pathway
0.1 1.1 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 3.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.4 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 7.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 4.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.4 4.9 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.3 5.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.2 2.4 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.2 5.1 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.2 2.0 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 2.1 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 3.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 1.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 3.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.6 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 4.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 2.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 2.0 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 9.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.0 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 0.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.1 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 2.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.3 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 2.0 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 1.0 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.2 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.1 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 2.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events