Motif ID: Gata2_Gata1

Z-value: 0.608

Transcription factors associated with Gata2_Gata1:

Gene SymbolEntrez IDGene Name
Gata1 ENSMUSG00000031162.8 Gata1
Gata2 ENSMUSG00000015053.8 Gata2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata2mm10_v2_chr6_+_88198656_881986750.412.0e-04Click!
Gata1mm10_v2_chrX_-_7967817_7967910-0.019.0e-01Click!


Activity profile for motif Gata2_Gata1.

activity profile for motif Gata2_Gata1


Sorted Z-values histogram for motif Gata2_Gata1

Sorted Z-values for motif Gata2_Gata1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata2_Gata1

PNG image of the network

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Top targets:


Showing 1 to 20 of 153 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_84701430 6.762 ENSMUST00000037165.4
 Lyl1
lymphoblastomic leukemia 1
chr6_+_30541582 5.755 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr16_+_45093611 5.105 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr1_-_162866502 5.059 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr16_+_45094036 4.550 ENSMUST00000061050.5
 Ccdc80
coiled-coil domain containing 80
chr4_-_14621805 4.296 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr13_-_91388079 4.090 ENSMUST00000181054.1
 A830009L08Rik
RIKEN cDNA A830009L08 gene
chr9_-_77251829 3.968 ENSMUST00000184322.1
ENSMUST00000184316.1
 Mlip

muscular LMNA-interacting protein

chr6_+_125552948 3.950 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chrX_+_150547375 3.834 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chr7_+_119900099 3.823 ENSMUST00000106516.1
 Lyrm1
LYR motif containing 1
chr10_-_62342674 3.805 ENSMUST00000143179.1
ENSMUST00000130422.1
 Hk1

hexokinase 1

chr16_-_95459245 3.733 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
 Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr3_+_135825788 3.638 ENSMUST00000167390.1
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr11_+_90030295 3.528 ENSMUST00000092788.3
 Tmem100
transmembrane protein 100
chr7_-_139582790 3.289 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr13_+_38345716 3.073 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr7_-_4522427 3.066 ENSMUST00000098859.3
 Tnni3
troponin I, cardiac 3
chr17_-_45593626 3.012 ENSMUST00000163905.1
ENSMUST00000167692.1
 Slc29a1

solute carrier family 29 (nucleoside transporters), member 1

chr9_-_32541589 2.973 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
1.1 8.0 GO:0019532 oxalate transport(GO:0019532)
1.0 6.8 GO:0001955 blood vessel maturation(GO:0001955)
0.2 6.8 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.6 5.7 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 5.3 GO:0030168 platelet activation(GO:0030168)
0.4 5.1 GO:0070995 toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995)
0.8 5.0 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.7 4.6 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.3 3.8 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.7 3.7 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.3 3.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.6 3.5 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.7 3.4 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.5 3.3 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.5 3.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.5 3.1 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.4 3.0 GO:0015862 uridine transport(GO:0015862)
0.1 3.0 GO:0035855 megakaryocyte development(GO:0035855)
0.2 2.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.0 GO:0005615 extracellular space(GO:0005615)
0.0 13.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 8.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.4 6.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 6.8 GO:0016605 PML body(GO:0016605)
1.3 5.0 GO:1990584 cardiac Troponin complex(GO:1990584)
0.2 4.6 GO:0097228 sperm principal piece(GO:0097228)
0.8 4.0 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 3.8 GO:0030496 midbody(GO:0030496)
0.0 3.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 3.5 GO:0043204 perikaryon(GO:0043204)
0.3 3.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 2.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.8 2.3 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
0.1 2.1 GO:0097449 astrocyte projection(GO:0097449)
0.0 1.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 1.4 GO:0031528 microvillus membrane(GO:0031528)
0.2 1.3 GO:0001520 outer dense fiber(GO:0001520)
0.0 1.3 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.7 GO:0001968 fibronectin binding(GO:0001968)
0.5 8.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.7 8.0 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 5.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.0 5.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
1.7 5.0 GO:0030172 troponin C binding(GO:0030172)
0.9 4.6 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.4 4.0 GO:0019865 immunoglobulin binding(GO:0019865)
1.3 3.8 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 3.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.7 3.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.0 3.4 GO:0003924 GTPase activity(GO:0003924)
0.0 3.3 GO:0005096 GTPase activator activity(GO:0005096)
0.5 3.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.3 3.1 GO:0070700 BMP receptor binding(GO:0070700)
0.1 3.0 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 3.0 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 2.9 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 2.8 GO:0035591 signaling adaptor activity(GO:0035591)
0.2 2.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 7.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 4.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.4 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 3.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 3.0 PID_ARF6_PATHWAY Arf6 signaling events
0.1 2.6 PID_EPO_PATHWAY EPO signaling pathway
0.0 2.4 PID_ENDOTHELIN_PATHWAY Endothelins
0.0 1.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.3 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.1 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.2 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 5.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.2 5.1 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.4 4.9 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 4.6 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.2 3.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.4 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 3.0 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 2.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 2.4 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.6 2.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 2.2 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 2.1 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 2.0 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 2.0 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 2.0 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 1.6 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 1.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 1.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors