Motif ID: Gata3

Z-value: 1.829


Transcription factors associated with Gata3:

Gene SymbolEntrez IDGene Name
Gata3 ENSMUSG00000015619.10 Gata3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata3mm10_v2_chr2_-_9890026_9890035-0.056.4e-01Click!


Activity profile for motif Gata3.

activity profile for motif Gata3


Sorted Z-values histogram for motif Gata3

Sorted Z-values for motif Gata3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_119053339 37.598 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr1_-_119053619 29.452 ENSMUST00000062483.8
 Gli2
GLI-Kruppel family member GLI2
chr6_-_23248264 25.389 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_+_102604370 21.817 ENSMUST00000057893.5
 Fzd2
frizzled homolog 2 (Drosophila)
chr1_+_6730051 18.455 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr4_-_117178726 18.162 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr14_+_67234620 16.729 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr3_+_102010138 16.342 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr2_+_25372315 15.562 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr4_+_148041172 15.403 ENSMUST00000069604.8
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr16_-_50432340 15.161 ENSMUST00000066037.6
ENSMUST00000089399.4
ENSMUST00000089404.3
ENSMUST00000114477.1
ENSMUST00000138166.1
 Bbx




bobby sox homolog (Drosophila)




chr7_-_116031047 14.463 ENSMUST00000106612.1
 Sox6
SRY-box containing gene 6
chr9_+_65265173 14.072 ENSMUST00000048762.1
 Cilp
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr7_-_37772868 13.873 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr6_-_48840988 13.308 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr6_-_48841098 13.282 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr1_+_6730135 13.214 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr10_-_42583628 13.053 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr4_-_117182623 12.921 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr6_-_48841373 12.856 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 404 entries
Log-likelihood per target Total log-likelihoodTermDescription
16.8 67.0 GO:0060032 notochord regression(GO:0060032)
8.9 62.4 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
4.4 48.2 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
6.2 31.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.7 30.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
4.8 28.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.4 28.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
2.5 27.2 GO:0060539 diaphragm development(GO:0060539)
6.5 25.9 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
4.4 21.9 GO:0015671 oxygen transport(GO:0015671)
4.4 21.8 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
2.9 20.5 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
1.2 19.9 GO:0035563 positive regulation of chromatin binding(GO:0035563)
4.9 19.6 GO:0070829 heterochromatin maintenance(GO:0070829)
1.4 19.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
1.3 19.4 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
2.7 18.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
1.1 18.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
6.0 18.1 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.6 17.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 184 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 159.1 GO:0005634 nucleus(GO:0005634)
5.2 67.7 GO:0097542 ciliary tip(GO:0097542)
0.1 50.7 GO:0005667 transcription factor complex(GO:0005667)
0.2 32.4 GO:0032993 protein-DNA complex(GO:0032993)
0.8 30.2 GO:0035371 microtubule plus-end(GO:0035371)
0.6 26.0 GO:0008180 COP9 signalosome(GO:0008180)
0.7 20.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.8 18.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.4 16.4 GO:0002102 podosome(GO:0002102)
0.3 16.4 GO:0005871 kinesin complex(GO:0005871)
1.0 15.1 GO:0042788 polysomal ribosome(GO:0042788)
1.8 14.2 GO:0033269 internode region of axon(GO:0033269)
0.0 13.4 GO:0005925 focal adhesion(GO:0005925)
2.6 13.0 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 12.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 11.7 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.5 10.2 GO:0060077 inhibitory synapse(GO:0060077)
4.9 9.9 GO:0005833 hemoglobin complex(GO:0005833)
0.3 9.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 9.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 253 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 97.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.0 72.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 41.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 38.3 GO:0001047 core promoter binding(GO:0001047)
1.9 32.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 28.6 GO:0033613 activating transcription factor binding(GO:0033613)
1.1 24.0 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.3 22.7 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
4.4 21.9 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 21.9 GO:0004386 helicase activity(GO:0004386)
3.2 19.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
3.7 18.4 GO:0043532 angiostatin binding(GO:0043532)
1.0 18.1 GO:0001848 complement binding(GO:0001848)
0.4 17.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
1.8 16.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
1.1 16.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 15.7 GO:0017091 AU-rich element binding(GO:0017091)
0.4 15.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
5.1 15.4 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
1.5 14.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 72.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
1.0 48.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.9 27.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.6 27.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 24.4 PID_E2F_PATHWAY E2F transcription factor network
0.3 21.7 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.3 17.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 17.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 16.0 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.6 12.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.3 11.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.3 11.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 8.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 7.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.3 7.7 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 7.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 6.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.3 5.3 SIG_CHEMOTAXIS Genes related to chemotaxis
0.2 4.6 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 4.6 PID_RAS_PATHWAY Regulation of Ras family activation

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 40.1 REACTOME_KINESINS Genes involved in Kinesins
0.8 24.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.6 20.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.3 18.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 18.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.7 17.1 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 15.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.6 15.2 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 14.6 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.6 14.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.2 14.1 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.5 13.8 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3 13.7 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 13.0 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.3 11.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 11.0 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 9.2 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 8.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 8.0 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.6 7.8 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway