Motif ID: Gata4

Z-value: 0.525


Transcription factors associated with Gata4:

Gene SymbolEntrez IDGene Name
Gata4 ENSMUSG00000021944.9 Gata4



Activity profile for motif Gata4.

activity profile for motif Gata4


Sorted Z-values histogram for motif Gata4

Sorted Z-values for motif Gata4



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata4

PNG image of the network

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Top targets:


Showing 1 to 20 of 137 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_45311538 4.806 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr1_-_56969864 4.566 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_+_177444653 4.381 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr1_-_56969827 4.326 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr6_+_103510874 3.738 ENSMUST00000066905.6
 Chl1
cell adhesion molecule with homology to L1CAM
chr3_+_135825788 3.272 ENSMUST00000167390.1
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr2_+_4559742 3.121 ENSMUST00000176828.1
 Frmd4a
FERM domain containing 4A
chr4_-_32923455 2.735 ENSMUST00000035719.4
ENSMUST00000084749.1
 Ankrd6

ankyrin repeat domain 6

chr14_-_64455903 2.369 ENSMUST00000067927.7
 Msra
methionine sulfoxide reductase A
chr6_+_17306335 2.298 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
 Cav1



caveolin 1, caveolae protein



chr3_+_135826075 2.248 ENSMUST00000029810.5
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr11_+_3330781 2.230 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr16_-_23520579 2.218 ENSMUST00000089883.5
 Masp1
mannan-binding lectin serine peptidase 1
chr5_+_64812336 2.063 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)
chr17_-_45593626 2.050 ENSMUST00000163905.1
ENSMUST00000167692.1
 Slc29a1

solute carrier family 29 (nucleoside transporters), member 1

chr15_-_50890396 1.903 ENSMUST00000185183.1
 Trps1
trichorhinophalangeal syndrome I (human)
chr4_-_87806276 1.864 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_-_14310198 1.825 ENSMUST00000168081.2
ENSMUST00000027066.6
 Eya1

eyes absent 1 homolog (Drosophila)

chr10_+_84576626 1.800 ENSMUST00000020223.7
 Tcp11l2
t-complex 11 (mouse) like 2
chr4_-_87806296 1.782 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 8.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.7 6.8 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.4 6.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
1.0 4.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 4.4 GO:0021766 hippocampus development(GO:0021766)
0.6 3.9 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 3.7 GO:0035640 exploration behavior(GO:0035640)
0.6 3.1 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.1 3.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 3.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 2.8 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.4 2.5 GO:0019532 oxalate transport(GO:0019532)
0.0 2.5 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 2.4 GO:0007568 aging(GO:0007568)
0.3 2.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.3 2.0 GO:0015862 uridine transport(GO:0015862)
0.6 1.9 GO:0060214 stem cell fate specification(GO:0048866) endocardium formation(GO:0060214) cardiac cell fate determination(GO:0060913) regulation of cardiac cell fate specification(GO:2000043)
0.1 1.9 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 1.9 GO:0046677 response to antibiotic(GO:0046677)
0.3 1.8 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.4 4.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 4.4 GO:0045171 intercellular bridge(GO:0045171)
0.1 3.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 3.5 GO:0045177 apical part of cell(GO:0045177)
0.2 3.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 3.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 2.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.9 GO:0005923 bicellular tight junction(GO:0005923)
0.1 2.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.7 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 1.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 1.4 GO:0030139 endocytic vesicle(GO:0030139)
0.2 1.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.1 GO:0097228 sperm principal piece(GO:0097228)
0.2 1.0 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 1.0 GO:1990246 uniplex complex(GO:1990246)
0.0 1.0 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.4 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.3 6.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 4.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 4.8 GO:0060090 binding, bridging(GO:0060090)
1.3 3.9 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 3.7 GO:0002020 protease binding(GO:0002020)
0.0 3.7 GO:0005096 GTPase activator activity(GO:0005096)
0.6 3.1 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.1 3.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 2.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 2.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.8 2.4 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.9 GO:0008013 beta-catenin binding(GO:0008013)
0.2 1.7 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.2 1.7 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 1.7 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 1.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.6 GO:0036002 pre-mRNA binding(GO:0036002)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 NABA_COLLAGENS Genes encoding collagen proteins
0.0 3.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.1 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 2.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 2.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.7 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 1.1 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.7 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 0.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.3 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.3 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.3 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.8 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 5.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 3.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 2.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.4 2.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 2.0 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 1.7 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 1.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.6 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 1.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 1.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.3 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.1 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.1 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.1 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 1.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK