Motif ID: Gata4

Z-value: 0.525


Transcription factors associated with Gata4:

Gene SymbolEntrez IDGene Name
Gata4 ENSMUSG00000021944.9 Gata4



Activity profile for motif Gata4.

activity profile for motif Gata4


Sorted Z-values histogram for motif Gata4

Sorted Z-values for motif Gata4



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_45311538 4.806 ENSMUST00000087883.6
Col3a1
collagen, type III, alpha 1
chr1_-_56969864 4.566 ENSMUST00000177424.1
Satb2
special AT-rich sequence binding protein 2
chr1_+_177444653 4.381 ENSMUST00000094276.3
Zbtb18
zinc finger and BTB domain containing 18
chr1_-_56969827 4.326 ENSMUST00000176759.1
Satb2
special AT-rich sequence binding protein 2
chr6_+_103510874 3.738 ENSMUST00000066905.6
Chl1
cell adhesion molecule with homology to L1CAM
chr3_+_135825788 3.272 ENSMUST00000167390.1
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr2_+_4559742 3.121 ENSMUST00000176828.1
Frmd4a
FERM domain containing 4A
chr4_-_32923455 2.735 ENSMUST00000035719.4
ENSMUST00000084749.1
Ankrd6

ankyrin repeat domain 6

chr14_-_64455903 2.369 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr6_+_17306335 2.298 ENSMUST00000007799.6
ENSMUST00000115456.1
ENSMUST00000115455.2
ENSMUST00000130505.1
Cav1



caveolin 1, caveolae protein



chr3_+_135826075 2.248 ENSMUST00000029810.5
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr11_+_3330781 2.230 ENSMUST00000136536.1
ENSMUST00000093399.4
Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr16_-_23520579 2.218 ENSMUST00000089883.5
Masp1
mannan-binding lectin serine peptidase 1
chr5_+_64812336 2.063 ENSMUST00000166409.1
Klf3
Kruppel-like factor 3 (basic)
chr17_-_45593626 2.050 ENSMUST00000163905.1
ENSMUST00000167692.1
Slc29a1

solute carrier family 29 (nucleoside transporters), member 1

chr15_-_50890396 1.903 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chr4_-_87806276 1.864 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr1_-_14310198 1.825 ENSMUST00000168081.2
ENSMUST00000027066.6
Eya1

eyes absent 1 homolog (Drosophila)

chr10_+_84576626 1.800 ENSMUST00000020223.7
Tcp11l2
t-complex 11 (mouse) like 2
chr4_-_87806296 1.782 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr1_-_171281181 1.775 ENSMUST00000073120.4
Ppox
protoporphyrinogen oxidase
chr11_+_3330401 1.716 ENSMUST00000045153.4
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr8_+_84701430 1.679 ENSMUST00000037165.4
Lyl1
lymphoblastomic leukemia 1
chr7_-_80403315 1.672 ENSMUST00000147150.1
Furin
furin (paired basic amino acid cleaving enzyme)
chrX_+_10485121 1.665 ENSMUST00000076354.6
ENSMUST00000115526.1
Tspan7

tetraspanin 7

chr4_-_82705735 1.651 ENSMUST00000155821.1
Nfib
nuclear factor I/B
chr15_+_60822947 1.629 ENSMUST00000180730.1
9930014A18Rik
RIKEN cDNA 9930014A18 gene
chr2_-_33087169 1.592 ENSMUST00000102810.3
Garnl3
GTPase activating RANGAP domain-like 3
chr10_-_83648631 1.515 ENSMUST00000146876.2
ENSMUST00000176294.1
Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

chr15_+_55307743 1.510 ENSMUST00000023053.5
ENSMUST00000110221.2
ENSMUST00000110217.3
Col14a1


collagen, type XIV, alpha 1


chrX_+_150547375 1.456 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chr2_-_33086366 1.433 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr6_-_55681257 1.393 ENSMUST00000044767.8
Neurod6
neurogenic differentiation 6
chr16_+_45093611 1.388 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80
chrX_+_159840463 1.322 ENSMUST00000112451.1
ENSMUST00000112453.2
Sh3kbp1

SH3-domain kinase binding protein 1

chr4_-_14621805 1.310 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr3_+_135825648 1.299 ENSMUST00000180196.1
Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr7_+_28833975 1.252 ENSMUST00000066723.8
Lgals4
lectin, galactose binding, soluble 4
chr4_+_102254993 1.235 ENSMUST00000106908.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr10_-_83648713 1.135 ENSMUST00000020500.7
Appl2
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
chr17_+_43389436 1.100 ENSMUST00000113599.1
Gpr116
G protein-coupled receptor 116
chr10_-_62342674 1.069 ENSMUST00000143179.1
ENSMUST00000130422.1
Hk1

hexokinase 1

chr1_-_162866502 1.064 ENSMUST00000046049.7
Fmo1
flavin containing monooxygenase 1
chr6_+_125552948 1.062 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr1_-_4496363 1.008 ENSMUST00000116652.2
Sox17
SRY-box containing gene 17
chr12_-_91849081 1.003 ENSMUST00000167466.1
ENSMUST00000021347.5
ENSMUST00000178462.1
Sel1l


sel-1 suppressor of lin-12-like (C. elegans)


chr10_-_59616667 0.977 ENSMUST00000020312.6
Mcu
mitochondrial calcium uniporter
chr3_+_66985680 0.967 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr4_+_102570065 0.963 ENSMUST00000097950.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr2_-_7081207 0.951 ENSMUST00000114923.2
ENSMUST00000182706.1
Celf2

CUGBP, Elav-like family member 2

chr14_-_70207637 0.900 ENSMUST00000022682.5
Sorbs3
sorbin and SH3 domain containing 3
chrX_+_93675088 0.879 ENSMUST00000045898.3
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr1_-_4496400 0.870 ENSMUST00000027035.3
Sox17
SRY-box containing gene 17
chr5_-_121836852 0.849 ENSMUST00000086310.1
Sh2b3
SH2B adaptor protein 3
chr16_-_95459245 0.826 ENSMUST00000176345.1
ENSMUST00000121809.2
ENSMUST00000118113.1
ENSMUST00000122199.1
Erg



avian erythroblastosis virus E-26 (v-ets) oncogene related



chr6_+_17306415 0.802 ENSMUST00000150901.1
Cav1
caveolin 1, caveolae protein
chr5_-_121836810 0.800 ENSMUST00000118580.1
ENSMUST00000040308.7
Sh2b3

SH2B adaptor protein 3

chr1_+_165788681 0.799 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
Cd247



CD247 antigen



chr13_+_42681513 0.795 ENSMUST00000149235.1
Phactr1
phosphatase and actin regulator 1
chr4_+_102254739 0.789 ENSMUST00000106907.2
Pde4b
phosphodiesterase 4B, cAMP specific
chr1_+_151344472 0.781 ENSMUST00000023918.6
ENSMUST00000097543.1
ENSMUST00000111887.3
Ivns1abp


influenza virus NS1A binding protein


chr13_+_42709482 0.778 ENSMUST00000066928.5
ENSMUST00000148891.1
Phactr1

phosphatase and actin regulator 1

chr4_-_14621494 0.748 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chrX_-_60403947 0.742 ENSMUST00000033480.6
ENSMUST00000101527.2
Atp11c

ATPase, class VI, type 11C

chr2_-_59948155 0.721 ENSMUST00000153136.1
Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr2_-_52558539 0.700 ENSMUST00000102760.3
ENSMUST00000102761.2
Cacnb4

calcium channel, voltage-dependent, beta 4 subunit

chr10_-_19011948 0.669 ENSMUST00000105527.1
Tnfaip3
tumor necrosis factor, alpha-induced protein 3
chrX_-_107403295 0.659 ENSMUST00000033591.5
Itm2a
integral membrane protein 2A
chr16_+_91647859 0.659 ENSMUST00000119368.1
ENSMUST00000114037.2
ENSMUST00000114036.2
ENSMUST00000122302.1
Son



Son DNA binding protein



chr2_-_7081256 0.654 ENSMUST00000183209.1
Celf2
CUGBP, Elav-like family member 2
chr2_-_20968881 0.653 ENSMUST00000114594.1
Arhgap21
Rho GTPase activating protein 21
chr5_-_73191848 0.651 ENSMUST00000176910.1
Fryl
furry homolog-like (Drosophila)
chr9_+_66350465 0.649 ENSMUST00000042824.6
Herc1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr2_+_71786923 0.611 ENSMUST00000112101.1
ENSMUST00000028522.3
Itga6

integrin alpha 6

chr16_-_34263179 0.605 ENSMUST00000114949.1
ENSMUST00000114954.1
Kalrn

kalirin, RhoGEF kinase

chr4_-_138326234 0.594 ENSMUST00000105817.3
ENSMUST00000030536.6
Pink1

PTEN induced putative kinase 1

chr9_-_77251829 0.585 ENSMUST00000184322.1
ENSMUST00000184316.1
Mlip

muscular LMNA-interacting protein

chr12_+_95692212 0.578 ENSMUST00000057324.3
Flrt2
fibronectin leucine rich transmembrane protein 2
chr1_+_165788746 0.567 ENSMUST00000161559.2
Cd247
CD247 antigen
chr12_-_69893162 0.564 ENSMUST00000049239.7
ENSMUST00000110570.1
Map4k5

mitogen-activated protein kinase kinase kinase kinase 5

chrX_+_56779437 0.553 ENSMUST00000114773.3
Fhl1
four and a half LIM domains 1
chrX_+_56779699 0.543 ENSMUST00000114772.2
ENSMUST00000114768.3
ENSMUST00000155882.1
Fhl1


four and a half LIM domains 1


chrX_+_93654863 0.504 ENSMUST00000113933.2
Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr4_+_124802543 0.504 ENSMUST00000138807.1
ENSMUST00000030723.2
ENSMUST00000175875.1
Mtf1


metal response element binding transcription factor 1


chr3_-_129755305 0.499 ENSMUST00000029653.2
Egf
epidermal growth factor
chr7_+_110627650 0.476 ENSMUST00000033054.8
Adm
adrenomedullin
chr5_-_125294107 0.475 ENSMUST00000127148.1
Scarb1
scavenger receptor class B, member 1
chr3_+_66985947 0.470 ENSMUST00000161726.1
ENSMUST00000160504.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr13_-_91388079 0.468 ENSMUST00000181054.1
A830009L08Rik
RIKEN cDNA A830009L08 gene
chr3_+_79885930 0.462 ENSMUST00000029567.8
Fam198b
family with sequence similarity 198, member B
chr3_+_79884496 0.442 ENSMUST00000118853.1
Fam198b
family with sequence similarity 198, member B
chr9_-_77251871 0.442 ENSMUST00000183955.1
Mlip
muscular LMNA-interacting protein
chr4_-_14621669 0.408 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr6_-_122609964 0.404 ENSMUST00000032211.4
Gdf3
growth differentiation factor 3
chrX_+_73757069 0.392 ENSMUST00000002079.6
Plxnb3
plexin B3
chr14_+_55560904 0.383 ENSMUST00000072530.4
ENSMUST00000128490.1
Dcaf11

DDB1 and CUL4 associated factor 11

chr2_+_72476159 0.378 ENSMUST00000102691.4
Cdca7
cell division cycle associated 7
chr4_-_43558386 0.349 ENSMUST00000130353.1
Tln1
talin 1
chr18_+_36952621 0.333 ENSMUST00000115661.2
Pcdha2
protocadherin alpha 2
chr1_-_82586781 0.329 ENSMUST00000087050.5
Col4a4
collagen, type IV, alpha 4
chr16_-_34262830 0.326 ENSMUST00000114947.1
Kalrn
kalirin, RhoGEF kinase
chr7_+_99535439 0.323 ENSMUST00000098266.2
ENSMUST00000179755.1
Arrb1

arrestin, beta 1

chr3_-_59262825 0.318 ENSMUST00000050360.7
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr13_+_56703504 0.306 ENSMUST00000109874.1
Smad5
SMAD family member 5
chr2_+_72476225 0.272 ENSMUST00000157019.1
Cdca7
cell division cycle associated 7
chr2_-_77170592 0.271 ENSMUST00000164114.2
ENSMUST00000049544.7
Ccdc141

coiled-coil domain containing 141

chr3_+_66985700 0.269 ENSMUST00000046542.6
ENSMUST00000162693.1
Rsrc1

arginine/serine-rich coiled-coil 1

chr16_-_63864114 0.268 ENSMUST00000064405.6
Epha3
Eph receptor A3
chr14_+_55561060 0.255 ENSMUST00000117701.1
Dcaf11
DDB1 and CUL4 associated factor 11
chr19_+_58670358 0.250 ENSMUST00000057270.7
Pnlip
pancreatic lipase
chr17_+_71204647 0.246 ENSMUST00000126681.1
Lpin2
lipin 2
chr1_-_173333503 0.241 ENSMUST00000038227.4
Darc
Duffy blood group, chemokine receptor
chr7_-_44892358 0.231 ENSMUST00000003049.6
Med25
mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)
chr3_+_66985647 0.199 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr11_+_5009515 0.187 ENSMUST00000101613.2
Ap1b1
adaptor protein complex AP-1, beta 1 subunit
chr16_-_34262945 0.184 ENSMUST00000114953.1
Kalrn
kalirin, RhoGEF kinase
chr6_-_124768330 0.178 ENSMUST00000135626.1
Eno2
enolase 2, gamma neuronal
chr3_+_84593547 0.165 ENSMUST00000062623.3
Tigd4
tigger transposable element derived 4
chr3_+_79884576 0.161 ENSMUST00000145992.1
Fam198b
family with sequence similarity 198, member B
chr17_-_33713372 0.161 ENSMUST00000173392.1
March2
membrane-associated ring finger (C3HC4) 2
chr5_+_124483458 0.151 ENSMUST00000111453.1
Snrnp35
small nuclear ribonucleoprotein 35 (U11/U12)
chr2_+_65845833 0.139 ENSMUST00000053910.3
Csrnp3
cysteine-serine-rich nuclear protein 3
chr17_+_57249450 0.129 ENSMUST00000019631.9
Trip10
thyroid hormone receptor interactor 10
chr4_+_102760294 0.123 ENSMUST00000072481.5
ENSMUST00000156596.1
ENSMUST00000080728.6
ENSMUST00000106882.2
Sgip1



SH3-domain GRB2-like (endophilin) interacting protein 1



chr6_-_127109517 0.121 ENSMUST00000039913.8
9630033F20Rik
RIKEN cDNA 9630033F20 gene
chr18_-_43477764 0.118 ENSMUST00000057110.9
Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr7_+_110773658 0.112 ENSMUST00000143786.1
Ampd3
adenosine monophosphate deaminase 3
chr7_-_139582790 0.105 ENSMUST00000106095.2
Nkx6-2
NK6 homeobox 2
chr16_+_13358375 0.105 ENSMUST00000149359.1
Mkl2
MKL/myocardin-like 2
chr3_-_20242173 0.089 ENSMUST00000001921.1
Cpa3
carboxypeptidase A3, mast cell
chr2_-_121037048 0.086 ENSMUST00000102490.3
Epb4.2
erythrocyte protein band 4.2
chr19_-_7295394 0.080 ENSMUST00000025921.8
Mark2
MAP/microtubule affinity-regulating kinase 2
chr11_+_82911253 0.068 ENSMUST00000164945.1
ENSMUST00000018989.7
Unc45b

unc-45 homolog B (C. elegans)

chr16_-_46010212 0.056 ENSMUST00000130481.1
Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr4_-_46404224 0.053 ENSMUST00000107764.2
Hemgn
hemogen
chr10_-_80421847 0.025 ENSMUST00000156244.1
Tcf3
transcription factor 3
chr9_-_21963568 0.017 ENSMUST00000006397.5
Epor
erythropoietin receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.7 6.8 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.6 1.9 GO:0060214 stem cell fate specification(GO:0048866) endocardium formation(GO:0060214) cardiac cell fate determination(GO:0060913) regulation of cardiac cell fate specification(GO:2000043)
0.6 3.1 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.6 3.9 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.6 8.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 1.7 GO:0090472 dibasic protein processing(GO:0090472)
0.4 1.7 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 6.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.4 2.5 GO:0019532 oxalate transport(GO:0019532)
0.3 1.7 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.3 2.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.3 1.8 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.3 2.0 GO:0015862 uridine transport(GO:0015862)
0.2 1.7 GO:0001955 blood vessel maturation(GO:0001955)
0.2 3.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 0.7 GO:0070428 granuloma formation(GO:0002432) negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.2 0.8 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.2 0.5 GO:0015920 regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920)
0.2 1.1 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.6 GO:0036482 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.1 1.1 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.4 GO:0048859 formation of anatomical boundary(GO:0048859)
0.1 0.7 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.5 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 1.0 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.7 GO:0002317 plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.1 0.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.6 GO:0035878 nail development(GO:0035878)
0.1 1.5 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 0.3 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.1 1.1 GO:0070995 toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995)
0.1 3.7 GO:0035640 exploration behavior(GO:0035640)
0.1 0.5 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.4 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.1 0.7 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 1.4 GO:0021542 dentate gyrus development(GO:0021542)
0.1 1.9 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.1 3.1 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.7 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.6 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.7 GO:0045332 phospholipid translocation(GO:0045332)
0.1 4.4 GO:0021766 hippocampus development(GO:0021766)
0.1 0.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 0.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.1 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 1.9 GO:0046677 response to antibiotic(GO:0046677)
0.0 1.4 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 1.0 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.0 0.3 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 1.3 GO:0061050 regulation of cell growth involved in cardiac muscle cell development(GO:0061050)
0.0 0.6 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.0 1.0 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.8 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 1.1 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 1.4 GO:0001541 ovarian follicle development(GO:0001541)
0.0 1.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 2.5 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.1 GO:0032264 IMP salvage(GO:0032264)
0.0 0.5 GO:0046686 response to cadmium ion(GO:0046686)
0.0 2.4 GO:0007568 aging(GO:0007568)
0.0 0.2 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 1.2 GO:0001889 liver development(GO:0001889)
0.0 0.1 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.0 0.7 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 2.8 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.3 1.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.2 3.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 1.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 1.0 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.2 1.0 GO:1990246 uniplex complex(GO:1990246)
0.2 2.9 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 8.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.7 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 4.4 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 3.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.6 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.3 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 0.6 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.1 GO:0097228 sperm principal piece(GO:0097228)
0.0 1.0 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 2.9 GO:0005923 bicellular tight junction(GO:0005923)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 5.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 3.5 GO:0045177 apical part of cell(GO:0045177)
0.0 0.2 GO:0000243 commitment complex(GO:0000243)
0.0 1.4 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.0 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.8 2.4 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.6 3.1 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.5 1.5 GO:0016748 succinyltransferase activity(GO:0016748)
0.3 4.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 1.4 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.3 6.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 2.5 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 1.1 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 1.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2 1.3 GO:0016936 galactoside binding(GO:0016936)
0.2 1.7 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.2 0.5 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.2 1.7 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.6 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.3 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 1.1 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 0.7 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 3.0 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 1.2 GO:0017166 vinculin binding(GO:0017166)
0.1 1.7 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 1.4 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.6 GO:0010857 calcium-dependent protein kinase activity(GO:0010857)
0.0 0.3 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 1.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.4 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.6 GO:0045499 chemorepellent activity(GO:0045499)
0.0 1.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 2.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.7 GO:0002020 protease binding(GO:0002020)
0.0 0.3 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 4.8 GO:0060090 binding, bridging(GO:0060090)
0.0 1.1 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.2 GO:0050733 RS domain binding(GO:0050733)
0.0 1.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 2.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.1 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.7 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 3.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.1 GO:0005262 calcium channel activity(GO:0005262)
0.0 10.4 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 0.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 1.4 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.2 GO:0046965 retinoid X receptor binding(GO:0046965)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.6 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.1 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 0.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 2.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 3.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.7 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.1 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.3 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.3 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.7 PID_CD40_PATHWAY CD40/CD40L signaling
0.0 1.9 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 2.6 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.3 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 PID_TNF_PATHWAY TNF receptor signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.8 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.4 2.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 1.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 1.7 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 3.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.1 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 5.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 3.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 1.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.1 1.6 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.0 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.7 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.3 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 2.0 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.1 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.5 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.1 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 2.5 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.7 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK