Motif ID: Gata5
Z-value: 0.806
Transcription factors associated with Gata5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Gata5 | ENSMUSG00000015627.5 | Gata5 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 21.8 | GO:0015671 | oxygen transport(GO:0015671) |
| 1.4 | 4.1 | GO:0060023 | soft palate development(GO:0060023) |
| 1.2 | 6.2 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 1.1 | 3.4 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.7 | 2.1 | GO:1902605 | heterotrimeric G-protein complex assembly(GO:1902605) |
| 0.7 | 3.4 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.4 | 2.6 | GO:0035878 | nail development(GO:0035878) |
| 0.4 | 1.3 | GO:0001830 | trophectodermal cell fate commitment(GO:0001830) |
| 0.4 | 1.2 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) |
| 0.4 | 1.4 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.3 | 15.0 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.3 | 2.9 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.3 | 0.8 | GO:2000616 | negative regulation of histone H3-K9 acetylation(GO:2000616) |
| 0.3 | 1.1 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.3 | 0.8 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.2 | 1.8 | GO:0061368 | maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.2 | 2.2 | GO:0090527 | actin filament reorganization(GO:0090527) |
| 0.2 | 0.6 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.2 | 0.6 | GO:0006106 | fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) |
| 0.2 | 2.6 | GO:0071257 | cellular response to electrical stimulus(GO:0071257) |
| 0.2 | 0.9 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 0.2 | 1.5 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.2 | 0.3 | GO:2000095 | regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000095) |
| 0.2 | 2.2 | GO:0006517 | protein deglycosylation(GO:0006517) |
| 0.2 | 1.1 | GO:0070814 | hydrogen sulfide biosynthetic process(GO:0070814) |
| 0.2 | 4.0 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
| 0.1 | 1.5 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.1 | 0.4 | GO:0098968 | neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968) |
| 0.1 | 1.2 | GO:0034242 | negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) |
| 0.1 | 0.7 | GO:0032229 | positive regulation of gamma-aminobutyric acid secretion(GO:0014054) negative regulation of synaptic transmission, GABAergic(GO:0032229) |
| 0.1 | 0.4 | GO:0001812 | positive regulation of type I hypersensitivity(GO:0001812) |
| 0.1 | 0.3 | GO:1903225 | regulation of endodermal cell fate specification(GO:0042663) negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 1.1 | GO:0032693 | negative regulation of interleukin-10 production(GO:0032693) |
| 0.1 | 0.5 | GO:0046501 | protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.1 | 1.4 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 0.6 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 1.1 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
| 0.1 | 0.5 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.1 | 2.1 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.1 | 3.0 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.1 | 0.3 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.1 | 2.2 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.1 | 1.6 | GO:0001523 | retinoid metabolic process(GO:0001523) |
| 0.1 | 6.6 | GO:0030177 | positive regulation of Wnt signaling pathway(GO:0030177) |
| 0.1 | 0.7 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
| 0.1 | 1.2 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186) |
| 0.0 | 0.1 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.0 | 8.9 | GO:0060348 | bone development(GO:0060348) |
| 0.0 | 1.6 | GO:0042491 | auditory receptor cell differentiation(GO:0042491) |
| 0.0 | 1.2 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.2 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
| 0.0 | 0.2 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
| 0.0 | 1.2 | GO:0006506 | GPI anchor biosynthetic process(GO:0006506) |
| 0.0 | 1.4 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.0 | 0.1 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.0 | 3.5 | GO:0051291 | protein heterooligomerization(GO:0051291) |
| 0.0 | 1.4 | GO:0006672 | ceramide metabolic process(GO:0006672) |
| 0.0 | 1.1 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.0 | 0.2 | GO:0034390 | smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) |
| 0.0 | 2.2 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.0 | 1.5 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.3 | GO:0015813 | L-glutamate transport(GO:0015813) |
| 0.0 | 0.5 | GO:0045668 | negative regulation of osteoblast differentiation(GO:0045668) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 17.0 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.6 | 3.4 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.3 | 2.6 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.2 | 1.0 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.2 | 0.8 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 0.2 | 2.5 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 2.3 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 0.7 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.1 | 2.6 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 2.6 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.1 | 0.9 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 3.0 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.1 | 0.4 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.1 | 4.0 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 1.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 13.9 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.0 | 1.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 0.2 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 1.8 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.4 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 1.2 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 0.5 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 0.2 | GO:1990635 | proximal dendrite(GO:1990635) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 21.8 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.5 | 2.6 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.5 | 1.4 | GO:0001729 | ceramide kinase activity(GO:0001729) |
| 0.4 | 1.2 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
| 0.4 | 1.5 | GO:0047275 | glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275) |
| 0.3 | 2.1 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.3 | 3.4 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.3 | 2.0 | GO:0052650 | retinal binding(GO:0016918) NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.3 | 0.8 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.2 | 2.6 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.2 | 1.6 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.2 | 0.6 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.2 | 1.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 0.6 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
| 0.2 | 1.1 | GO:0016803 | ether hydrolase activity(GO:0016803) |
| 0.2 | 2.9 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 0.4 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
| 0.1 | 1.8 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.1 | 0.8 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.1 | 0.7 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.1 | 0.3 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.1 | 1.0 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.1 | 0.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.1 | 1.4 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.1 | 4.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 0.3 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.1 | 1.5 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 1.8 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 0.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 1.2 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.1 | 3.4 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 0.3 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.0 | 2.9 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 0.2 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.0 | 1.1 | GO:0008376 | acetylgalactosaminyltransferase activity(GO:0008376) |
| 0.0 | 1.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 1.2 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 4.1 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 1.4 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 8.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.9 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.3 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.0 | 1.0 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 0.3 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 1.4 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.1 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 1.0 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 9.5 | GO:0019904 | protein domain specific binding(GO:0019904) |
| 0.0 | 0.5 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.5 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 1.4 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.7 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.6 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 7.3 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.1 | 1.2 | PID_CONE_PATHWAY | Visual signal transduction: Cones |
| 0.1 | 3.2 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 1.4 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.4 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 1.3 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.0 | 2.6 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 1.1 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.6 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.4 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.4 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 4.0 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 2.8 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 1.5 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.1 | 10.1 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.6 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 1.4 | REACTOME_IL_RECEPTOR_SHC_SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.7 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.2 | REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 3.4 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.6 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.1 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 1.1 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.4 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.1 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.2 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.5 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.3 | REACTOME_ELONGATION_ARREST_AND_RECOVERY | Genes involved in Elongation arrest and recovery |
