Motif ID: Gata6

Z-value: 0.322


Transcription factors associated with Gata6:

Gene SymbolEntrez IDGene Name
Gata6 ENSMUSG00000005836.8 Gata6



Activity profile for motif Gata6.

activity profile for motif Gata6


Sorted Z-values histogram for motif Gata6

Sorted Z-values for motif Gata6



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 3.129 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_-_103853199 2.837 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr8_+_45628176 2.458 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr8_+_45627946 2.388 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr8_+_45627709 2.311 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr12_+_95692212 1.556 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2
chr16_-_46010212 1.010 ENSMUST00000130481.1
 Plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr4_+_13751297 0.990 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_179803376 0.931 ENSMUST00000097454.2
 Gm10518
predicted gene 10518
chr9_+_66350465 0.847 ENSMUST00000042824.6
 Herc1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr8_-_122699066 0.821 ENSMUST00000127984.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr2_+_71786923 0.769 ENSMUST00000112101.1
ENSMUST00000028522.3
 Itga6

integrin alpha 6

chr4_-_110287479 0.739 ENSMUST00000106598.1
ENSMUST00000102723.4
ENSMUST00000153906.1
 Elavl4


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)


chr3_-_154330543 0.665 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr5_-_73191848 0.634 ENSMUST00000176910.1
 Fryl
furry homolog-like (Drosophila)
chr2_+_65930117 0.598 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr16_-_34262945 0.592 ENSMUST00000114953.1
 Kalrn
kalirin, RhoGEF kinase
chr1_-_25829511 0.590 ENSMUST00000135518.1
ENSMUST00000151309.1
 Bai3

brain-specific angiogenesis inhibitor 3

chr2_-_59948155 0.501 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr2_+_68104671 0.479 ENSMUST00000042456.3
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr2_+_80617045 0.467 ENSMUST00000028384.4
 Dusp19
dual specificity phosphatase 19
chr17_+_71204647 0.416 ENSMUST00000126681.1
 Lpin2
lipin 2
chr2_-_172370506 0.411 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
 Aurka


aurora kinase A


chr6_-_127109517 0.396 ENSMUST00000039913.8
 9630033F20Rik
RIKEN cDNA 9630033F20 gene
chr2_-_7081207 0.390 ENSMUST00000114923.2
ENSMUST00000182706.1
 Celf2

CUGBP, Elav-like family member 2

chr2_-_125859139 0.376 ENSMUST00000110463.1
ENSMUST00000028635.5
 Cops2

COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)

chr2_-_7081256 0.360 ENSMUST00000183209.1
 Celf2
CUGBP, Elav-like family member 2
chr9_+_62342449 0.349 ENSMUST00000156461.1
 Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr18_-_43477764 0.333 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr10_-_40883073 0.324 ENSMUST00000044166.7
 Cdc40
cell division cycle 40
chr2_-_7396192 0.314 ENSMUST00000137733.2
 Celf2
CUGBP, Elav-like family member 2
chr11_-_53707269 0.313 ENSMUST00000124352.1
ENSMUST00000020649.7
 Rad50

RAD50 homolog (S. cerevisiae)

chr9_+_44379490 0.309 ENSMUST00000066601.6
 Hyou1
hypoxia up-regulated 1
chr11_+_95712673 0.300 ENSMUST00000107717.1
 Zfp652
zinc finger protein 652
chr11_+_67586675 0.287 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr2_-_7395879 0.280 ENSMUST00000182404.1
 Celf2
CUGBP, Elav-like family member 2
chr2_+_125859134 0.279 ENSMUST00000028636.6
ENSMUST00000125084.1
 Galk2

galactokinase 2

chr9_+_65032413 0.269 ENSMUST00000034960.6
 Dpp8
dipeptidylpeptidase 8
chr5_+_121777929 0.263 ENSMUST00000160821.1
 Atxn2
ataxin 2
chr16_-_64786321 0.258 ENSMUST00000052588.4
 Zfp654
zinc finger protein 654
chrX_-_37110257 0.242 ENSMUST00000076265.6
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr10_+_52417532 0.221 ENSMUST00000023830.8
 Nus1
nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)
chr6_-_38124568 0.219 ENSMUST00000040259.4
 Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr2_-_7395968 0.200 ENSMUST00000002176.6
 Celf2
CUGBP, Elav-like family member 2
chr6_+_58831748 0.196 ENSMUST00000126292.1
ENSMUST00000031823.5
 Herc3

hect domain and RLD 3

chr2_+_143915273 0.171 ENSMUST00000103172.3
 Dstn
destrin
chr8_-_64205970 0.170 ENSMUST00000066166.4
 Tll1
tolloid-like
chr11_+_4883186 0.167 ENSMUST00000139737.1
 Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr7_-_119895446 0.158 ENSMUST00000098080.2
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr6_+_58833689 0.157 ENSMUST00000041401.8
 Herc3
hect domain and RLD 3
chr6_+_86078070 0.156 ENSMUST00000032069.5
 Add2
adducin 2 (beta)
chr11_-_102365111 0.154 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr17_+_34604819 0.150 ENSMUST00000173242.1
 Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr15_-_103251465 0.143 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chr17_-_33713372 0.126 ENSMUST00000173392.1
 March2
membrane-associated ring finger (C3HC4) 2
chr6_-_136875794 0.111 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr19_+_4711153 0.105 ENSMUST00000008991.6
 Sptbn2
spectrin beta, non-erythrocytic 2
chr16_+_58670208 0.087 ENSMUST00000060077.5
 Cpox
coproporphyrinogen oxidase
chr10_-_34207551 0.085 ENSMUST00000048010.7
 Dse
dermatan sulfate epimerase
chr9_-_95815389 0.084 ENSMUST00000119760.1
 Pls1
plastin 1 (I-isoform)
chr3_-_20242173 0.081 ENSMUST00000001921.1
 Cpa3
carboxypeptidase A3, mast cell
chr7_-_99238564 0.080 ENSMUST00000064231.7
 Mogat2
monoacylglycerol O-acyltransferase 2
chr1_-_144177259 0.078 ENSMUST00000111941.1
ENSMUST00000052375.1
 Rgs13

regulator of G-protein signaling 13

chr13_+_24802020 0.054 ENSMUST00000155575.1
 BC005537
cDNA sequence BC005537
chr17_+_57249450 0.053 ENSMUST00000019631.9
 Trip10
thyroid hormone receptor interactor 10
chr10_+_40883469 0.044 ENSMUST00000019975.7
 Wasf1
WAS protein family, member 1
chr16_+_91647859 0.037 ENSMUST00000119368.1
ENSMUST00000114037.2
ENSMUST00000114036.2
ENSMUST00000122302.1
 Son



Son DNA binding protein



chr2_+_110597298 0.015 ENSMUST00000045972.6
ENSMUST00000111026.2
 Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr15_-_83170168 0.005 ENSMUST00000162834.1
 Cyb5r3
cytochrome b5 reductase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:0015671 oxygen transport(GO:0015671)
0.5 3.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 1.6 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.2 7.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.8 GO:0035878 nail development(GO:0035878)
0.1 0.8 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.1 0.4 GO:0007056 spindle assembly involved in female meiosis(GO:0007056) positive regulation of oocyte development(GO:0060282)
0.1 0.6 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.6 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.3 GO:0000019 regulation of mitotic recombination(GO:0000019) telomeric 3' overhang formation(GO:0031860)
0.1 0.5 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 1.1 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 1.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.3 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.0 0.2 GO:0032380 dolichol metabolic process(GO:0019348) regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0 0.1 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462)
0.0 0.1 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.2 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.3 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.4 GO:0000338 protein deneddylation(GO:0000338)
0.0 1.0 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.1 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 0.1 GO:0002002 regulation of angiotensin levels in blood(GO:0002002)
0.0 0.7 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.8 GO:0005833 hemoglobin complex(GO:0005833)
0.2 1.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 0.8 GO:0030056 hemidesmosome(GO:0030056)
0.1 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.7 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.1 GO:0008091 spectrin(GO:0008091)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 7.5 GO:0014069 postsynaptic density(GO:0014069)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 1.3 GO:0016363 nuclear matrix(GO:0016363)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.2 0.5 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.2 0.8 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.4 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.5 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 1.6 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.3 GO:0004335 galactokinase activity(GO:0004335)
0.1 0.4 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.3 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 1.5 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.7 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.2 GO:0004659 prenyltransferase activity(GO:0004659)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.6 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.8 PID_ERBB4_PATHWAY ErbB4 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks