Motif ID: Gbx1_Nobox_Alx3
Z-value: 0.575
Transcription factors associated with Gbx1_Nobox_Alx3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Alx3 | ENSMUSG00000014603.1 | Alx3 |
Gbx1 | ENSMUSG00000067724.4 | Gbx1 |
Nobox | ENSMUSG00000029736.9 | Nobox |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Alx3 | mm10_v2_chr3_+_107595031_107595164 | 0.23 | 4.2e-02 | Click! |
Gbx1 | mm10_v2_chr5_-_24527276_24527276 | 0.13 | 2.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.9 | 20.3 | GO:0019532 | oxalate transport(GO:0019532) |
1.9 | 20.5 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
1.2 | 3.7 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
1.0 | 3.1 | GO:0071336 | white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) |
0.9 | 3.5 | GO:0061743 | motor learning(GO:0061743) |
0.8 | 3.4 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
0.8 | 2.5 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
0.7 | 3.0 | GO:0015825 | L-serine transport(GO:0015825) |
0.7 | 2.9 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
0.7 | 2.1 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
0.7 | 1.3 | GO:0042663 | regulation of endodermal cell fate specification(GO:0042663) |
0.6 | 3.7 | GO:1902261 | positive regulation of delayed rectifier potassium channel activity(GO:1902261) |
0.6 | 1.7 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
0.5 | 4.3 | GO:0016198 | axon choice point recognition(GO:0016198) |
0.5 | 1.8 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
0.5 | 5.0 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
0.4 | 1.3 | GO:0009838 | abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
0.4 | 3.6 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
0.4 | 1.6 | GO:0010749 | regulation of nitric oxide mediated signal transduction(GO:0010749) |
0.4 | 3.0 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
0.4 | 1.9 | GO:0060648 | mammary gland bud morphogenesis(GO:0060648) |
0.4 | 1.1 | GO:1903538 | meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
0.3 | 1.4 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
0.3 | 1.0 | GO:2000224 | regulation of testosterone biosynthetic process(GO:2000224) |
0.3 | 1.3 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
0.3 | 1.3 | GO:0061055 | myotome development(GO:0061055) |
0.3 | 1.6 | GO:0002677 | negative regulation of chronic inflammatory response(GO:0002677) |
0.3 | 1.2 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.3 | 7.0 | GO:0008340 | determination of adult lifespan(GO:0008340) |
0.3 | 1.1 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.3 | 4.9 | GO:0008210 | luteinization(GO:0001553) estrogen metabolic process(GO:0008210) |
0.3 | 0.8 | GO:0030916 | otic vesicle formation(GO:0030916) |
0.2 | 1.4 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
0.2 | 1.9 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
0.2 | 0.7 | GO:0035934 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
0.2 | 0.9 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
0.2 | 1.9 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
0.2 | 1.0 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
0.2 | 1.9 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
0.2 | 2.3 | GO:0021891 | olfactory bulb interneuron development(GO:0021891) |
0.2 | 0.5 | GO:1900149 | positive regulation of Schwann cell migration(GO:1900149) |
0.2 | 6.0 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
0.2 | 1.2 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
0.2 | 0.5 | GO:0051342 | regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344) |
0.2 | 4.8 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
0.2 | 0.5 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
0.2 | 1.7 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
0.2 | 0.5 | GO:0060166 | olfactory pit development(GO:0060166) |
0.2 | 0.5 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
0.1 | 3.4 | GO:0090036 | regulation of protein kinase C signaling(GO:0090036) |
0.1 | 1.0 | GO:0098707 | positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707) |
0.1 | 0.9 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
0.1 | 0.4 | GO:0045113 | regulation of integrin biosynthetic process(GO:0045113) |
0.1 | 0.7 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
0.1 | 1.1 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
0.1 | 0.5 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
0.1 | 1.8 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
0.1 | 1.4 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
0.1 | 0.4 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
0.1 | 0.9 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
0.1 | 1.7 | GO:1902259 | regulation of delayed rectifier potassium channel activity(GO:1902259) |
0.1 | 0.4 | GO:0006706 | steroid catabolic process(GO:0006706) |
0.1 | 0.9 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
0.1 | 0.5 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
0.1 | 1.6 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
0.1 | 6.5 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
0.1 | 0.5 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) |
0.1 | 0.8 | GO:0046085 | adenosine metabolic process(GO:0046085) |
0.1 | 0.5 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
0.1 | 0.6 | GO:0050957 | equilibrioception(GO:0050957) |
0.1 | 2.7 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
0.1 | 0.9 | GO:2000671 | regulation of motor neuron apoptotic process(GO:2000671) |
0.1 | 3.0 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
0.1 | 1.5 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
0.1 | 0.5 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
0.1 | 3.4 | GO:0060395 | SMAD protein signal transduction(GO:0060395) |
0.1 | 2.1 | GO:0097178 | ruffle assembly(GO:0097178) |
0.1 | 0.9 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
0.1 | 0.7 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
0.1 | 0.3 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
0.1 | 0.6 | GO:1901550 | regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140) |
0.1 | 0.2 | GO:0006667 | sphinganine metabolic process(GO:0006667) regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504) |
0.1 | 0.6 | GO:1904861 | excitatory synapse assembly(GO:1904861) |
0.1 | 0.9 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
0.1 | 1.4 | GO:0006907 | pinocytosis(GO:0006907) |
0.1 | 1.8 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
0.1 | 0.2 | GO:2000974 | comma-shaped body morphogenesis(GO:0072049) negative regulation of pro-B cell differentiation(GO:2000974) |
0.1 | 0.2 | GO:1904578 | response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579) |
0.1 | 0.8 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
0.1 | 0.6 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
0.1 | 0.8 | GO:0006337 | nucleosome disassembly(GO:0006337) |
0.1 | 0.5 | GO:0097186 | amelogenesis(GO:0097186) |
0.1 | 0.3 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
0.0 | 0.2 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
0.0 | 0.1 | GO:0061144 | alveolar secondary septum development(GO:0061144) |
0.0 | 0.4 | GO:0033572 | transferrin transport(GO:0033572) |
0.0 | 0.4 | GO:0044144 | regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144) |
0.0 | 0.3 | GO:0042795 | snRNA transcription from RNA polymerase II promoter(GO:0042795) |
0.0 | 0.3 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.0 | 0.9 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
0.0 | 0.6 | GO:0021756 | striatum development(GO:0021756) |
0.0 | 0.2 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
0.0 | 0.1 | GO:0003356 | regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) |
0.0 | 0.6 | GO:0048670 | regulation of collateral sprouting(GO:0048670) |
0.0 | 0.5 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
0.0 | 0.8 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
0.0 | 0.5 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
0.0 | 3.1 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
0.0 | 3.4 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
0.0 | 0.6 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
0.0 | 1.5 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
0.0 | 1.1 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
0.0 | 0.9 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
0.0 | 0.5 | GO:0021702 | cerebellar Purkinje cell differentiation(GO:0021702) |
0.0 | 0.1 | GO:0015867 | ATP transport(GO:0015867) |
0.0 | 0.1 | GO:0006987 | activation of signaling protein activity involved in unfolded protein response(GO:0006987) |
0.0 | 0.3 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
0.0 | 0.8 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
0.0 | 3.5 | GO:0007416 | synapse assembly(GO:0007416) |
0.0 | 0.1 | GO:0070317 | negative regulation of G0 to G1 transition(GO:0070317) |
0.0 | 0.1 | GO:0002317 | plasma cell differentiation(GO:0002317) |
0.0 | 0.7 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.0 | 0.3 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
0.0 | 0.1 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
0.0 | 6.1 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
0.0 | 0.9 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
0.0 | 0.5 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
0.0 | 1.0 | GO:0042982 | amyloid precursor protein metabolic process(GO:0042982) |
0.0 | 1.3 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
0.0 | 3.4 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
0.0 | 0.1 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
0.0 | 2.5 | GO:0030178 | negative regulation of Wnt signaling pathway(GO:0030178) |
0.0 | 1.5 | GO:0043149 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
0.0 | 0.5 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
0.0 | 0.4 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
0.0 | 0.4 | GO:0003009 | skeletal muscle contraction(GO:0003009) |
0.0 | 0.1 | GO:0042053 | regulation of dopamine metabolic process(GO:0042053) neuromuscular process controlling posture(GO:0050884) |
0.0 | 0.3 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
0.0 | 0.1 | GO:0060363 | cranial suture morphogenesis(GO:0060363) |
0.0 | 0.1 | GO:0007320 | insemination(GO:0007320) |
0.0 | 1.6 | GO:0007050 | cell cycle arrest(GO:0007050) |
0.0 | 0.3 | GO:0060674 | placenta blood vessel development(GO:0060674) |
0.0 | 0.6 | GO:0043407 | negative regulation of MAP kinase activity(GO:0043407) |
0.0 | 1.0 | GO:1904892 | regulation of JAK-STAT cascade(GO:0046425) regulation of STAT cascade(GO:1904892) |
0.0 | 0.2 | GO:0044458 | motile cilium assembly(GO:0044458) |
0.0 | 0.8 | GO:0030168 | platelet activation(GO:0030168) |
0.0 | 0.9 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 2.9 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.4 | 6.3 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.4 | 1.8 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
0.3 | 2.7 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
0.3 | 1.3 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
0.3 | 0.8 | GO:0071953 | elastic fiber(GO:0071953) |
0.2 | 0.4 | GO:0005859 | muscle myosin complex(GO:0005859) |
0.2 | 2.9 | GO:0043083 | synaptic cleft(GO:0043083) |
0.2 | 3.9 | GO:0031527 | filopodium membrane(GO:0031527) |
0.2 | 3.6 | GO:0071564 | npBAF complex(GO:0071564) |
0.2 | 0.4 | GO:0071438 | invadopodium membrane(GO:0071438) |
0.2 | 0.5 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
0.1 | 1.3 | GO:0090543 | Flemming body(GO:0090543) |
0.1 | 1.0 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
0.1 | 0.9 | GO:0071437 | invadopodium(GO:0071437) |
0.1 | 1.1 | GO:0097433 | dense body(GO:0097433) |
0.1 | 0.5 | GO:0097450 | astrocyte end-foot(GO:0097450) |
0.1 | 0.7 | GO:0031258 | lamellipodium membrane(GO:0031258) |
0.1 | 0.5 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.1 | 0.4 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
0.1 | 0.5 | GO:0060091 | kinocilium(GO:0060091) |
0.1 | 0.5 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
0.1 | 0.9 | GO:0071439 | clathrin complex(GO:0071439) |
0.1 | 1.0 | GO:0005915 | zonula adherens(GO:0005915) |
0.1 | 3.0 | GO:0035371 | microtubule plus-end(GO:0035371) |
0.1 | 0.9 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.1 | 0.5 | GO:0044615 | nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615) |
0.1 | 3.4 | GO:0031672 | A band(GO:0031672) |
0.1 | 2.7 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
0.1 | 1.0 | GO:0031045 | dense core granule(GO:0031045) |
0.1 | 2.1 | GO:0032590 | dendrite membrane(GO:0032590) |
0.1 | 3.0 | GO:0005882 | intermediate filament(GO:0005882) |
0.1 | 1.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
0.1 | 0.5 | GO:0016272 | prefoldin complex(GO:0016272) |
0.1 | 0.3 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
0.1 | 2.3 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
0.0 | 3.7 | GO:0016529 | sarcoplasmic reticulum(GO:0016529) |
0.0 | 0.3 | GO:0005916 | fascia adherens(GO:0005916) |
0.0 | 0.9 | GO:0098644 | complex of collagen trimers(GO:0098644) |
0.0 | 1.0 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
0.0 | 1.7 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.0 | 2.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.0 | 1.3 | GO:0055038 | recycling endosome membrane(GO:0055038) |
0.0 | 0.7 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.0 | 0.3 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
0.0 | 0.2 | GO:0017059 | serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211) |
0.0 | 0.3 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
0.0 | 7.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.0 | 4.4 | GO:0001650 | fibrillar center(GO:0001650) |
0.0 | 0.4 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
0.0 | 2.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 0.5 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
0.0 | 0.3 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
0.0 | 0.2 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
0.0 | 0.7 | GO:0034707 | chloride channel complex(GO:0034707) |
0.0 | 0.1 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
0.0 | 0.7 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 1.8 | GO:0016363 | nuclear matrix(GO:0016363) |
0.0 | 0.4 | GO:0014704 | intercalated disc(GO:0014704) |
0.0 | 0.4 | GO:0030673 | axolemma(GO:0030673) |
0.0 | 5.4 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 0.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.0 | 0.4 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
0.0 | 1.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
0.0 | 0.1 | GO:0000812 | Swr1 complex(GO:0000812) |
0.0 | 0.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
0.0 | 0.1 | GO:0005869 | dynactin complex(GO:0005869) |
0.0 | 0.9 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 0.2 | GO:0043034 | costamere(GO:0043034) |
0.0 | 0.1 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 20.3 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
1.5 | 6.0 | GO:0004966 | galanin receptor activity(GO:0004966) |
0.8 | 3.1 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
0.8 | 4.6 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
0.6 | 4.8 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
0.5 | 5.4 | GO:0019865 | immunoglobulin binding(GO:0019865) |
0.4 | 3.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
0.4 | 3.0 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.4 | 3.4 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
0.4 | 3.0 | GO:0015180 | L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858) |
0.4 | 2.9 | GO:0099583 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) |
0.3 | 3.1 | GO:0048185 | activin binding(GO:0048185) |
0.3 | 2.3 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
0.3 | 1.6 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
0.3 | 3.7 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.3 | 1.8 | GO:0070699 | type II activin receptor binding(GO:0070699) |
0.3 | 1.1 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
0.3 | 0.8 | GO:0016748 | succinyltransferase activity(GO:0016748) |
0.3 | 1.0 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
0.2 | 1.0 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.2 | 1.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.2 | 6.4 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
0.2 | 3.8 | GO:0016208 | AMP binding(GO:0016208) |
0.2 | 2.7 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.2 | 0.5 | GO:0036004 | GAF domain binding(GO:0036004) |
0.2 | 0.9 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
0.2 | 1.9 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.2 | 1.1 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.1 | 1.0 | GO:0015091 | ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510) |
0.1 | 1.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.1 | 0.4 | GO:0030171 | voltage-gated proton channel activity(GO:0030171) |
0.1 | 0.5 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
0.1 | 0.9 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
0.1 | 0.6 | GO:0050694 | galactose 3-O-sulfotransferase activity(GO:0050694) |
0.1 | 0.5 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
0.1 | 0.9 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
0.1 | 0.5 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
0.1 | 3.8 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
0.1 | 0.3 | GO:0015254 | glycerol channel activity(GO:0015254) |
0.1 | 2.9 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
0.1 | 0.6 | GO:0038036 | sphingosine-1-phosphate receptor activity(GO:0038036) |
0.1 | 3.4 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.1 | 0.5 | GO:0001849 | complement component C1q binding(GO:0001849) |
0.1 | 1.8 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
0.1 | 0.9 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
0.1 | 0.3 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
0.1 | 2.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
0.1 | 0.3 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
0.1 | 1.2 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.1 | 0.7 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
0.1 | 0.2 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
0.1 | 3.6 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
0.1 | 1.0 | GO:0097602 | cullin family protein binding(GO:0097602) |
0.1 | 0.3 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
0.1 | 1.7 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
0.1 | 1.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.1 | 0.7 | GO:0070097 | delta-catenin binding(GO:0070097) |
0.1 | 0.6 | GO:0038191 | neuropilin binding(GO:0038191) |
0.1 | 0.8 | GO:0003688 | DNA replication origin binding(GO:0003688) |
0.1 | 1.0 | GO:0042056 | chemoattractant activity(GO:0042056) |
0.1 | 0.5 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
0.1 | 0.8 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
0.0 | 1.1 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
0.0 | 17.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
0.0 | 6.2 | GO:0030165 | PDZ domain binding(GO:0030165) |
0.0 | 0.4 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
0.0 | 1.2 | GO:0017147 | Wnt-protein binding(GO:0017147) |
0.0 | 0.4 | GO:0015248 | sterol transporter activity(GO:0015248) |
0.0 | 1.0 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
0.0 | 0.2 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
0.0 | 0.2 | GO:0032027 | myosin light chain binding(GO:0032027) |
0.0 | 1.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.9 | GO:0001968 | fibronectin binding(GO:0001968) |
0.0 | 3.1 | GO:0002039 | p53 binding(GO:0002039) |
0.0 | 0.7 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
0.0 | 0.5 | GO:0002162 | dystroglycan binding(GO:0002162) |
0.0 | 0.1 | GO:0015228 | coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122) |
0.0 | 0.3 | GO:0015288 | porin activity(GO:0015288) |
0.0 | 1.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.0 | 0.2 | GO:0004954 | icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955) |
0.0 | 0.4 | GO:0017166 | vinculin binding(GO:0017166) |
0.0 | 1.0 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
0.0 | 6.8 | GO:0000287 | magnesium ion binding(GO:0000287) |
0.0 | 1.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
0.0 | 0.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
0.0 | 0.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 2.6 | GO:0017048 | Rho GTPase binding(GO:0017048) |
0.0 | 1.6 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
0.0 | 0.1 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
0.0 | 0.3 | GO:0035004 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) phosphatidylinositol 3-kinase activity(GO:0035004) |
0.0 | 0.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
0.0 | 5.5 | GO:0003924 | GTPase activity(GO:0003924) |
0.0 | 4.7 | GO:0008017 | microtubule binding(GO:0008017) |
0.0 | 0.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.0 | 0.5 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
0.0 | 1.0 | GO:0015485 | cholesterol binding(GO:0015485) |
0.0 | 0.5 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
0.0 | 0.5 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
0.0 | 1.4 | GO:0051082 | unfolded protein binding(GO:0051082) |
0.0 | 0.7 | GO:0004601 | peroxidase activity(GO:0004601) |
0.0 | 1.4 | GO:0005525 | GTP binding(GO:0005525) |
0.0 | 0.3 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 0.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 0.1 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.0 | 1.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
0.0 | 0.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.0 | 0.4 | GO:0031369 | translation initiation factor binding(GO:0031369) |
0.0 | 0.5 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
0.0 | 2.8 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
0.0 | 0.4 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 20.8 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
0.1 | 6.5 | PID_BMP_PATHWAY | BMP receptor signaling |
0.1 | 1.0 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
0.1 | 1.9 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
0.1 | 3.1 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
0.1 | 2.9 | PID_NCADHERIN_PATHWAY | N-cadherin signaling events |
0.1 | 3.8 | PID_REELIN_PATHWAY | Reelin signaling pathway |
0.1 | 2.0 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
0.1 | 1.4 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
0.1 | 3.7 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
0.1 | 3.1 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
0.1 | 2.5 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
0.1 | 1.4 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
0.0 | 1.3 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
0.0 | 0.9 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 1.3 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.0 | 0.5 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.0 | 1.4 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
0.0 | 6.1 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.0 | 0.9 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
0.0 | 1.5 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
0.0 | 1.4 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
0.0 | 1.1 | PID_INSULIN_PATHWAY | Insulin Pathway |
0.0 | 0.2 | PID_S1P_S1P3_PATHWAY | S1P3 pathway |
0.0 | 0.5 | ST_ADRENERGIC | Adrenergic Pathway |
0.0 | 0.3 | PID_IL8_CXCR2_PATHWAY | IL8- and CXCR2-mediated signaling events |
0.0 | 1.3 | PID_CXCR4_PATHWAY | CXCR4-mediated signaling events |
0.0 | 0.1 | ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY | PI3K Pathway |
0.0 | 0.4 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
0.0 | 0.5 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 6.4 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
0.3 | 3.8 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
0.3 | 2.9 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
0.2 | 25.0 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.2 | 3.0 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
0.2 | 1.1 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
0.1 | 2.9 | REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
0.1 | 1.3 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
0.1 | 1.1 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
0.1 | 3.4 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
0.1 | 0.9 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
0.1 | 8.3 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.1 | 1.8 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
0.1 | 3.4 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.1 | 3.1 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
0.1 | 1.1 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
0.1 | 1.0 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
0.1 | 0.6 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
0.1 | 0.9 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.1 | 1.7 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
0.1 | 0.2 | REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
0.1 | 1.4 | REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS | Genes involved in Activation of BH3-only proteins |
0.1 | 1.8 | REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
0.0 | 1.3 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
0.0 | 3.5 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
0.0 | 0.7 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 1.6 | REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE | Genes involved in GPVI-mediated activation cascade |
0.0 | 0.3 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.0 | 1.0 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.0 | 0.9 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
0.0 | 1.1 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
0.0 | 0.7 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
0.0 | 0.8 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
0.0 | 0.2 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
0.0 | 0.6 | REACTOME_OTHER_SEMAPHORIN_INTERACTIONS | Genes involved in Other semaphorin interactions |
0.0 | 0.9 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
0.0 | 0.5 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
0.0 | 0.5 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
0.0 | 0.6 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.0 | 0.5 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
0.0 | 0.1 | REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |