Motif ID: Gbx1_Nobox_Alx3

Z-value: 0.575

Transcription factors associated with Gbx1_Nobox_Alx3:

Gene SymbolEntrez IDGene Name
Alx3 ENSMUSG00000014603.1 Alx3
Gbx1 ENSMUSG00000067724.4 Gbx1
Nobox ENSMUSG00000029736.9 Nobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx3mm10_v2_chr3_+_107595031_1075951640.234.2e-02Click!
Gbx1mm10_v2_chr5_-_24527276_245272760.132.6e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx1_Nobox_Alx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_14621805 9.322 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr12_+_109545390 7.040 ENSMUST00000146701.1
Meg3
maternally expressed 3
chr12_+_38780817 6.802 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr12_+_38780284 6.697 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr15_-_11037968 5.983 ENSMUST00000058007.5
Rxfp3
relaxin family peptide receptor 3
chr12_-_40037387 5.789 ENSMUST00000146905.1
Arl4a
ADP-ribosylation factor-like 4A
chr4_-_14621494 5.555 ENSMUST00000149633.1
Slc26a7
solute carrier family 26, member 7
chr4_-_14621669 5.418 ENSMUST00000143105.1
Slc26a7
solute carrier family 26, member 7
chr3_+_68572245 4.942 ENSMUST00000170788.2
Schip1
schwannomin interacting protein 1
chr13_-_102906046 4.889 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr15_+_92597104 4.860 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr18_+_23415400 4.859 ENSMUST00000115832.2
ENSMUST00000047954.7
Dtna

dystrobrevin alpha

chr2_+_125136692 4.662 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr1_-_152625212 4.563 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr15_-_37459327 4.361 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr12_+_38781093 3.991 ENSMUST00000161513.1
Etv1
ets variant gene 1
chr3_+_134236483 3.912 ENSMUST00000181904.1
ENSMUST00000053048.9
Cxxc4

CXXC finger 4

chr16_-_42340595 3.888 ENSMUST00000102817.4
Gap43
growth associated protein 43
chr10_-_25200110 3.781 ENSMUST00000100012.2
Akap7
A kinase (PRKA) anchor protein 7
chr2_+_109917639 3.683 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr15_+_21111452 3.497 ENSMUST00000075132.6
Cdh12
cadherin 12
chr3_-_116253467 3.473 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr8_-_36249292 3.378 ENSMUST00000065297.5
Lonrf1
LON peptidase N-terminal domain and ring finger 1
chr3_-_141982224 3.378 ENSMUST00000029948.8
Bmpr1b
bone morphogenetic protein receptor, type 1B
chr10_+_85386813 3.364 ENSMUST00000105307.1
ENSMUST00000020231.3
Btbd11

BTB (POZ) domain containing 11

chr13_-_102905740 3.236 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_114458720 3.129 ENSMUST00000022287.5
Fst
follistatin
chr5_-_137684665 3.081 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
Agfg2


ArfGAP with FG repeats 2


chr9_+_32116040 3.077 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr13_+_118714678 3.055 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chr13_-_113663670 3.022 ENSMUST00000054650.4
Hspb3
heat shock protein 3
chr3_+_55461758 2.973 ENSMUST00000070418.4
Dclk1
doublecortin-like kinase 1
chr18_+_23752333 2.972 ENSMUST00000170802.1
ENSMUST00000155708.1
ENSMUST00000118826.2
Mapre2


microtubule-associated protein, RP/EB family, member 2


chr6_-_136171722 2.943 ENSMUST00000053880.6
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr6_+_125552948 2.936 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr13_+_94083490 2.905 ENSMUST00000156071.1
Lhfpl2
lipoma HMGIC fusion partner-like 2
chr6_+_8948608 2.711 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr18_+_37518341 2.669 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chr19_+_26749726 2.565 ENSMUST00000175842.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr7_-_45103747 2.500 ENSMUST00000003512.7
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr11_+_103133333 2.484 ENSMUST00000124928.1
ENSMUST00000062530.4
Hexim2

hexamethylene bis-acetamide inducible 2

chr16_-_76373827 2.475 ENSMUST00000121927.1
Nrip1
nuclear receptor interacting protein 1
chr1_-_158356258 2.407 ENSMUST00000004133.8
Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr11_+_103133303 2.311 ENSMUST00000107037.1
Hexim2
hexamethylene bis-acetamide inducible 2
chr18_-_80986578 2.305 ENSMUST00000057950.7
Sall3
sal-like 3 (Drosophila)
chr3_+_62419668 2.100 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr3_+_159839729 2.055 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr15_-_37458523 2.005 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr3_+_55782500 1.925 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr5_+_139543889 1.879 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr6_-_147264124 1.862 ENSMUST00000052296.6
Pthlh
parathyroid hormone-like peptide
chr19_-_14598031 1.839 ENSMUST00000167776.2
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr12_-_91849081 1.837 ENSMUST00000167466.1
ENSMUST00000021347.5
ENSMUST00000178462.1
Sel1l


sel-1 suppressor of lin-12-like (C. elegans)


chr10_+_39612934 1.835 ENSMUST00000019987.6
Traf3ip2
TRAF3 interacting protein 2
chr5_-_66514815 1.831 ENSMUST00000161879.1
ENSMUST00000159357.1
Apbb2

amyloid beta (A4) precursor protein-binding, family B, member 2

chr4_+_13751297 1.828 ENSMUST00000105566.2
Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr7_+_126950518 1.792 ENSMUST00000106335.1
ENSMUST00000146017.1
Sez6l2

seizure related 6 homolog like 2

chr8_+_121116163 1.741 ENSMUST00000054691.6
Foxc2
forkhead box C2
chr19_-_14597983 1.729 ENSMUST00000052011.7
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr3_+_125404292 1.726 ENSMUST00000144344.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr13_+_42680565 1.722 ENSMUST00000128646.1
Phactr1
phosphatase and actin regulator 1
chr2_-_164171113 1.705 ENSMUST00000045196.3
Kcns1
K+ voltage-gated channel, subfamily S, 1
chr2_+_152754156 1.699 ENSMUST00000010020.5
Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr2_-_77519565 1.630 ENSMUST00000111830.2
Zfp385b
zinc finger protein 385B
chr19_-_29334646 1.611 ENSMUST00000044143.5
Rln1
relaxin 1
chr11_-_20332689 1.582 ENSMUST00000109594.1
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr9_-_120068263 1.565 ENSMUST00000064165.3
ENSMUST00000177637.1
Cx3cr1

chemokine (C-X3-C) receptor 1

chr3_+_109573907 1.562 ENSMUST00000106576.2
Vav3
vav 3 oncogene
chr12_+_38783503 1.536 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr8_+_23669653 1.489 ENSMUST00000042352.4
Zmat4
zinc finger, matrin type 4
chr3_+_86070915 1.484 ENSMUST00000182666.1
Sh3d19
SH3 domain protein D19
chr6_+_145934113 1.458 ENSMUST00000032383.7
Sspn
sarcospan
chr6_+_29853746 1.458 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
Ahcyl2



S-adenosylhomocysteine hydrolase-like 2



chr17_-_49564262 1.443 ENSMUST00000057610.6
Daam2
dishevelled associated activator of morphogenesis 2
chr7_-_116198487 1.439 ENSMUST00000181981.1
Plekha7
pleckstrin homology domain containing, family A member 7
chr12_+_38783455 1.427 ENSMUST00000161980.1
ENSMUST00000160701.1
Etv1

ets variant gene 1

chr2_-_120154600 1.425 ENSMUST00000028755.7
Ehd4
EH-domain containing 4
chr11_-_20332654 1.405 ENSMUST00000004634.6
Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr9_-_55919605 1.395 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr18_+_66458587 1.387 ENSMUST00000025399.7
Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
chr5_+_81021583 1.375 ENSMUST00000121707.1
Lphn3
latrophilin 3
chr9_+_106368594 1.368 ENSMUST00000172306.2
Dusp7
dual specificity phosphatase 7
chr3_+_125404072 1.358 ENSMUST00000173932.1
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_122419772 1.339 ENSMUST00000029766.4
Bcar3
breast cancer anti-estrogen resistance 3
chr1_-_22315792 1.335 ENSMUST00000164877.1
Rims1
regulating synaptic membrane exocytosis 1
chr11_-_98053415 1.323 ENSMUST00000017544.2
Stac2
SH3 and cysteine rich domain 2
chr7_+_126950687 1.320 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr2_+_65930117 1.311 ENSMUST00000176109.1
Csrnp3
cysteine-serine-rich nuclear protein 3
chr2_-_144527341 1.308 ENSMUST00000163701.1
ENSMUST00000081982.5
Dzank1

double zinc ribbon and ankyrin repeat domains 1

chr10_+_99263224 1.306 ENSMUST00000020118.4
Dusp6
dual specificity phosphatase 6
chr8_+_107031218 1.303 ENSMUST00000034388.9
Vps4a
vacuolar protein sorting 4a (yeast)
chr19_+_25672408 1.280 ENSMUST00000053068.5
Dmrt2
doublesex and mab-3 related transcription factor 2
chr5_+_81021202 1.228 ENSMUST00000117253.1
ENSMUST00000120128.1
Lphn3

latrophilin 3

chr2_-_5676046 1.227 ENSMUST00000114987.3
Camk1d
calcium/calmodulin-dependent protein kinase ID
chr1_+_72284367 1.166 ENSMUST00000027380.5
ENSMUST00000141783.1
Tmem169

transmembrane protein 169

chr6_+_30541582 1.160 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr3_-_59220150 1.135 ENSMUST00000170388.1
P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr15_-_67113909 1.135 ENSMUST00000092640.5
St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr2_-_64975762 1.115 ENSMUST00000156765.1
Grb14
growth factor receptor bound protein 14
chr12_+_108334341 1.098 ENSMUST00000021684.4
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr5_+_15516489 1.095 ENSMUST00000178227.1
Gm21847
predicted gene, 21847
chr3_+_122044428 1.085 ENSMUST00000013995.8
Abca4
ATP-binding cassette, sub-family A (ABC1), member 4
chr1_-_126830632 1.080 ENSMUST00000112583.1
ENSMUST00000094609.3
Nckap5

NCK-associated protein 5

chr19_+_26750939 1.072 ENSMUST00000175953.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_+_19907502 1.065 ENSMUST00000101558.3
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr10_+_116018213 1.059 ENSMUST00000063470.4
Ptprr
protein tyrosine phosphatase, receptor type, R
chr6_-_99266494 1.054 ENSMUST00000113326.2
Foxp1
forkhead box P1
chrX_-_143933089 1.040 ENSMUST00000087313.3
Dcx
doublecortin
chr19_-_31765027 1.029 ENSMUST00000065067.6
Prkg1
protein kinase, cGMP-dependent, type I
chr9_-_103222063 1.025 ENSMUST00000170904.1
Trf
transferrin
chr4_+_108719649 1.022 ENSMUST00000178992.1
3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr1_-_79440039 1.021 ENSMUST00000049972.4
Scg2
secretogranin II
chr17_-_24073479 1.014 ENSMUST00000017090.5
Kctd5
potassium channel tetramerisation domain containing 5
chr18_+_24603952 1.013 ENSMUST00000025120.6
Elp2
elongator acetyltransferase complex subunit 2
chr3_+_121967822 1.003 ENSMUST00000137089.1
Arhgap29
Rho GTPase activating protein 29
chr10_+_102158858 0.996 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr1_-_132390301 0.989 ENSMUST00000132435.1
Tmcc2
transmembrane and coiled-coil domains 2
chr6_-_50456085 0.966 ENSMUST00000146341.1
ENSMUST00000071728.4
Osbpl3

oxysterol binding protein-like 3

chr15_-_33687840 0.949 ENSMUST00000042021.3
Tspyl5
testis-specific protein, Y-encoded-like 5
chr2_-_27475622 0.946 ENSMUST00000138693.1
ENSMUST00000113941.2
ENSMUST00000077737.6
Brd3


bromodomain containing 3


chr3_-_127225847 0.942 ENSMUST00000182726.1
ENSMUST00000182779.1
Ank2

ankyrin 2, brain

chr18_-_75697639 0.939 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor
chr15_-_79285502 0.920 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr3_-_127225917 0.917 ENSMUST00000182064.1
ENSMUST00000182662.1
Ank2

ankyrin 2, brain

chr9_+_94669876 0.912 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr15_+_81936753 0.912 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr3_-_152193803 0.900 ENSMUST00000050073.6
Dnajb4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr5_-_62765618 0.887 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_99028251 0.884 ENSMUST00000177437.1
ENSMUST00000177229.1
ENSMUST00000113321.1
ENSMUST00000124058.1
Foxp1



forkhead box P1



chr17_-_90088343 0.883 ENSMUST00000173917.1
Nrxn1
neurexin I
chr16_+_45094036 0.881 ENSMUST00000061050.5
Ccdc80
coiled-coil domain containing 80
chr5_+_29195983 0.873 ENSMUST00000160888.1
ENSMUST00000159272.1
ENSMUST00000001247.5
ENSMUST00000161398.1
ENSMUST00000160246.1
Rnf32




ring finger protein 32




chr9_+_54980880 0.872 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr10_+_97482350 0.857 ENSMUST00000163448.2
Dcn
decorin
chr5_+_88583527 0.851 ENSMUST00000031229.6
Rufy3
RUN and FYVE domain containing 3
chr1_-_134955847 0.803 ENSMUST00000168381.1
Ppp1r12b
protein phosphatase 1, regulatory (inhibitor) subunit 12B
chr9_-_79977782 0.800 ENSMUST00000093811.4
Filip1
filamin A interacting protein 1
chr6_-_124779686 0.796 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr15_+_82252397 0.790 ENSMUST00000136948.1
1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr1_-_126830786 0.786 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chrX_+_150547375 0.777 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chr5_-_134747241 0.775 ENSMUST00000015138.9
Eln
elastin
chr7_+_144838590 0.770 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chr5_+_19907774 0.770 ENSMUST00000115267.2
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr7_-_45830776 0.753 ENSMUST00000107723.2
ENSMUST00000131384.1
Grwd1

glutamate-rich WD repeat containing 1

chr1_-_134955908 0.732 ENSMUST00000045665.6
ENSMUST00000086444.4
ENSMUST00000112163.1
Ppp1r12b


protein phosphatase 1, regulatory (inhibitor) subunit 12B


chr4_-_35845204 0.728 ENSMUST00000164772.1
ENSMUST00000065173.2
Lingo2

leucine rich repeat and Ig domain containing 2

chr15_+_81936911 0.724 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr9_+_45370185 0.718 ENSMUST00000085939.6
Fxyd6
FXYD domain-containing ion transport regulator 6
chr13_-_41273977 0.718 ENSMUST00000163881.1
Gm17364
predicted gene, 17364
chr2_+_36230426 0.714 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr6_+_7555053 0.704 ENSMUST00000090679.2
ENSMUST00000184986.1
Tac1

tachykinin 1

chr5_-_77115145 0.681 ENSMUST00000081964.5
Hopx
HOP homeobox
chr15_-_8710409 0.679 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_70842617 0.652 ENSMUST00000031119.1
Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr11_-_79504078 0.646 ENSMUST00000164465.2
Omg
oligodendrocyte myelin glycoprotein
chr13_+_51408618 0.645 ENSMUST00000087978.3
S1pr3
sphingosine-1-phosphate receptor 3
chr10_+_73821857 0.628 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
Pcdh15



















protocadherin 15



















chrX_-_139871637 0.621 ENSMUST00000033811.7
ENSMUST00000087401.5
Morc4

microrchidia 4

chr3_+_13946368 0.618 ENSMUST00000171075.1
ENSMUST00000108372.2
Ralyl

RALY RNA binding protein-like

chr7_+_101896817 0.609 ENSMUST00000143835.1
Anapc15
anaphase prompoting complex C subunit 15
chr6_-_56923927 0.597 ENSMUST00000031793.5
Nt5c3
5'-nucleotidase, cytosolic III
chr1_+_87183310 0.594 ENSMUST00000044533.8
Prss56
protease, serine 56
chr5_+_14025305 0.593 ENSMUST00000073957.6
Sema3e
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr14_+_111675113 0.586 ENSMUST00000042767.7
Slitrk5
SLIT and NTRK-like family, member 5
chr4_-_129261394 0.577 ENSMUST00000145261.1
C77080
expressed sequence C77080
chr6_+_29859374 0.576 ENSMUST00000115238.3
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr6_+_63255971 0.557 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr2_-_10130638 0.555 ENSMUST00000042290.7
Itih2
inter-alpha trypsin inhibitor, heavy chain 2
chr4_+_59035088 0.554 ENSMUST00000041160.6
Gng10
guanine nucleotide binding protein (G protein), gamma 10
chr2_-_153015331 0.544 ENSMUST00000028972.8
Pdrg1
p53 and DNA damage regulated 1
chr3_+_66219909 0.542 ENSMUST00000029421.5
Ptx3
pentraxin related gene
chr5_+_121777929 0.539 ENSMUST00000160821.1
Atxn2
ataxin 2
chrX_-_150814265 0.536 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
Maged2


melanoma antigen, family D, 2


chr3_-_88425094 0.536 ENSMUST00000168755.1
ENSMUST00000057935.6
Slc25a44

solute carrier family 25, member 44

chr16_-_89818338 0.529 ENSMUST00000164263.2
Tiam1
T cell lymphoma invasion and metastasis 1
chr2_-_33086366 0.521 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr19_-_4121536 0.520 ENSMUST00000025767.7
Aip
aryl-hydrocarbon receptor-interacting protein
chr16_-_92400067 0.519 ENSMUST00000023672.8
Rcan1
regulator of calcineurin 1
chr8_-_54724474 0.512 ENSMUST00000175915.1
Wdr17
WD repeat domain 17
chr6_+_29859662 0.510 ENSMUST00000128927.2
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr4_+_150853919 0.510 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr2_+_9882622 0.506 ENSMUST00000114919.1
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr6_-_23248264 0.491 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr15_-_8710734 0.489 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr7_-_100583072 0.485 ENSMUST00000152876.1
ENSMUST00000150042.1
Mrpl48

mitochondrial ribosomal protein L48

chr11_-_102897123 0.483 ENSMUST00000067444.3
Gfap
glial fibrillary acidic protein
chr8_+_4238815 0.483 ENSMUST00000003027.7
ENSMUST00000110999.1
Map2k7

mitogen-activated protein kinase kinase 7

chr1_+_110099295 0.477 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr12_+_102128718 0.476 ENSMUST00000159329.1
Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr12_+_88953399 0.475 ENSMUST00000057634.7
Nrxn3
neurexin III
chr2_+_80638798 0.472 ENSMUST00000028382.6
ENSMUST00000124377.1
Nup35

nucleoporin 35

chr9_+_113812547 0.471 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chr6_+_29859686 0.471 ENSMUST00000134438.1
Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr7_-_66427469 0.466 ENSMUST00000015278.7
Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
chr18_+_30272747 0.464 ENSMUST00000115812.3
ENSMUST00000115811.1
ENSMUST00000091978.5
Pik3c3


phosphoinositide-3-kinase, class 3


chr17_-_24886304 0.463 ENSMUST00000044252.5
Nubp2
nucleotide binding protein 2
chr5_+_66968559 0.454 ENSMUST00000127184.1
Limch1
LIM and calponin homology domains 1
chr18_+_84851338 0.444 ENSMUST00000160180.1
Cyb5
cytochrome b-5
chr2_+_121956651 0.439 ENSMUST00000110574.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 20.3 GO:0019532 oxalate transport(GO:0019532)
1.9 20.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.2 3.7 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
1.0 3.1 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.9 3.5 GO:0061743 motor learning(GO:0061743)
0.8 3.4 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.8 2.5 GO:0001543 ovarian follicle rupture(GO:0001543)
0.7 3.0 GO:0015825 L-serine transport(GO:0015825)
0.7 2.9 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.7 2.1 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.7 1.3 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.6 3.7 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.6 1.7 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.5 4.3 GO:0016198 axon choice point recognition(GO:0016198)
0.5 1.8 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.5 5.0 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.4 1.3 GO:0009838 abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.4 3.6 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.4 1.6 GO:0010749 regulation of nitric oxide mediated signal transduction(GO:0010749)
0.4 3.0 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.4 1.9 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.4 1.1 GO:1903538 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.3 1.4 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.3 1.0 GO:2000224 regulation of testosterone biosynthetic process(GO:2000224)
0.3 1.3 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.3 1.3 GO:0061055 myotome development(GO:0061055)
0.3 1.6 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.3 1.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.3 7.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.3 1.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 4.9 GO:0008210 luteinization(GO:0001553) estrogen metabolic process(GO:0008210)
0.3 0.8 GO:0030916 otic vesicle formation(GO:0030916)
0.2 1.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 1.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 0.7 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.2 0.9 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.2 1.9 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 1.0 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.2 1.9 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.2 2.3 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.2 0.5 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
0.2 6.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.2 1.2 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.2 0.5 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.2 4.8 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 0.5 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.2 1.7 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 0.5 GO:0060166 olfactory pit development(GO:0060166)
0.2 0.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 3.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 1.0 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 0.9 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.4 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.1 0.7 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.1 1.1 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.5 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.1 1.8 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 1.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.4 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.9 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 1.7 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.1 0.4 GO:0006706 steroid catabolic process(GO:0006706)
0.1 0.9 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 0.5 GO:0070294 renal sodium ion absorption(GO:0070294)
0.1 1.6 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.1 6.5 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 0.5 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.1 0.8 GO:0046085 adenosine metabolic process(GO:0046085)
0.1 0.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.6 GO:0050957 equilibrioception(GO:0050957)
0.1 2.7 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 0.9 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.1 3.0 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.1 1.5 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 3.4 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.1 2.1 GO:0097178 ruffle assembly(GO:0097178)
0.1 0.9 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 0.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 0.3 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.6 GO:1901550 regulation of endothelial cell development(GO:1901550) regulation of establishment of endothelial barrier(GO:1903140)
0.1 0.2 GO:0006667 sphinganine metabolic process(GO:0006667) regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.1 0.6 GO:1904861 excitatory synapse assembly(GO:1904861)
0.1 0.9 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 1.4 GO:0006907 pinocytosis(GO:0006907)
0.1 1.8 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.2 GO:2000974 comma-shaped body morphogenesis(GO:0072049) negative regulation of pro-B cell differentiation(GO:2000974)
0.1 0.2 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.1 0.8 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 0.6 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.8 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 0.5 GO:0097186 amelogenesis(GO:0097186)
0.1 0.3 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 0.1 GO:0061144 alveolar secondary septum development(GO:0061144)
0.0 0.4 GO:0033572 transferrin transport(GO:0033572)
0.0 0.4 GO:0044144 regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.0 0.3 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0 0.9 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.6 GO:0021756 striatum development(GO:0021756)
0.0 0.2 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 0.1 GO:0003356 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356)
0.0 0.6 GO:0048670 regulation of collateral sprouting(GO:0048670)
0.0 0.5 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.0 0.8 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.5 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 3.1 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 3.4 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.6 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 1.5 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 1.1 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.9 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.5 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.1 GO:0015867 ATP transport(GO:0015867)
0.0 0.1 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.8 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 3.5 GO:0007416 synapse assembly(GO:0007416)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.1 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.3 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0 0.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 6.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.9 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.5 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.0 GO:0042982 amyloid precursor protein metabolic process(GO:0042982)
0.0 1.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 3.4 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.1 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 2.5 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.0 1.5 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.5 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.4 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.1 GO:0042053 regulation of dopamine metabolic process(GO:0042053) neuromuscular process controlling posture(GO:0050884)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.0 0.1 GO:0007320 insemination(GO:0007320)
0.0 1.6 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.3 GO:0060674 placenta blood vessel development(GO:0060674)
0.0 0.6 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.0 1.0 GO:1904892 regulation of JAK-STAT cascade(GO:0046425) regulation of STAT cascade(GO:1904892)
0.0 0.2 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.8 GO:0030168 platelet activation(GO:0030168)
0.0 0.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 6.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.4 1.8 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.3 2.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 1.3 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.3 0.8 GO:0071953 elastic fiber(GO:0071953)
0.2 0.4 GO:0005859 muscle myosin complex(GO:0005859)
0.2 2.9 GO:0043083 synaptic cleft(GO:0043083)
0.2 3.9 GO:0031527 filopodium membrane(GO:0031527)
0.2 3.6 GO:0071564 npBAF complex(GO:0071564)
0.2 0.4 GO:0071438 invadopodium membrane(GO:0071438)
0.2 0.5 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1 1.3 GO:0090543 Flemming body(GO:0090543)
0.1 1.0 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.9 GO:0071437 invadopodium(GO:0071437)
0.1 1.1 GO:0097433 dense body(GO:0097433)
0.1 0.5 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.1 0.4 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.1 0.5 GO:0060091 kinocilium(GO:0060091)
0.1 0.5 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 0.9 GO:0071439 clathrin complex(GO:0071439)
0.1 1.0 GO:0005915 zonula adherens(GO:0005915)
0.1 3.0 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.5 GO:0044615 nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615)
0.1 3.4 GO:0031672 A band(GO:0031672)
0.1 2.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 1.0 GO:0031045 dense core granule(GO:0031045)
0.1 2.1 GO:0032590 dendrite membrane(GO:0032590)
0.1 3.0 GO:0005882 intermediate filament(GO:0005882)
0.1 1.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.5 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.3 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 2.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.7 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.3 GO:0005916 fascia adherens(GO:0005916)
0.0 0.9 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 7.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.4 GO:0001650 fibrillar center(GO:0001650)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 2.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 1.8 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.4 GO:0014704 intercalated disc(GO:0014704)
0.0 0.4 GO:0030673 axolemma(GO:0030673)
0.0 5.4 GO:0016607 nuclear speck(GO:0016607)
0.0 0.5 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.1 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.9 GO:0005604 basement membrane(GO:0005604)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 20.3 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
1.5 6.0 GO:0004966 galanin receptor activity(GO:0004966)
0.8 3.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.8 4.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.6 4.8 GO:0097322 7SK snRNA binding(GO:0097322)
0.5 5.4 GO:0019865 immunoglobulin binding(GO:0019865)
0.4 3.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.4 3.0 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.4 3.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.4 3.0 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.4 2.9 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.3 3.1 GO:0048185 activin binding(GO:0048185)
0.3 2.3 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.3 1.6 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.3 3.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.3 1.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 1.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.3 0.8 GO:0016748 succinyltransferase activity(GO:0016748)
0.3 1.0 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 1.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.2 1.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 6.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 3.8 GO:0016208 AMP binding(GO:0016208)
0.2 2.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 0.5 GO:0036004 GAF domain binding(GO:0036004)
0.2 0.9 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.2 1.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 1.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.0 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 1.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.4 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.1 0.5 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.9 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.6 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.5 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.5 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 3.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 0.3 GO:0015254 glycerol channel activity(GO:0015254)
0.1 2.9 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 0.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 3.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.5 GO:0001849 complement component C1q binding(GO:0001849)
0.1 1.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.9 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.3 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 2.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.3 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 1.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.2 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 3.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 1.0 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 1.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.5 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.7 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.0 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.5 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.8 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 17.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 6.2 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 1.2 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.4 GO:0015248 sterol transporter activity(GO:0015248)
0.0 1.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0032027 myosin light chain binding(GO:0032027)
0.0 1.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.9 GO:0001968 fibronectin binding(GO:0001968)
0.0 3.1 GO:0002039 p53 binding(GO:0002039)
0.0 0.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 0.3 GO:0015288 porin activity(GO:0015288)
0.0 1.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.2 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 1.0 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 6.8 GO:0000287 magnesium ion binding(GO:0000287)
0.0 1.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.6 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 1.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.3 GO:0035004 1-phosphatidylinositol-3-kinase activity(GO:0016303) phosphatidylinositol 3-kinase activity(GO:0035004)
0.0 0.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 5.5 GO:0003924 GTPase activity(GO:0003924)
0.0 4.7 GO:0008017 microtubule binding(GO:0008017)
0.0 0.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.0 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 1.4 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.7 GO:0004601 peroxidase activity(GO:0004601)
0.0 1.4 GO:0005525 GTP binding(GO:0005525)
0.0 0.3 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 1.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 2.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.4 GO:0003743 translation initiation factor activity(GO:0003743)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 20.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 6.5 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.0 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.1 1.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 2.0 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 1.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.5 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.4 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 6.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.9 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.1 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.2 PID_S1P_S1P3_PATHWAY S1P3 pathway
0.0 0.5 ST_ADRENERGIC Adrenergic Pathway
0.0 0.3 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 1.3 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 0.1 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.4 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 3.8 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.3 2.9 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 25.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 3.0 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.2 1.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 2.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.1 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 3.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 0.9 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 8.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.8 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.1 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 1.0 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 0.6 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 0.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 0.2 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 1.4 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.8 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 1.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 3.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 1.6 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 1.1 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.7 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.8 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.9 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 0.5 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease