Motif ID: Gbx1_Nobox_Alx3

Z-value: 0.575

Transcription factors associated with Gbx1_Nobox_Alx3:

Gene SymbolEntrez IDGene Name
Alx3 ENSMUSG00000014603.1 Alx3
Gbx1 ENSMUSG00000067724.4 Gbx1
Nobox ENSMUSG00000029736.9 Nobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx3mm10_v2_chr3_+_107595031_1075951640.234.2e-02Click!
Gbx1mm10_v2_chr5_-_24527276_245272760.132.6e-01Click!


Activity profile for motif Gbx1_Nobox_Alx3.

activity profile for motif Gbx1_Nobox_Alx3


Sorted Z-values histogram for motif Gbx1_Nobox_Alx3

Sorted Z-values for motif Gbx1_Nobox_Alx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx1_Nobox_Alx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 9.322 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr12_+_109545390 7.040 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr12_+_38780817 6.802 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr12_+_38780284 6.697 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr15_-_11037968 5.983 ENSMUST00000058007.5
 Rxfp3
relaxin family peptide receptor 3
chr12_-_40037387 5.789 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr4_-_14621494 5.555 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621669 5.418 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr3_+_68572245 4.942 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr13_-_102906046 4.889 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr15_+_92597104 4.860 ENSMUST00000035399.8
 Pdzrn4
PDZ domain containing RING finger 4
chr18_+_23415400 4.859 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr2_+_125136692 4.662 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr1_-_152625212 4.563 ENSMUST00000027760.7
 Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr15_-_37459327 4.361 ENSMUST00000119730.1
ENSMUST00000120746.1
 Ncald

neurocalcin delta

chr12_+_38781093 3.991 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr3_+_134236483 3.912 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr16_-_42340595 3.888 ENSMUST00000102817.4
 Gap43
growth associated protein 43
chr10_-_25200110 3.781 ENSMUST00000100012.2
 Akap7
A kinase (PRKA) anchor protein 7
chr2_+_109917639 3.683 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 20.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
2.9 20.3 GO:0019532 oxalate transport(GO:0019532)
0.3 7.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.1 6.5 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 6.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.2 6.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.5 5.0 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.3 4.9 GO:0008210 luteinization(GO:0001553) estrogen metabolic process(GO:0008210)
0.2 4.8 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.5 4.3 GO:0016198 axon choice point recognition(GO:0016198)
1.2 3.7 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.6 3.7 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.4 3.6 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.9 3.5 GO:0061743 motor learning(GO:0061743)
0.0 3.5 GO:0007416 synapse assembly(GO:0007416)
0.8 3.4 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 3.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 3.4 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 3.4 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 3.4 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.4 6.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 5.4 GO:0016607 nuclear speck(GO:0016607)
0.0 4.4 GO:0001650 fibrillar center(GO:0001650)
0.2 3.9 GO:0031527 filopodium membrane(GO:0031527)
0.0 3.7 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.2 3.6 GO:0071564 npBAF complex(GO:0071564)
0.1 3.4 GO:0031672 A band(GO:0031672)
0.1 3.0 GO:0035371 microtubule plus-end(GO:0035371)
0.1 3.0 GO:0005882 intermediate filament(GO:0005882)
0.6 2.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 2.9 GO:0043083 synaptic cleft(GO:0043083)
0.0 2.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 2.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 2.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 2.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 2.1 GO:0032590 dendrite membrane(GO:0032590)
0.4 1.8 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 1.8 GO:0016363 nuclear matrix(GO:0016363)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 20.3 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 17.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 6.8 GO:0000287 magnesium ion binding(GO:0000287)
0.2 6.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 6.2 GO:0030165 PDZ domain binding(GO:0030165)
1.5 6.0 GO:0004966 galanin receptor activity(GO:0004966)
0.0 5.5 GO:0003924 GTPase activity(GO:0003924)
0.5 5.4 GO:0019865 immunoglobulin binding(GO:0019865)
0.6 4.8 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 4.7 GO:0008017 microtubule binding(GO:0008017)
0.8 4.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 3.8 GO:0016208 AMP binding(GO:0016208)
0.1 3.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 3.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 3.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.4 3.4 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 3.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.8 3.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.4 3.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.3 3.1 GO:0048185 activin binding(GO:0048185)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 20.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 6.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 6.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 3.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 3.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.9 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.5 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.0 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 1.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.5 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.4 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.3 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.3 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 1.1 PID_INSULIN_PATHWAY Insulin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 8.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.4 6.4 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 3.8 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 3.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 3.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 3.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 3.0 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.3 2.9 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 2.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.8 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 1.8 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.1 1.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.6 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.1 1.4 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 1.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 1.1 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis