Motif ID: Gbx2

Z-value: 0.623


Transcription factors associated with Gbx2:

Gene SymbolEntrez IDGene Name
Gbx2 ENSMUSG00000034486.7 Gbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx2mm10_v2_chr1_-_89933290_89933290-0.084.9e-01Click!


Activity profile for motif Gbx2.

activity profile for motif Gbx2


Sorted Z-values histogram for motif Gbx2

Sorted Z-values for motif Gbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 56 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_97747373 9.538 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_-_36784924 9.318 ENSMUST00000168279.1
ENSMUST00000164579.1
ENSMUST00000023616.2
 Slc15a2


solute carrier family 15 (H+/peptide transporter), member 2


chr13_-_97747399 8.848 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr16_-_36784784 8.186 ENSMUST00000165531.1
 Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr3_+_94372794 4.931 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr3_-_116129615 4.730 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr4_+_118961578 4.636 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr2_-_160619971 4.624 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr14_-_48667508 4.316 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr4_+_110397661 4.066 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
 Agbl4



ATP/GTP binding protein-like 4



chr5_-_111761697 3.987 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr12_+_79297345 3.769 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr4_+_110397764 3.690 ENSMUST00000097920.2
ENSMUST00000080744.6
 Agbl4

ATP/GTP binding protein-like 4

chr9_+_96258697 3.501 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chrX_+_106920618 3.140 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chrM_-_14060 2.858 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr5_+_117781017 2.853 ENSMUST00000138579.2
 Nos1
nitric oxide synthase 1, neuronal
chr17_-_36032682 2.763 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr7_+_75455534 2.645 ENSMUST00000147005.1
ENSMUST00000166315.1
 Akap13

A kinase (PRKA) anchor protein 13

chr3_+_88615367 2.380 ENSMUST00000176539.1
 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 17.5 GO:0042891 antibiotic transport(GO:0042891) dipeptide transport(GO:0042938)
1.9 7.8 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.6 4.9 GO:0072615 interleukin-17 secretion(GO:0072615)
0.4 4.7 GO:0061032 visceral serous pericardium development(GO:0061032)
0.1 4.6 GO:0009063 cellular amino acid catabolic process(GO:0009063)
1.1 4.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 4.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.6 3.8 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 3.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
1.0 2.9 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.9 2.8 GO:2000564 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.4 2.6 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0 2.3 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.6 1.7 GO:0016554 cytidine to uridine editing(GO:0016554)
0.3 1.7 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 1.5 GO:0051225 spindle assembly(GO:0051225)
0.0 1.4 GO:0042742 defense response to bacterium(GO:0042742)
0.1 1.0 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 0.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.7 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.8 GO:0002102 podosome(GO:0002102)
0.1 7.8 GO:0005814 centriole(GO:0005814)
0.8 3.8 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 3.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.0 GO:0070469 respiratory chain(GO:0070469)
0.3 2.9 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 2.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 2.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 2.3 GO:0000786 nucleosome(GO:0000786)
0.2 1.5 GO:0070652 HAUS complex(GO:0070652)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.7 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.4 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.8 17.5 GO:0042936 dipeptide transporter activity(GO:0042936)
0.4 7.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.2 4.9 GO:0008142 oxysterol binding(GO:0008142)
1.2 4.7 GO:0008131 primary amine oxidase activity(GO:0008131)
1.5 4.6 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 4.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 4.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 3.8 GO:0000150 recombinase activity(GO:0000150)
0.4 3.1 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
1.0 2.9 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 2.9 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 2.8 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.3 2.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 2.3 GO:0008201 heparin binding(GO:0008201)
0.4 1.7 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 1.7 GO:0005518 collagen binding(GO:0005518)
0.0 0.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.7 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.7 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.2 0.5 GO:0019966 interleukin-1 binding(GO:0019966)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.3 4.7 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 3.1 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 1.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.5 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 6.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 4.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 4.7 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3 3.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.9 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1 2.3 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.0 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.3 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors