Motif ID: Gcm2

Z-value: 1.763


Transcription factors associated with Gcm2:

Gene SymbolEntrez IDGene Name
Gcm2 ENSMUSG00000021362.6 Gcm2



Activity profile for motif Gcm2.

activity profile for motif Gcm2


Sorted Z-values histogram for motif Gcm2

Sorted Z-values for motif Gcm2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gcm2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065737 44.302 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr15_-_66831625 33.886 ENSMUST00000164163.1
 Sla
src-like adaptor
chr7_+_121392266 29.985 ENSMUST00000084628.3
 Hs3st2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr11_-_6065538 24.929 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr4_-_138396438 23.856 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr15_-_44788016 19.079 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr19_+_6400523 14.898 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr2_-_32353247 14.098 ENSMUST00000078352.5
ENSMUST00000113352.2
ENSMUST00000113365.1
 Dnm1


dynamin 1


chr9_+_112234257 13.253 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr15_+_44787746 13.140 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr11_+_98348404 13.013 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr3_+_96596628 11.947 ENSMUST00000058943.7
 Ankrd34a
ankyrin repeat domain 34A
chr14_+_62555737 11.603 ENSMUST00000039064.7
 Fam124a
family with sequence similarity 124, member A
chr5_+_110544326 11.449 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr19_+_8664005 11.269 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr1_+_50927511 11.242 ENSMUST00000081851.3
 Tmeff2
transmembrane protein with EGF-like and two follistatin-like domains 2
chr17_+_48932368 11.184 ENSMUST00000046254.2
 Lrfn2
leucine rich repeat and fibronectin type III domain containing 2
chr4_+_13743424 10.858 ENSMUST00000006761.3
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr5_-_37717122 10.795 ENSMUST00000094836.4
 Stk32b
serine/threonine kinase 32B
chr12_-_79007276 10.562 ENSMUST00000056660.6
ENSMUST00000174721.1
 Tmem229b

transmembrane protein 229B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 471 entries
Log-likelihood per target Total log-likelihoodTermDescription
23.1 69.2 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.5 31.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
3.4 23.8 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.3 15.7 GO:0034605 cellular response to heat(GO:0034605)
0.5 15.5 GO:0071625 vocalization behavior(GO:0071625)
4.3 13.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
1.8 12.6 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 12.6 GO:0022900 electron transport chain(GO:0022900)
1.8 12.3 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
2.3 11.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
2.8 11.2 GO:0045113 regulation of integrin biosynthetic process(GO:0045113)
0.6 10.8 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.6 10.5 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.9 10.2 GO:0048484 enteric nervous system development(GO:0048484)
0.4 10.2 GO:0035067 negative regulation of histone acetylation(GO:0035067)
3.4 10.1 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.6 10.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
2.0 9.9 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
3.3 9.8 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.4 9.8 GO:0048148 behavioral response to cocaine(GO:0048148)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 201 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 97.7 GO:0016021 integral component of membrane(GO:0016021)
1.7 58.6 GO:0051233 spindle midzone(GO:0051233)
0.2 42.7 GO:0008021 synaptic vesicle(GO:0008021)
0.3 41.9 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
2.5 39.5 GO:0043196 varicosity(GO:0043196)
0.1 37.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.3 29.1 GO:0031225 anchored component of membrane(GO:0031225)
2.6 20.4 GO:0097433 dense body(GO:0097433)
0.1 20.2 GO:0043025 neuronal cell body(GO:0043025)
0.1 17.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4 15.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.4 14.2 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 12.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.6 12.7 GO:0032279 asymmetric synapse(GO:0032279)
1.9 11.7 GO:0008091 spectrin(GO:0008091)
0.2 11.5 GO:0005581 collagen trimer(GO:0005581)
0.2 11.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 11.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.4 10.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.3 10.2 GO:0044295 axonal growth cone(GO:0044295)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 319 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 75.2 GO:0043274 phospholipase binding(GO:0043274)
1.9 35.2 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.7 26.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 25.1 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
3.0 23.8 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 21.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.8 19.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.6 17.5 GO:0017046 peptide hormone binding(GO:0017046)
1.3 17.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.4 13.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 13.4 GO:0030165 PDZ domain binding(GO:0030165)
4.3 13.0 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.6 11.7 GO:0008179 adenylate cyclase binding(GO:0008179)
2.3 11.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.5 10.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.4 10.4 GO:0030506 ankyrin binding(GO:0030506)
1.5 9.2 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
1.8 9.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 8.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.7 8.5 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 69.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 29.2 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.6 25.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 12.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 12.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.3 11.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 10.3 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.6 9.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.2 8.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 8.0 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.2 7.5 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.2 7.5 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 7.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 6.5 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.3 6.4 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 6.4 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.3 5.6 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.3 5.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 5.1 PID_FGF_PATHWAY FGF signaling pathway
0.2 4.1 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 72.0 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.9 36.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
1.7 33.5 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.8 28.4 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.6 24.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.5 16.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 12.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.3 11.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.7 10.7 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 10.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.3 9.7 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.1 9.5 REACTOME_TRANSLATION Genes involved in Translation
1.5 9.1 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 8.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.9 8.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.3 8.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 7.3 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.4 7.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.4 7.1 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
2.3 7.0 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors