Motif ID: Gfi1_Gfi1b
Z-value: 1.548
Transcription factors associated with Gfi1_Gfi1b:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Gfi1 | ENSMUSG00000029275.11 | Gfi1 |
| Gfi1b | ENSMUSG00000026815.8 | Gfi1b |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 22.9 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 2.1 | 8.5 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 2.1 | 6.2 | GO:0030070 | insulin processing(GO:0030070) |
| 2.1 | 6.2 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 1.9 | 11.7 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
| 1.8 | 5.5 | GO:1904339 | negative regulation of dopaminergic neuron differentiation(GO:1904339) |
| 1.8 | 5.4 | GO:0007525 | somatic muscle development(GO:0007525) |
| 1.6 | 4.9 | GO:0072284 | cervix development(GO:0060067) metanephric S-shaped body morphogenesis(GO:0072284) anterior head development(GO:0097065) regulation of anterior head development(GO:2000742) positive regulation of anterior head development(GO:2000744) |
| 1.5 | 4.5 | GO:0001830 | trophectodermal cell fate commitment(GO:0001830) |
| 1.5 | 5.8 | GO:0061055 | myotome development(GO:0061055) |
| 1.3 | 7.9 | GO:0046880 | regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884) |
| 1.3 | 3.9 | GO:1902336 | neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336) |
| 1.1 | 3.2 | GO:0033566 | gamma-tubulin complex localization(GO:0033566) |
| 1.0 | 14.0 | GO:0051127 | positive regulation of actin nucleation(GO:0051127) |
| 1.0 | 1.0 | GO:2000137 | negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137) |
| 1.0 | 6.7 | GO:1902866 | regulation of retina development in camera-type eye(GO:1902866) |
| 0.9 | 2.8 | GO:0002842 | positive regulation of T cell mediated immune response to tumor cell(GO:0002842) protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.9 | 3.7 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 0.9 | 24.3 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.9 | 2.7 | GO:0042275 | error-free postreplication DNA repair(GO:0042275) |
| 0.9 | 2.6 | GO:1903538 | meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538) |
| 0.8 | 2.4 | GO:0035523 | protein K29-linked deubiquitination(GO:0035523) protein K6-linked deubiquitination(GO:0044313) |
| 0.7 | 0.7 | GO:0071335 | hair follicle cell proliferation(GO:0071335) |
| 0.7 | 5.6 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.7 | 1.4 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.7 | 2.7 | GO:0090126 | protein complex assembly involved in synapse maturation(GO:0090126) |
| 0.6 | 2.9 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313) |
| 0.6 | 2.3 | GO:0038145 | macrophage colony-stimulating factor signaling pathway(GO:0038145) |
| 0.6 | 1.7 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
| 0.6 | 7.2 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.6 | 1.7 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.5 | 2.2 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.5 | 6.9 | GO:0048875 | chemical homeostasis within a tissue(GO:0048875) regulation of store-operated calcium entry(GO:2001256) |
| 0.5 | 1.6 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.5 | 1.5 | GO:0032240 | RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.5 | 1.0 | GO:1902174 | positive regulation of keratinocyte apoptotic process(GO:1902174) |
| 0.5 | 4.1 | GO:0060046 | regulation of acrosome reaction(GO:0060046) |
| 0.5 | 1.5 | GO:2000501 | natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501) |
| 0.5 | 1.4 | GO:1903977 | positive regulation of Schwann cell migration(GO:1900149) positive regulation of glial cell migration(GO:1903977) |
| 0.5 | 1.9 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.5 | 1.8 | GO:0010986 | positive regulation of lipoprotein particle clearance(GO:0010986) |
| 0.5 | 1.8 | GO:1900150 | neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) regulation of defense response to fungus(GO:1900150) |
| 0.5 | 0.9 | GO:0097168 | mesenchymal stem cell proliferation(GO:0097168) |
| 0.4 | 1.8 | GO:1900623 | positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.4 | 4.0 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.4 | 3.5 | GO:0031424 | keratinization(GO:0031424) |
| 0.4 | 3.0 | GO:0002674 | negative regulation of acute inflammatory response(GO:0002674) |
| 0.4 | 16.4 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.4 | 1.2 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.4 | 1.2 | GO:0097274 | urea homeostasis(GO:0097274) |
| 0.4 | 2.0 | GO:0090666 | scaRNA localization to Cajal body(GO:0090666) |
| 0.4 | 5.4 | GO:0045161 | neuronal ion channel clustering(GO:0045161) |
| 0.4 | 0.8 | GO:0071873 | response to norepinephrine(GO:0071873) |
| 0.4 | 1.1 | GO:0019255 | glucose 1-phosphate metabolic process(GO:0019255) |
| 0.4 | 4.7 | GO:0033005 | positive regulation of mast cell activation(GO:0033005) positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306) |
| 0.4 | 2.9 | GO:0035588 | G-protein coupled purinergic receptor signaling pathway(GO:0035588) |
| 0.4 | 1.1 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 0.3 | 0.7 | GO:1900147 | Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147) |
| 0.3 | 2.7 | GO:0055064 | carbon dioxide transport(GO:0015670) chloride ion homeostasis(GO:0055064) |
| 0.3 | 1.7 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.3 | 3.9 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.3 | 2.9 | GO:0007182 | common-partner SMAD protein phosphorylation(GO:0007182) |
| 0.3 | 1.9 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.3 | 0.9 | GO:0000448 | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448) rRNA export from nucleus(GO:0006407) |
| 0.3 | 2.1 | GO:0046549 | retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.3 | 1.2 | GO:0014005 | microglia differentiation(GO:0014004) microglia development(GO:0014005) |
| 0.3 | 0.9 | GO:1900145 | negative regulation of nodal signaling pathway(GO:1900108) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145) regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900175) |
| 0.3 | 0.9 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) cell wall macromolecule metabolic process(GO:0044036) cell wall organization or biogenesis(GO:0071554) |
| 0.3 | 1.8 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
| 0.3 | 0.9 | GO:0061744 | motor behavior(GO:0061744) |
| 0.3 | 1.7 | GO:0098964 | dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964) |
| 0.3 | 1.1 | GO:0006166 | purine ribonucleoside salvage(GO:0006166) |
| 0.3 | 0.8 | GO:0090646 | mitochondrial tRNA processing(GO:0090646) |
| 0.3 | 0.8 | GO:0014826 | vein smooth muscle contraction(GO:0014826) |
| 0.2 | 1.0 | GO:0098735 | cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735) |
| 0.2 | 1.2 | GO:0042117 | monocyte activation(GO:0042117) |
| 0.2 | 0.7 | GO:0009106 | lipoate metabolic process(GO:0009106) |
| 0.2 | 7.4 | GO:0030325 | adrenal gland development(GO:0030325) |
| 0.2 | 8.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.2 | 0.4 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 0.2 | 1.4 | GO:0016114 | terpenoid biosynthetic process(GO:0016114) |
| 0.2 | 2.3 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 0.2 | 1.2 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.2 | 3.2 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.2 | 2.7 | GO:0060013 | righting reflex(GO:0060013) |
| 0.2 | 0.6 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.2 | 2.4 | GO:0070842 | aggresome assembly(GO:0070842) |
| 0.2 | 13.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.2 | 1.5 | GO:0010764 | negative regulation of fibroblast migration(GO:0010764) |
| 0.2 | 0.4 | GO:0061370 | testosterone biosynthetic process(GO:0061370) |
| 0.2 | 1.9 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.2 | 0.4 | GO:0036363 | transforming growth factor beta activation(GO:0036363) |
| 0.2 | 0.9 | GO:0060849 | regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.2 | 0.5 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.2 | 0.3 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 0.2 | 0.3 | GO:0045414 | regulation of interleukin-8 biosynthetic process(GO:0045414) |
| 0.2 | 0.9 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
| 0.2 | 13.3 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.2 | 0.8 | GO:1903756 | regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758) |
| 0.2 | 1.2 | GO:0071816 | tail-anchored membrane protein insertion into ER membrane(GO:0071816) |
| 0.2 | 1.8 | GO:0042403 | thyroid hormone metabolic process(GO:0042403) |
| 0.1 | 0.4 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.1 | 1.4 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.1 | 0.5 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.1 | 2.6 | GO:0051968 | positive regulation of synaptic transmission, glutamatergic(GO:0051968) |
| 0.1 | 7.0 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 0.5 | GO:0030576 | Cajal body organization(GO:0030576) |
| 0.1 | 7.8 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.1 | 1.0 | GO:2000303 | regulation of ceramide biosynthetic process(GO:2000303) |
| 0.1 | 0.7 | GO:0072396 | response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) |
| 0.1 | 0.6 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.1 | 1.7 | GO:0090331 | negative regulation of platelet aggregation(GO:0090331) |
| 0.1 | 1.1 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 0.1 | 0.2 | GO:0007621 | negative regulation of female receptivity(GO:0007621) regulation of cellular pH reduction(GO:0032847) |
| 0.1 | 2.7 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 1.2 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 0.6 | GO:0042795 | snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.1 | 1.9 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.1 | 1.8 | GO:0071625 | vocalization behavior(GO:0071625) |
| 0.1 | 4.1 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.1 | 2.0 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.1 | 1.5 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 0.7 | GO:0042119 | neutrophil activation(GO:0042119) |
| 0.1 | 1.1 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 3.2 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 0.1 | 1.4 | GO:0048714 | positive regulation of oligodendrocyte differentiation(GO:0048714) |
| 0.1 | 2.2 | GO:0019432 | triglyceride biosynthetic process(GO:0019432) |
| 0.1 | 1.7 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.1 | 5.1 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 0.1 | 0.6 | GO:0014010 | Schwann cell proliferation(GO:0014010) |
| 0.1 | 0.3 | GO:0060060 | post-embryonic retina morphogenesis in camera-type eye(GO:0060060) |
| 0.1 | 0.5 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.1 | 0.6 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.1 | 1.1 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.1 | 0.7 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.1 | 0.8 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.1 | 1.6 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.1 | 2.6 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 0.1 | 0.3 | GO:0032930 | positive regulation of superoxide anion generation(GO:0032930) |
| 0.1 | 0.3 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.1 | 0.9 | GO:0001711 | endodermal cell fate commitment(GO:0001711) |
| 0.1 | 0.3 | GO:0036394 | amylase secretion(GO:0036394) |
| 0.1 | 0.2 | GO:0030974 | thiamine pyrophosphate transport(GO:0030974) |
| 0.1 | 0.5 | GO:0061088 | sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088) |
| 0.1 | 0.9 | GO:0007413 | axonal fasciculation(GO:0007413) |
| 0.1 | 0.6 | GO:0051895 | negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) |
| 0.1 | 0.2 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 0.1 | 0.6 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.1 | 2.6 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
| 0.1 | 0.2 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
| 0.1 | 0.2 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
| 0.1 | 1.4 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.1 | 0.5 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.1 | 1.9 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.1 | 0.2 | GO:0015793 | glycerol transport(GO:0015793) renal water absorption(GO:0070295) |
| 0.1 | 3.4 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.0 | 0.1 | GO:0090037 | positive regulation of protein kinase C signaling(GO:0090037) |
| 0.0 | 0.6 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
| 0.0 | 2.2 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.1 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 0.0 | 0.9 | GO:0031572 | G2 DNA damage checkpoint(GO:0031572) |
| 0.0 | 0.9 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.0 | 2.8 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.0 | 1.0 | GO:0031952 | regulation of protein autophosphorylation(GO:0031952) |
| 0.0 | 2.6 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.2 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
| 0.0 | 2.0 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
| 0.0 | 2.4 | GO:0051897 | positive regulation of protein kinase B signaling(GO:0051897) |
| 0.0 | 1.7 | GO:0010633 | negative regulation of epithelial cell migration(GO:0010633) |
| 0.0 | 0.2 | GO:1902416 | positive regulation of mRNA binding(GO:1902416) |
| 0.0 | 1.4 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 5.4 | GO:0001666 | response to hypoxia(GO:0001666) |
| 0.0 | 0.6 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.0 | 0.5 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 1.5 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 0.7 | GO:0007617 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
| 0.0 | 1.3 | GO:0042632 | cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092) |
| 0.0 | 0.7 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
| 0.0 | 0.2 | GO:0018377 | N-terminal protein myristoylation(GO:0006499) protein myristoylation(GO:0018377) |
| 0.0 | 0.5 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 1.3 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.0 | 0.3 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.0 | 0.8 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 0.0 | GO:0032632 | interleukin-3 production(GO:0032632) |
| 0.0 | 1.1 | GO:0016202 | regulation of striated muscle tissue development(GO:0016202) regulation of muscle tissue development(GO:1901861) |
| 0.0 | 0.1 | GO:0070345 | negative regulation of fat cell proliferation(GO:0070345) |
| 0.0 | 0.3 | GO:0035308 | negative regulation of protein dephosphorylation(GO:0035308) |
| 0.0 | 0.3 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 4.0 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 0.0 | 2.0 | GO:0030048 | actin filament-based movement(GO:0030048) |
| 0.0 | 2.0 | GO:0071805 | potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 0.9 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.0 | 0.5 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 0.4 | GO:0045943 | positive regulation of transcription from RNA polymerase I promoter(GO:0045943) |
| 0.0 | 0.9 | GO:2000045 | regulation of G1/S transition of mitotic cell cycle(GO:2000045) |
| 0.0 | 0.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.2 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 0.0 | 0.4 | GO:0000578 | embryonic axis specification(GO:0000578) |
| 0.0 | 0.4 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 0.7 | GO:0007606 | sensory perception of chemical stimulus(GO:0007606) |
| 0.0 | 0.9 | GO:0032091 | negative regulation of protein binding(GO:0032091) |
| 0.0 | 2.3 | GO:0050773 | regulation of dendrite development(GO:0050773) |
| 0.0 | 0.4 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 0.0 | 2.1 | GO:0045930 | negative regulation of mitotic cell cycle(GO:0045930) |
| 0.0 | 0.3 | GO:0042026 | protein refolding(GO:0042026) |
| 0.0 | 0.8 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 2.4 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.0 | 0.2 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.0 | 0.2 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 1.5 | GO:0006457 | protein folding(GO:0006457) |
| 0.0 | 0.2 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.0 | 0.3 | GO:0045747 | positive regulation of Notch signaling pathway(GO:0045747) |
| 0.0 | 1.1 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 4.9 | GO:0043512 | inhibin A complex(GO:0043512) |
| 1.5 | 3.0 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 1.4 | 5.6 | GO:0090537 | CERF complex(GO:0090537) |
| 1.2 | 3.5 | GO:0002142 | stereocilia ankle link complex(GO:0002142) |
| 0.9 | 2.7 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.8 | 5.7 | GO:0042627 | chylomicron(GO:0042627) |
| 0.8 | 2.3 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.8 | 1.5 | GO:1990075 | periciliary membrane compartment(GO:1990075) |
| 0.7 | 3.5 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.7 | 6.2 | GO:0005883 | neurofilament(GO:0005883) |
| 0.6 | 1.9 | GO:1903095 | microprocessor complex(GO:0070877) ribonuclease III complex(GO:1903095) |
| 0.6 | 2.3 | GO:0000818 | nuclear MIS12/MIND complex(GO:0000818) |
| 0.5 | 3.1 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.5 | 5.5 | GO:1990909 | Wnt signalosome(GO:1990909) |
| 0.5 | 2.9 | GO:0008091 | spectrin(GO:0008091) |
| 0.4 | 3.6 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.4 | 2.6 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.4 | 13.9 | GO:0030904 | retromer complex(GO:0030904) |
| 0.3 | 5.6 | GO:0031045 | dense core granule(GO:0031045) |
| 0.3 | 2.6 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
| 0.3 | 2.7 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.3 | 7.7 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.3 | 5.4 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.3 | 1.5 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.2 | 1.0 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.2 | 5.4 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.2 | 5.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 0.7 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 0.2 | 3.5 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 0.6 | GO:0034272 | phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272) |
| 0.2 | 1.9 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.2 | 0.9 | GO:0001652 | granular component(GO:0001652) |
| 0.2 | 8.1 | GO:0043034 | costamere(GO:0043034) |
| 0.2 | 19.6 | GO:0016605 | PML body(GO:0016605) |
| 0.2 | 0.9 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.2 | 1.6 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.2 | 1.4 | GO:0060091 | kinocilium(GO:0060091) |
| 0.2 | 4.0 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.2 | 1.2 | GO:0032982 | myosin filament(GO:0032982) |
| 0.2 | 2.0 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.2 | 1.0 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.1 | 0.7 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.1 | 0.4 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.1 | 10.0 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.1 | 26.0 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 2.2 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.1 | 0.7 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.1 | 1.3 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.1 | 11.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 1.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 0.3 | GO:0097637 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
| 0.1 | 0.6 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.1 | 3.4 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 5.0 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 0.1 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.1 | 0.4 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 0.4 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.1 | 2.6 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.1 | 0.3 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.1 | 1.6 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 1.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 1.3 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 0.2 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 3.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 1.0 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.1 | 0.5 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 0.7 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 3.0 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.2 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.0 | 0.3 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 0.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.0 | 0.2 | GO:0001520 | outer dense fiber(GO:0001520) meiotic spindle(GO:0072687) |
| 0.0 | 1.0 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 2.9 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.8 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 0.6 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.2 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 0.0 | 0.8 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 0.1 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.0 | 0.3 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 0.7 | GO:0030118 | clathrin coat(GO:0030118) |
| 0.0 | 0.4 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.5 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 0.3 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 3.5 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 1.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 1.0 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 1.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 1.1 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 3.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 0.4 | GO:0005840 | ribosome(GO:0005840) |
| 0.0 | 5.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 4.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 0.6 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.0 | 0.4 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 1.0 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 1.5 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.2 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 0.3 | GO:0030175 | filopodium(GO:0030175) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 2.6 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 1.9 | 5.6 | GO:0070615 | nucleosome-dependent ATPase activity(GO:0070615) |
| 1.7 | 11.9 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 1.6 | 8.2 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 1.4 | 5.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 1.3 | 3.9 | GO:0043183 | vascular endothelial growth factor receptor 1 binding(GO:0043183) |
| 0.9 | 8.1 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.7 | 2.2 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.7 | 2.1 | GO:0000253 | 3-keto sterol reductase activity(GO:0000253) |
| 0.7 | 2.7 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.7 | 3.9 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.6 | 6.9 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.6 | 7.5 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.6 | 4.2 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.6 | 4.7 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.6 | 1.8 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.6 | 1.7 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.5 | 1.6 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.5 | 2.6 | GO:0004525 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.5 | 6.8 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.5 | 5.6 | GO:0015924 | mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
| 0.5 | 3.0 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.5 | 2.4 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.5 | 2.8 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.4 | 1.6 | GO:0005093 | Rab GDP-dissociation inhibitor activity(GO:0005093) |
| 0.4 | 1.1 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.4 | 1.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.3 | 1.0 | GO:0034190 | apolipoprotein receptor binding(GO:0034190) |
| 0.3 | 1.7 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.3 | 12.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.3 | 0.9 | GO:0016015 | morphogen activity(GO:0016015) |
| 0.3 | 0.9 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.3 | 5.5 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.3 | 0.8 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.2 | 1.0 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
| 0.2 | 1.4 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.2 | 1.9 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.2 | 6.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 2.5 | GO:0004745 | retinol dehydrogenase activity(GO:0004745) |
| 0.2 | 5.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.2 | 2.7 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.2 | 3.3 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.2 | 0.9 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.2 | 7.2 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.2 | 1.5 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.2 | 1.0 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.2 | 0.7 | GO:0019863 | IgE binding(GO:0019863) |
| 0.2 | 0.7 | GO:0036033 | mediator complex binding(GO:0036033) |
| 0.2 | 0.5 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 0.2 | 1.0 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.2 | 0.5 | GO:0070140 | isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140) |
| 0.2 | 1.0 | GO:0051429 | corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.2 | 1.8 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 0.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.2 | 1.0 | GO:0016453 | acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453) |
| 0.2 | 1.5 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.2 | 2.2 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.2 | 1.1 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.1 | 0.9 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.1 | 0.7 | GO:0034604 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604) |
| 0.1 | 1.0 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.1 | 4.1 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 2.0 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.1 | 2.9 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.1 | 2.9 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 5.0 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 1.5 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 0.4 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 0.1 | 2.4 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 1.0 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 0.9 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 3.2 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 0.9 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.1 | 2.2 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 0.5 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.1 | 4.6 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 0.8 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.1 | 17.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 4.6 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.1 | 2.7 | GO:0070840 | dynein complex binding(GO:0070840) |
| 0.1 | 1.2 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 0.4 | GO:0043559 | insulin binding(GO:0043559) |
| 0.1 | 0.6 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.1 | 0.5 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.1 | 0.9 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.1 | 1.5 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.1 | 1.1 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.1 | 1.5 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 4.2 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.1 | 2.5 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.1 | 4.3 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.1 | 1.5 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.1 | 2.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 1.9 | GO:0035250 | UDP-galactosyltransferase activity(GO:0035250) |
| 0.1 | 7.9 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.1 | 0.4 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.1 | 0.7 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 0.5 | GO:0004118 | cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) |
| 0.1 | 2.5 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.1 | 4.5 | GO:0017022 | myosin binding(GO:0017022) |
| 0.1 | 0.7 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 0.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.1 | 0.3 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.1 | 6.5 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 3.2 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.1 | 1.2 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.1 | 0.7 | GO:0019206 | nucleoside kinase activity(GO:0019206) |
| 0.1 | 1.0 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.6 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 1.3 | GO:0016866 | intramolecular transferase activity(GO:0016866) |
| 0.1 | 0.4 | GO:0002135 | CTP binding(GO:0002135) sulfonylurea receptor binding(GO:0017098) |
| 0.1 | 3.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 1.0 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 22.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 0.6 | GO:0035004 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) phosphatidylinositol 3-kinase activity(GO:0035004) |
| 0.1 | 0.4 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.0 | 0.3 | GO:0048185 | activin binding(GO:0048185) |
| 0.0 | 1.2 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.2 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.0 | 17.0 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 0.3 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 0.0 | 0.2 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.0 | 0.3 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.0 | 0.2 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.0 | 2.3 | GO:0019955 | cytokine binding(GO:0019955) |
| 0.0 | 4.2 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 0.8 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.0 | 1.6 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 0.6 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.0 | 0.8 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.2 | GO:0015234 | thiamine transmembrane transporter activity(GO:0015234) |
| 0.0 | 0.8 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 1.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.3 | GO:0070739 | protein-glutamic acid ligase activity(GO:0070739) |
| 0.0 | 2.0 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 1.4 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 4.9 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.0 | 0.5 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 0.6 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 9.8 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 0.4 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 0.0 | 0.2 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.5 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 1.0 | GO:0019209 | kinase activator activity(GO:0019209) |
| 0.0 | 0.3 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.0 | 0.5 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 1.1 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 1.7 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 1.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.2 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.4 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.1 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.0 | 0.0 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.0 | 0.2 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.1 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.3 | 5.8 | PID_HIF1A_PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.2 | 9.2 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.2 | 6.1 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.2 | 2.6 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.2 | 5.5 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.2 | 16.1 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.2 | 4.9 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.1 | 1.0 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.1 | 5.6 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 1.8 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 1.8 | PID_IL23_PATHWAY | IL23-mediated signaling events |
| 0.1 | 1.9 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.8 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.1 | 5.3 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 7.7 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 2.4 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 2.6 | PID_INSULIN_PATHWAY | Insulin Pathway |
| 0.1 | 4.4 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 0.7 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 2.3 | PID_PTP1B_PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 7.7 | PID_PDGFRB_PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 1.0 | PID_IFNG_PATHWAY | IFN-gamma pathway |
| 0.1 | 2.2 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 0.4 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.1 | 2.2 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
| 0.1 | 2.9 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.1 | 1.5 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.1 | 0.6 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.7 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 1.0 | PID_FAS_PATHWAY | FAS (CD95) signaling pathway |
| 0.0 | 2.8 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 1.2 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.9 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.3 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.8 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 2.4 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.8 | PID_ENDOTHELIN_PATHWAY | Endothelins |
| 0.0 | 0.3 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.3 | PID_BCR_5PATHWAY | BCR signaling pathway |
| 0.0 | 0.4 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.0 | 1.3 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.4 | PID_ERBB1_DOWNSTREAM_PATHWAY | ErbB1 downstream signaling |
| 0.0 | 0.5 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.9 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 1.1 | 3.2 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.6 | 5.6 | REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.5 | 14.4 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.5 | 12.2 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.4 | 5.7 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.4 | 10.9 | REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.3 | 1.0 | REACTOME_G_PROTEIN_ACTIVATION | Genes involved in G-protein activation |
| 0.3 | 6.2 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.2 | 0.2 | REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |
| 0.2 | 1.5 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.2 | 6.2 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.2 | 2.2 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.2 | 4.4 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 2.7 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.2 | 4.3 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 7.2 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 6.7 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 2.3 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.2 | 1.4 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.2 | 1.7 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 4.0 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.1 | 1.1 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.1 | 10.6 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 4.2 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 2.6 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 1.8 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 1.2 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.1 | 11.3 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.3 | REACTOME_MICRORNA_MIRNA_BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.1 | 2.0 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 1.5 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 2.2 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 1.9 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 4.7 | REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 3.1 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.1 | 1.6 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.1 | 0.7 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 1.1 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 1.5 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 2.5 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.7 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.7 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.5 | REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.0 | 0.6 | REACTOME_SIGNALING_BY_ROBO_RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 2.2 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.5 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.3 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.5 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 1.0 | REACTOME_SIGNALING_BY_HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.4 | REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 2.8 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.5 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 0.0 | 0.2 | REACTOME_TRANSPORT_OF_ORGANIC_ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 1.7 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 0.5 | REACTOME_KERATAN_SULFATE_BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 2.3 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.0 | 0.9 | REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS | Genes involved in Host Interactions of HIV factors |
| 0.0 | 0.4 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.7 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.2 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 0.2 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 0.3 | REACTOME_DOUBLE_STRAND_BREAK_REPAIR | Genes involved in Double-Strand Break Repair |
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