Motif ID: Gfi1_Gfi1b

Z-value: 1.548

Transcription factors associated with Gfi1_Gfi1b:

Gene SymbolEntrez IDGene Name
Gfi1 ENSMUSG00000029275.11 Gfi1
Gfi1b ENSMUSG00000026815.8 Gfi1b



Activity profile for motif Gfi1_Gfi1b.

activity profile for motif Gfi1_Gfi1b


Sorted Z-values histogram for motif Gfi1_Gfi1b

Sorted Z-values for motif Gfi1_Gfi1b



Network of associatons between targets according to the STRING database.



First level regulatory network of Gfi1_Gfi1b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 22.883 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_+_62376979 13.868 ENSMUST00000080403.5
 Magel2
melanoma antigen, family L, 2
chrX_-_61185558 12.730 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr12_+_109545390 12.662 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr9_+_3027439 11.640 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr12_+_109544498 11.395 ENSMUST00000126289.1
 Meg3
maternally expressed 3
chr9_+_3000922 11.384 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3005125 11.163 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr12_+_74297474 10.943 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr9_+_3013140 10.545 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3034599 10.307 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr8_+_106935720 9.736 ENSMUST00000047425.3
 Sntb2
syntrophin, basic 2
chr15_-_66831625 9.575 ENSMUST00000164163.1
 Sla
src-like adaptor
chr9_+_3017408 9.319 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 9.247 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr16_-_26989974 9.229 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr9_+_3023547 9.199 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3025417 9.126 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3037111 8.218 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3036877 7.786 ENSMUST00000155807.2
 Gm10715
predicted gene 10715

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 213 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 24.3 GO:0008340 determination of adult lifespan(GO:0008340)
3.8 22.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 16.4 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
1.0 14.0 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.2 13.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 13.3 GO:0030032 lamellipodium assembly(GO:0030032)
1.9 11.7 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 8.8 GO:0006270 DNA replication initiation(GO:0006270)
2.1 8.5 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
1.3 7.9 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
0.1 7.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 7.4 GO:0030325 adrenal gland development(GO:0030325)
0.6 7.2 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 7.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5 6.9 GO:0048875 chemical homeostasis within a tissue(GO:0048875) regulation of store-operated calcium entry(GO:2001256)
1.0 6.7 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
2.1 6.2 GO:0030070 insulin processing(GO:0030070)
2.1 6.2 GO:0045110 intermediate filament bundle assembly(GO:0045110)
1.5 5.8 GO:0061055 myotome development(GO:0061055)
0.7 5.6 GO:0005513 detection of calcium ion(GO:0005513)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 26.0 GO:0030027 lamellipodium(GO:0030027)
0.2 19.6 GO:0016605 PML body(GO:0016605)
0.4 13.9 GO:0030904 retromer complex(GO:0030904)
0.1 11.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 10.0 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 8.1 GO:0043034 costamere(GO:0043034)
0.3 7.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.7 6.2 GO:0005883 neurofilament(GO:0005883)
0.8 5.7 GO:0042627 chylomicron(GO:0042627)
1.4 5.6 GO:0090537 CERF complex(GO:0090537)
0.3 5.6 GO:0031045 dense core granule(GO:0031045)
0.5 5.5 GO:1990909 Wnt signalosome(GO:1990909)
0.0 5.5 GO:0016607 nuclear speck(GO:0016607)
0.3 5.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.2 5.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 5.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 5.0 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
1.6 4.9 GO:0043512 inhibin A complex(GO:0043512)
0.0 4.6 GO:0005925 focal adhesion(GO:0005925)
0.2 4.0 GO:0005797 Golgi medial cisterna(GO:0005797)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 22.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 17.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 17.0 GO:0003779 actin binding(GO:0003779)
0.3 12.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.7 11.9 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 9.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.6 8.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.9 8.1 GO:0034711 inhibin binding(GO:0034711)
0.1 7.9 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.6 7.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 7.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.6 6.9 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.5 6.8 GO:0015643 toxic substance binding(GO:0015643)
0.1 6.5 GO:0030674 protein binding, bridging(GO:0030674)
0.2 6.4 GO:0070064 proline-rich region binding(GO:0070064)
1.9 5.6 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
1.4 5.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.5 5.6 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.3 5.5 GO:0050321 tau-protein kinase activity(GO:0050321)
0.2 5.4 GO:0004385 guanylate kinase activity(GO:0004385)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 9.2 PID_ALK1_PATHWAY ALK1 signaling events
0.1 7.7 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 7.7 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.2 6.1 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.3 5.8 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 5.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 5.5 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 5.3 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.2 4.9 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 4.4 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.3 4.1 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 2.9 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 2.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 2.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.2 2.6 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 2.6 PID_INSULIN_PATHWAY Insulin Pathway
0.1 2.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 2.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.3 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 14.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.5 12.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 11.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 10.9 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.1 10.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 7.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 6.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 6.2 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 6.2 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.4 5.7 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.6 5.6 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
1.2 4.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 4.7 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.2 4.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 4.3 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 4.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 4.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
1.1 3.2 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 3.1 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.0 2.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase