Motif ID: Gli1

Z-value: 0.803


Transcription factors associated with Gli1:

Gene SymbolEntrez IDGene Name
Gli1 ENSMUSG00000025407.6 Gli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli1mm10_v2_chr10_-_127341583_127341614-0.561.2e-07Click!


Activity profile for motif Gli1.

activity profile for motif Gli1


Sorted Z-values histogram for motif Gli1

Sorted Z-values for motif Gli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 169 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_64090265 8.014 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr10_-_64090241 7.630 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr12_-_81333129 6.870 ENSMUST00000085238.6
ENSMUST00000182208.1
 Slc8a3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr4_-_68954351 6.613 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr2_-_54085542 5.722 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr2_+_118111876 5.486 ENSMUST00000039559.8
 Thbs1
thrombospondin 1
chr13_-_114458720 5.417 ENSMUST00000022287.5
 Fst
follistatin
chr15_-_95528228 5.384 ENSMUST00000075275.2
 Nell2
NEL-like 2
chr15_-_85581809 5.329 ENSMUST00000023015.7
 Wnt7b
wingless-related MMTV integration site 7B
chr5_+_30588078 5.290 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr15_-_95528702 4.954 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr12_+_44328882 4.507 ENSMUST00000020939.8
ENSMUST00000110748.2
 Nrcam

neuron-glia-CAM-related cell adhesion molecule

chr13_+_118714678 4.420 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr6_-_52012476 4.175 ENSMUST00000078214.5
 Skap2
src family associated phosphoprotein 2
chr5_+_5573952 3.873 ENSMUST00000101627.2
 Gm8773
predicted gene 8773
chr3_+_68494208 3.763 ENSMUST00000182719.1
 Schip1
schwannomin interacting protein 1
chr7_+_73391160 3.762 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr8_+_54954728 3.566 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr13_+_5861489 3.394 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr1_-_25228814 3.345 ENSMUST00000126626.1
 Bai3
brain-specific angiogenesis inhibitor 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 15.6 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.9 10.3 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.8 7.6 GO:0071420 cellular response to histamine(GO:0071420)
1.4 6.9 GO:1990034 calcium ion export from cell(GO:1990034)
2.3 6.8 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.3 6.6 GO:0042711 maternal behavior(GO:0042711)
0.0 5.5 GO:0002757 immune response-activating signal transduction(GO:0002757)
0.7 5.4 GO:0051798 positive regulation of hair follicle development(GO:0051798)
1.8 5.3 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.5 5.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 4.8 GO:0007050 cell cycle arrest(GO:0007050)
0.8 4.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.4 4.5 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.5 4.4 GO:2000331 regulation of terminal button organization(GO:2000331)
1.5 4.4 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
1.1 4.3 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.1 4.2 GO:0046967 cytosol to ER transport(GO:0046967)
0.3 3.8 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.2 3.8 GO:0001553 luteinization(GO:0001553)
0.1 3.6 GO:0003407 neural retina development(GO:0003407)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 9.6 GO:0043204 perikaryon(GO:0043204)
0.3 9.0 GO:0043194 axon initial segment(GO:0043194)
0.1 8.7 GO:0030139 endocytic vesicle(GO:0030139)
0.0 7.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.5 7.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 6.9 GO:0031594 neuromuscular junction(GO:0031594)
0.1 6.9 GO:0030175 filopodium(GO:0030175)
1.8 5.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 4.4 GO:0031012 extracellular matrix(GO:0031012)
0.6 4.2 GO:0042825 TAP complex(GO:0042825)
0.0 3.6 GO:0001650 fibrillar center(GO:0001650)
0.0 3.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 2.8 GO:0031941 filamentous actin(GO:0031941)
0.1 2.6 GO:0060170 ciliary membrane(GO:0060170)
0.2 2.5 GO:0031209 SCAR complex(GO:0031209)
0.8 2.4 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 2.2 GO:0005770 late endosome(GO:0005770)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.6 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 10.3 GO:0005080 protein kinase C binding(GO:0005080)
0.4 7.6 GO:0004890 GABA-A receptor activity(GO:0004890)
0.8 6.9 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
1.8 5.5 GO:0070052 collagen V binding(GO:0070052)
0.5 5.4 GO:0048185 activin binding(GO:0048185)
1.3 5.3 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.5 5.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 4.9 GO:0048487 beta-tubulin binding(GO:0048487)
0.9 4.5 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 4.5 GO:0030507 spectrin binding(GO:0030507)
1.1 4.4 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 4.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.6 4.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
1.1 4.2 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 4.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 3.8 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 3.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 3.5 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 3.4 GO:0005262 calcium channel activity(GO:0005262)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 9.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 7.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.2 5.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.7 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 2.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 2.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 2.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.9 PID_BCR_5PATHWAY BCR signaling pathway
0.0 1.7 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 1.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.4 PID_PLK1_PATHWAY PLK1 signaling events
0.0 1.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.5 7.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.5 6.9 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 6.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 5.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.8 5.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 5.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 4.4 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.3 4.2 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 4.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 3.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 2.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.8 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 2.5 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.2 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.9 REACTOME_MYOGENESIS Genes involved in Myogenesis