Motif ID: Gli2

Z-value: 0.801


Transcription factors associated with Gli2:

Gene SymbolEntrez IDGene Name
Gli2 ENSMUSG00000048402.8 Gli2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_119053619_1190536380.161.7e-01Click!


Activity profile for motif Gli2.

activity profile for motif Gli2


Sorted Z-values histogram for motif Gli2

Sorted Z-values for motif Gli2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli2

PNG image of the network

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Top targets:


Showing 1 to 20 of 140 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 13.623 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_141725181 9.784 ENSMUST00000067841.7
 Irs4
insulin receptor substrate 4
chr15_-_56694525 9.640 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr12_+_58211772 7.243 ENSMUST00000110671.2
ENSMUST00000044299.2
 Sstr1

somatostatin receptor 1

chr6_-_72789240 6.633 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr12_+_38780284 6.571 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr6_-_72788952 6.244 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr7_-_137314394 6.004 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr8_+_127064022 5.763 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr7_-_4752972 5.759 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr8_+_127064107 5.599 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr8_+_127063893 4.661 ENSMUST00000162309.1
 Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr6_+_120666388 4.170 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chrX_-_9662950 4.018 ENSMUST00000033519.2
 Dynlt3
dynein light chain Tctex-type 3
chr1_+_55406163 3.537 ENSMUST00000042986.8
 Plcl1
phospholipase C-like 1
chr5_-_53213447 3.470 ENSMUST00000031090.6
 Sel1l3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr9_-_43239816 3.368 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr1_-_51915901 3.271 ENSMUST00000018561.7
ENSMUST00000114537.2
 Myo1b

myosin IB

chr3_+_107036156 3.251 ENSMUST00000052718.3
 Kcna3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr4_+_36952930 3.200 ENSMUST00000144029.1
 Gm12371
predicted gene 12371

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 16.0 GO:0003383 apical constriction(GO:0003383)
2.3 13.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
4.3 12.9 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
2.4 9.6 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 7.8 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.3 7.2 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.6 6.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 6.2 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.6 5.8 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.6 4.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.4 4.5 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.5 4.2 GO:0001842 neural fold formation(GO:0001842)
0.9 3.8 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.7 3.5 GO:1900122 positive regulation of receptor binding(GO:1900122)
1.1 3.2 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.1 3.2 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.3 3.0 GO:0071420 cellular response to histamine(GO:0071420)
0.1 2.7 GO:0043171 peptide catabolic process(GO:0043171)
0.0 2.6 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.2 2.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 16.0 GO:0033269 internode region of axon(GO:0033269)
0.0 11.6 GO:0005667 transcription factor complex(GO:0005667)
0.2 8.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 6.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 5.8 GO:0030061 mitochondrial crista(GO:0030061)
0.3 5.8 GO:0097470 ribbon synapse(GO:0097470)
0.2 4.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
1.0 4.2 GO:0090537 CERF complex(GO:0090537)
0.0 4.1 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.6 3.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 2.7 GO:0034707 chloride channel complex(GO:0034707)
0.1 2.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 2.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.5 2.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 2.1 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 2.1 GO:0001650 fibrillar center(GO:0001650)
0.3 2.0 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 1.8 GO:0033270 paranode region of axon(GO:0033270)
0.0 1.8 GO:0005643 nuclear pore(GO:0005643)
0.1 1.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 22.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 13.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 12.9 GO:0008013 beta-catenin binding(GO:0008013)
0.1 10.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 8.9 GO:0005158 insulin receptor binding(GO:0005158)
2.7 8.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
2.4 7.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.7 5.8 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
1.1 4.6 GO:0097100 supercoiled DNA binding(GO:0097100)
0.3 4.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.3 3.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 3.7 GO:0003774 motor activity(GO:0003774)
0.8 3.2 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.2 3.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2 2.8 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.1 2.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.9 2.6 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.2 2.6 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 2.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.2 2.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 25.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.3 14.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 4.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 4.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 4.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 3.7 NABA_COLLAGENS Genes encoding collagen proteins
0.1 3.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 2.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 16.0 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.5 8.1 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 6.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 5.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.6 4.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 4.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 3.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 3.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 3.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.8 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 2.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 2.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.8 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 1.4 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 1.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 0.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME_MRNA_CAPPING Genes involved in mRNA Capping
0.0 0.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis