Motif ID: Gli2

Z-value: 0.801


Transcription factors associated with Gli2:

Gene SymbolEntrez IDGene Name
Gli2 ENSMUSG00000048402.8 Gli2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli2mm10_v2_chr1_-_119053619_1190536380.161.7e-01Click!


Activity profile for motif Gli2.

activity profile for motif Gli2


Sorted Z-values histogram for motif Gli2

Sorted Z-values for motif Gli2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 13.623 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chrX_-_141725181 9.784 ENSMUST00000067841.7
Irs4
insulin receptor substrate 4
chr15_-_56694525 9.640 ENSMUST00000050544.7
Has2
hyaluronan synthase 2
chr12_+_58211772 7.243 ENSMUST00000110671.2
ENSMUST00000044299.2
Sstr1

somatostatin receptor 1

chr6_-_72789240 6.633 ENSMUST00000069536.5
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr12_+_38780284 6.571 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr6_-_72788952 6.244 ENSMUST00000114053.2
Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr7_-_137314394 6.004 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
Ebf3



early B cell factor 3



chr8_+_127064022 5.763 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr7_-_4752972 5.759 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr8_+_127064107 5.599 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr8_+_127063893 4.661 ENSMUST00000162309.1
Pard3
par-3 (partitioning defective 3) homolog (C. elegans)
chr6_+_120666388 4.170 ENSMUST00000112686.1
Cecr2
cat eye syndrome chromosome region, candidate 2
chrX_-_9662950 4.018 ENSMUST00000033519.2
Dynlt3
dynein light chain Tctex-type 3
chr1_+_55406163 3.537 ENSMUST00000042986.8
Plcl1
phospholipase C-like 1
chr5_-_53213447 3.470 ENSMUST00000031090.6
Sel1l3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr9_-_43239816 3.368 ENSMUST00000034512.5
Oaf
OAF homolog (Drosophila)
chr1_-_51915901 3.271 ENSMUST00000018561.7
ENSMUST00000114537.2
Myo1b

myosin IB

chr3_+_107036156 3.251 ENSMUST00000052718.3
Kcna3
potassium voltage-gated channel, shaker-related subfamily, member 3
chr4_+_36952930 3.200 ENSMUST00000144029.1
Gm12371
predicted gene 12371
chr15_-_85581809 3.154 ENSMUST00000023015.7
Wnt7b
wingless-related MMTV integration site 7B
chr1_-_51915968 2.940 ENSMUST00000046390.7
Myo1b
myosin IB
chr1_+_167001417 2.859 ENSMUST00000165874.1
Fam78b
family with sequence similarity 78, member B
chr10_-_114801364 2.659 ENSMUST00000061632.7
Trhde
TRH-degrading enzyme
chr16_+_19760902 2.585 ENSMUST00000119468.1
B3gnt5
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
chr13_+_44730726 2.512 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
Jarid2


jumonji, AT rich interactive domain 2


chr4_-_83486453 2.448 ENSMUST00000107214.2
ENSMUST00000107215.2
ENSMUST00000030207.8
Psip1


PC4 and SFRS1 interacting protein 1


chr15_+_95790831 2.385 ENSMUST00000071874.6
Ano6
anoctamin 6
chr4_-_135971894 2.382 ENSMUST00000105852.1
Lypla2
lysophospholipase 2
chr4_-_19708922 2.326 ENSMUST00000108246.2
Wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr19_+_6975048 2.311 ENSMUST00000070850.6
Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr3_-_135608221 2.275 ENSMUST00000132668.1
Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
chr5_-_24527276 2.223 ENSMUST00000088311.4
Gbx1
gastrulation brain homeobox 1
chr4_-_83486178 2.145 ENSMUST00000130626.1
Psip1
PC4 and SFRS1 interacting protein 1
chr13_+_5861489 2.121 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr18_+_86394952 2.103 ENSMUST00000058829.2
Neto1
neuropilin (NRP) and tolloid (TLL)-like 1
chr4_+_121039385 2.056 ENSMUST00000030372.5
Col9a2
collagen, type IX, alpha 2
chr16_-_88056176 2.033 ENSMUST00000072256.5
ENSMUST00000023652.8
ENSMUST00000114137.1
Grik1


glutamate receptor, ionotropic, kainate 1


chr4_-_126256226 2.024 ENSMUST00000122129.1
ENSMUST00000061143.8
ENSMUST00000106132.2
Map7d1


MAP7 domain containing 1


chr7_-_133123160 2.002 ENSMUST00000166439.1
Ctbp2
C-terminal binding protein 2
chr13_+_35741313 1.971 ENSMUST00000163595.2
Cdyl
chromodomain protein, Y chromosome-like
chr4_+_117096049 1.969 ENSMUST00000030443.5
Ptch2
patched homolog 2
chr2_+_69861562 1.923 ENSMUST00000090852.4
ENSMUST00000166411.1
Ssb

Sjogren syndrome antigen B

chrX_+_137049586 1.909 ENSMUST00000047852.7
Fam199x
family with sequence similarity 199, X-linked
chr2_+_69861638 1.855 ENSMUST00000112260.1
Ssb
Sjogren syndrome antigen B
chr11_+_101176041 1.827 ENSMUST00000103109.3
Cntnap1
contactin associated protein-like 1
chr3_+_28781305 1.789 ENSMUST00000060500.7
Eif5a2
eukaryotic translation initiation factor 5A2
chr11_-_42000284 1.756 ENSMUST00000109292.2
ENSMUST00000109290.1
Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr2_+_71211706 1.696 ENSMUST00000112142.1
ENSMUST00000112139.1
ENSMUST00000112140.1
ENSMUST00000112138.1
Dync1i2



dynein cytoplasmic 1 intermediate chain 2



chr12_-_69357120 1.683 ENSMUST00000021368.8
Nemf
nuclear export mediator factor
chr19_+_6047081 1.675 ENSMUST00000025723.8
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr3_+_127633134 1.606 ENSMUST00000029587.7
Neurog2
neurogenin 2
chr4_+_63215402 1.603 ENSMUST00000036300.6
Col27a1
collagen, type XXVII, alpha 1
chr18_-_35662180 1.562 ENSMUST00000025209.4
ENSMUST00000096573.2
Spata24

spermatogenesis associated 24

chr9_+_62342449 1.558 ENSMUST00000156461.1
Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr7_-_133123409 1.481 ENSMUST00000170459.1
ENSMUST00000166400.1
Ctbp2

C-terminal binding protein 2

chr19_+_6047055 1.476 ENSMUST00000134667.1
Syvn1
synovial apoptosis inhibitor 1, synoviolin
chr11_+_100619217 1.458 ENSMUST00000107376.1
Nkiras2
NFKB inhibitor interacting Ras-like protein 2
chr7_-_133123312 1.446 ENSMUST00000124096.1
ENSMUST00000171022.1
ENSMUST00000163601.1
ENSMUST00000165534.1
ENSMUST00000033269.8
Fgfr2
Ctbp2



fibroblast growth factor receptor 2
C-terminal binding protein 2



chr5_-_115300957 1.420 ENSMUST00000009157.3
Dynll1
dynein light chain LC8-type 1
chr2_+_121955964 1.389 ENSMUST00000036647.6
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr3_+_9250602 1.378 ENSMUST00000155203.1
Zbtb10
zinc finger and BTB domain containing 10
chr5_-_115300912 1.373 ENSMUST00000112090.1
Dynll1
dynein light chain LC8-type 1
chr4_-_121098190 1.323 ENSMUST00000058754.2
Zmpste24
zinc metallopeptidase, STE24
chr9_+_55149364 1.291 ENSMUST00000121677.1
Ube2q2
ubiquitin-conjugating enzyme E2Q (putative) 2
chr11_-_42000532 1.247 ENSMUST00000070735.3
Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr11_+_117308135 1.203 ENSMUST00000153668.1
Sept9
septin 9
chr4_-_59783800 1.188 ENSMUST00000107526.1
ENSMUST00000095063.4
Inip

INTS3 and NABP interacting protein

chr16_-_17132377 1.180 ENSMUST00000023453.7
Sdf2l1
stromal cell-derived factor 2-like 1
chr4_+_32800246 1.162 ENSMUST00000062802.4
Lyrm2
LYR motif containing 2
chr3_+_36552600 1.147 ENSMUST00000029269.5
ENSMUST00000136890.1
Exosc9

exosome component 9

chr11_-_100620165 1.121 ENSMUST00000014339.8
Dnajc7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr10_+_83543941 1.088 ENSMUST00000038388.5
A230046K03Rik
RIKEN cDNA A230046K03 gene
chr2_+_130576170 1.054 ENSMUST00000028764.5
Oxt
oxytocin
chr18_-_38250157 1.021 ENSMUST00000181871.1
1700086O06Rik
RIKEN cDNA 1700086O06 gene
chr6_+_67266979 1.001 ENSMUST00000042990.4
Serbp1
serpine1 mRNA binding protein 1
chr10_+_80151154 0.993 ENSMUST00000146516.1
ENSMUST00000144526.1
Midn

midnolin

chr3_+_105452326 0.959 ENSMUST00000098761.3
Kcnd3
potassium voltage-gated channel, Shal-related family, member 3
chr11_+_70844745 0.956 ENSMUST00000076270.6
ENSMUST00000179114.1
ENSMUST00000100928.4
ENSMUST00000177731.1
ENSMUST00000108533.3
ENSMUST00000081362.6
ENSMUST00000178245.1
Rabep1






rabaptin, RAB GTPase binding effector protein 1






chrX_+_161717055 0.947 ENSMUST00000112338.1
Rai2
retinoic acid induced 2
chr7_+_81571246 0.893 ENSMUST00000165460.1
Whamm
WAS protein homolog associated with actin, golgi membranes and microtubules
chr7_-_133122615 0.881 ENSMUST00000167218.1
Ctbp2
C-terminal binding protein 2
chr2_+_69897255 0.849 ENSMUST00000131553.1
Ubr3
ubiquitin protein ligase E3 component n-recognin 3
chr9_-_107770945 0.846 ENSMUST00000183248.1
ENSMUST00000182022.1
ENSMUST00000035199.6
ENSMUST00000182659.1
Rbm5



RNA binding motif protein 5



chr7_-_116308241 0.806 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
Plekha7


pleckstrin homology domain containing, family A member 7


chr2_-_37703275 0.792 ENSMUST00000072186.5
Strbp
spermatid perinuclear RNA binding protein
chr14_+_64950037 0.791 ENSMUST00000043914.5
Ints9
integrator complex subunit 9
chr5_+_23850590 0.766 ENSMUST00000181574.1
2700038G22Rik
RIKEN cDNA 2700038G22 gene
chr4_+_33310306 0.764 ENSMUST00000108153.2
ENSMUST00000029942.7
Rngtt

RNA guanylyltransferase and 5'-phosphatase

chr11_-_118909487 0.755 ENSMUST00000117731.1
ENSMUST00000106278.2
ENSMUST00000120061.1
ENSMUST00000017576.4
Rbfox3



RNA binding protein, fox-1 homolog (C. elegans) 3



chr4_-_126968124 0.744 ENSMUST00000106108.2
Zmym4
zinc finger, MYM-type 4
chr2_-_157566319 0.691 ENSMUST00000109528.2
ENSMUST00000088494.2
Blcap

bladder cancer associated protein homolog (human)

chr11_+_95712673 0.684 ENSMUST00000107717.1
Zfp652
zinc finger protein 652
chrX_+_161717498 0.674 ENSMUST00000061514.7
Rai2
retinoic acid induced 2
chr11_-_100619576 0.656 ENSMUST00000155152.1
Dnajc7
DnaJ (Hsp40) homolog, subfamily C, member 7
chr2_+_49451486 0.639 ENSMUST00000092123.4
Epc2
enhancer of polycomb homolog 2 (Drosophila)
chr10_+_76531593 0.616 ENSMUST00000048678.6
Lss
lanosterol synthase
chr10_-_99126321 0.615 ENSMUST00000060761.5
Phxr2
per-hexamer repeat gene 2
chr2_-_120563795 0.610 ENSMUST00000055241.6
ENSMUST00000135625.1
Zfp106

zinc finger protein 106

chr2_-_120609319 0.609 ENSMUST00000102497.3
Lrrc57
leucine rich repeat containing 57
chr11_+_29526407 0.607 ENSMUST00000133452.1
Mtif2
mitochondrial translational initiation factor 2
chr2_+_164486455 0.598 ENSMUST00000069385.8
ENSMUST00000143690.1
Dbndd2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr9_+_109095427 0.593 ENSMUST00000072093.6
Plxnb1
plexin B1
chr14_-_70443442 0.586 ENSMUST00000000793.5
Polr3d
polymerase (RNA) III (DNA directed) polypeptide D
chr1_+_71652837 0.582 ENSMUST00000097699.2
Apol7d
apolipoprotein L 7d
chr3_+_95427575 0.561 ENSMUST00000181809.1
Gm4349
predicted gene 4349
chr2_-_120609283 0.553 ENSMUST00000102496.1
Lrrc57
leucine rich repeat containing 57
chr9_+_108795971 0.540 ENSMUST00000085018.4
Ip6k2
inositol hexaphosphate kinase 2
chr6_-_137649211 0.527 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
Eps8


epidermal growth factor receptor pathway substrate 8


chr11_+_29526423 0.504 ENSMUST00000136351.1
ENSMUST00000020749.6
ENSMUST00000144321.1
ENSMUST00000093239.4
Mtif2



mitochondrial translational initiation factor 2



chr2_-_120609500 0.501 ENSMUST00000133612.1
ENSMUST00000102498.1
ENSMUST00000102499.1
Lrrc57


leucine rich repeat containing 57


chr5_-_134456227 0.487 ENSMUST00000111244.1
Gtf2ird1
general transcription factor II I repeat domain-containing 1
chrX_-_95956890 0.404 ENSMUST00000079987.6
ENSMUST00000113864.2
Las1l

LAS1-like (S. cerevisiae)

chr11_-_107794557 0.390 ENSMUST00000021066.3
Cacng4
calcium channel, voltage-dependent, gamma subunit 4
chr9_-_108578657 0.375 ENSMUST00000068700.5
Wdr6
WD repeat domain 6
chr5_-_117319242 0.327 ENSMUST00000100834.1
Gm10399
predicted gene 10399
chr14_-_64949838 0.296 ENSMUST00000067843.3
ENSMUST00000176489.1
ENSMUST00000175905.1
ENSMUST00000022544.7
ENSMUST00000175744.1
ENSMUST00000176128.1
Hmbox1





homeobox containing 1





chr2_-_104712122 0.285 ENSMUST00000111118.1
ENSMUST00000028597.3
Tcp11l1

t-complex 11 like 1

chr9_+_100643605 0.283 ENSMUST00000041418.6
Stag1
stromal antigen 1
chr5_+_105519388 0.266 ENSMUST00000067924.6
ENSMUST00000150981.1
Lrrc8c

leucine rich repeat containing 8 family, member C

chr2_+_120609383 0.264 ENSMUST00000124187.1
Haus2
HAUS augmin-like complex, subunit 2
chr13_+_55445301 0.246 ENSMUST00000001115.8
ENSMUST00000099482.3
Grk6

G protein-coupled receptor kinase 6

chr8_-_27174623 0.232 ENSMUST00000033878.6
ENSMUST00000054212.6
Rab11fip1

RAB11 family interacting protein 1 (class I)

chr9_+_114401076 0.215 ENSMUST00000063042.9
ENSMUST00000111820.2
Glb1
Tmppe
galactosidase, beta 1
transmembrane protein with metallophosphoesterase domain
chr1_-_38664947 0.202 ENSMUST00000039827.7
ENSMUST00000027250.7
Aff3

AF4/FMR2 family, member 3

chr5_-_20882072 0.193 ENSMUST00000118174.1
Phtf2
putative homeodomain transcription factor 2
chr18_+_61555689 0.182 ENSMUST00000167187.1
Csnk1a1
casein kinase 1, alpha 1
chr4_-_46536096 0.169 ENSMUST00000102924.2
Trim14
tripartite motif-containing 14
chr18_+_80206887 0.164 ENSMUST00000127234.1
Gm16286
predicted gene 16286
chr2_+_121956411 0.156 ENSMUST00000110578.1
Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr18_+_80206775 0.131 ENSMUST00000125127.1
ENSMUST00000025463.7
ENSMUST00000145963.1
ENSMUST00000025464.7
Gm16286

Txnl4a

predicted gene 16286

thioredoxin-like 4A

chr7_-_81454751 0.113 ENSMUST00000098331.3
ENSMUST00000178892.1
Cpeb1

cytoplasmic polyadenylation element binding protein 1

chr1_+_97770158 0.105 ENSMUST00000112844.3
ENSMUST00000112842.1
ENSMUST00000027571.6
Gin1


gypsy retrotransposon integrase 1


chr9_-_69760924 0.105 ENSMUST00000071281.4
Foxb1
forkhead box B1
chr12_+_72085847 0.095 ENSMUST00000117449.1
ENSMUST00000057257.8
Jkamp

JNK1/MAPK8-associated membrane protein

chr11_+_51619731 0.047 ENSMUST00000127405.1
Nhp2
NHP2 ribonucleoprotein
chr5_-_137786651 0.044 ENSMUST00000031740.9
Mepce
methylphosphate capping enzyme
chr16_-_20302358 0.031 ENSMUST00000048642.8
Parl
presenilin associated, rhomboid-like
chr17_-_31658729 0.021 ENSMUST00000166526.1
ENSMUST00000014684.4
U2af1

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1

chr17_+_24669730 0.004 ENSMUST00000047179.5
Zfp598
zinc finger protein 598

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 12.9 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
2.7 16.0 GO:0003383 apical constriction(GO:0003383)
2.4 9.6 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
2.3 13.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.1 3.2 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
0.9 3.8 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.8 2.4 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591) phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.7 3.5 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.7 2.1 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.6 6.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.6 5.8 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.6 4.6 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.6 2.3 GO:1903416 negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) regulation of calcidiol 1-monooxygenase activity(GO:0060558) response to glycoside(GO:1903416)
0.6 2.2 GO:0019230 proprioception(GO:0019230) sensory neuron axon guidance(GO:0097374)
0.5 2.0 GO:0009957 epidermal cell fate specification(GO:0009957)
0.5 4.2 GO:0001842 neural fold formation(GO:0001842)
0.5 1.8 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.4 1.3 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.4 4.5 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.4 2.4 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.4 1.1 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.4 1.1 GO:0042713 sperm ejaculation(GO:0042713) negative regulation of gastric acid secretion(GO:0060455)
0.3 2.0 GO:0032229 negative regulation of synaptic transmission, GABAergic(GO:0032229)
0.3 3.0 GO:0071420 cellular response to histamine(GO:0071420)
0.3 7.2 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.3 1.8 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.3 1.6 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.2 2.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 0.8 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.2 1.0 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.6 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 1.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.8 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.5 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 3.2 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 1.0 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.1 0.5 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.8 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 2.7 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.2 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.1 1.2 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 0.9 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.1 0.3 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.1 0.2 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.1 6.2 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.1 7.8 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.1 0.1 GO:0007412 axon target recognition(GO:0007412)
0.1 1.2 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 1.5 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.8 GO:0016180 snRNA processing(GO:0016180)
0.0 0.5 GO:0006817 phosphate ion transport(GO:0006817)
0.0 2.6 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.0 0.8 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 1.4 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.4 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
0.0 0.3 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.2 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.7 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.0 1.3 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.6 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)
0.0 1.7 GO:0051168 nuclear export(GO:0051168)
0.0 0.6 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 1.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 2.0 GO:0000226 microtubule cytoskeleton organization(GO:0000226)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 16.0 GO:0033269 internode region of axon(GO:0033269)
1.0 4.2 GO:0090537 CERF complex(GO:0090537)
0.6 3.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.5 2.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.4 5.8 GO:0030061 mitochondrial crista(GO:0030061)
0.3 2.0 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.3 2.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.3 5.8 GO:0097470 ribbon synapse(GO:0097470)
0.2 1.2 GO:0070876 SOSS complex(GO:0070876)
0.2 8.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 4.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 6.2 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 1.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 1.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 0.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 2.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.2 GO:0031105 septin complex(GO:0031105)
0.1 2.1 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 0.8 GO:0005915 zonula adherens(GO:0005915)
0.1 1.8 GO:0033270 paranode region of axon(GO:0033270)
0.1 2.7 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.8 GO:0032039 integrator complex(GO:0032039)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 1.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 1.1 GO:0043195 terminal bouton(GO:0043195)
0.0 4.1 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 11.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.8 GO:0005643 nuclear pore(GO:0005643)
0.0 0.6 GO:0005811 lipid particle(GO:0005811)
0.0 1.6 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.1 GO:0072687 meiotic spindle(GO:0072687)
0.0 2.1 GO:0001650 fibrillar center(GO:0001650)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
2.4 7.2 GO:0004994 somatostatin receptor activity(GO:0004994)
1.1 4.6 GO:0097100 supercoiled DNA binding(GO:0097100)
0.9 2.6 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.8 3.2 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.7 5.8 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.7 2.0 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.4 22.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.3 2.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.3 4.2 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.3 3.8 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.3 0.8 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.2 2.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 2.8 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.2 2.6 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.2 1.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.2 8.9 GO:0005158 insulin receptor binding(GO:0005158)
0.2 3.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2 1.8 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 0.8 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.5 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 2.7 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 12.9 GO:0008013 beta-catenin binding(GO:0008013)
0.1 1.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.6 GO:0001515 opioid peptide activity(GO:0001515)
0.1 1.6 GO:0070888 E-box binding(GO:0070888)
0.1 0.9 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 1.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 2.3 GO:0042805 actinin binding(GO:0042805)
0.1 1.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.2 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 0.3 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.1 10.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 2.0 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.2 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 2.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 13.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 2.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 3.7 GO:0003774 motor activity(GO:0003774)
0.0 0.4 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 1.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.3 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.6 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 1.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.6 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.8 GO:0003725 double-stranded RNA binding(GO:0003725)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 25.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.2 4.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 4.4 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 3.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 2.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.7 NABA_COLLAGENS Genes encoding collagen proteins
0.0 4.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 16.0 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.6 4.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.5 8.1 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.2 4.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.4 REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 1.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 2.0 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.8 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 3.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 6.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.8 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 2.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.1 5.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 3.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME_MRNA_CAPPING Genes involved in mRNA Capping
0.0 2.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.2 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 3.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements