Motif ID: Gli3_Zic1
Z-value: 0.889
Transcription factors associated with Gli3_Zic1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Gli3 | ENSMUSG00000021318.9 | Gli3 |
| Zic1 | ENSMUSG00000032368.8 | Zic1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gli3 | mm10_v2_chr13_+_15463202_15463240 | -0.54 | 5.2e-07 | Click! |
| Zic1 | mm10_v2_chr9_-_91365778_91365815 | -0.25 | 2.7e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 28.2 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 2.2 | 20.2 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 2.2 | 8.7 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 1.9 | 5.8 | GO:0071336 | white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) |
| 1.7 | 10.2 | GO:2000672 | negative regulation of motor neuron apoptotic process(GO:2000672) |
| 1.4 | 7.2 | GO:0060591 | chondroblast differentiation(GO:0060591) |
| 1.4 | 4.1 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
| 1.3 | 5.2 | GO:0060032 | notochord regression(GO:0060032) |
| 1.2 | 7.1 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
| 1.1 | 5.7 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 1.1 | 4.5 | GO:0046391 | 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391) |
| 1.1 | 3.3 | GO:0038095 | positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095) |
| 1.1 | 6.5 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.1 | 7.5 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 1.0 | 4.1 | GO:0006558 | L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) |
| 0.9 | 2.6 | GO:0032242 | regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) |
| 0.8 | 5.1 | GO:1904936 | cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.8 | 1.5 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
| 0.7 | 8.1 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.7 | 4.4 | GO:2000465 | regulation of glycogen (starch) synthase activity(GO:2000465) |
| 0.7 | 2.0 | GO:1905072 | detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072) |
| 0.7 | 2.0 | GO:0010512 | negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) |
| 0.6 | 0.6 | GO:0007521 | muscle cell fate determination(GO:0007521) |
| 0.6 | 3.9 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.5 | 1.1 | GO:0060025 | regulation of synaptic activity(GO:0060025) |
| 0.5 | 2.2 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.5 | 3.2 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 0.5 | 2.1 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 0.5 | 3.1 | GO:0014053 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) |
| 0.5 | 1.5 | GO:1903903 | striated muscle atrophy(GO:0014891) positive regulation of keratinocyte apoptotic process(GO:1902174) regulation of establishment of T cell polarity(GO:1903903) |
| 0.5 | 2.1 | GO:0098912 | smooth muscle contraction involved in micturition(GO:0060083) membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) |
| 0.5 | 1.9 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
| 0.5 | 2.4 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.5 | 3.8 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.5 | 6.9 | GO:0001553 | luteinization(GO:0001553) |
| 0.5 | 2.7 | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909) |
| 0.4 | 1.3 | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) |
| 0.4 | 4.3 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.4 | 2.0 | GO:1900748 | positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748) |
| 0.4 | 2.0 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.4 | 1.2 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.4 | 2.8 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 0.4 | 6.5 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.4 | 2.6 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.4 | 1.1 | GO:0035880 | embryonic nail plate morphogenesis(GO:0035880) |
| 0.4 | 2.1 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.4 | 1.4 | GO:0072069 | DCT cell differentiation(GO:0072069) metanephric DCT cell differentiation(GO:0072240) |
| 0.3 | 2.1 | GO:0048597 | post-embryonic camera-type eye morphogenesis(GO:0048597) |
| 0.3 | 3.7 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.3 | 1.6 | GO:2000987 | positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987) |
| 0.3 | 3.1 | GO:0015838 | proline transport(GO:0015824) amino-acid betaine transport(GO:0015838) |
| 0.3 | 4.4 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.3 | 3.0 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.3 | 2.4 | GO:0000050 | urea cycle(GO:0000050) urea metabolic process(GO:0019627) |
| 0.3 | 3.1 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 0.3 | 1.4 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.3 | 1.6 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.3 | 1.1 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 0.3 | 2.4 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.3 | 0.8 | GO:1903722 | regulation of centriole elongation(GO:1903722) |
| 0.3 | 0.8 | GO:0045204 | MAPK export from nucleus(GO:0045204) |
| 0.2 | 1.2 | GO:0021914 | negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914) |
| 0.2 | 0.7 | GO:2000331 | regulation of terminal button organization(GO:2000331) |
| 0.2 | 0.9 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.2 | 1.2 | GO:1903587 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) |
| 0.2 | 0.7 | GO:2000812 | regulation of barbed-end actin filament capping(GO:2000812) |
| 0.2 | 8.3 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.2 | 4.8 | GO:0042092 | type 2 immune response(GO:0042092) |
| 0.2 | 1.3 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
| 0.2 | 0.4 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.2 | 0.6 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.2 | 0.4 | GO:0036292 | DNA rewinding(GO:0036292) |
| 0.2 | 0.8 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.2 | 1.0 | GO:0072014 | proximal tubule development(GO:0072014) |
| 0.2 | 0.6 | GO:0035426 | extracellular matrix-cell signaling(GO:0035426) |
| 0.2 | 1.3 | GO:0006498 | N-terminal protein lipidation(GO:0006498) |
| 0.2 | 0.9 | GO:0070197 | meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240) |
| 0.2 | 0.5 | GO:0006167 | AMP biosynthetic process(GO:0006167) |
| 0.2 | 12.0 | GO:0048663 | neuron fate commitment(GO:0048663) |
| 0.2 | 1.5 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) lipid glycosylation(GO:0030259) |
| 0.2 | 1.2 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
| 0.2 | 1.4 | GO:0044539 | long-chain fatty acid import(GO:0044539) |
| 0.2 | 1.2 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.2 | 1.1 | GO:0019348 | dolichol metabolic process(GO:0019348) |
| 0.1 | 3.6 | GO:0014067 | negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067) |
| 0.1 | 0.7 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.1 | 0.3 | GO:0010726 | positive regulation of hydrogen peroxide metabolic process(GO:0010726) |
| 0.1 | 1.4 | GO:0031118 | rRNA pseudouridine synthesis(GO:0031118) |
| 0.1 | 1.6 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.1 | 0.4 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
| 0.1 | 0.7 | GO:0010961 | cellular magnesium ion homeostasis(GO:0010961) |
| 0.1 | 0.3 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 0.1 | 0.4 | GO:0045950 | negative regulation of mitotic recombination(GO:0045950) negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.1 | 1.8 | GO:0097119 | postsynaptic density protein 95 clustering(GO:0097119) |
| 0.1 | 1.7 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.1 | 0.6 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.1 | 0.3 | GO:0001180 | transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) |
| 0.1 | 1.3 | GO:1900121 | negative regulation of receptor binding(GO:1900121) |
| 0.1 | 0.3 | GO:0002408 | myeloid dendritic cell chemotaxis(GO:0002408) |
| 0.1 | 1.3 | GO:0097011 | cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) |
| 0.1 | 0.3 | GO:0046077 | dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077) |
| 0.1 | 0.3 | GO:0006533 | aspartate catabolic process(GO:0006533) D-amino acid metabolic process(GO:0046416) |
| 0.1 | 0.7 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.1 | 0.5 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 0.1 | 0.3 | GO:0071579 | regulation of zinc ion transport(GO:0071579) |
| 0.1 | 0.5 | GO:0032796 | uropod organization(GO:0032796) |
| 0.1 | 3.6 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.1 | 0.7 | GO:0071397 | cellular response to cholesterol(GO:0071397) |
| 0.1 | 1.7 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.1 | 3.9 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.1 | 0.8 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.1 | 0.3 | GO:0061743 | motor learning(GO:0061743) |
| 0.1 | 0.3 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.1 | 0.3 | GO:0000957 | mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960) |
| 0.1 | 1.5 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.1 | 0.3 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.1 | 0.8 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.1 | 1.9 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.1 | 0.5 | GO:0050882 | voluntary musculoskeletal movement(GO:0050882) |
| 0.1 | 0.4 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.1 | 0.4 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.1 | 0.6 | GO:0030539 | male genitalia development(GO:0030539) |
| 0.1 | 0.3 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
| 0.1 | 1.0 | GO:0048305 | immunoglobulin secretion(GO:0048305) |
| 0.1 | 0.1 | GO:0071499 | response to laminar fluid shear stress(GO:0034616) cellular response to laminar fluid shear stress(GO:0071499) |
| 0.1 | 0.4 | GO:0038089 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) positive regulation of cell migration by vascular endothelial growth factor signaling pathway(GO:0038089) |
| 0.1 | 1.7 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 1.5 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.1 | 3.3 | GO:0030216 | keratinocyte differentiation(GO:0030216) |
| 0.1 | 0.2 | GO:0031017 | exocrine pancreas development(GO:0031017) |
| 0.1 | 1.3 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.1 | 0.7 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.1 | 0.2 | GO:0021940 | positive regulation of cerebellar granule cell precursor proliferation(GO:0021940) |
| 0.1 | 0.5 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.0 | 0.9 | GO:0019430 | removal of superoxide radicals(GO:0019430) |
| 0.0 | 0.2 | GO:1903898 | positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493) negative regulation of PERK-mediated unfolded protein response(GO:1903898) |
| 0.0 | 1.2 | GO:0071800 | podosome assembly(GO:0071800) |
| 0.0 | 1.1 | GO:0033198 | response to ATP(GO:0033198) |
| 0.0 | 0.2 | GO:1903028 | regulation of opsonization(GO:1903027) positive regulation of opsonization(GO:1903028) |
| 0.0 | 0.8 | GO:0006828 | manganese ion transport(GO:0006828) |
| 0.0 | 0.3 | GO:0036506 | maintenance of unfolded protein(GO:0036506) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) |
| 0.0 | 0.2 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.0 | 0.6 | GO:0005980 | polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247) |
| 0.0 | 0.4 | GO:2001197 | regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197) |
| 0.0 | 1.3 | GO:0034243 | regulation of transcription elongation from RNA polymerase II promoter(GO:0034243) |
| 0.0 | 1.9 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 0.2 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.0 | 2.3 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade(GO:0070373) |
| 0.0 | 2.8 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
| 0.0 | 0.2 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.0 | 1.2 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.0 | 0.2 | GO:0036265 | RNA (guanine-N7)-methylation(GO:0036265) |
| 0.0 | 1.8 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.0 | 0.6 | GO:0052646 | alditol phosphate metabolic process(GO:0052646) |
| 0.0 | 0.1 | GO:2000282 | regulation of cellular amino acid biosynthetic process(GO:2000282) |
| 0.0 | 0.4 | GO:0032469 | endoplasmic reticulum calcium ion homeostasis(GO:0032469) |
| 0.0 | 0.5 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.0 | 0.6 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.0 | 1.4 | GO:0050729 | positive regulation of inflammatory response(GO:0050729) |
| 0.0 | 0.4 | GO:0042407 | cristae formation(GO:0042407) |
| 0.0 | 0.3 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.0 | 1.0 | GO:0048821 | erythrocyte development(GO:0048821) |
| 0.0 | 0.9 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.0 | 1.1 | GO:1903078 | positive regulation of protein localization to plasma membrane(GO:1903078) |
| 0.0 | 0.4 | GO:0006744 | ubiquinone biosynthetic process(GO:0006744) |
| 0.0 | 0.7 | GO:0090083 | regulation of inclusion body assembly(GO:0090083) |
| 0.0 | 0.6 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.0 | 0.1 | GO:0001978 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) |
| 0.0 | 0.2 | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) |
| 0.0 | 0.4 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 0.9 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.0 | 0.9 | GO:0021799 | cerebral cortex radially oriented cell migration(GO:0021799) |
| 0.0 | 0.6 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.4 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.0 | 0.1 | GO:0036465 | synaptic vesicle recycling(GO:0036465) |
| 0.0 | 0.4 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
| 0.0 | 0.2 | GO:2000507 | positive regulation of energy homeostasis(GO:2000507) |
| 0.0 | 0.8 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 1.5 | GO:0035308 | negative regulation of protein dephosphorylation(GO:0035308) |
| 0.0 | 1.1 | GO:0045839 | negative regulation of mitotic nuclear division(GO:0045839) |
| 0.0 | 0.3 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
| 0.0 | 0.2 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.0 | 0.3 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.0 | 0.2 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 1.1 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 2.5 | GO:0006887 | exocytosis(GO:0006887) |
| 0.0 | 0.4 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.1 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
| 0.0 | 0.6 | GO:0048286 | lung alveolus development(GO:0048286) |
| 0.0 | 0.3 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.0 | 0.0 | GO:0072367 | regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter(GO:0072368) |
| 0.0 | 0.0 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.0 | 0.2 | GO:0030317 | sperm motility(GO:0030317) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 10.0 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 1.4 | 7.1 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
| 1.4 | 4.1 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 1.3 | 20.2 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 1.2 | 6.9 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.0 | 3.8 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.8 | 2.4 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
| 0.7 | 2.0 | GO:0045160 | myosin I complex(GO:0045160) |
| 0.6 | 3.1 | GO:1902710 | G-protein coupled receptor heterodimeric complex(GO:0038039) GABA receptor complex(GO:1902710) |
| 0.5 | 5.7 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.5 | 2.3 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 0.4 | 4.2 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.4 | 1.6 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.4 | 5.2 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.4 | 2.4 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.4 | 26.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.4 | 4.3 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.4 | 1.5 | GO:0042627 | chylomicron(GO:0042627) |
| 0.3 | 1.3 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.3 | 1.1 | GO:0033185 | dolichol-phosphate-mannose synthase complex(GO:0033185) |
| 0.3 | 3.8 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.2 | 1.7 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.2 | 2.4 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.2 | 0.7 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.2 | 0.8 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.2 | 2.1 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.2 | 6.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.2 | 1.2 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.2 | 4.2 | GO:0045178 | basal part of cell(GO:0045178) |
| 0.2 | 0.8 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.1 | 1.3 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.1 | 2.0 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.1 | 0.5 | GO:0097447 | dendritic tree(GO:0097447) |
| 0.1 | 1.0 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 4.1 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 1.6 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 4.1 | GO:0032420 | stereocilium(GO:0032420) |
| 0.1 | 2.9 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.1 | 0.5 | GO:0099524 | region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524) |
| 0.1 | 1.6 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 3.1 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 0.1 | GO:0031501 | mannosyltransferase complex(GO:0031501) |
| 0.1 | 3.9 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 0.9 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.1 | 0.8 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 0.3 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.1 | 2.2 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 1.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 0.3 | GO:0090661 | box H/ACA telomerase RNP complex(GO:0090661) |
| 0.1 | 0.7 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.1 | 0.4 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 0.9 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 0.5 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.1 | 0.5 | GO:0030478 | actin cap(GO:0030478) |
| 0.1 | 2.6 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 1.2 | GO:0098839 | postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634) |
| 0.0 | 0.4 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 1.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 4.6 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.2 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.2 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.0 | 0.3 | GO:0071818 | BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379) |
| 0.0 | 0.2 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.0 | 2.0 | GO:0098858 | actin-based cell projection(GO:0098858) |
| 0.0 | 7.4 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.7 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.0 | 3.8 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 7.6 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.3 | GO:0071598 | neuronal ribonucleoprotein granule(GO:0071598) |
| 0.0 | 7.2 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 0.4 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 1.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 3.7 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.6 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 0.4 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.0 | 0.4 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.0 | 1.1 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 1.7 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.0 | 0.2 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.1 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.0 | 0.2 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 8.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.2 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 0.3 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.6 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 4.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 0.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 2.2 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 0.4 | GO:0043596 | nuclear replication fork(GO:0043596) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.1 | 28.2 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 2.3 | 13.5 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 1.9 | 5.7 | GO:0070905 | serine binding(GO:0070905) |
| 1.5 | 5.8 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 1.4 | 10.0 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 1.4 | 7.1 | GO:0097643 | amylin receptor activity(GO:0097643) |
| 1.4 | 4.1 | GO:0046911 | hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 1.2 | 11.0 | GO:0036122 | BMP binding(GO:0036122) |
| 1.1 | 4.4 | GO:2001069 | glycogen binding(GO:2001069) |
| 1.0 | 3.8 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
| 0.8 | 5.8 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.7 | 7.9 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.6 | 1.9 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 0.6 | 4.1 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.6 | 6.7 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.5 | 1.6 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.5 | 4.3 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.5 | 4.2 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
| 0.5 | 3.1 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.5 | 4.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.5 | 1.4 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
| 0.5 | 1.9 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.5 | 2.4 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.5 | 2.4 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.4 | 3.1 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.4 | 3.1 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.4 | 1.2 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.4 | 2.6 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.4 | 4.3 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.3 | 2.6 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.3 | 1.0 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.3 | 1.2 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
| 0.3 | 0.9 | GO:0001888 | glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888) |
| 0.3 | 2.1 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.3 | 3.9 | GO:0048038 | quinone binding(GO:0048038) |
| 0.3 | 1.1 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.3 | 1.1 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.3 | 2.9 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.2 | 7.5 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.2 | 0.9 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 0.2 | 1.4 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.2 | 1.6 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.2 | 1.3 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.2 | 4.1 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 1.2 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.2 | 0.6 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.2 | 0.7 | GO:0005113 | patched binding(GO:0005113) |
| 0.2 | 1.1 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 0.7 | GO:0070404 | NADH binding(GO:0070404) |
| 0.1 | 2.0 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.1 | 0.4 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.1 | 2.0 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 3.8 | GO:0008376 | acetylgalactosaminyltransferase activity(GO:0008376) |
| 0.1 | 2.1 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.1 | 1.5 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.1 | 1.0 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 4.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 3.8 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 3.6 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 0.3 | GO:0009041 | uridylate kinase activity(GO:0009041) |
| 0.1 | 6.9 | GO:0042562 | hormone binding(GO:0042562) |
| 0.1 | 1.3 | GO:1990459 | transferrin receptor binding(GO:1990459) |
| 0.1 | 3.3 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.1 | 1.2 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 2.3 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 0.7 | GO:0070290 | phospholipase D activity(GO:0004630) N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.1 | 2.1 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.1 | 1.7 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 0.8 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.1 | 3.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 8.2 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 0.2 | GO:0008176 | tRNA (guanine-N7-)-methyltransferase activity(GO:0008176) |
| 0.1 | 0.8 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 8.1 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 2.1 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 1.0 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.1 | 0.6 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.1 | 0.8 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.1 | 0.5 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 1.8 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.1 | 0.3 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.0 | 1.0 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 0.5 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.0 | 0.7 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.6 | GO:0016701 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.0 | 0.5 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.0 | 1.0 | GO:0043236 | laminin binding(GO:0043236) |
| 0.0 | 0.4 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.0 | 0.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.2 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
| 0.0 | 0.5 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 1.1 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 2.4 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.4 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.0 | 1.8 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 1.6 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.6 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.0 | 0.7 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.1 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.0 | 0.4 | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) |
| 0.0 | 2.3 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 1.2 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 0.3 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.0 | 1.5 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 1.2 | GO:0019239 | deaminase activity(GO:0019239) |
| 0.0 | 0.3 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.0 | 0.4 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 0.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.6 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 0.3 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 0.1 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.0 | 0.3 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.0 | 0.1 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.0 | 0.2 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 1.7 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.0 | 1.4 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.0 | 0.6 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 1.4 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 2.4 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.4 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 0.1 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.0 | 0.4 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.0 | 0.1 | GO:0015108 | chloride transmembrane transporter activity(GO:0015108) |
| 0.0 | 0.4 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 1.5 | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616) |
| 0.0 | 0.1 | GO:0004467 | long-chain fatty acid-CoA ligase activity(GO:0004467) decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 0.5 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.2 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.4 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 0.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.2 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.4 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 0.1 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 0.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.3 | GO:0045503 | dynein light chain binding(GO:0045503) |
| 0.0 | 0.3 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 28.9 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.3 | 3.4 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.2 | 2.1 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
| 0.1 | 28.0 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.2 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 3.4 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.1 | 3.5 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.1 | 3.8 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.1 | 1.5 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
| 0.1 | 4.2 | PID_A6B1_A6B4_INTEGRIN_PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 2.9 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 5.9 | PID_HEDGEHOG_GLI_PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.1 | 0.3 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 2.4 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.1 | 2.3 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.1 | 3.6 | PID_LYSOPHOSPHOLIPID_PATHWAY | LPA receptor mediated events |
| 0.1 | 2.0 | PID_ALK1_PATHWAY | ALK1 signaling events |
| 0.1 | 0.7 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.7 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 0.5 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.9 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 0.9 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.7 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.4 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.3 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.8 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 0.3 | PID_HDAC_CLASSI_PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.2 | PID_IGF1_PATHWAY | IGF1 pathway |
| 0.0 | 0.6 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.7 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.4 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.2 | PID_RAS_PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 20.2 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.7 | 28.2 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.7 | 8.8 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.5 | 5.7 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.4 | 2.9 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.4 | 5.6 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.3 | 7.0 | REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.2 | 4.3 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.2 | 1.3 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.2 | 2.6 | REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS | Genes involved in Nucleotide-like (purinergic) receptors |
| 0.2 | 2.1 | REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 2.9 | REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 3.8 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 1.9 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.1 | 2.8 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 5.9 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.2 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 1.3 | REACTOME_POST_NMDA_RECEPTOR_ACTIVATION_EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.1 | 8.6 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 1.2 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 1.5 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 1.1 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 0.9 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 1.1 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 0.6 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.1 | 1.7 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 2.4 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 3.9 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.5 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 3.1 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 3.4 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.0 | REACTOME_METAL_ION_SLC_TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 0.5 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.0 | 3.6 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.8 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 0.4 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.7 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.3 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 4.0 | REACTOME_METABOLISM_OF_CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.0 | 0.2 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.0 | 1.1 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.3 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 0.1 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 0.2 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.2 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 0.3 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.7 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.1 | REACTOME_GAP_JUNCTION_TRAFFICKING | Genes involved in Gap junction trafficking |
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