Motif ID: Glis2

Z-value: 1.182


Transcription factors associated with Glis2:

Gene SymbolEntrez IDGene Name
Glis2 ENSMUSG00000014303.7 Glis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis2mm10_v2_chr16_+_4594683_45947350.351.7e-03Click!


Activity profile for motif Glis2.

activity profile for motif Glis2


Sorted Z-values histogram for motif Glis2

Sorted Z-values for motif Glis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 178 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 26.656 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr6_-_48840988 17.573 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr6_-_48841098 12.838 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr6_-_48841373 12.521 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr19_+_7268296 12.455 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr11_+_101468164 12.418 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr4_+_109978004 11.571 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr6_+_48841476 10.418 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_+_48841633 10.236 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr6_+_120666388 9.431 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr14_+_55854115 8.620 ENSMUST00000168479.1
 Nynrin
NYN domain and retroviral integrase containing
chr5_+_136083916 8.132 ENSMUST00000042135.7
 Rasa4
RAS p21 protein activator 4
chr17_-_56830916 7.979 ENSMUST00000002444.7
ENSMUST00000086801.5
 Rfx2

regulatory factor X, 2 (influences HLA class II expression)

chr2_-_54085542 7.951 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr5_+_136084022 7.727 ENSMUST00000100570.3
 Rasa4
RAS p21 protein activator 4
chr7_-_103843154 7.628 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr2_-_26294550 6.840 ENSMUST00000057224.3
 4932418E24Rik
RIKEN cDNA 4932418E24 gene
chr2_+_4976113 6.428 ENSMUST00000167607.1
ENSMUST00000115010.2
 Ucma

upper zone of growth plate and cartilage matrix associated

chr2_-_170427828 6.412 ENSMUST00000013667.2
ENSMUST00000109152.2
ENSMUST00000068137.4
 Bcas1


breast carcinoma amplified sequence 1


chr5_+_30105161 6.371 ENSMUST00000058045.4
 Gareml
GRB2 associated, regulator of MAPK1-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.1 63.6 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
2.6 39.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.4 15.9 GO:0034260 negative regulation of GTPase activity(GO:0034260)
1.2 11.8 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
1.1 11.6 GO:0021796 cerebral cortex regionalization(GO:0021796)
2.0 10.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) positive regulation of cell fate specification(GO:0042660) sensory neuron migration(GO:1904937)
1.0 9.4 GO:0001842 neural fold formation(GO:0001842)
1.1 8.6 GO:0015074 DNA integration(GO:0015074)
0.8 8.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.6 8.0 GO:0001675 acrosome assembly(GO:0001675)
0.1 8.0 GO:0007050 cell cycle arrest(GO:0007050)
1.3 7.8 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
1.5 7.6 GO:0015671 oxygen transport(GO:0015671)
0.1 6.4 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.7 6.3 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
1.5 5.8 GO:1902037 proteasomal ubiquitin-independent protein catabolic process(GO:0010499) positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091) negative regulation of hematopoietic stem cell differentiation(GO:1902037)
1.1 5.7 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
1.8 5.5 GO:0016332 establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
1.0 4.9 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.4 4.8 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 29.8 GO:0005654 nucleoplasm(GO:0005654)
1.1 15.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 14.8 GO:0005769 early endosome(GO:0005769)
0.1 13.8 GO:0017053 transcriptional repressor complex(GO:0017053)
1.5 11.8 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
2.4 9.4 GO:0090537 CERF complex(GO:0090537)
0.0 8.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 8.7 GO:0005925 focal adhesion(GO:0005925)
0.6 8.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 8.0 GO:0016235 aggresome(GO:0016235)
1.0 7.6 GO:0005833 hemoglobin complex(GO:0005833)
0.0 6.5 GO:0032993 protein-DNA complex(GO:0032993)
0.2 5.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 5.5 GO:0009986 cell surface(GO:0009986)
0.0 5.4 GO:0001726 ruffle(GO:0001726)
0.0 5.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 5.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 4.3 GO:0031225 anchored component of membrane(GO:0031225)
0.3 4.2 GO:0002178 palmitoyltransferase complex(GO:0002178)
1.2 3.5 GO:0005577 fibrinogen complex(GO:0005577)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.4 26.7 GO:0019841 retinol binding(GO:0019841)
0.0 17.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 12.4 GO:0047485 protein N-terminus binding(GO:0047485)
1.7 11.8 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.6 10.1 GO:0003680 AT DNA binding(GO:0003680)
1.3 8.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 7.9 GO:0001047 core promoter binding(GO:0001047)
0.0 7.9 GO:0003714 transcription corepressor activity(GO:0003714)
1.9 7.6 GO:0031721 hemoglobin alpha binding(GO:0031721)
2.1 6.3 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.1 5.8 GO:0001221 transcription cofactor binding(GO:0001221)
1.0 5.7 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.4 5.5 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
1.1 5.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 5.2 GO:0005096 GTPase activator activity(GO:0005096)
0.1 4.9 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 4.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
1.5 4.5 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 4.4 GO:0017124 SH3 domain binding(GO:0017124)
0.1 4.0 GO:0046875 ephrin receptor binding(GO:0046875)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.4 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.2 10.2 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 10.1 PID_CDC42_PATHWAY CDC42 signaling events
0.1 8.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 5.6 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 5.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 5.0 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 4.9 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 4.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 4.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 4.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 3.5 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.2 2.8 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 2.4 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.0 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.2 PID_ARF_3PATHWAY Arf1 pathway
0.0 1.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.0 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.2 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.7 10.1 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1 8.8 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.7 7.8 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 6.6 REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 6.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 5.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 4.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 4.3 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 4.0 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.9 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 3.9 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 3.5 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 3.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 3.2 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 2.9 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 2.1 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 2.0 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 1.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex