Motif ID: Glis3

Z-value: 0.703


Transcription factors associated with Glis3:

Gene SymbolEntrez IDGene Name
Glis3 ENSMUSG00000052942.7 Glis3
Glis3 ENSMUSG00000091294.1 Glis3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Glis3mm10_v2_chr19_-_28680077_286801220.333.0e-03Click!


Activity profile for motif Glis3.

activity profile for motif Glis3


Sorted Z-values histogram for motif Glis3

Sorted Z-values for motif Glis3



Network of associatons between targets according to the STRING database.



First level regulatory network of Glis3

PNG image of the network

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Top targets:


Showing 1 to 20 of 124 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144892813 9.661 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr6_+_108660616 9.361 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr4_+_144893077 7.956 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr8_+_70501116 7.720 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr4_+_144893127 7.190 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr6_+_17463749 5.847 ENSMUST00000115443.1
 Met
met proto-oncogene
chr6_+_17463927 4.889 ENSMUST00000115442.1
 Met
met proto-oncogene
chr6_+_17463826 4.545 ENSMUST00000140070.1
 Met
met proto-oncogene
chr6_+_108660772 4.410 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr7_-_142657466 3.582 ENSMUST00000097936.2
ENSMUST00000000033.5
 Igf2

insulin-like growth factor 2

chr2_+_32646586 2.900 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr10_-_68278713 2.370 ENSMUST00000020106.7
 Arid5b
AT rich interactive domain 5B (MRF1-like)
chr7_+_45017953 2.307 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr13_+_38345716 1.639 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr11_-_102296618 1.607 ENSMUST00000107132.2
ENSMUST00000073234.2
 Atxn7l3

ataxin 7-like 3

chr14_-_55560340 1.592 ENSMUST00000066106.3
 A730061H03Rik
RIKEN cDNA A730061H03 gene
chr3_+_52268337 1.537 ENSMUST00000053764.5
 Foxo1
forkhead box O1
chr14_-_62292959 1.536 ENSMUST00000063169.8
 Dleu7
deleted in lymphocytic leukemia, 7
chr4_-_134018829 1.453 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr11_+_5861886 1.452 ENSMUST00000102923.3
 Aebp1
AE binding protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 24.8 GO:0042572 retinol metabolic process(GO:0042572)
2.2 15.3 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.5 13.8 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
1.3 7.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.4 3.6 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.0 2.9 GO:1905072 detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072)
0.3 2.4 GO:0060613 fat pad development(GO:0060613)
0.0 2.3 GO:0060325 face morphogenesis(GO:0060325)
0.3 1.6 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.1 1.6 GO:0016578 histone deubiquitination(GO:0016578)
0.2 1.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 1.5 GO:0071455 response to hyperoxia(GO:0055093) cellular response to hyperoxia(GO:0071455)
0.5 1.4 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
0.2 1.4 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 1.4 GO:0048286 lung alveolus development(GO:0048286)
0.4 1.3 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 1.3 GO:0071385 cellular response to glucocorticoid stimulus(GO:0071385)
0.0 1.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.3 1.1 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.0 1.1 GO:0009060 aerobic respiration(GO:0009060)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 13.1 GO:0016604 nuclear body(GO:0016604)
2.6 7.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 3.3 GO:0072562 blood microparticle(GO:0072562)
0.2 2.5 GO:0016589 NURF complex(GO:0016589)
0.1 1.6 GO:0000124 SAGA complex(GO:0000124)
0.0 1.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 1.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.9 GO:0071203 WASH complex(GO:0071203)
0.1 0.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.9 GO:0005844 polysome(GO:0005844)
0.0 0.8 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.8 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 0.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.6 GO:0033503 HULC complex(GO:0033503)
0.0 0.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 0.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.4 GO:0005642 annulate lamellae(GO:0005642)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.5 24.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
3.8 15.3 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
2.3 13.8 GO:0043426 MRF binding(GO:0043426)
1.1 7.7 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 3.6 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.0 3.1 GO:0019003 GDP binding(GO:0019003)
0.6 2.9 GO:0005534 galactose binding(GO:0005534)
0.0 1.7 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 1.6 GO:0070700 BMP receptor binding(GO:0070700)
0.0 1.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 1.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.5 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 1.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.3 1.4 GO:2001069 glycogen binding(GO:2001069)
0.0 1.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 1.3 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.0 1.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 1.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 1.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.0 GO:0031386 protein tag(GO:0031386)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 24.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.4 15.7 PID_ARF6_PATHWAY Arf6 signaling events
0.7 13.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 4.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.9 PID_ALK1_PATHWAY ALK1 signaling events
0.1 2.5 PID_BMP_PATHWAY BMP receptor signaling
0.1 2.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 1.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 1.1 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 0.9 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.7 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 18.5 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 13.8 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 3.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.5 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.3 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 1.1 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.0 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 0.9 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.9 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.7 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.6 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.3 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.2 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.1 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation