Motif ID: Gmeb1

Z-value: 0.424


Transcription factors associated with Gmeb1:

Gene SymbolEntrez IDGene Name
Gmeb1 ENSMUSG00000028901.7 Gmeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gmeb1mm10_v2_chr4_-_132261596_1322616220.637.3e-10Click!


Activity profile for motif Gmeb1.

activity profile for motif Gmeb1


Sorted Z-values histogram for motif Gmeb1

Sorted Z-values for motif Gmeb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gmeb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 75 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_113531675 4.014 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr3_+_127553462 3.465 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr15_+_99074968 3.293 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr3_+_40800054 3.225 ENSMUST00000168287.1
 Plk4
polo-like kinase 4
chr3_+_40800013 3.052 ENSMUST00000026858.5
ENSMUST00000170825.1
 Plk4

polo-like kinase 4

chr11_-_40733373 2.937 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr1_+_175880775 2.734 ENSMUST00000039725.6
 Exo1
exonuclease 1
chr2_-_157007039 2.655 ENSMUST00000103129.2
ENSMUST00000103130.1
 Dsn1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr2_-_157007015 2.545 ENSMUST00000146413.1
 Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr15_-_58135047 1.831 ENSMUST00000038194.3
 Atad2
ATPase family, AAA domain containing 2
chr12_+_4917376 1.613 ENSMUST00000045664.5
 Atad2b
ATPase family, AAA domain containing 2B
chr2_+_75659253 1.421 ENSMUST00000111964.1
ENSMUST00000111962.1
ENSMUST00000111961.1
ENSMUST00000164947.2
ENSMUST00000090792.4
 Hnrnpa3




heterogeneous nuclear ribonucleoprotein A3




chr3_+_138143483 1.386 ENSMUST00000162864.1
 Trmt10a
tRNA methyltransferase 10A
chr18_+_36559972 1.342 ENSMUST00000134146.1
 Ankhd1
ankyrin repeat and KH domain containing 1
chr3_+_138143429 1.322 ENSMUST00000040321.6
 Trmt10a
tRNA methyltransferase 10A
chrX_+_112311334 1.143 ENSMUST00000026599.3
ENSMUST00000113415.1
 Apool

apolipoprotein O-like

chr4_-_40269778 1.132 ENSMUST00000042575.6
 Topors
topoisomerase I binding, arginine/serine-rich
chr11_-_100822525 1.030 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr2_+_69723071 1.027 ENSMUST00000040915.8
 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr18_+_23954668 1.022 ENSMUST00000060762.4
 Zfp397
zinc finger protein 397

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.3 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
1.3 5.2 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
0.6 4.0 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.3 3.4 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.3 2.7 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 2.7 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.7 2.0 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.1 2.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 1.1 GO:0042407 cristae formation(GO:0042407)
0.0 1.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.3 1.0 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.2 1.0 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 0.9 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.2 0.7 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.2 0.7 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.0 0.7 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.1 0.6 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.1 0.5 GO:1902570 protein localization to nucleolus(GO:1902570)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.4 GO:0035562 negative regulation of chromatin binding(GO:0035562)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 6.3 GO:0098536 deuterosome(GO:0098536)
1.3 5.2 GO:0000939 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
0.0 3.2 GO:0000793 condensed chromosome(GO:0000793)
0.0 2.9 GO:0016363 nuclear matrix(GO:0016363)
0.1 2.0 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 1.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 1.1 GO:0061617 MICOS complex(GO:0061617)
0.0 1.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.0 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.5 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.4 GO:0000235 astral microtubule(GO:0000235)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.3 GO:0071942 XPC complex(GO:0071942)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.1 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 3.8 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 2.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.7 2.7 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.3 2.7 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.1 2.0 GO:0043236 laminin binding(GO:0043236)
0.0 2.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 1.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.4 1.4 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2 1.1 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 1.0 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 1.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 0.9 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 0.6 GO:0032564 dATP binding(GO:0032564)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 PID_BARD1_PATHWAY BARD1 signaling events
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.9 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.4 4.0 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 3.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 2.9 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.1 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 1.0 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.3 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.3 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER