Motif ID: Gmeb1

Z-value: 0.424


Transcription factors associated with Gmeb1:

Gene SymbolEntrez IDGene Name
Gmeb1 ENSMUSG00000028901.7 Gmeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gmeb1mm10_v2_chr4_-_132261596_1322616220.637.3e-10Click!


Activity profile for motif Gmeb1.

activity profile for motif Gmeb1


Sorted Z-values histogram for motif Gmeb1

Sorted Z-values for motif Gmeb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gmeb1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_113531675 4.014 ENSMUST00000036340.5
ENSMUST00000101051.2
 Fancd2

Fanconi anemia, complementation group D2

chr3_+_127553462 3.465 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr15_+_99074968 3.293 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr3_+_40800054 3.225 ENSMUST00000168287.1
 Plk4
polo-like kinase 4
chr3_+_40800013 3.052 ENSMUST00000026858.5
ENSMUST00000170825.1
 Plk4

polo-like kinase 4

chr11_-_40733373 2.937 ENSMUST00000020579.8
 Hmmr
hyaluronan mediated motility receptor (RHAMM)
chr1_+_175880775 2.734 ENSMUST00000039725.6
 Exo1
exonuclease 1
chr2_-_157007039 2.655 ENSMUST00000103129.2
ENSMUST00000103130.1
 Dsn1

DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)

chr2_-_157007015 2.545 ENSMUST00000146413.1
 Dsn1
DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)
chr15_-_58135047 1.831 ENSMUST00000038194.3
 Atad2
ATPase family, AAA domain containing 2
chr12_+_4917376 1.613 ENSMUST00000045664.5
 Atad2b
ATPase family, AAA domain containing 2B
chr2_+_75659253 1.421 ENSMUST00000111964.1
ENSMUST00000111962.1
ENSMUST00000111961.1
ENSMUST00000164947.2
ENSMUST00000090792.4
 Hnrnpa3




heterogeneous nuclear ribonucleoprotein A3




chr3_+_138143483 1.386 ENSMUST00000162864.1
 Trmt10a
tRNA methyltransferase 10A
chr18_+_36559972 1.342 ENSMUST00000134146.1
 Ankhd1
ankyrin repeat and KH domain containing 1
chr3_+_138143429 1.322 ENSMUST00000040321.6
 Trmt10a
tRNA methyltransferase 10A
chrX_+_112311334 1.143 ENSMUST00000026599.3
ENSMUST00000113415.1
 Apool

apolipoprotein O-like

chr4_-_40269778 1.132 ENSMUST00000042575.6
 Topors
topoisomerase I binding, arginine/serine-rich
chr11_-_100822525 1.030 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr2_+_69723071 1.027 ENSMUST00000040915.8
 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr18_+_23954668 1.022 ENSMUST00000060762.4
 Zfp397
zinc finger protein 397
chr3_-_138143352 1.019 ENSMUST00000098580.2
 Mttp
microsomal triglyceride transfer protein
chr8_-_25016901 1.012 ENSMUST00000084035.5
 Adam9
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr2_+_69722797 1.004 ENSMUST00000090858.3
 Ppig
peptidyl-prolyl isomerase G (cyclophilin G)
chr8_-_25016743 0.993 ENSMUST00000084032.5
 Adam9
a disintegrin and metallopeptidase domain 9 (meltrin gamma)
chr11_-_86544754 0.913 ENSMUST00000138810.1
ENSMUST00000058286.2
ENSMUST00000154617.1
 Rps6kb1


ribosomal protein S6 kinase, polypeptide 1


chr11_+_51263114 0.823 ENSMUST00000093132.6
ENSMUST00000109113.1
 Clk4

CDC like kinase 4

chr9_-_45906837 0.790 ENSMUST00000161203.1
ENSMUST00000058720.5
ENSMUST00000160699.1
 Rnf214


ring finger protein 214


chr17_+_84511832 0.747 ENSMUST00000047206.5
 Plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr8_+_26119361 0.722 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
 Rnf170



ring finger protein 170



chr18_-_53744509 0.710 ENSMUST00000049811.6
 Cep120
centrosomal protein 120
chr11_+_86544982 0.695 ENSMUST00000108030.2
ENSMUST00000020821.3
ENSMUST00000069503.6
ENSMUST00000167178.2
 Tubd1



tubulin, delta 1



chr1_+_82316452 0.679 ENSMUST00000027322.7
 Rhbdd1
rhomboid domain containing 1
chr8_+_26119611 0.607 ENSMUST00000140819.1
 Rnf170
ring finger protein 170
chr11_+_40733639 0.557 ENSMUST00000020578.4
 Nudcd2
NudC domain containing 2
chr13_+_49653297 0.522 ENSMUST00000021824.7
 Nol8
nucleolar protein 8
chr4_+_128727585 0.496 ENSMUST00000106079.3
ENSMUST00000133439.1
 Phc2

polyhomeotic-like 2 (Drosophila)

chr4_-_135353126 0.473 ENSMUST00000030613.4
ENSMUST00000131373.1
 Srrm1

serine/arginine repetitive matrix 1

chr4_-_135353164 0.421 ENSMUST00000084846.5
ENSMUST00000136342.2
ENSMUST00000105861.1
 Srrm1


serine/arginine repetitive matrix 1


chr15_-_81399594 0.398 ENSMUST00000023039.8
 St13
suppression of tumorigenicity 13
chr7_+_5020561 0.397 ENSMUST00000085427.3
 Zfp865
zinc finger protein 865
chr9_-_48495321 0.392 ENSMUST00000170000.2
 Rbm7
RNA binding motif protein 7
chr3_-_127553233 0.389 ENSMUST00000029588.5
 Larp7
La ribonucleoprotein domain family, member 7
chr11_-_74724670 0.383 ENSMUST00000021091.8
 Pafah1b1
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1
chr11_-_113751309 0.372 ENSMUST00000106616.1
 Cdc42ep4
CDC42 effector protein (Rho GTPase binding) 4
chr5_-_31291026 0.338 ENSMUST00000041565.7
 Ift172
intraflagellar transport 172
chr3_-_108086590 0.295 ENSMUST00000102638.1
ENSMUST00000102637.1
 Ampd2

adenosine monophosphate deaminase 2

chr7_+_5020376 0.272 ENSMUST00000076251.4
 Zfp865
zinc finger protein 865
chr17_-_46327949 0.259 ENSMUST00000047970.7
 Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr4_+_55350043 0.256 ENSMUST00000030134.8
 Rad23b
RAD23b homolog (S. cerevisiae)
chr11_+_69095217 0.254 ENSMUST00000101004.2
 Per1
period circadian clock 1
chr3_-_19311269 0.242 ENSMUST00000099195.3
 Pde7a
phosphodiesterase 7A
chr4_-_126202583 0.224 ENSMUST00000106142.1
ENSMUST00000169403.1
ENSMUST00000130334.1
 Thrap3


thyroid hormone receptor associated protein 3


chr17_+_83350925 0.204 ENSMUST00000096766.4
ENSMUST00000112363.2
ENSMUST00000049503.8
 Eml4


echinoderm microtubule associated protein like 4


chr9_+_48495345 0.201 ENSMUST00000048824.7
 Gm5617
predicted gene 5617
chr17_-_46327990 0.194 ENSMUST00000167360.1
 Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr4_-_72200833 0.189 ENSMUST00000102848.2
ENSMUST00000072695.6
ENSMUST00000107337.1
ENSMUST00000074216.7
 Tle1



transducin-like enhancer of split 1, homolog of Drosophila E(spl)



chr14_+_20694956 0.171 ENSMUST00000048016.1
 Fut11
fucosyltransferase 11
chr4_-_126202757 0.171 ENSMUST00000080919.5
 Thrap3
thyroid hormone receptor associated protein 3
chr16_-_87432597 0.163 ENSMUST00000039449.7
 Ltn1
listerin E3 ubiquitin protein ligase 1
chr15_-_81400043 0.161 ENSMUST00000172107.1
ENSMUST00000169204.1
ENSMUST00000163382.1
 St13


suppression of tumorigenicity 13


chr3_+_95434386 0.159 ENSMUST00000102749.4
ENSMUST00000090804.5
ENSMUST00000107161.1
ENSMUST00000107160.1
ENSMUST00000015666.10
 Arnt




aryl hydrocarbon receptor nuclear translocator




chr1_-_160212864 0.159 ENSMUST00000014370.5
 Cacybp
calcyclin binding protein
chr7_+_35397046 0.158 ENSMUST00000079414.5
 Cep89
centrosomal protein 89
chr7_-_111082997 0.135 ENSMUST00000161051.1
ENSMUST00000160132.1
ENSMUST00000106666.3
ENSMUST00000162415.1
 Eif4g2



eukaryotic translation initiation factor 4, gamma 2



chr6_+_90619241 0.126 ENSMUST00000032177.8
 Slc41a3
solute carrier family 41, member 3
chr17_+_23679363 0.111 ENSMUST00000024699.2
 Cldn6
claudin 6
chr13_-_53473074 0.098 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr11_+_69914179 0.084 ENSMUST00000057884.5
 Gps2
G protein pathway suppressor 2
chrX_+_150588223 0.075 ENSMUST00000153221.1
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr15_-_79546741 0.073 ENSMUST00000054014.7
 Ddx17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr8_-_45333189 0.071 ENSMUST00000095328.4
 Cyp4v3
cytochrome P450, family 4, subfamily v, polypeptide 3
chr16_+_49699198 0.062 ENSMUST00000046777.4
ENSMUST00000142682.1
 Ift57

intraflagellar transport 57

chr11_+_97315716 0.061 ENSMUST00000019026.3
ENSMUST00000132168.1
 Mrpl45

mitochondrial ribosomal protein L45

chr14_+_32085804 0.051 ENSMUST00000170600.1
ENSMUST00000168986.1
ENSMUST00000169649.1
 Oxnad1


oxidoreductase NAD-binding domain containing 1


chr7_+_100607410 0.026 ENSMUST00000107048.1
ENSMUST00000032946.3
 Rab6a

RAB6A, member RAS oncogene family


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 GO:0051316 attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation(GO:0051316)
0.9 6.3 GO:0098535 positive regulation of centriole replication(GO:0046601) de novo centriole assembly(GO:0098535)
0.7 2.0 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.6 4.0 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.3 1.0 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.3 3.4 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.3 2.7 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.2 0.9 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.2 0.7 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.2 1.0 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 0.7 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.1 2.7 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 0.3 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 1.1 GO:0042407 cristae formation(GO:0042407)
0.1 2.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.6 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.1 0.5 GO:1902570 protein localization to nucleolus(GO:1902570)
0.0 1.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.3 GO:0032264 IMP salvage(GO:0032264)
0.0 0.3 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.4 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.0 0.4 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.3 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.4 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.2 GO:0060416 response to growth hormone(GO:0060416)
0.0 0.7 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.2 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.2 GO:0000939 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
1.0 6.3 GO:0098536 deuterosome(GO:0098536)
0.1 2.0 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 1.1 GO:0061617 MICOS complex(GO:0061617)
0.1 1.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.4 GO:0000235 astral microtubule(GO:0000235)
0.1 0.3 GO:0071942 XPC complex(GO:0071942)
0.1 1.0 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 1.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.5 GO:0035102 PRC1 complex(GO:0035102)
0.0 2.9 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.1 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 3.2 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.2 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.4 GO:0035145 exon-exon junction complex(GO:0035145)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.7 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.4 1.4 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.3 2.7 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.3 0.9 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.2 1.1 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.2 0.6 GO:0032564 dATP binding(GO:0032564)
0.2 2.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 3.8 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 1.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 2.0 GO:0043236 laminin binding(GO:0043236)
0.0 2.0 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.2 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 1.0 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 1.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.4 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 5.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.0 PID_BARD1_PATHWAY BARD1 signaling events
0.1 1.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.9 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.0 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.3 2.9 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.0 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 5.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 3.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.7 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.1 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 0.3 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER