Motif ID: Gmeb2

Z-value: 0.798


Transcription factors associated with Gmeb2:

Gene SymbolEntrez IDGene Name
Gmeb2 ENSMUSG00000038705.7 Gmeb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gmeb2mm10_v2_chr2_-_181288016_1812880410.299.5e-03Click!


Activity profile for motif Gmeb2.

activity profile for motif Gmeb2


Sorted Z-values histogram for motif Gmeb2

Sorted Z-values for motif Gmeb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gmeb2

PNG image of the network

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Top targets:


Showing 1 to 20 of 182 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_78544345 6.406 ENSMUST00000053239.2
 Sstr3
somatostatin receptor 3
chr1_+_185454803 5.928 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr1_-_77515048 4.193 ENSMUST00000027451.6
 Epha4
Eph receptor A4
chr4_+_101419696 4.132 ENSMUST00000131397.1
ENSMUST00000133055.1
 Ak4

adenylate kinase 4

chr7_+_66839726 3.973 ENSMUST00000098382.3
 Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr7_+_66839752 3.819 ENSMUST00000107478.1
 Adamts17
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
chr5_-_31291026 3.349 ENSMUST00000041565.7
 Ift172
intraflagellar transport 172
chr12_+_102554966 3.232 ENSMUST00000021610.5
 Chga
chromogranin A
chr3_+_127553462 3.231 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr4_+_101419277 3.149 ENSMUST00000102780.1
ENSMUST00000106946.1
ENSMUST00000106945.1
 Ak4


adenylate kinase 4


chr6_-_39725193 3.075 ENSMUST00000101497.3
 Braf
Braf transforming gene
chr9_-_56928350 3.048 ENSMUST00000050916.5
 Snx33
sorting nexin 33
chr15_-_50889691 3.003 ENSMUST00000165201.2
ENSMUST00000184458.1
 Trps1

trichorhinophalangeal syndrome I (human)

chr15_+_82016420 2.981 ENSMUST00000168581.1
ENSMUST00000170630.1
ENSMUST00000164779.1
 Xrcc6


X-ray repair complementing defective repair in Chinese hamster cells 6


chr10_-_42583628 2.944 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr7_-_119896285 2.878 ENSMUST00000106519.1
 Dcun1d3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr1_+_82316452 2.844 ENSMUST00000027322.7
 Rhbdd1
rhomboid domain containing 1
chr1_-_162740350 2.606 ENSMUST00000182331.1
ENSMUST00000183011.1
ENSMUST00000182593.1
ENSMUST00000182149.1
 Prrc2c



proline-rich coiled-coil 2C



chr3_-_95217690 2.530 ENSMUST00000107209.1
 Gabpb2
GA repeat binding protein, beta 2
chr1_-_156035891 2.466 ENSMUST00000126448.1
 Tor1aip1
torsin A interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.3 GO:0010225 response to UV-C(GO:0010225)
0.3 7.3 GO:0046033 AMP metabolic process(GO:0046033)
0.1 6.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
2.0 5.9 GO:0071579 regulation of zinc ion transport(GO:0071579)
1.5 5.9 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
1.3 5.1 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.6 4.7 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.5 4.6 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 3.3 GO:0070986 left/right axis specification(GO:0070986)
1.1 3.2 GO:1901079 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of muscle(GO:1901079)
0.0 3.2 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.5 3.0 GO:0044351 macropinocytosis(GO:0044351)
0.1 3.0 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.6 2.9 GO:0021764 amygdala development(GO:0021764)
0.0 2.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.9 2.8 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.9 2.7 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.3 2.3 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 2.3 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.7 2.1 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.4 GO:0060170 ciliary membrane(GO:0060170)
0.0 5.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
1.3 5.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 5.1 GO:0055037 recycling endosome(GO:0055037)
0.0 4.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 4.2 GO:0031901 early endosome membrane(GO:0031901)
0.2 3.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 3.3 GO:0019898 extrinsic component of membrane(GO:0019898)
0.6 3.2 GO:0042583 chromaffin granule(GO:0042583)
0.2 3.2 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 3.0 GO:0016363 nuclear matrix(GO:0016363)
0.2 2.8 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.4 2.7 GO:0000322 storage vacuole(GO:0000322)
0.6 2.5 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.1 2.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.2 2.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 2.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.4 2.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 2.0 GO:1990391 DNA repair complex(GO:1990391)
0.1 1.8 GO:0005662 DNA replication factor A complex(GO:0005662)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.4 7.3 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.3 7.3 GO:0097602 cullin family protein binding(GO:0097602)
0.6 6.9 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.3 6.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
2.1 6.4 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 4.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.2 4.6 GO:0005521 lamin binding(GO:0005521)
0.1 4.6 GO:0035064 methylated histone binding(GO:0035064)
0.7 4.5 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 3.7 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 3.1 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.0 2.9 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.7 2.7 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 2.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 2.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 2.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 2.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 2.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.3 1.9 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 1.9 GO:0070064 proline-rich region binding(GO:0070064)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 5.1 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 4.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.2 4.0 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 3.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 3.2 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 2.6 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.1 PID_LKB1_PATHWAY LKB1 signaling events
0.0 2.1 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 1.7 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 1.7 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.0 PID_ATM_PATHWAY ATM pathway
0.0 0.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 5.1 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.2 4.7 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 2.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.8 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 1.7 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 1.7 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.2 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.1 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.0 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 1.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.0 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.0 REACTOME_RNA_POL_I_TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
0.0 0.9 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.9 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.7 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.7 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.6 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs