Motif ID: Grhl1

Z-value: 0.421


Transcription factors associated with Grhl1:

Gene SymbolEntrez IDGene Name
Grhl1 ENSMUSG00000020656.9 Grhl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Grhl1mm10_v2_chr12_+_24572276_245723080.123.1e-01Click!


Activity profile for motif Grhl1.

activity profile for motif Grhl1


Sorted Z-values histogram for motif Grhl1

Sorted Z-values for motif Grhl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Grhl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 57 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_85722474 2.768 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr3_-_87263518 1.878 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr1_-_192855723 1.790 ENSMUST00000155579.1
 Sertad4
SERTA domain containing 4
chr8_-_71381907 1.552 ENSMUST00000002466.8
 Nr2f6
nuclear receptor subfamily 2, group F, member 6
chr14_+_75136326 1.388 ENSMUST00000145303.1
 Lcp1
lymphocyte cytosolic protein 1
chr3_-_87263703 1.384 ENSMUST00000146512.1
 Fcrls
Fc receptor-like S, scavenger receptor
chr2_-_151973387 1.242 ENSMUST00000109863.1
 Fam110a
family with sequence similarity 110, member A
chr18_+_56432116 1.220 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr14_-_57133268 1.170 ENSMUST00000160703.1
 Gjb6
gap junction protein, beta 6
chr17_+_87635974 1.077 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr14_-_73385225 1.048 ENSMUST00000022704.7
 Itm2b
integral membrane protein 2B
chr8_+_80494032 0.990 ENSMUST00000063359.6
 Gypa
glycophorin A
chr2_-_30205794 0.970 ENSMUST00000113663.2
ENSMUST00000044038.3
 Ccbl1

cysteine conjugate-beta lyase 1

chr2_-_105399286 0.944 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr2_-_30205772 0.934 ENSMUST00000113662.1
 Ccbl1
cysteine conjugate-beta lyase 1
chr7_+_101321703 0.908 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
 Stard10




START domain containing 10




chrX_+_100730178 0.867 ENSMUST00000113744.1
 Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr14_+_79481164 0.755 ENSMUST00000040131.5
 Elf1
E74-like factor 1
chr2_+_172550761 0.750 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr14_+_63943666 0.748 ENSMUST00000079652.5
 Sox7
SRY-box containing gene 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.1 1.6 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 1.4 GO:0051639 actin filament network formation(GO:0051639)
0.3 1.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.2 1.0 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.1 1.0 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.1 0.9 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.1 0.9 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.8 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 0.7 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 0.7 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.7 GO:0001706 endoderm formation(GO:0001706)
0.0 0.7 GO:0006270 DNA replication initiation(GO:0006270)
0.2 0.6 GO:0071211 protein targeting to vacuole involved in autophagy(GO:0071211)
0.1 0.5 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.5 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 0.3 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.3 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.3 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.1 GO:0090043 regulation of tubulin deacetylation(GO:0090043)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.4 GO:0001891 phagocytic cup(GO:0001891)
0.1 1.2 GO:0005922 connexon complex(GO:0005922)
0.0 1.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.0 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 0.9 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 0.6 GO:0031088 platelet dense granule membrane(GO:0031088) intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 0.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.4 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 0.3 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.1 GO:0005745 m-AAA complex(GO:0005745)

Gene overrepresentation in molecular_function category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 1.6 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 1.1 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 1.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.9 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.9 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.2 0.5 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0 0.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.4 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.0 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.3 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.9 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 1.0 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 0.7 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.7 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis