Motif ID: Gsc2_Dmbx1
Z-value: 0.597
Transcription factors associated with Gsc2_Dmbx1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Dmbx1 | ENSMUSG00000028707.9 | Dmbx1 |
| Gsc2 | ENSMUSG00000022738.6 | Gsc2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Dmbx1 | mm10_v2_chr4_-_115939923_115939928 | 0.13 | 2.6e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 14.5 | GO:0044838 | cell quiescence(GO:0044838) |
| 0.9 | 2.8 | GO:0016056 | photoreceptor cell morphogenesis(GO:0008594) rhodopsin mediated signaling pathway(GO:0016056) post-embryonic retina morphogenesis in camera-type eye(GO:0060060) |
| 0.9 | 2.8 | GO:0051892 | negative regulation of cardioblast differentiation(GO:0051892) |
| 0.7 | 2.1 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.5 | 2.7 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.4 | 1.3 | GO:1904049 | negative regulation of spontaneous neurotransmitter secretion(GO:1904049) |
| 0.4 | 1.1 | GO:0015747 | urate transport(GO:0015747) |
| 0.4 | 1.5 | GO:0090472 | dibasic protein processing(GO:0090472) |
| 0.3 | 1.2 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.3 | 4.3 | GO:0090331 | negative regulation of platelet aggregation(GO:0090331) |
| 0.3 | 8.1 | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) |
| 0.2 | 1.9 | GO:0002681 | somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153) |
| 0.2 | 3.2 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.2 | 0.7 | GO:0045358 | negative regulation of interferon-beta biosynthetic process(GO:0045358) |
| 0.2 | 0.5 | GO:0097401 | synaptic vesicle lumen acidification(GO:0097401) |
| 0.2 | 0.8 | GO:0036089 | cleavage furrow formation(GO:0036089) |
| 0.1 | 1.3 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 2.9 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 1.5 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.1 | 1.0 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.1 | 0.5 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.1 | 0.5 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.1 | 8.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 0.9 | GO:0007602 | phototransduction(GO:0007602) |
| 0.1 | 0.5 | GO:0060576 | regulation of microvillus assembly(GO:0032534) intestinal epithelial cell development(GO:0060576) |
| 0.1 | 1.1 | GO:0010818 | T cell chemotaxis(GO:0010818) |
| 0.1 | 1.2 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.1 | 0.5 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 0.1 | 0.2 | GO:1904778 | regulation of metaphase plate congression(GO:0090235) regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778) |
| 0.1 | 0.4 | GO:0032782 | bile acid secretion(GO:0032782) |
| 0.1 | 0.4 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 0.1 | 0.3 | GO:0086028 | bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043) |
| 0.1 | 1.4 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) |
| 0.0 | 0.5 | GO:0097475 | motor neuron migration(GO:0097475) |
| 0.0 | 0.1 | GO:0009182 | purine deoxyribonucleotide biosynthetic process(GO:0009153) purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066) GDP metabolic process(GO:0046710) |
| 0.0 | 2.9 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 1.9 | GO:0010389 | regulation of G2/M transition of mitotic cell cycle(GO:0010389) |
| 0.0 | 0.3 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 2.0 | GO:0021766 | hippocampus development(GO:0021766) |
| 0.0 | 0.3 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.0 | 1.8 | GO:0007286 | spermatid development(GO:0007286) |
| 0.0 | 0.4 | GO:0097352 | autophagosome maturation(GO:0097352) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.3 | 1.3 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.1 | 2.7 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 1.5 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.1 | 3.7 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 1.5 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 0.2 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.1 | 1.9 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.1 | 1.0 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 8.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 0.4 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.5 | GO:0042581 | specific granule(GO:0042581) |
| 0.0 | 2.0 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 0.3 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 3.6 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.3 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 0.4 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.4 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 3.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 1.2 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 1.1 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 14.5 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.7 | 2.8 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.5 | 3.2 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
| 0.4 | 2.1 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 0.3 | 1.1 | GO:0015143 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.2 | 2.9 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.2 | 1.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.2 | 2.9 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.2 | 1.3 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.2 | 2.7 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.1 | 1.6 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.1 | 1.5 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 0.5 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.1 | 1.1 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.1 | 0.6 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.1 | 1.4 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.1 | 3.4 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin binding(GO:0030332) |
| 0.1 | 0.4 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 0.5 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.1 | 1.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 4.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 1.3 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.2 | GO:0043426 | MRF binding(GO:0043426) |
| 0.0 | 0.3 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 1.0 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.2 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 0.0 | 6.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 1.9 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 1.8 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 0.8 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 5.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.4 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.7 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.3 | 14.5 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 6.8 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 3.2 | PID_KIT_PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 1.4 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 5.5 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 2.2 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.5 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.0 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.5 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.2 | 8.4 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 1.1 | REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.2 | 0.9 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 1.5 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 2.1 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 0.3 | REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS | Genes involved in Peptide hormone biosynthesis |
| 0.1 | 0.4 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 1.1 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.3 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.2 | REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 0.3 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 0.5 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.2 | REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.4 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.1 | REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM | Genes involved in Abacavir transport and metabolism |
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