Motif ID: Gsc2_Dmbx1

Z-value: 0.597

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_1159399280.132.6e-01Click!


Activity profile for motif Gsc2_Dmbx1.

activity profile for motif Gsc2_Dmbx1


Sorted Z-values histogram for motif Gsc2_Dmbx1

Sorted Z-values for motif Gsc2_Dmbx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 85 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_18818895 8.353 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr5_+_3344194 7.263 ENSMUST00000042410.4
 Cdk6
cyclin-dependent kinase 6
chr5_+_3343893 7.219 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr3_-_103737995 5.351 ENSMUST00000029440.8
 Olfml3
olfactomedin-like 3
chr2_-_104257400 5.168 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr8_-_113848615 4.258 ENSMUST00000093113.4
 Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr7_-_15879844 2.946 ENSMUST00000172758.1
ENSMUST00000044434.6
 Crx

cone-rod homeobox containing gene

chr2_+_91259822 2.917 ENSMUST00000138470.1
 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr1_-_168431502 2.857 ENSMUST00000064438.4
 Pbx1
pre B cell leukemia homeobox 1
chr8_+_13405080 2.845 ENSMUST00000033827.7
 Grk1
G protein-coupled receptor kinase 1
chr15_-_93595877 2.842 ENSMUST00000048982.4
 Prickle1
prickle homolog 1 (Drosophila)
chr14_-_118052235 2.744 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr1_-_168431695 2.669 ENSMUST00000176790.1
 Pbx1
pre B cell leukemia homeobox 1
chr1_-_168431896 2.571 ENSMUST00000176540.1
 Pbx1
pre B cell leukemia homeobox 1
chr1_-_44218952 2.163 ENSMUST00000054801.3
 Mettl21e
methyltransferase like 21E
chr7_-_25398697 2.124 ENSMUST00000105177.2
ENSMUST00000149349.1
 Lipe

lipase, hormone sensitive

chr1_+_177444653 2.037 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr13_+_3361029 1.905 ENSMUST00000179981.1
 Gm16505
predicted gene 16505
chr11_-_52282564 1.884 ENSMUST00000086844.3
 Tcf7
transcription factor 7, T cell specific
chr11_+_19924403 1.864 ENSMUST00000093298.5
 Spred2
sprouty-related, EVH1 domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 14.5 GO:0044838 cell quiescence(GO:0044838)
0.1 8.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 8.1 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.3 4.3 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.2 3.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 2.9 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 2.9 GO:0007601 visual perception(GO:0007601)
0.9 2.8 GO:0016056 photoreceptor cell morphogenesis(GO:0008594) rhodopsin mediated signaling pathway(GO:0016056) post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.9 2.8 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.5 2.7 GO:0006570 tyrosine metabolic process(GO:0006570)
0.7 2.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 2.0 GO:0021766 hippocampus development(GO:0021766)
0.2 1.9 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 1.9 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 1.8 GO:0007286 spermatid development(GO:0007286)
0.4 1.5 GO:0090472 dibasic protein processing(GO:0090472)
0.1 1.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 1.4 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.4 1.3 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 1.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 8.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 3.6 GO:0005901 caveola(GO:0005901)
0.1 2.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.0 GO:0045171 intercellular bridge(GO:0045171)
0.1 1.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.1 1.5 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 1.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.3 1.3 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 1.2 GO:0005814 centriole(GO:0005814)
0.0 1.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.0 GO:0071564 npBAF complex(GO:0071564)
0.0 0.5 GO:0042581 specific granule(GO:0042581)
0.0 0.4 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.4 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.4 GO:0005921 gap junction(GO:0005921)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0005642 annulate lamellae(GO:0005642)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.8 14.5 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 6.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 5.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 4.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.4 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin binding(GO:0030332)
0.5 3.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.2 2.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 2.9 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.7 2.8 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.2 2.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.4 2.1 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.0 1.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 1.6 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 1.5 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 1.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.4 GO:0030553 cGMP binding(GO:0030553)
0.2 1.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 1.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 6.8 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 5.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 3.7 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.1 3.2 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 2.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.4 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.0 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 8.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.1 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 1.5 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 1.1 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 0.9 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 0.4 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 0.3 REACTOME_PEPTIDE_HORMONE_BIOSYNTHESIS Genes involved in Peptide hormone biosynthesis
0.0 0.3 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.2 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.1 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism