Motif ID: Gsx1_Alx1_Mixl1_Lbx2

Z-value: 0.727

Transcription factors associated with Gsx1_Alx1_Mixl1_Lbx2:

Gene SymbolEntrez IDGene Name
Alx1 ENSMUSG00000036602.7 Alx1
Gsx1 ENSMUSG00000053129.5 Gsx1
Lbx2 ENSMUSG00000034968.2 Lbx2
Mixl1 ENSMUSG00000026497.7 Mixl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gsx1mm10_v2_chr5_+_147188678_147188696-0.243.7e-02Click!
Alx1mm10_v2_chr10_-_103029043_1030290540.066.3e-01Click!


Activity profile for motif Gsx1_Alx1_Mixl1_Lbx2.

activity profile for motif Gsx1_Alx1_Mixl1_Lbx2


Sorted Z-values histogram for motif Gsx1_Alx1_Mixl1_Lbx2

Sorted Z-values for motif Gsx1_Alx1_Mixl1_Lbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsx1_Alx1_Mixl1_Lbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_49757257 14.329 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr5_-_62766153 13.329 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_+_116067213 10.139 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr1_-_190170671 9.474 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr18_+_57468478 8.878 ENSMUST00000091892.2
 Ctxn3
cortexin 3
chr5_-_84417359 8.587 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr13_+_44121167 8.308 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr2_+_20737306 8.108 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chrX_+_56454871 7.535 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr2_-_116067391 7.210 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr16_+_33684538 7.135 ENSMUST00000126532.1
 Heg1
HEG homolog 1 (zebrafish)
chr7_+_103550368 6.960 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr9_+_118478182 6.850 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 6.692 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr15_+_25773985 5.964 ENSMUST00000125667.1
 Myo10
myosin X
chr9_+_96258697 4.710 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr8_+_23411490 4.457 ENSMUST00000033952.7
 Sfrp1
secreted frizzled-related protein 1
chr1_-_163725123 4.258 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr3_-_66296807 4.094 ENSMUST00000029419.7
 Veph1
ventricular zone expressed PH domain-containing 1
chr5_+_17574726 4.083 ENSMUST00000169603.1
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 164 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 15.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 14.1 GO:0008360 regulation of cell shape(GO:0008360)
4.5 13.5 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.2 12.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
1.2 11.9 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.2 11.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
3.2 9.5 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
1.3 9.4 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
3.0 8.9 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.2 7.2 GO:0007608 sensory perception of smell(GO:0007608)
2.0 5.9 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 5.4 GO:0046488 phosphatidylinositol metabolic process(GO:0046488)
0.0 5.2 GO:0048706 embryonic skeletal system development(GO:0048706)
1.5 4.6 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
1.5 4.5 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 4.3 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
1.1 3.3 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.7 3.3 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.2 3.1 GO:0046548 retinal rod cell development(GO:0046548)
0.2 3.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.0 GO:0070469 respiratory chain(GO:0070469)
0.1 8.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 7.1 GO:0016459 myosin complex(GO:0016459)
0.0 6.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 6.1 GO:0005667 transcription factor complex(GO:0005667)
1.5 5.9 GO:0060187 cell pole(GO:0060187)
0.9 4.6 GO:0031523 Myb complex(GO:0031523)
0.0 4.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 4.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.3 4.0 GO:0005614 interstitial matrix(GO:0005614)
0.3 3.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 3.6 GO:0009986 cell surface(GO:0009986)
1.1 3.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 3.2 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 3.1 GO:0051286 cell tip(GO:0051286)
0.1 3.0 GO:0033270 paranode region of axon(GO:0033270)
0.1 2.9 GO:0097440 apical dendrite(GO:0097440)
0.0 2.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.4 GO:0030426 growth cone(GO:0030426)
0.4 2.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.7 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 15.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.4 13.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.5 11.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 11.6 GO:0005509 calcium ion binding(GO:0005509)
0.8 9.5 GO:0050693 LBD domain binding(GO:0050693)
0.7 9.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 8.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.2 7.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 7.0 GO:0030507 spectrin binding(GO:0030507)
1.1 4.6 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 4.5 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 4.3 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 3.8 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.6 3.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 3.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.1 3.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 3.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 3.1 GO:0005262 calcium channel activity(GO:0005262)
0.2 3.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.3 PID_ARF6_PATHWAY Arf6 signaling events
0.2 14.1 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 10.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 9.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 6.3 PID_E2F_PATHWAY E2F transcription factor network
0.2 6.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.2 5.5 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 4.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 3.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 3.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.0 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.1 2.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 2.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.8 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 7.3 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 5.8 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 4.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 4.1 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 3.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 2.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 2.6 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 2.2 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 2.1 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.8 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 1.3 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 1.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.2 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.1 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions