Motif ID: Gsx2_Hoxd3_Vax1
Z-value: 0.622
Transcription factors associated with Gsx2_Hoxd3_Vax1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Gsx2 | ENSMUSG00000035946.6 | Gsx2 |
| Hoxd3 | ENSMUSG00000079277.3 | Hoxd3 |
| Vax1 | ENSMUSG00000006270.6 | Vax1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gsx2 | mm10_v2_chr5_+_75075464_75075601 | 0.47 | 1.4e-05 | Click! |
| Vax1 | mm10_v2_chr19_-_59170978_59170978 | 0.42 | 1.2e-04 | Click! |
Top targets:
Showing 1 to 20 of 149 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 71 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 28.0 | GO:0019532 | oxalate transport(GO:0019532) |
| 4.7 | 18.6 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 1.8 | 7.2 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
| 0.0 | 6.7 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.5 | 5.2 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 0.2 | 4.3 | GO:0002495 | antigen processing and presentation of peptide antigen via MHC class II(GO:0002495) |
| 0.0 | 3.5 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
| 0.0 | 3.2 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 1.0 | 3.1 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.6 | 2.9 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 0.0 | 2.8 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.6 | 2.4 | GO:0061743 | motor learning(GO:0061743) |
| 0.8 | 2.3 | GO:0097212 | lysosomal membrane organization(GO:0097212) |
| 0.6 | 2.3 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.1 | 2.2 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.2 | 2.0 | GO:0002098 | tRNA wobble uridine modification(GO:0002098) |
| 0.1 | 2.0 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
| 0.1 | 1.7 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.0 | 1.7 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.3 | 1.6 | GO:0098706 | ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 30 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 50.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 7.6 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 3.6 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 2.7 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.2 | 2.4 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.2 | 2.2 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.0 | 2.0 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 1.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.3 | 1.6 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.1 | 1.5 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.3 | 1.4 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.4 | 1.1 | GO:0097637 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
| 0.0 | 0.9 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.2 | 0.8 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 0.8 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) |
| 0.0 | 0.8 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 0.7 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.0 | 0.7 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 0.6 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.1 | 0.6 | GO:0034709 | methylosome(GO:0034709) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 52 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 28.0 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
| 3.1 | 18.6 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 6.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.7 | 5.2 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 5.2 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 3.5 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.4 | 3.2 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.3 | 3.1 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.4 | 2.9 | GO:0046790 | virion binding(GO:0046790) |
| 0.1 | 2.8 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.2 | 2.7 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 2.3 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.7 | 2.0 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.3 | 2.0 | GO:0016300 | tRNA (uracil) methyltransferase activity(GO:0016300) |
| 0.0 | 2.0 | GO:0004601 | peroxidase activity(GO:0004601) |
| 0.6 | 1.9 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.3 | 1.7 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.2 | 1.5 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 1.5 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.3 | 1.4 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
Gene overrepresentation in C2:CP category:
Showing 1 to 12 of 12 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.2 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 2.9 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.7 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 1.6 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.3 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 1.0 | PID_S1P_META_PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 1.0 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 0.9 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.7 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 0.6 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 0.5 | PID_EPHA2_FWD_PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.5 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 17 of 17 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 47.9 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 3.5 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 3.5 | REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.3 | 3.1 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 2.7 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 2.7 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.0 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 1.5 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 1.5 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 1.4 | REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 1.1 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.9 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 0.8 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.6 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.5 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 0.4 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 0.2 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
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