Motif ID: Gtf2i_Gtf2f1

Z-value: 1.556

Transcription factors associated with Gtf2i_Gtf2f1:

Gene SymbolEntrez IDGene Name
Gtf2f1 ENSMUSG00000002658.9 Gtf2f1
Gtf2i ENSMUSG00000060261.9 Gtf2i

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gtf2imm10_v2_chr5_-_134314678_134314760-0.488.1e-06Click!
Gtf2f1mm10_v2_chr17_-_57011271_570113260.252.6e-02Click!


Activity profile for motif Gtf2i_Gtf2f1.

activity profile for motif Gtf2i_Gtf2f1


Sorted Z-values histogram for motif Gtf2i_Gtf2f1

Sorted Z-values for motif Gtf2i_Gtf2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gtf2i_Gtf2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66948419 51.480 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr5_-_44799643 29.199 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr13_+_91461050 21.731 ENSMUST00000004094.8
ENSMUST00000042122.8
 Ssbp2

single-stranded DNA binding protein 2

chr1_-_56971762 21.249 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr7_+_44310213 19.048 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chrX_-_104201126 18.348 ENSMUST00000056502.6
ENSMUST00000118314.1
 C77370

expressed sequence C77370

chr19_+_8664005 17.450 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr7_+_36698002 16.475 ENSMUST00000021641.6
 Tshz3
teashirt zinc finger family member 3
chr7_-_78578308 14.646 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chrX_-_72656135 13.530 ENSMUST00000055966.6
 Gabra3
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3
chrX_-_104201099 12.602 ENSMUST00000087879.4
 C77370
expressed sequence C77370
chr10_+_13966268 11.785 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr15_+_83791939 11.740 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr2_-_45112890 11.553 ENSMUST00000076836.6
 Zeb2
zinc finger E-box binding homeobox 2
chr13_+_42709482 11.417 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr7_-_78577771 11.143 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr4_+_13751297 11.050 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_-_168431896 11.039 ENSMUST00000176540.1
 Pbx1
pre B cell leukemia homeobox 1
chr1_-_72536930 10.983 ENSMUST00000047786.5
 March4
membrane-associated ring finger (C3HC4) 4
chr12_+_105336922 10.886 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 667 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 51.5 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
3.2 51.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
6.6 39.7 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
5.6 33.5 GO:0042276 error-prone translesion synthesis(GO:0042276)
2.7 27.2 GO:0046959 habituation(GO:0046959)
0.4 27.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.6 26.6 GO:0001919 regulation of receptor recycling(GO:0001919)
8.6 25.8 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.4 25.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
1.2 23.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.4 21.6 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.5 20.0 GO:0048536 spleen development(GO:0048536)
1.2 19.6 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
1.1 19.2 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
6.4 19.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
2.1 18.6 GO:0071420 cellular response to histamine(GO:0071420)
4.6 18.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
3.5 17.5 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
1.1 17.2 GO:0071625 vocalization behavior(GO:0071625)
5.7 17.0 GO:0072194 kidney smooth muscle tissue development(GO:0072194)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 281 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 93.0 GO:0045211 postsynaptic membrane(GO:0045211)
1.4 51.7 GO:0055038 recycling endosome membrane(GO:0055038)
1.9 40.9 GO:0032279 asymmetric synapse(GO:0032279)
2.4 40.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
2.5 37.0 GO:1902711 GABA-A receptor complex(GO:1902711)
1.0 33.9 GO:0030673 axolemma(GO:0030673)
5.6 33.4 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.5 23.6 GO:0042734 presynaptic membrane(GO:0042734)
0.1 22.5 GO:0098794 postsynapse(GO:0098794)
4.4 21.9 GO:0030314 junctional membrane complex(GO:0030314)
1.2 21.3 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.2 19.9 GO:0000118 histone deacetylase complex(GO:0000118)
1.5 19.8 GO:0030057 desmosome(GO:0030057)
0.1 18.5 GO:0000139 Golgi membrane(GO:0000139)
0.5 18.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
1.5 17.9 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
1.7 15.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
2.9 14.7 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.8 14.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
2.4 14.6 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 395 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 51.4 GO:0043015 gamma-tubulin binding(GO:0043015)
1.0 38.6 GO:0070412 R-SMAD binding(GO:0070412)
0.2 35.4 GO:0017124 SH3 domain binding(GO:0017124)
0.7 28.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 25.9 GO:0008017 microtubule binding(GO:0008017)
5.2 25.8 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 24.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
2.0 23.7 GO:0004890 GABA-A receptor activity(GO:0004890)
2.8 22.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
5.1 20.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
1.6 19.4 GO:0097109 neuroligin family protein binding(GO:0097109)
2.1 19.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 18.9 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.3 18.4 GO:0035254 glutamate receptor binding(GO:0035254)
0.1 18.2 GO:0005096 GTPase activator activity(GO:0005096)
0.2 17.7 GO:0032947 protein complex scaffold(GO:0032947)
3.5 17.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.5 16.9 GO:0046965 retinoid X receptor binding(GO:0046965)
5.0 15.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
3.0 14.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 47.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.5 42.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
1.0 27.9 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.3 23.7 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.4 22.0 PID_SHP2_PATHWAY SHP2 signaling
0.5 17.2 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.6 15.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.8 14.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.5 13.1 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.4 13.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.4 12.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.5 12.0 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.4 12.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 11.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.3 10.5 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.5 10.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3 10.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 8.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.4 8.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.3 7.9 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 44.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
1.7 40.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.5 21.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.8 17.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
1.7 17.0 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
1.3 16.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.8 15.7 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.4 13.3 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
1.0 12.9 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.3 12.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.4 11.4 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.4 11.3 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling
0.7 9.7 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 9.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 9.4 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.4 9.3 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.3 9.2 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.4 8.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.6 8.5 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.3 7.9 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation