Motif ID: Hand1
Z-value: 1.371

Transcription factors associated with Hand1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Hand1 | ENSMUSG00000037335.7 | Hand1 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 161 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.9 | 41.2 | GO:0097091 | synaptic vesicle clustering(GO:0097091) |
0.2 | 26.4 | GO:0007416 | synapse assembly(GO:0007416) |
0.1 | 20.5 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
0.3 | 19.6 | GO:0003073 | regulation of systemic arterial blood pressure(GO:0003073) |
0.1 | 17.4 | GO:0031032 | actomyosin structure organization(GO:0031032) |
0.8 | 16.6 | GO:2000310 | regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310) |
5.5 | 16.4 | GO:0072378 | blood coagulation, fibrin clot formation(GO:0072378) |
3.2 | 16.1 | GO:1905169 | protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171) |
3.2 | 15.9 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
2.0 | 13.9 | GO:2001023 | regulation of response to drug(GO:2001023) |
0.3 | 13.7 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
2.2 | 13.5 | GO:0046880 | regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884) |
2.2 | 13.1 | GO:0097646 | calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647) |
4.2 | 12.5 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
0.8 | 12.0 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
3.0 | 11.9 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
0.5 | 11.4 | GO:0051764 | actin crosslink formation(GO:0051764) |
1.6 | 11.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
2.2 | 11.0 | GO:2000427 | eosinophil chemotaxis(GO:0048245) T cell extravasation(GO:0072683) positive regulation of apoptotic cell clearance(GO:2000427) |
0.1 | 11.0 | GO:0006906 | vesicle fusion(GO:0006906) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 105 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 29.4 | GO:0031901 | early endosome membrane(GO:0031901) |
0.2 | 21.1 | GO:0072562 | blood microparticle(GO:0072562) |
0.1 | 21.0 | GO:0043197 | dendritic spine(GO:0043197) |
4.0 | 20.1 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
0.0 | 17.9 | GO:0005794 | Golgi apparatus(GO:0005794) |
0.3 | 17.8 | GO:0045335 | phagocytic vesicle(GO:0045335) |
5.3 | 16.0 | GO:1990667 | PCSK9-AnxA2 complex(GO:1990667) |
1.0 | 15.7 | GO:1990635 | proximal dendrite(GO:1990635) |
0.1 | 14.8 | GO:0043209 | myelin sheath(GO:0043209) |
4.5 | 13.5 | GO:0043512 | inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512) |
2.6 | 13.1 | GO:1903440 | calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440) |
0.9 | 13.0 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
0.3 | 12.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.1 | 11.4 | GO:0032432 | actin filament bundle(GO:0032432) |
0.1 | 11.3 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
0.8 | 11.1 | GO:0098644 | complex of collagen trimers(GO:0098644) |
3.7 | 11.0 | GO:0044299 | C-fiber(GO:0044299) |
0.1 | 10.5 | GO:0036126 | sperm flagellum(GO:0036126) |
1.1 | 10.2 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
1.5 | 8.8 | GO:0044308 | axonal spine(GO:0044308) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 128 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 45.1 | GO:0035254 | glutamate receptor binding(GO:0035254) |
0.6 | 19.6 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
4.1 | 16.4 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
0.7 | 16.1 | GO:0017160 | Ral GTPase binding(GO:0017160) |
4.0 | 16.0 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834) |
0.2 | 15.4 | GO:0005518 | collagen binding(GO:0005518) |
0.1 | 14.6 | GO:0030246 | carbohydrate binding(GO:0030246) |
0.5 | 13.7 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
1.9 | 13.5 | GO:0034711 | inhibin binding(GO:0034711) |
2.6 | 13.1 | GO:0097643 | amylin receptor activity(GO:0097643) |
0.7 | 12.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
3.0 | 11.9 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
2.3 | 11.5 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
0.4 | 11.2 | GO:0070064 | proline-rich region binding(GO:0070064) |
2.7 | 11.0 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
0.8 | 10.8 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
2.6 | 10.5 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
1.7 | 10.2 | GO:0070699 | type II activin receptor binding(GO:0070699) |
1.9 | 9.3 | GO:0003945 | N-acetyllactosamine synthase activity(GO:0003945) |
1.6 | 9.3 | GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 39 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 22.1 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.6 | 20.1 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
0.1 | 18.1 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
0.6 | 17.8 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
0.7 | 14.4 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
0.2 | 13.4 | PID_ATF2_PATHWAY | ATF-2 transcription factor network |
0.3 | 11.7 | PID_ARF6_PATHWAY | Arf6 signaling events |
0.3 | 10.1 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.2 | 9.1 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
0.1 | 9.0 | PID_NOTCH_PATHWAY | Notch signaling pathway |
0.2 | 7.8 | PID_AP1_PATHWAY | AP-1 transcription factor network |
0.7 | 7.5 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
0.2 | 6.6 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
0.2 | 5.7 | PID_MAPK_TRK_PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
0.2 | 4.5 | PID_MYC_PATHWAY | C-MYC pathway |
0.1 | 4.5 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
0.6 | 4.4 | PID_VEGF_VEGFR_PATHWAY | VEGF and VEGFR signaling network |
0.1 | 4.2 | PID_ATR_PATHWAY | ATR signaling pathway |
0.1 | 4.0 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
0.1 | 3.7 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 68 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 18.8 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
1.1 | 17.0 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
2.7 | 16.4 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
0.4 | 15.4 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
0.6 | 15.0 | REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
0.8 | 14.7 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
3.4 | 13.5 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
0.2 | 12.7 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
0.2 | 12.0 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
0.2 | 11.8 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
0.8 | 11.1 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.5 | 11.0 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
0.4 | 10.2 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
0.1 | 9.4 | REACTOME_TOLL_RECEPTOR_CASCADES | Genes involved in Toll Receptor Cascades |
1.3 | 9.3 | REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
0.5 | 9.3 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
0.1 | 8.9 | REACTOME_SIGNALING_BY_PDGF | Genes involved in Signaling by PDGF |
0.4 | 8.5 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
2.8 | 8.3 | REACTOME_SEROTONIN_RECEPTORS | Genes involved in Serotonin receptors |
0.5 | 8.2 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |