Motif ID: Hand1

Z-value: 1.371


Transcription factors associated with Hand1:

Gene SymbolEntrez IDGene Name
Hand1 ENSMUSG00000037335.7 Hand1



Activity profile for motif Hand1.

activity profile for motif Hand1


Sorted Z-values histogram for motif Hand1

Sorted Z-values for motif Hand1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hand1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_138396438 18.948 ENSMUST00000105032.2
Fam43b
family with sequence similarity 43, member B
chr13_-_37049203 16.366 ENSMUST00000037491.8
F13a1
coagulation factor XIII, A1 subunit
chr19_-_59076069 15.707 ENSMUST00000047511.7
ENSMUST00000163821.1
4930506M07Rik

RIKEN cDNA 4930506M07 gene

chr13_-_92131494 14.445 ENSMUST00000099326.3
ENSMUST00000146492.1
Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr15_+_92051153 14.105 ENSMUST00000169825.1
Cntn1
contactin 1
chr9_+_53771499 13.556 ENSMUST00000048670.8
Slc35f2
solute carrier family 35, member F2
chr1_+_75507077 13.451 ENSMUST00000037330.4
Inha
inhibin alpha
chr17_-_47692466 13.289 ENSMUST00000113300.1
Prickle4
prickle homolog 4 (Drosophila)
chr11_+_101246960 13.050 ENSMUST00000107282.3
Ramp2
receptor (calcitonin) activity modifying protein 2
chr2_+_149830840 12.818 ENSMUST00000109934.1
ENSMUST00000140870.1
Syndig1

synapse differentiation inducing 1

chr11_-_81968415 12.524 ENSMUST00000066197.6
Asic2
acid-sensing (proton-gated) ion channel 2
chr2_+_155940728 12.049 ENSMUST00000109629.1
Gm15557
predicted gene 15557
chr2_+_149830894 11.894 ENSMUST00000137280.1
ENSMUST00000149705.1
Syndig1

synapse differentiation inducing 1

chr4_+_130913264 11.338 ENSMUST00000156225.1
ENSMUST00000156742.1
Laptm5

lysosomal-associated protein transmembrane 5

chr3_+_86084434 11.192 ENSMUST00000107664.2
Sh3d19
SH3 domain protein D19
chr10_+_97479470 11.121 ENSMUST00000105287.3
Dcn
decorin
chr8_+_11312805 11.070 ENSMUST00000033899.7
Col4a2
collagen, type IV, alpha 2
chr11_+_82035569 10.995 ENSMUST00000000193.5
Ccl2
chemokine (C-C motif) ligand 2
chr9_-_51077064 10.796 ENSMUST00000098782.3
Layn
layilin
chr8_-_11312731 10.783 ENSMUST00000033898.9
Col4a1
collagen, type IV, alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 41.2 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.2 26.4 GO:0007416 synapse assembly(GO:0007416)
0.1 20.5 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.3 19.6 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.1 17.4 GO:0031032 actomyosin structure organization(GO:0031032)
0.8 16.6 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
5.5 16.4 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
3.2 16.1 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
3.2 15.9 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
2.0 13.9 GO:2001023 regulation of response to drug(GO:2001023)
0.3 13.7 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
2.2 13.5 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
2.2 13.1 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
4.2 12.5 GO:0050915 sensory perception of sour taste(GO:0050915)
0.8 12.0 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
3.0 11.9 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.5 11.4 GO:0051764 actin crosslink formation(GO:0051764)
1.6 11.1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
2.2 11.0 GO:2000427 eosinophil chemotaxis(GO:0048245) T cell extravasation(GO:0072683) positive regulation of apoptotic cell clearance(GO:2000427)
0.1 11.0 GO:0006906 vesicle fusion(GO:0006906)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 29.4 GO:0031901 early endosome membrane(GO:0031901)
0.2 21.1 GO:0072562 blood microparticle(GO:0072562)
0.1 21.0 GO:0043197 dendritic spine(GO:0043197)
4.0 20.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 17.9 GO:0005794 Golgi apparatus(GO:0005794)
0.3 17.8 GO:0045335 phagocytic vesicle(GO:0045335)
5.3 16.0 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
1.0 15.7 GO:1990635 proximal dendrite(GO:1990635)
0.1 14.8 GO:0043209 myelin sheath(GO:0043209)
4.5 13.5 GO:0043512 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512)
2.6 13.1 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.9 13.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 12.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 11.4 GO:0032432 actin filament bundle(GO:0032432)
0.1 11.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.8 11.1 GO:0098644 complex of collagen trimers(GO:0098644)
3.7 11.0 GO:0044299 C-fiber(GO:0044299)
0.1 10.5 GO:0036126 sperm flagellum(GO:0036126)
1.1 10.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
1.5 8.8 GO:0044308 axonal spine(GO:0044308)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 45.1 GO:0035254 glutamate receptor binding(GO:0035254)
0.6 19.6 GO:0043014 alpha-tubulin binding(GO:0043014)
4.1 16.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.7 16.1 GO:0017160 Ral GTPase binding(GO:0017160)
4.0 16.0 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.2 15.4 GO:0005518 collagen binding(GO:0005518)
0.1 14.6 GO:0030246 carbohydrate binding(GO:0030246)
0.5 13.7 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
1.9 13.5 GO:0034711 inhibin binding(GO:0034711)
2.6 13.1 GO:0097643 amylin receptor activity(GO:0097643)
0.7 12.5 GO:0005540 hyaluronic acid binding(GO:0005540)
3.0 11.9 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
2.3 11.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.4 11.2 GO:0070064 proline-rich region binding(GO:0070064)
2.7 11.0 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.8 10.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
2.6 10.5 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
1.7 10.2 GO:0070699 type II activin receptor binding(GO:0070699)
1.9 9.3 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
1.6 9.3 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 22.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.6 20.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 18.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.6 17.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.7 14.4 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.2 13.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.3 11.7 PID_ARF6_PATHWAY Arf6 signaling events
0.3 10.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 9.1 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 9.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 7.8 PID_AP1_PATHWAY AP-1 transcription factor network
0.7 7.5 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.2 6.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 5.7 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 4.5 PID_MYC_PATHWAY C-MYC pathway
0.1 4.5 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.6 4.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 4.2 PID_ATR_PATHWAY ATR signaling pathway
0.1 4.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 3.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
1.1 17.0 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
2.7 16.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.4 15.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.6 15.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.8 14.7 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
3.4 13.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 12.7 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 12.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 11.8 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.8 11.1 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.5 11.0 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.4 10.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 9.4 REACTOME_TOLL_RECEPTOR_CASCADES Genes involved in Toll Receptor Cascades
1.3 9.3 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.5 9.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 8.9 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.4 8.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
2.8 8.3 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.5 8.2 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway