Motif ID: Hcfc1_Six5_Smarcc2_Zfp143

Z-value: 2.873

Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143:

Gene SymbolEntrez IDGene Name
Hcfc1 ENSMUSG00000031386.8 Hcfc1
Six5 ENSMUSG00000040841.5 Six5
Smarcc2 ENSMUSG00000025369.8 Smarcc2
Zfp143 ENSMUSG00000061079.7 Zfp143

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp143mm10_v2_chr7_+_110061702_1100617320.673.4e-11Click!
Hcfc1mm10_v2_chrX_-_73966329_739663760.438.2e-05Click!
Smarcc2mm10_v2_chr10_+_128459236_1284592480.333.2e-03Click!
Six5mm10_v2_chr7_+_19094594_190946330.208.2e-02Click!


Activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143.

activity profile for motif Hcfc1_Six5_Smarcc2_Zfp143


Sorted Z-values histogram for motif Hcfc1_Six5_Smarcc2_Zfp143

Sorted Z-values for motif Hcfc1_Six5_Smarcc2_Zfp143



Network of associatons between targets according to the STRING database.



First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_116708571 32.755 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
 Ccdc163



coiled-coil domain containing 163



chr4_+_116708624 30.750 ENSMUST00000106463.1
 Ccdc163
coiled-coil domain containing 163
chr4_+_116708687 24.875 ENSMUST00000135499.1
 Ccdc163
coiled-coil domain containing 163
chr4_+_116708467 22.302 ENSMUST00000030452.6
 Ccdc163
coiled-coil domain containing 163
chr7_-_44997221 17.207 ENSMUST00000152341.1
 Bcl2l12
BCL2-like 12 (proline rich)
chr2_+_118598209 17.004 ENSMUST00000038341.7
 Bub1b
budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)
chr11_-_101551837 16.149 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr6_+_124829540 14.648 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr7_-_44997535 14.267 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr14_-_64949838 14.243 ENSMUST00000067843.3
ENSMUST00000176489.1
ENSMUST00000175905.1
ENSMUST00000022544.7
ENSMUST00000175744.1
ENSMUST00000176128.1
 Hmbox1





homeobox containing 1





chr2_-_69206146 14.133 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr5_+_33658123 14.059 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr2_+_152847961 12.962 ENSMUST00000164120.1
ENSMUST00000178997.1
ENSMUST00000109816.1
 Tpx2


TPX2, microtubule-associated protein homolog (Xenopus laevis)


chr9_+_83548309 12.790 ENSMUST00000113215.3
 Sh3bgrl2
SH3 domain binding glutamic acid-rich protein like 2
chr2_-_69206133 12.762 ENSMUST00000112320.1
 Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr2_+_152847993 12.108 ENSMUST00000028969.8
 Tpx2
TPX2, microtubule-associated protein homolog (Xenopus laevis)
chr14_-_64949632 11.842 ENSMUST00000176832.1
 Hmbox1
homeobox containing 1
chr11_+_117849223 11.815 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr3_+_89520152 9.306 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr7_-_45092198 9.229 ENSMUST00000140449.1
ENSMUST00000117546.1
ENSMUST00000019683.3
 Rcn3


reticulocalbin 3, EF-hand calcium binding domain



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 368 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 60.9 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
4.5 49.9 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
1.5 26.1 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 25.9 GO:0051301 cell division(GO:0051301)
0.1 25.6 GO:0000375 RNA splicing, via transesterification reactions(GO:0000375)
0.3 22.0 GO:0007052 mitotic spindle organization(GO:0007052)
0.3 18.8 GO:0030500 regulation of bone mineralization(GO:0030500)
5.7 17.0 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
5.4 16.1 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.1 14.6 GO:0016579 protein deubiquitination(GO:0016579)
3.6 14.4 GO:0044565 dendritic cell proliferation(GO:0044565)
1.5 13.7 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.1 12.4 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
2.4 12.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
2.9 11.8 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
2.3 11.5 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
1.6 11.5 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.8 11.3 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090)
1.4 11.1 GO:0042148 strand invasion(GO:0042148)
1.1 10.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 170 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 57.0 GO:0005813 centrosome(GO:0005813)
4.5 26.9 GO:0031262 Ndc80 complex(GO:0031262)
1.0 26.0 GO:0005697 telomerase holoenzyme complex(GO:0005697)
3.1 25.1 GO:0005818 aster(GO:0005818)
0.2 25.0 GO:0005913 cell-cell adherens junction(GO:0005913)
4.9 24.5 GO:0032133 chromosome passenger complex(GO:0032133)
0.2 19.3 GO:0030175 filopodium(GO:0030175)
1.6 19.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.3 17.0 GO:0016328 lateral plasma membrane(GO:0016328)
2.8 16.7 GO:0070531 BRCA1-A complex(GO:0070531)
1.1 15.0 GO:0035748 myelin sheath abaxonal region(GO:0035748)
3.3 13.3 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.2 11.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.7 11.4 GO:0010369 chromocenter(GO:0010369)
0.3 10.8 GO:0035371 microtubule plus-end(GO:0035371)
0.2 9.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 9.5 GO:0000407 pre-autophagosomal structure(GO:0000407)
1.3 9.2 GO:0001940 male pronucleus(GO:0001940)
0.6 9.0 GO:0032039 integrator complex(GO:0032039)
0.8 8.5 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 250 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 27.9 GO:0002039 p53 binding(GO:0002039)
2.5 25.3 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.4 25.1 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
2.6 23.5 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 23.1 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.3 19.1 GO:0003684 damaged DNA binding(GO:0003684)
0.5 18.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 18.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 18.0 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.7 13.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
2.1 12.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 12.9 GO:0003735 structural constituent of ribosome(GO:0003735)
2.4 11.8 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.7 10.7 GO:1990226 histone methyltransferase binding(GO:1990226)
1.5 10.4 GO:0048256 flap endonuclease activity(GO:0048256)
0.1 10.1 GO:0017137 Rab GTPase binding(GO:0017137)
1.6 9.9 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.4 9.9 GO:0000403 Y-form DNA binding(GO:0000403)
0.1 9.9 GO:0017124 SH3 domain binding(GO:0017124)
0.4 9.6 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 84.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.5 23.2 PID_PLK1_PATHWAY PLK1 signaling events
0.6 22.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.5 14.2 PID_MYC_PATHWAY C-MYC pathway
0.1 13.6 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.3 11.4 PID_ATR_PATHWAY ATR signaling pathway
0.2 7.8 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 7.3 PID_CDC42_PATHWAY CDC42 signaling events
0.3 6.4 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.7 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 5.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.6 4.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 4.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 4.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.1 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 3.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.1 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 3.0 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 66.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.5 26.1 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
1.1 22.9 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.4 14.6 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.4 12.0 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.6 10.9 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.7 10.3 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.2 10.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.3 9.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
1.1 7.8 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.5 7.6 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.2 7.0 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.3 5.7 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 5.4 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.8 5.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.5 5.3 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.9 5.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 5.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 4.9 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.3 4.7 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation