Motif ID: Hcfc1_Six5_Smarcc2_Zfp143
Z-value: 2.873
Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hcfc1 | ENSMUSG00000031386.8 | Hcfc1 |
| Six5 | ENSMUSG00000040841.5 | Six5 |
| Smarcc2 | ENSMUSG00000025369.8 | Smarcc2 |
| Zfp143 | ENSMUSG00000061079.7 | Zfp143 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfp143 | mm10_v2_chr7_+_110061702_110061732 | 0.67 | 3.4e-11 | Click! |
| Hcfc1 | mm10_v2_chrX_-_73966329_73966376 | 0.43 | 8.2e-05 | Click! |
| Smarcc2 | mm10_v2_chr10_+_128459236_128459248 | 0.33 | 3.2e-03 | Click! |
| Six5 | mm10_v2_chr7_+_19094594_19094633 | 0.20 | 8.2e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 17.0 | GO:0051754 | meiotic sister chromatid cohesion, centromeric(GO:0051754) |
| 5.4 | 16.1 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 4.5 | 49.9 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
| 4.0 | 8.0 | GO:0061511 | centriole elongation(GO:0061511) |
| 3.6 | 14.4 | GO:0044565 | dendritic cell proliferation(GO:0044565) |
| 2.9 | 11.8 | GO:2001045 | closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 2.4 | 12.2 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 2.3 | 11.5 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 2.3 | 9.0 | GO:0045358 | negative regulation of interferon-beta biosynthetic process(GO:0045358) |
| 2.2 | 4.4 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 2.0 | 6.0 | GO:0098968 | neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968) |
| 1.9 | 7.5 | GO:2001106 | regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106) |
| 1.8 | 5.5 | GO:0023016 | signal transduction by trans-phosphorylation(GO:0023016) |
| 1.8 | 60.9 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 1.8 | 9.0 | GO:0051697 | protein delipidation(GO:0051697) |
| 1.7 | 5.1 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
| 1.7 | 8.5 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
| 1.7 | 6.6 | GO:0032053 | ciliary basal body organization(GO:0032053) |
| 1.7 | 8.3 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 1.6 | 11.5 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
| 1.6 | 7.8 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 1.5 | 26.1 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 1.5 | 7.7 | GO:0002667 | lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911) |
| 1.5 | 13.7 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 1.4 | 7.1 | GO:0060447 | bud outgrowth involved in lung branching(GO:0060447) |
| 1.4 | 11.1 | GO:0042148 | strand invasion(GO:0042148) |
| 1.3 | 7.8 | GO:0032483 | regulation of Rab protein signal transduction(GO:0032483) |
| 1.3 | 3.9 | GO:2000616 | negative regulation of histone H3-K9 acetylation(GO:2000616) |
| 1.3 | 5.1 | GO:0060971 | embryonic heart tube left/right pattern formation(GO:0060971) |
| 1.1 | 4.5 | GO:0045343 | MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135) |
| 1.1 | 1.1 | GO:0072069 | DCT cell differentiation(GO:0072069) metanephric DCT cell differentiation(GO:0072240) |
| 1.1 | 8.6 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 1.1 | 10.7 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 1.1 | 3.2 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 1.1 | 3.2 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 1.0 | 6.7 | GO:0051461 | regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461) |
| 1.0 | 4.8 | GO:1902916 | positive regulation of protein polyubiquitination(GO:1902916) |
| 0.9 | 2.7 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.9 | 2.7 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.9 | 3.6 | GO:1903463 | regulation of mitotic cell cycle DNA replication(GO:1903463) |
| 0.9 | 3.5 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.9 | 3.5 | GO:1904729 | regulation of intestinal lipid absorption(GO:1904729) |
| 0.9 | 2.6 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 0.8 | 5.0 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.8 | 3.3 | GO:0006014 | D-ribose metabolic process(GO:0006014) |
| 0.8 | 4.9 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.8 | 9.7 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.8 | 7.8 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.8 | 8.5 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.8 | 2.3 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
| 0.8 | 11.3 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) |
| 0.7 | 3.0 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.7 | 7.3 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.7 | 1.4 | GO:0036090 | cleavage furrow ingression(GO:0036090) |
| 0.7 | 7.9 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.7 | 7.8 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.7 | 2.1 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 0.7 | 2.1 | GO:1903896 | positive regulation of IRE1-mediated unfolded protein response(GO:1903896) |
| 0.7 | 2.1 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.7 | 2.7 | GO:0048633 | positive regulation of skeletal muscle tissue growth(GO:0048633) |
| 0.7 | 2.7 | GO:0030647 | polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598) |
| 0.7 | 3.4 | GO:0006842 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
| 0.7 | 6.1 | GO:0098937 | dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) |
| 0.7 | 5.4 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
| 0.7 | 3.3 | GO:0031392 | regulation of prostaglandin biosynthetic process(GO:0031392) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) |
| 0.7 | 2.0 | GO:0006116 | NADH oxidation(GO:0006116) |
| 0.7 | 3.3 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.6 | 2.5 | GO:0046368 | GDP-L-fucose metabolic process(GO:0046368) |
| 0.6 | 3.0 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.6 | 1.8 | GO:0035574 | histone H4-K20 demethylation(GO:0035574) |
| 0.6 | 9.9 | GO:0006085 | acetyl-CoA biosynthetic process(GO:0006085) |
| 0.6 | 10.4 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.6 | 2.9 | GO:1902774 | late endosome to lysosome transport(GO:1902774) |
| 0.6 | 5.1 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.5 | 2.2 | GO:0000733 | DNA strand renaturation(GO:0000733) |
| 0.5 | 3.2 | GO:0016078 | tRNA catabolic process(GO:0016078) |
| 0.5 | 2.2 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.5 | 2.1 | GO:0006742 | NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364) |
| 0.5 | 3.1 | GO:0010730 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) negative regulation of hydrogen peroxide biosynthetic process(GO:0010730) |
| 0.5 | 9.2 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.5 | 2.5 | GO:0033499 | galactose catabolic process via UDP-galactose(GO:0033499) |
| 0.5 | 4.5 | GO:0090209 | negative regulation of triglyceride metabolic process(GO:0090209) |
| 0.5 | 4.9 | GO:0016446 | somatic hypermutation of immunoglobulin genes(GO:0016446) |
| 0.5 | 2.0 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
| 0.5 | 1.4 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) |
| 0.5 | 1.9 | GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) |
| 0.5 | 5.1 | GO:0031145 | anaphase-promoting complex-dependent catabolic process(GO:0031145) |
| 0.5 | 7.7 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.4 | 4.5 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.4 | 0.4 | GO:0034140 | negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) |
| 0.4 | 2.2 | GO:0089700 | protein kinase D signaling(GO:0089700) |
| 0.4 | 0.9 | GO:0071034 | CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) |
| 0.4 | 3.5 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.4 | 1.7 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.4 | 4.3 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.4 | 2.1 | GO:0002121 | inter-male aggressive behavior(GO:0002121) |
| 0.4 | 3.0 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.4 | 6.6 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.4 | 1.2 | GO:1905000 | regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000) |
| 0.4 | 0.4 | GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) |
| 0.4 | 2.3 | GO:0048793 | pronephros development(GO:0048793) |
| 0.4 | 2.3 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 0.4 | 2.7 | GO:0009301 | snRNA transcription(GO:0009301) |
| 0.4 | 1.5 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.4 | 1.9 | GO:0001561 | fatty acid alpha-oxidation(GO:0001561) |
| 0.4 | 1.1 | GO:1904578 | response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579) |
| 0.4 | 4.6 | GO:0051307 | meiotic chromosome separation(GO:0051307) |
| 0.4 | 2.1 | GO:0035826 | rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476) |
| 0.4 | 1.1 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) |
| 0.3 | 1.0 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.3 | 5.2 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.3 | 1.7 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
| 0.3 | 2.4 | GO:0019370 | leukotriene biosynthetic process(GO:0019370) |
| 0.3 | 22.0 | GO:0007052 | mitotic spindle organization(GO:0007052) |
| 0.3 | 3.2 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 0.3 | 0.9 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 0.3 | 0.3 | GO:0030997 | regulation of centriole-centriole cohesion(GO:0030997) |
| 0.3 | 2.2 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.3 | 2.1 | GO:0034145 | positive regulation of toll-like receptor 4 signaling pathway(GO:0034145) |
| 0.3 | 3.3 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.3 | 1.5 | GO:0010992 | ubiquitin homeostasis(GO:0010992) |
| 0.3 | 5.0 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
| 0.3 | 0.3 | GO:0061470 | T follicular helper cell differentiation(GO:0061470) |
| 0.3 | 1.2 | GO:1902037 | negative regulation of hematopoietic stem cell differentiation(GO:1902037) |
| 0.3 | 1.1 | GO:1905077 | T-helper 17 cell lineage commitment(GO:0072540) negative regulation of interleukin-17 secretion(GO:1905077) |
| 0.3 | 3.9 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.3 | 0.8 | GO:0060399 | positive regulation of growth hormone receptor signaling pathway(GO:0060399) |
| 0.3 | 1.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 0.8 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 0.3 | 1.3 | GO:0035356 | cellular triglyceride homeostasis(GO:0035356) |
| 0.3 | 18.8 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.3 | 0.5 | GO:1905154 | negative regulation of membrane invagination(GO:1905154) |
| 0.3 | 1.3 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 0.3 | 6.7 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.3 | 0.3 | GO:1905076 | regulation of interleukin-17 secretion(GO:1905076) |
| 0.2 | 1.5 | GO:0032202 | telomere assembly(GO:0032202) |
| 0.2 | 4.7 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.2 | 8.5 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.2 | 0.5 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
| 0.2 | 1.2 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 0.2 | 2.7 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.2 | 1.1 | GO:0008655 | pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097) |
| 0.2 | 2.9 | GO:0034377 | plasma lipoprotein particle assembly(GO:0034377) |
| 0.2 | 1.1 | GO:0006777 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) |
| 0.2 | 1.1 | GO:0008616 | queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116) |
| 0.2 | 0.6 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 0.2 | 1.7 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.2 | 2.1 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.2 | 1.2 | GO:0021965 | spinal cord ventral commissure morphogenesis(GO:0021965) |
| 0.2 | 6.4 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
| 0.2 | 1.6 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
| 0.2 | 1.8 | GO:1903351 | response to dopamine(GO:1903350) cellular response to dopamine(GO:1903351) |
| 0.2 | 0.6 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.2 | 0.8 | GO:0016480 | negative regulation of transcription from RNA polymerase III promoter(GO:0016480) |
| 0.2 | 1.4 | GO:0030242 | pexophagy(GO:0030242) |
| 0.2 | 6.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.2 | 1.0 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.2 | 2.5 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
| 0.2 | 0.8 | GO:0032289 | central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912) |
| 0.2 | 4.4 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.2 | 0.4 | GO:1904192 | cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193) |
| 0.2 | 5.9 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.2 | 0.9 | GO:0010820 | positive regulation of T cell chemotaxis(GO:0010820) |
| 0.2 | 2.9 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.2 | 2.0 | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 0.2 | 0.2 | GO:0015822 | ornithine transport(GO:0015822) |
| 0.2 | 0.5 | GO:0071287 | cellular response to manganese ion(GO:0071287) |
| 0.2 | 1.1 | GO:0072015 | glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310) |
| 0.2 | 1.8 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.2 | 0.5 | GO:1901187 | regulation of ephrin receptor signaling pathway(GO:1901187) |
| 0.2 | 1.4 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.2 | 1.9 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.2 | 2.3 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) |
| 0.2 | 1.7 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.2 | 0.5 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.2 | 1.0 | GO:0036112 | medium-chain fatty-acyl-CoA metabolic process(GO:0036112) |
| 0.2 | 1.0 | GO:0010747 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) |
| 0.2 | 5.3 | GO:0001893 | maternal placenta development(GO:0001893) |
| 0.2 | 2.5 | GO:0071803 | keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 4.2 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.2 | 1.1 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) ribosomal small subunit export from nucleus(GO:0000056) |
| 0.2 | 0.3 | GO:2001160 | regulation of histone H3-K79 methylation(GO:2001160) |
| 0.2 | 0.5 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.2 | 0.6 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 0.1 | 0.7 | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway(GO:0060340) |
| 0.1 | 0.9 | GO:0017185 | peptidyl-lysine hydroxylation(GO:0017185) |
| 0.1 | 2.9 | GO:0044253 | positive regulation of collagen metabolic process(GO:0010714) positive regulation of multicellular organismal metabolic process(GO:0044253) |
| 0.1 | 1.5 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 0.1 | 1.0 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.1 | 2.1 | GO:0019184 | nonribosomal peptide biosynthetic process(GO:0019184) |
| 0.1 | 0.4 | GO:0019085 | early viral transcription(GO:0019085) |
| 0.1 | 1.3 | GO:0034088 | maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088) |
| 0.1 | 1.1 | GO:0048341 | paraxial mesoderm formation(GO:0048341) |
| 0.1 | 1.0 | GO:1903551 | regulation of extracellular exosome assembly(GO:1903551) |
| 0.1 | 2.2 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.1 | 1.0 | GO:0061002 | negative regulation of dendritic spine morphogenesis(GO:0061002) |
| 0.1 | 0.5 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.1 | 1.9 | GO:0070102 | interleukin-6-mediated signaling pathway(GO:0070102) |
| 0.1 | 1.2 | GO:0044336 | canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336) |
| 0.1 | 0.8 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.1 | 1.9 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.1 | 1.9 | GO:0045948 | positive regulation of translational initiation(GO:0045948) |
| 0.1 | 2.8 | GO:1902751 | positive regulation of cell cycle G2/M phase transition(GO:1902751) |
| 0.1 | 12.4 | GO:0030518 | intracellular steroid hormone receptor signaling pathway(GO:0030518) |
| 0.1 | 1.7 | GO:0006767 | water-soluble vitamin metabolic process(GO:0006767) |
| 0.1 | 14.6 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.1 | 0.4 | GO:0048209 | regulation of vesicle targeting, to, from or within Golgi(GO:0048209) |
| 0.1 | 0.6 | GO:0072553 | terminal button organization(GO:0072553) |
| 0.1 | 0.2 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
| 0.1 | 1.3 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 0.6 | GO:0038032 | termination of G-protein coupled receptor signaling pathway(GO:0038032) |
| 0.1 | 1.8 | GO:0007530 | sex determination(GO:0007530) |
| 0.1 | 6.8 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
| 0.1 | 0.4 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 0.1 | 0.3 | GO:0010520 | regulation of reciprocal meiotic recombination(GO:0010520) positive regulation of reciprocal meiotic recombination(GO:0010845) |
| 0.1 | 0.7 | GO:0032308 | positive regulation of prostaglandin secretion(GO:0032308) |
| 0.1 | 2.0 | GO:0006103 | 2-oxoglutarate metabolic process(GO:0006103) |
| 0.1 | 0.4 | GO:0035795 | negative regulation of mitochondrial membrane permeability(GO:0035795) |
| 0.1 | 1.2 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.1 | 0.3 | GO:0009446 | putrescine biosynthetic process(GO:0009446) |
| 0.1 | 1.2 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.1 | 0.4 | GO:0097211 | response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211) |
| 0.1 | 2.8 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 0.3 | GO:0006868 | glutamine transport(GO:0006868) |
| 0.1 | 1.3 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.1 | 1.5 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.1 | 0.4 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.1 | 0.4 | GO:0001306 | age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571) |
| 0.1 | 0.3 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
| 0.1 | 0.2 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.1 | 0.9 | GO:0098532 | negative regulation of chemokine production(GO:0032682) histone H3-K27 trimethylation(GO:0098532) |
| 0.1 | 0.5 | GO:1900246 | positive regulation of RIG-I signaling pathway(GO:1900246) |
| 0.1 | 0.4 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.1 | 0.3 | GO:2001286 | regulation of caveolin-mediated endocytosis(GO:2001286) |
| 0.1 | 0.7 | GO:0034351 | regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351) |
| 0.1 | 2.5 | GO:0034508 | centromere complex assembly(GO:0034508) |
| 0.1 | 0.5 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.1 | 25.6 | GO:0000375 | RNA splicing, via transesterification reactions(GO:0000375) |
| 0.1 | 1.3 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.1 | 0.2 | GO:0051292 | nuclear pore organization(GO:0006999) nuclear pore complex assembly(GO:0051292) |
| 0.1 | 0.3 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.1 | 0.5 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.1 | 2.5 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.1 | 0.6 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.1 | 1.8 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 0.1 | 0.5 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.1 | 4.4 | GO:0017145 | stem cell division(GO:0017145) |
| 0.1 | 1.1 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
| 0.1 | 0.4 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 0.1 | 5.1 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.1 | 0.8 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.1 | 0.2 | GO:1902990 | leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990) |
| 0.1 | 1.0 | GO:0090344 | negative regulation of cell aging(GO:0090344) |
| 0.1 | 1.1 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.1 | 3.2 | GO:0061512 | protein localization to cilium(GO:0061512) |
| 0.1 | 0.5 | GO:0030865 | cortical cytoskeleton organization(GO:0030865) |
| 0.1 | 0.3 | GO:0019254 | carnitine metabolic process, CoA-linked(GO:0019254) |
| 0.1 | 6.3 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.1 | 0.4 | GO:0021869 | forebrain ventricular zone progenitor cell division(GO:0021869) |
| 0.1 | 0.2 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
| 0.1 | 0.3 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.1 | 5.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 0.7 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
| 0.1 | 1.3 | GO:0009268 | response to pH(GO:0009268) |
| 0.1 | 0.8 | GO:1902894 | negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
| 0.1 | 0.2 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.1 | 0.6 | GO:1904294 | regulation of ERAD pathway(GO:1904292) positive regulation of ERAD pathway(GO:1904294) |
| 0.1 | 0.6 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
| 0.1 | 0.3 | GO:0008298 | intracellular mRNA localization(GO:0008298) |
| 0.1 | 1.5 | GO:0009994 | oocyte differentiation(GO:0009994) |
| 0.1 | 0.9 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.1 | 1.8 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 1.8 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
| 0.1 | 0.9 | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742) positive regulation of ERBB signaling pathway(GO:1901186) |
| 0.1 | 0.4 | GO:0071397 | cellular response to cholesterol(GO:0071397) |
| 0.1 | 0.7 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
| 0.1 | 1.0 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 9.3 | GO:0042113 | B cell activation(GO:0042113) |
| 0.1 | 4.9 | GO:0032092 | positive regulation of protein binding(GO:0032092) |
| 0.1 | 0.3 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.1 | 2.8 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.1 | 1.6 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.1 | 0.3 | GO:0030091 | protein repair(GO:0030091) |
| 0.1 | 25.9 | GO:0051301 | cell division(GO:0051301) |
| 0.1 | 0.9 | GO:0048820 | hair follicle maturation(GO:0048820) |
| 0.1 | 0.2 | GO:0010587 | miRNA catabolic process(GO:0010587) |
| 0.1 | 0.4 | GO:0033564 | anterior/posterior axon guidance(GO:0033564) |
| 0.1 | 1.0 | GO:0019430 | removal of superoxide radicals(GO:0019430) cellular oxidant detoxification(GO:0098869) |
| 0.1 | 0.2 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 0.1 | 1.7 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.1 | 1.4 | GO:1901992 | positive regulation of mitotic cell cycle phase transition(GO:1901992) |
| 0.1 | 0.6 | GO:0031100 | organ regeneration(GO:0031100) |
| 0.1 | 1.9 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.1 | 0.6 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
| 0.1 | 0.3 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.1 | 0.2 | GO:0021747 | cochlear nucleus development(GO:0021747) |
| 0.1 | 0.4 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.0 | 3.7 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 0.1 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
| 0.0 | 5.8 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.2 | GO:0044130 | negative regulation of growth of symbiont in host(GO:0044130) negative regulation of growth of symbiont involved in interaction with host(GO:0044146) |
| 0.0 | 1.8 | GO:0035904 | aorta development(GO:0035904) |
| 0.0 | 0.5 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.0 | 1.3 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.0 | 0.7 | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.0 | 0.3 | GO:0045739 | positive regulation of DNA repair(GO:0045739) |
| 0.0 | 1.1 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.0 | 0.1 | GO:2001168 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 0.0 | 0.2 | GO:0060040 | retinal bipolar neuron differentiation(GO:0060040) |
| 0.0 | 0.2 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.0 | 0.4 | GO:0043486 | histone exchange(GO:0043486) |
| 0.0 | 0.2 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.0 | 0.5 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.0 | 0.4 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 0.1 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.0 | 0.4 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.0 | 0.3 | GO:0051043 | regulation of membrane protein ectodomain proteolysis(GO:0051043) positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 0.3 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.0 | 0.1 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.0 | 0.5 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
| 0.0 | 0.3 | GO:0070072 | vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.0 | 1.0 | GO:0032755 | positive regulation of interleukin-6 production(GO:0032755) |
| 0.0 | 0.3 | GO:0034067 | protein localization to Golgi apparatus(GO:0034067) |
| 0.0 | 0.3 | GO:0006907 | pinocytosis(GO:0006907) |
| 0.0 | 0.6 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.3 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 1.3 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.0 | 0.2 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.0 | 0.3 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.0 | 2.2 | GO:0006821 | chloride transport(GO:0006821) |
| 0.0 | 1.3 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 1.0 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
| 0.0 | 0.4 | GO:0034968 | histone lysine methylation(GO:0034968) |
| 0.0 | 0.9 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.0 | 1.2 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 0.0 | 0.2 | GO:0006627 | protein processing involved in protein targeting to mitochondrion(GO:0006627) |
| 0.0 | 0.6 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.0 | 0.3 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.0 | 0.3 | GO:0046548 | retinal rod cell development(GO:0046548) |
| 0.0 | 0.3 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.0 | 0.5 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 0.1 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.0 | 0.3 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity(GO:0051443) |
| 0.0 | 0.1 | GO:0002489 | antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) |
| 0.0 | 3.3 | GO:0016042 | lipid catabolic process(GO:0016042) |
| 0.0 | 0.0 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.0 | 0.6 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.3 | GO:0030166 | proteoglycan biosynthetic process(GO:0030166) |
| 0.0 | 0.7 | GO:0051966 | regulation of synaptic transmission, glutamatergic(GO:0051966) |
| 0.0 | 0.2 | GO:0070555 | response to interleukin-1(GO:0070555) |
| 0.0 | 0.2 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.0 | 0.2 | GO:0039703 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.0 | 0.2 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.0 | 0.2 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.0 | 0.5 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
| 0.0 | 0.7 | GO:0002062 | chondrocyte differentiation(GO:0002062) |
| 0.0 | 0.0 | GO:0071596 | ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596) |
| 0.0 | 0.1 | GO:0044872 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 0.0 | 0.5 | GO:0006023 | aminoglycan biosynthetic process(GO:0006023) |
| 0.0 | 0.2 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.0 | 0.7 | GO:0007179 | transforming growth factor beta receptor signaling pathway(GO:0007179) |
| 0.0 | 0.0 | GO:0046077 | dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate metabolic process(GO:0009138) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077) |
| 0.0 | 0.2 | GO:0060999 | positive regulation of dendritic spine development(GO:0060999) |
| 0.0 | 0.7 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 0.3 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 0.1 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.0 | 0.1 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
| 0.0 | 1.0 | GO:0006664 | glycolipid metabolic process(GO:0006664) liposaccharide metabolic process(GO:1903509) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 24.5 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 4.5 | 26.9 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 3.3 | 13.3 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
| 3.3 | 3.3 | GO:0070552 | BRISC complex(GO:0070552) |
| 3.1 | 25.1 | GO:0005818 | aster(GO:0005818) |
| 2.8 | 16.7 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 2.6 | 7.9 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 1.9 | 5.8 | GO:1990423 | RZZ complex(GO:1990423) |
| 1.7 | 5.1 | GO:0097543 | ciliary inversin compartment(GO:0097543) |
| 1.6 | 19.1 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 1.6 | 4.7 | GO:0000801 | central element(GO:0000801) |
| 1.5 | 4.6 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 1.5 | 4.4 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
| 1.3 | 9.2 | GO:0001940 | male pronucleus(GO:0001940) |
| 1.2 | 4.6 | GO:0045251 | mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251) |
| 1.1 | 6.6 | GO:0071986 | Ragulator complex(GO:0071986) |
| 1.1 | 5.5 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 1.1 | 5.4 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 1.1 | 15.0 | GO:0035748 | myelin sheath abaxonal region(GO:0035748) |
| 1.0 | 26.0 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.9 | 2.7 | GO:0055087 | Ski complex(GO:0055087) |
| 0.8 | 8.5 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.8 | 6.7 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.8 | 2.5 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
| 0.7 | 11.4 | GO:0010369 | chromocenter(GO:0010369) |
| 0.7 | 3.4 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.7 | 3.9 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 0.6 | 1.9 | GO:0005673 | transcription factor TFIIE complex(GO:0005673) |
| 0.6 | 5.5 | GO:0030478 | actin cap(GO:0030478) |
| 0.6 | 9.0 | GO:0032039 | integrator complex(GO:0032039) |
| 0.5 | 3.9 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.5 | 3.9 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.5 | 5.1 | GO:0034464 | BBSome(GO:0034464) |
| 0.4 | 7.0 | GO:0051286 | cell tip(GO:0051286) |
| 0.4 | 1.3 | GO:1990047 | spindle matrix(GO:1990047) |
| 0.4 | 5.0 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.4 | 2.4 | GO:0005687 | U4 snRNP(GO:0005687) |
| 0.4 | 1.6 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.4 | 1.2 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.4 | 2.3 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.3 | 3.5 | GO:0000796 | condensin complex(GO:0000796) |
| 0.3 | 2.8 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.3 | 1.3 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.3 | 1.6 | GO:0032389 | MutLalpha complex(GO:0032389) |
| 0.3 | 1.6 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.3 | 1.3 | GO:0000818 | nuclear MIS12/MIND complex(GO:0000818) |
| 0.3 | 10.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.3 | 2.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.3 | 5.4 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.3 | 6.9 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.3 | 2.2 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.3 | 1.1 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) |
| 0.3 | 2.7 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.3 | 9.5 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.3 | 6.8 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.3 | 7.2 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.3 | 0.5 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.3 | 17.0 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.2 | 1.7 | GO:0005664 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.2 | 1.2 | GO:0031523 | Myb complex(GO:0031523) |
| 0.2 | 1.9 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.2 | 1.4 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.2 | 2.8 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.2 | 25.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.2 | 3.4 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.2 | 9.6 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.2 | 2.6 | GO:0070938 | contractile ring(GO:0070938) |
| 0.2 | 7.8 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.2 | 19.3 | GO:0030175 | filopodium(GO:0030175) |
| 0.2 | 2.7 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.2 | 1.7 | GO:0090543 | Flemming body(GO:0090543) |
| 0.2 | 2.9 | GO:0042555 | MCM complex(GO:0042555) |
| 0.2 | 5.1 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.2 | 1.2 | GO:0032983 | kainate selective glutamate receptor complex(GO:0032983) |
| 0.2 | 6.9 | GO:0035869 | ciliary transition zone(GO:0035869) |
| 0.2 | 0.9 | GO:0089701 | U2AF(GO:0089701) |
| 0.2 | 1.7 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.2 | 0.5 | GO:0031251 | PAN complex(GO:0031251) |
| 0.2 | 6.1 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.2 | 11.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.2 | 7.5 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 2.5 | GO:0000800 | lateral element(GO:0000800) |
| 0.1 | 1.0 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.1 | 2.0 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.1 | 2.0 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.1 | 0.8 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.1 | 0.5 | GO:0031310 | integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310) |
| 0.1 | 2.7 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 5.3 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 0.9 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.1 | 3.8 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 8.0 | GO:0005844 | polysome(GO:0005844) |
| 0.1 | 1.2 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 0.4 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.1 | 0.2 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
| 0.1 | 0.6 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 6.5 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 57.0 | GO:0005813 | centrosome(GO:0005813) |
| 0.1 | 5.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.1 | 0.2 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 0.1 | 0.6 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.1 | 3.1 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.1 | 1.1 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.1 | 0.6 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.1 | 1.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 0.7 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.1 | 2.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 0.6 | GO:0097422 | tubular endosome(GO:0097422) |
| 0.1 | 0.6 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 8.0 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 0.6 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.1 | 2.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 0.9 | GO:0031105 | septin complex(GO:0031105) |
| 0.1 | 0.7 | GO:0005686 | U2 snRNP(GO:0005686) |
| 0.1 | 2.5 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 0.4 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 2.1 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.1 | 2.1 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 3.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 1.0 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.1 | 0.9 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.1 | 4.8 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.1 | 0.3 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 0.4 | GO:0031415 | NatA complex(GO:0031415) |
| 0.1 | 2.2 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.1 | 0.2 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.1 | 1.6 | GO:0097038 | perinuclear endoplasmic reticulum(GO:0097038) |
| 0.1 | 6.8 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 0.4 | GO:0071664 | beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664) |
| 0.1 | 0.4 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.1 | 0.5 | GO:0098533 | ATPase dependent transmembrane transport complex(GO:0098533) |
| 0.0 | 0.0 | GO:0070876 | SOSS complex(GO:0070876) |
| 0.0 | 0.1 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
| 0.0 | 0.1 | GO:0018444 | translation release factor complex(GO:0018444) |
| 0.0 | 0.3 | GO:0048500 | signal recognition particle(GO:0048500) |
| 0.0 | 0.5 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 1.5 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 1.5 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
| 0.0 | 0.0 | GO:0000346 | transcription export complex(GO:0000346) |
| 0.0 | 0.7 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 1.0 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.2 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.0 | 3.3 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 0.0 | 1.8 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.2 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
| 0.0 | 2.7 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.0 | 0.2 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.0 | 2.2 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.2 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 2.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.4 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.2 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 1.2 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 1.3 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.0 | 0.1 | GO:0098842 | postsynaptic early endosome(GO:0098842) |
| 0.0 | 3.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 1.6 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.0 | 0.1 | GO:1990357 | terminal web(GO:1990357) |
| 0.0 | 0.3 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.5 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.9 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.1 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.0 | 0.2 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 1.3 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 0.1 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 0.1 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
| 0.0 | 2.2 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 0.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 0.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.1 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) TAP complex(GO:0042825) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 23.5 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 2.5 | 25.3 | GO:0003964 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 2.4 | 11.8 | GO:0072542 | protein phosphatase activator activity(GO:0072542) |
| 2.3 | 9.3 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 2.1 | 12.9 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 2.0 | 7.9 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 1.9 | 5.7 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 1.8 | 7.1 | GO:0000700 | mismatch base pair DNA N-glycosylase activity(GO:0000700) |
| 1.6 | 9.9 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 1.6 | 7.8 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 1.5 | 10.4 | GO:0048256 | flap endonuclease activity(GO:0048256) |
| 1.5 | 7.3 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 1.4 | 4.3 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 1.4 | 9.9 | GO:0000403 | Y-form DNA binding(GO:0000403) |
| 1.3 | 9.1 | GO:0000150 | recombinase activity(GO:0000150) |
| 1.3 | 7.8 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 1.2 | 6.2 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 1.2 | 4.6 | GO:0004174 | electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649) |
| 1.1 | 3.2 | GO:0000171 | ribonuclease MRP activity(GO:0000171) |
| 1.1 | 6.4 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 1.0 | 3.0 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
| 1.0 | 7.8 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.9 | 4.4 | GO:0030621 | U4 snRNA binding(GO:0030621) |
| 0.8 | 6.7 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.8 | 3.2 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 0.7 | 5.0 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.7 | 2.1 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.7 | 4.9 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.7 | 3.4 | GO:0015142 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 0.7 | 10.7 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.7 | 13.7 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.7 | 3.9 | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) |
| 0.6 | 2.4 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.6 | 1.8 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
| 0.6 | 5.8 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.6 | 3.9 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.5 | 2.7 | GO:1990715 | mRNA CDS binding(GO:1990715) |
| 0.5 | 1.6 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.5 | 8.6 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.5 | 5.8 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.5 | 2.1 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
| 0.5 | 4.5 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.5 | 8.3 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.5 | 2.4 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 0.5 | 2.8 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 0.5 | 18.7 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.5 | 2.8 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.5 | 4.6 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.5 | 2.7 | GO:0070728 | leucine binding(GO:0070728) |
| 0.5 | 1.4 | GO:0004711 | ribosomal protein S6 kinase activity(GO:0004711) |
| 0.5 | 4.1 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.4 | 25.1 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.4 | 3.8 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.4 | 3.3 | GO:0016742 | hydroxymethyl-, formyl- and related transferase activity(GO:0016742) |
| 0.4 | 2.9 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.4 | 2.7 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.4 | 1.2 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 0.4 | 9.6 | GO:0098632 | protein binding involved in cell-cell adhesion(GO:0098632) |
| 0.4 | 6.7 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.3 | 19.1 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.3 | 4.4 | GO:0043138 | 3'-5' DNA helicase activity(GO:0043138) |
| 0.3 | 5.1 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.3 | 4.1 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.3 | 2.3 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.3 | 1.0 | GO:0001729 | ceramide kinase activity(GO:0001729) |
| 0.3 | 27.9 | GO:0002039 | p53 binding(GO:0002039) |
| 0.3 | 3.9 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.3 | 1.2 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 0.3 | 0.9 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.3 | 2.1 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.3 | 0.9 | GO:0016901 | glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901) |
| 0.3 | 2.3 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
| 0.3 | 1.6 | GO:0005042 | netrin receptor activity(GO:0005042) |
| 0.3 | 8.2 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.3 | 0.8 | GO:0015173 | aromatic amino acid transmembrane transporter activity(GO:0015173) |
| 0.2 | 6.0 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.2 | 18.1 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.2 | 1.0 | GO:0016508 | long-chain-enoyl-CoA hydratase activity(GO:0016508) |
| 0.2 | 2.7 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.2 | 4.7 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.2 | 0.7 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.2 | 1.1 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.2 | 1.8 | GO:0035326 | enhancer binding(GO:0035326) |
| 0.2 | 0.9 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.2 | 0.9 | GO:0035241 | protein-arginine omega-N monomethyltransferase activity(GO:0035241) |
| 0.2 | 1.9 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.2 | 8.5 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.2 | 4.0 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.2 | 18.0 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.2 | 1.0 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.2 | 1.2 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.2 | 7.2 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.2 | 0.6 | GO:0001565 | phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566) |
| 0.2 | 1.7 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.2 | 1.1 | GO:0008479 | queuine tRNA-ribosyltransferase activity(GO:0008479) |
| 0.2 | 0.5 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 0.2 | 1.4 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.2 | 0.5 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 0.2 | 2.6 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
| 0.2 | 3.4 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.2 | 7.8 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.2 | 1.2 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.2 | 1.5 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.2 | 2.0 | GO:0031386 | protein tag(GO:0031386) |
| 0.2 | 4.3 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.2 | 1.7 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.2 | 2.7 | GO:0070402 | NADPH binding(GO:0070402) |
| 0.2 | 1.1 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 2.5 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.1 | 2.0 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 1.1 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.1 | 1.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 0.7 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.1 | 0.1 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.1 | 0.7 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.1 | 5.1 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.1 | 1.6 | GO:0035613 | RNA stem-loop binding(GO:0035613) |
| 0.1 | 1.5 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 0.1 | 6.3 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 2.2 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.1 | 1.3 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.1 | 4.8 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.1 | 1.1 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.1 | 1.2 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.1 | 4.4 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.1 | 0.3 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.1 | 0.6 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.1 | 4.4 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.1 | 1.1 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 0.7 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 0.6 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.1 | 5.6 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 0.4 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.1 | 2.2 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 7.9 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.1 | 2.8 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.1 | 1.4 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 1.6 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.1 | 0.9 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.1 | 8.2 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.1 | 0.3 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.1 | 0.4 | GO:0008865 | fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.1 | 1.3 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.1 | 2.1 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.4 | GO:0019961 | interferon binding(GO:0019961) |
| 0.1 | 3.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 3.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 0.8 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.1 | 2.4 | GO:0008376 | acetylgalactosaminyltransferase activity(GO:0008376) |
| 0.1 | 1.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.2 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
| 0.1 | 0.5 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.1 | 1.8 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.1 | 0.3 | GO:0004092 | carnitine O-acetyltransferase activity(GO:0004092) |
| 0.1 | 0.8 | GO:0048531 | beta-1,3-galactosyltransferase activity(GO:0048531) |
| 0.1 | 2.0 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.2 | GO:0036132 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
| 0.1 | 3.9 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 12.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 10.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 1.2 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.1 | 6.2 | GO:0008514 | organic anion transmembrane transporter activity(GO:0008514) |
| 0.1 | 1.2 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.1 | 0.3 | GO:0000995 | transcription factor activity, core RNA polymerase III binding(GO:0000995) |
| 0.1 | 9.9 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 1.1 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.1 | 1.1 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 0.3 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.1 | 0.7 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062) |
| 0.1 | 0.7 | GO:0015299 | solute:proton antiporter activity(GO:0015299) |
| 0.1 | 0.2 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
| 0.1 | 1.5 | GO:0005112 | Notch binding(GO:0005112) |
| 0.1 | 0.5 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 0.1 | 0.3 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) |
| 0.1 | 3.5 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 1.0 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 1.6 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.4 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.0 | 0.4 | GO:0000182 | rDNA binding(GO:0000182) |
| 0.0 | 5.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.7 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.5 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 1.5 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 3.9 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 1.4 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 23.1 | GO:0000982 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) |
| 0.0 | 0.2 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.2 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.0 | 2.3 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.2 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.0 | 0.2 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.0 | 0.2 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 0.0 | 0.3 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.0 | 0.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.4 | GO:0004630 | phospholipase D activity(GO:0004630) |
| 0.0 | 1.8 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 0.5 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.0 | 0.3 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.0 | 5.1 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 2.3 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.8 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.3 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 1.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 6.4 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 3.3 | GO:0070851 | growth factor receptor binding(GO:0070851) |
| 0.0 | 0.4 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.0 | 0.5 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 0.1 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.0 | 0.2 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 3.5 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.0 | 0.3 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.0 | 0.2 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.0 | 0.2 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.0 | 0.3 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 0.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 0.3 | GO:0015266 | protein channel activity(GO:0015266) |
| 0.0 | 0.4 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 0.3 | GO:0070990 | snRNP binding(GO:0070990) |
| 0.0 | 0.7 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 1.0 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 3.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.5 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.9 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.0 | 0.4 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 1.1 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 0.7 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 0.7 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.5 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.3 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 1.7 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 0.7 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.1 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.0 | 0.1 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 1.3 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 0.0 | 0.9 | GO:0015293 | symporter activity(GO:0015293) |
| 0.0 | 0.1 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.0 | 0.3 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 1.5 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 5.3 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.0 | 0.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.1 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
| 0.0 | 0.2 | GO:0005225 | volume-sensitive anion channel activity(GO:0005225) |
| 0.0 | 0.3 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.0 | 0.1 | GO:0008525 | phosphatidylcholine transporter activity(GO:0008525) |
| 0.0 | 0.2 | GO:0001098 | basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099) |
| 0.0 | 0.1 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.0 | GO:0004127 | cytidylate kinase activity(GO:0004127) uridylate kinase activity(GO:0009041) |
| 0.0 | 0.6 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 0.2 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.4 | GO:0032934 | cholesterol binding(GO:0015485) sterol binding(GO:0032934) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 84.3 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.6 | 4.8 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.6 | 22.7 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.5 | 23.2 | PID_PLK1_PATHWAY | PLK1 signaling events |
| 0.5 | 14.2 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.3 | 11.4 | PID_ATR_PATHWAY | ATR signaling pathway |
| 0.3 | 6.4 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.2 | 7.8 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 0.5 | PID_SYNDECAN_1_PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 13.6 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 4.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 0.1 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 5.6 | PID_INTEGRIN_A4B1_PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 1.4 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 3.0 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 5.7 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 7.3 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.1 | 3.1 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.1 | 3.1 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 3.1 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.1 | 1.9 | PID_ATM_PATHWAY | ATM pathway |
| 0.1 | 0.3 | PID_SYNDECAN_4_PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 4.7 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 1.8 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 2.6 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.1 | 1.1 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 1.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.1 | 0.7 | PID_UPA_UPAR_PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 1.6 | PID_IL2_1PATHWAY | IL2-mediated signaling events |
| 0.1 | 1.4 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.6 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.7 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.7 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.7 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 2.4 | PID_MYC_ACTIV_PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 4.8 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 1.4 | PID_RB_1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.6 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.6 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.3 | PID_TGFBR_PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.2 | PID_P75_NTR_PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 1.7 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.2 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.2 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.2 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.4 | PID_AP1_PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.3 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.2 | PID_CXCR4_PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 0.4 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 26.1 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 1.1 | 7.8 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 1.1 | 22.9 | REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.9 | 5.2 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.8 | 5.3 | REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.7 | 10.3 | REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.7 | 2.1 | REACTOME_PHOSPHORYLATION_OF_THE_APC_C | Genes involved in Phosphorylation of the APC/C |
| 0.6 | 66.3 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.6 | 10.9 | REACTOME_G1_S_SPECIFIC_TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.5 | 7.6 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.5 | 5.3 | REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.4 | 14.6 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.4 | 12.0 | REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.3 | 4.9 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.3 | 5.7 | REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.3 | 9.7 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.3 | 4.7 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.3 | 3.5 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
| 0.2 | 2.7 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.2 | 5.4 | REACTOME_MRNA_3_END_PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.2 | 3.7 | REACTOME_ABORTIVE_ELONGATION_OF_HIV1_TRANSCRIPT_IN_THE_ABSENCE_OF_TAT | Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat |
| 0.2 | 2.9 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.2 | 7.0 | REACTOME_RNA_POL_III_TRANSCRIPTION | Genes involved in RNA Polymerase III Transcription |
| 0.2 | 4.3 | REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.2 | 1.6 | REACTOME_SIGNAL_TRANSDUCTION_BY_L1 | Genes involved in Signal transduction by L1 |
| 0.2 | 1.4 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.2 | 1.3 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.2 | 5.0 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.2 | 10.1 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 1.9 | REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.1 | 1.7 | REACTOME_IRAK1_RECRUITS_IKK_COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.1 | 1.6 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 0.6 | REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 2.6 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 3.6 | REACTOME_PEROXISOMAL_LIPID_METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.1 | 0.5 | REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE | Genes involved in p53-Dependent G1 DNA Damage Response |
| 0.1 | 2.2 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.1 | 2.7 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 0.5 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 2.0 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 2.0 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.1 | 1.9 | REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.1 | 2.1 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 4.4 | REACTOME_ER_PHAGOSOME_PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 1.1 | REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.1 | 0.6 | REACTOME_SIGNALING_BY_NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.1 | 1.2 | REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 0.6 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 1.4 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.1 | 1.6 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 0.4 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 1.0 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 1.0 | REACTOME_EGFR_DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 1.3 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 1.2 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 0.9 | REACTOME_EXTENSION_OF_TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 0.2 | REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.0 | 0.7 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 1.1 | REACTOME_MRNA_SPLICING_MINOR_PATHWAY | Genes involved in mRNA Splicing - Minor Pathway |
| 0.0 | 4.6 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 0.4 | REACTOME_GLUCOSE_TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 3.8 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.0 | 0.4 | REACTOME_CD28_DEPENDENT_VAV1_PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.5 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.7 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 1.1 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 0.8 | REACTOME_SMOOTH_MUSCLE_CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.6 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 1.1 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.7 | REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING | Genes involved in Growth hormone receptor signaling |
| 0.0 | 2.5 | REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.0 | 0.2 | REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.0 | 0.6 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 1.0 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
| 0.0 | 0.7 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.1 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.2 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 0.2 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.7 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.1 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.2 | REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.0 | 0.3 | REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| 0.0 | 0.1 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.2 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
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