Motif ID: Hdx

Z-value: 7.518


Transcription factors associated with Hdx:

Gene SymbolEntrez IDGene Name
Hdx ENSMUSG00000034551.6 Hdx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hdxmm10_v2_chrX_-_111697069_1116971270.066.3e-01Click!


Activity profile for motif Hdx.

activity profile for motif Hdx


Sorted Z-values histogram for motif Hdx

Sorted Z-values for motif Hdx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hdx

PNG image of the network

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Top targets:


Showing 1 to 20 of 63 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3017408 846.839 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 726.828 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3023547 678.344 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3005125 629.447 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3034599 589.084 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3000922 582.823 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 562.561 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3025417 503.629 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr14_-_19418930 476.069 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 416.266 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3004457 382.179 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3036877 368.556 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3037111 344.820 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3013140 319.518 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr2_-_98667264 241.505 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr6_-_23248264 40.681 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_21089229 13.376 ENSMUST00000040667.6
 Zfp300
zinc finger protein 300
chr5_-_27501362 12.914 ENSMUST00000155721.1
ENSMUST00000053257.3
 Speer4b

spermatogenesis associated glutamate (E)-rich protein 4b

chr15_+_10177623 10.141 ENSMUST00000124470.1
 Prlr
prolactin receptor
chr18_-_47333311 9.826 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5270.4 GO:0008150 biological_process(GO:0008150)
6.8 40.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.6 12.8 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
2.5 10.1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.5 9.8 GO:2001224 positive regulation of neuron migration(GO:2001224)
2.8 8.5 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.4 6.1 GO:0010818 T cell chemotaxis(GO:0010818)
2.0 5.9 GO:0070488 neutrophil aggregation(GO:0070488)
1.0 5.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.7 3.4 GO:0015871 choline transport(GO:0015871) negative regulation of RIG-I signaling pathway(GO:0039536)
1.5 3.0 GO:0050883 musculoskeletal movement, spinal reflex action(GO:0050883)
0.7 3.0 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.7 2.7 GO:0001692 histamine metabolic process(GO:0001692) histidine metabolic process(GO:0006547) imidazole-containing compound catabolic process(GO:0052805)
0.5 1.5 GO:0045410 positive regulation of interleukin-6 biosynthetic process(GO:0045410)
0.4 1.1 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)

Gene overrepresentation in cellular_component category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5341.7 GO:0005575 cellular_component(GO:0005575)

Gene overrepresentation in molecular_function category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5357.8 GO:0003674 molecular_function(GO:0003674)
0.3 10.1 GO:0017046 peptide hormone binding(GO:0017046)
0.5 9.8 GO:0030215 semaphorin receptor binding(GO:0030215)
1.2 6.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.0 5.9 GO:0050786 arachidonic acid binding(GO:0050544) RAGE receptor binding(GO:0050786)
1.1 5.7 GO:0070330 aromatase activity(GO:0070330)
0.3 5.1 GO:0003680 AT DNA binding(GO:0003680)
0.6 3.0 GO:0043532 angiostatin binding(GO:0043532)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 10.1 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 8.5 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 5.9 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 1.5 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.2 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 10.1 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.4 9.8 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.2 5.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.4 5.1 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 3.0 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.1 3.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 3.0 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.0 1.5 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling