Motif ID: Hes1

Z-value: 1.626


Transcription factors associated with Hes1:

Gene SymbolEntrez IDGene Name
Hes1 ENSMUSG00000022528.7 Hes1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes1mm10_v2_chr16_+_30065333_30065351-0.132.7e-01Click!


Activity profile for motif Hes1.

activity profile for motif Hes1


Sorted Z-values histogram for motif Hes1

Sorted Z-values for motif Hes1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 73.053 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 68.889 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr9_+_118478182 21.303 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 20.320 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr3_+_127633134 19.413 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr10_-_127534540 18.148 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr6_+_120666388 18.019 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr1_+_153652943 17.231 ENSMUST00000041776.5
 Rgs8
regulator of G-protein signaling 8
chr1_-_189688074 16.709 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr4_+_116877376 15.557 ENSMUST00000044823.3
 Zswim5
zinc finger SWIM-type containing 5
chr11_+_113619318 15.172 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr4_+_65124174 11.838 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr9_-_75409951 11.816 ENSMUST00000049355.10
 Mapk6
mitogen-activated protein kinase 6
chr17_-_25797032 11.651 ENSMUST00000165838.1
ENSMUST00000002344.6
 Metrn

meteorin, glial cell differentiation regulator

chr12_+_110279228 11.531 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr18_+_82910863 11.497 ENSMUST00000171238.1
 Zfp516
zinc finger protein 516
chr11_-_102925086 10.775 ENSMUST00000021311.9
 Kif18b
kinesin family member 18B
chr1_+_132316112 10.577 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr5_+_93093428 10.364 ENSMUST00000074733.7
 Sept11
septin 11
chr1_-_118982551 9.644 ENSMUST00000159678.1
 Gli2
GLI-Kruppel family member GLI2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 151 entries
Log-likelihood per target Total log-likelihoodTermDescription
15.8 141.9 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
13.9 41.6 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
2.2 20.1 GO:0001842 neural fold formation(GO:0001842)
1.3 17.2 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
4.2 17.0 GO:0003360 brainstem development(GO:0003360)
0.4 16.7 GO:0021591 ventricular system development(GO:0021591)
1.4 15.2 GO:0030432 peristalsis(GO:0030432)
3.6 14.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 11.8 GO:0051384 response to glucocorticoid(GO:0051384)
1.6 11.5 GO:0046549 phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549)
0.3 11.5 GO:0009409 response to cold(GO:0009409)
0.2 10.7 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 10.3 GO:0008380 RNA splicing(GO:0008380)
0.1 9.9 GO:0050772 positive regulation of axonogenesis(GO:0050772)
2.4 9.6 GO:0060032 notochord regression(GO:0060032)
1.9 9.5 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
3.0 9.1 GO:0018298 protein-chromophore linkage(GO:0018298)
2.3 9.1 GO:0044565 dendritic cell proliferation(GO:0044565)
1.1 8.7 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 8.7 GO:0006334 nucleosome assembly(GO:0006334)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 74.3 GO:0043234 protein complex(GO:0043234)
0.0 18.9 GO:0005615 extracellular space(GO:0005615)
4.5 18.0 GO:0090537 CERF complex(GO:0090537)
0.4 17.2 GO:0032809 neuronal cell body membrane(GO:0032809)
5.7 17.0 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
1.3 16.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 13.0 GO:0030139 endocytic vesicle(GO:0030139)
0.7 11.8 GO:0032156 septin cytoskeleton(GO:0032156)
1.8 10.8 GO:0000235 astral microtubule(GO:0000235)
0.1 10.6 GO:0001726 ruffle(GO:0001726)
0.1 10.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.7 9.6 GO:0097542 ciliary tip(GO:0097542)
0.6 9.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.5 9.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 9.1 GO:0016607 nuclear speck(GO:0016607)
0.2 8.9 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 7.3 GO:0005681 spliceosomal complex(GO:0005681)
0.4 6.8 GO:0035102 PRC1 complex(GO:0035102)
0.5 6.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 5.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 142.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.7 45.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.6 26.7 GO:0070888 E-box binding(GO:0070888)
0.5 17.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
2.8 17.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.5 16.7 GO:0070840 dynein complex binding(GO:0070840)
5.1 15.2 GO:0004994 somatostatin receptor activity(GO:0004994)
0.2 15.1 GO:0003777 microtubule motor activity(GO:0003777)
2.1 14.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 14.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.7 13.0 GO:0004707 MAP kinase activity(GO:0004707)
0.1 12.6 GO:0042393 histone binding(GO:0042393)
0.3 11.3 GO:0033613 activating transcription factor binding(GO:0033613)
0.3 9.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 9.5 GO:0005112 Notch binding(GO:0005112)
0.2 9.2 GO:0005158 insulin receptor binding(GO:0005158)
0.1 9.2 GO:0031490 chromatin DNA binding(GO:0031490)
3.0 9.1 GO:0009881 photoreceptor activity(GO:0009881)
0.5 8.7 GO:0003680 AT DNA binding(GO:0003680)
0.3 8.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 155.5 PID_IGF1_PATHWAY IGF1 pathway
0.7 41.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 12.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.3 12.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.4 10.7 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 9.2 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 9.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 8.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.4 8.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 7.0 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 7.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 6.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 5.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 5.8 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 5.4 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 4.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 4.1 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.4 PID_LKB1_PATHWAY LKB1 signaling events
0.1 3.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 3.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.8 141.9 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.3 48.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
1.1 17.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.0 11.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.6 10.1 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.8 9.7 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.5 8.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.3 8.6 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.2 7.5 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.1 7.2 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.1 7.1 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 7.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 6.6 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.2 6.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 5.4 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.3 5.1 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.6 5.0 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 4.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 4.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 4.3 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex