Motif ID: Hes5_Hes7

Z-value: 1.573

Transcription factors associated with Hes5_Hes7:

Gene SymbolEntrez IDGene Name
Hes5 ENSMUSG00000048001.7 Hes5
Hes7 ENSMUSG00000023781.2 Hes7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hes7mm10_v2_chr11_+_69120404_69120404-0.226.0e-02Click!
Hes5mm10_v2_chr4_+_154960915_154960930-0.084.7e-01Click!


Activity profile for motif Hes5_Hes7.

activity profile for motif Hes5_Hes7


Sorted Z-values histogram for motif Hes5_Hes7

Sorted Z-values for motif Hes5_Hes7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hes5_Hes7

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_12026237 127.049 ENSMUST00000150972.1
 Grb10
growth factor receptor bound protein 10
chr11_-_12026732 126.696 ENSMUST00000143915.1
 Grb10
growth factor receptor bound protein 10
chr13_+_51846673 31.187 ENSMUST00000021903.2
 Gadd45g
growth arrest and DNA-damage-inducible 45 gamma
chr13_+_108316332 15.279 ENSMUST00000051594.5
 Depdc1b
DEP domain containing 1B
chr13_+_108316395 14.146 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr8_-_87804411 13.094 ENSMUST00000165770.2
 Zfp423
zinc finger protein 423
chr15_+_32244801 12.607 ENSMUST00000067458.6
 Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
chr12_+_109459843 12.487 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr15_+_72913357 12.447 ENSMUST00000166418.2
 Gm3150
predicted gene 3150
chr9_-_36726374 9.491 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr6_+_4755327 9.030 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr1_+_72824482 8.293 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr1_-_75219245 8.139 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr14_+_31019125 7.828 ENSMUST00000112095.1
ENSMUST00000112098.3
ENSMUST00000112106.1
ENSMUST00000146325.1
 Pbrm1



polybromo 1



chr15_-_32244632 7.729 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr14_+_59201209 6.777 ENSMUST00000173547.1
ENSMUST00000043227.6
ENSMUST00000022551.7
 Rcbtb1


regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1


chr9_+_64121501 6.517 ENSMUST00000118215.1
 Lctl
lactase-like
chr15_+_39076885 6.440 ENSMUST00000067072.3
 Cthrc1
collagen triple helix repeat containing 1
chr18_-_46280820 6.359 ENSMUST00000025354.3
 Pggt1b
protein geranylgeranyltransferase type I, beta subunit
chr10_+_79682169 5.417 ENSMUST00000020550.5
 Cdc34
cell division cycle 34

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
28.2 253.7 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
3.1 31.2 GO:0042095 interferon-gamma biosynthetic process(GO:0042095)
0.2 26.9 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
5.8 17.4 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.3 13.1 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
1.6 12.6 GO:0090091 positive regulation of axon extension involved in axon guidance(GO:0048842) positive regulation of extracellular matrix disassembly(GO:0090091)
0.6 12.5 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
1.7 11.7 GO:0006344 maintenance of chromatin silencing(GO:0006344)
1.7 9.9 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 9.7 GO:0016569 covalent chromatin modification(GO:0016569)
1.1 9.5 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.2 9.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.5 8.3 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
2.1 6.4 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.6 6.4 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
1.2 4.7 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
1.4 4.3 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 4.1 GO:0045214 sarcomere organization(GO:0045214)
0.3 4.0 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
1.2 3.6 GO:0021759 globus pallidus development(GO:0021759)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 193.1 GO:0005829 cytosol(GO:0005829)
0.6 22.5 GO:0090544 BAF-type complex(GO:0090544)
0.0 18.9 GO:0005615 extracellular space(GO:0005615)
0.0 13.4 GO:0005654 nucleoplasm(GO:0005654)
0.1 12.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 9.5 GO:0005657 replication fork(GO:0005657)
0.0 9.5 GO:0005874 microtubule(GO:0005874)
0.8 6.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 6.5 GO:0005903 brush border(GO:0005903)
0.1 6.4 GO:0005581 collagen trimer(GO:0005581)
0.0 5.4 GO:1990234 transferase complex(GO:1990234)
1.6 4.7 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 4.1 GO:0043034 costamere(GO:0043034)
0.5 4.0 GO:0046581 intercellular canaliculus(GO:0046581)
1.1 3.4 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 3.1 GO:0005923 bicellular tight junction(GO:0005923)
0.5 2.9 GO:1990356 sumoylated E2 ligase complex(GO:1990356)
0.1 2.7 GO:0097225 sperm midpiece(GO:0097225)
0.1 2.6 GO:0005652 nuclear lamina(GO:0005652)
0.0 2.6 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.5 253.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 22.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 13.7 GO:0003682 chromatin binding(GO:0003682)
0.2 13.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
4.2 12.6 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 11.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 9.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
3.2 9.5 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.3 8.5 GO:0017147 Wnt-protein binding(GO:0017147)
1.0 8.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
1.7 6.7 GO:0035851 histone deacetylase activity (H4-K16 specific)(GO:0034739) Krueppel-associated box domain binding(GO:0035851)
1.6 6.5 GO:0008422 beta-glucosidase activity(GO:0008422)
1.3 6.4 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.1 5.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
1.2 4.7 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
1.1 4.3 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.4 4.0 GO:0071253 connexin binding(GO:0071253)
0.3 3.9 GO:0031996 thioesterase binding(GO:0031996)
0.1 3.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.3 3.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.9 253.7 PID_IGF1_PATHWAY IGF1 pathway
0.9 31.2 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.4 16.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
1.1 9.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 9.4 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 8.5 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 8.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 6.7 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 4.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.2 3.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 2.9 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 2.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 2.2 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 1.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 1.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.7 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 1.6 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.4 PID_LKB1_PATHWAY LKB1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
12.1 253.7 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 29.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 12.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.3 12.5 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 9.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.9 9.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 8.4 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.5 8.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5 8.1 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.4 4.7 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 3.6 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 3.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 3.1 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 2.9 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 2.3 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.7 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 1.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 1.4 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 1.1 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.6 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein