Motif ID: Hey1_Myc_Mxi1

Z-value: 0.982

Transcription factors associated with Hey1_Myc_Mxi1:

Gene SymbolEntrez IDGene Name
Hey1 ENSMUSG00000040289.3 Hey1
Mxi1 ENSMUSG00000025025.7 Mxi1
Myc ENSMUSG00000022346.8 Myc

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mxi1mm10_v2_chr19_+_53329413_53329478-0.453.8e-05Click!
Hey1mm10_v2_chr3_-_8667033_8667046-0.421.3e-04Click!
Mycmm10_v2_chr15_+_61987034_619870590.161.6e-01Click!


Activity profile for motif Hey1_Myc_Mxi1.

activity profile for motif Hey1_Myc_Mxi1


Sorted Z-values histogram for motif Hey1_Myc_Mxi1

Sorted Z-values for motif Hey1_Myc_Mxi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey1_Myc_Mxi1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_44788016 18.773 ENSMUST00000090057.4
ENSMUST00000110269.1
 Sybu

syntabulin (syntaxin-interacting)

chr4_+_148591482 12.329 ENSMUST00000006611.8
 Srm
spermidine synthase
chr11_+_98348404 10.816 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr6_+_108660616 10.468 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr15_+_44787746 10.333 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr8_+_13159135 9.103 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr6_+_108660772 8.780 ENSMUST00000163617.1
 Bhlhe40
basic helix-loop-helix family, member e40
chr15_-_77956658 8.753 ENSMUST00000117725.1
ENSMUST00000016696.6
 Foxred2

FAD-dependent oxidoreductase domain containing 2

chr17_-_26201363 8.593 ENSMUST00000121959.1
 Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr15_+_83791939 7.585 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr19_+_43440404 7.332 ENSMUST00000165311.1
 Cnnm1
cyclin M1
chr3_-_95882031 7.321 ENSMUST00000161994.1
 Gm129
predicted gene 129
chr3_+_104638658 7.008 ENSMUST00000046212.1
 Slc16a1
solute carrier family 16 (monocarboxylic acid transporters), member 1
chr6_+_88724412 6.927 ENSMUST00000113585.2
 Mgll
monoglyceride lipase
chr4_-_155992604 6.860 ENSMUST00000052185.3
 B3galt6
UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6
chr13_-_54055650 6.823 ENSMUST00000021932.5
 Drd1a
dopamine receptor D1A
chr9_+_34486125 6.800 ENSMUST00000115148.2
ENSMUST00000183580.1
 Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr6_+_88724828 6.627 ENSMUST00000089449.2
 Mgll
monoglyceride lipase
chr1_-_119422239 6.536 ENSMUST00000038765.5
 Inhbb
inhibin beta-B
chr11_-_55033398 6.475 ENSMUST00000108883.3
ENSMUST00000102727.2
 Anxa6

annexin A6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 478 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 25.9 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
3.4 24.0 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
2.3 16.4 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.5 14.6 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.2 14.0 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.2 12.7 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
3.1 12.3 GO:0008295 spermidine biosynthetic process(GO:0008295)
1.1 11.7 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
2.2 10.8 GO:0008355 olfactory learning(GO:0008355)
2.6 10.4 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
3.3 9.8 GO:0007621 negative regulation of female receptivity(GO:0007621)
3.2 9.5 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.6 9.0 GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000466)
1.4 8.6 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.5 8.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.8 8.5 GO:0006228 UTP biosynthetic process(GO:0006228)
1.6 8.1 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.4 8.1 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
2.0 8.0 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
1.5 7.7 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 214 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 26.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 24.8 GO:0070062 extracellular exosome(GO:0070062)
2.4 19.1 GO:0097433 dense body(GO:0097433)
1.0 16.3 GO:0043196 varicosity(GO:0043196)
0.3 14.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 14.1 GO:0043198 dendritic shaft(GO:0043198)
0.7 13.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 12.5 GO:0009925 basal plasma membrane(GO:0009925)
4.1 12.4 GO:0044194 cytolytic granule(GO:0044194)
0.0 12.4 GO:0014069 postsynaptic density(GO:0014069)
0.9 10.3 GO:0005642 annulate lamellae(GO:0005642)
2.6 10.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 10.2 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.3 10.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 9.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 9.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.4 9.6 GO:0030686 90S preribosome(GO:0030686)
0.2 9.6 GO:0005882 intermediate filament(GO:0005882)
0.7 9.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
1.7 8.6 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 337 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 28.8 GO:0003735 structural constituent of ribosome(GO:0003735)
1.0 27.3 GO:0017075 syntaxin-1 binding(GO:0017075)
1.8 24.0 GO:0047372 acylglycerol lipase activity(GO:0047372)
3.0 18.1 GO:0043426 MRF binding(GO:0043426)
0.4 15.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
2.4 14.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
1.9 13.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.7 11.9 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
2.9 11.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.4 11.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
3.6 10.8 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.5 10.8 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.6 10.3 GO:0017070 U6 snRNA binding(GO:0017070)
2.6 10.2 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.5 9.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.7 8.6 GO:0097643 amylin receptor activity(GO:0097643)
0.1 8.1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
2.7 8.0 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.4 7.9 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.6 7.8 GO:0008097 5S rRNA binding(GO:0008097)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 24.6 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
1.0 17.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 16.3 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 16.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.3 16.0 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 15.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 10.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 9.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 9.4 PID_P53_REGULATION_PATHWAY p53 pathway
0.2 9.0 PID_IL4_2PATHWAY IL4-mediated signaling events
0.1 9.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 7.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 6.0 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.3 5.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 5.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 5.3 PID_BMP_PATHWAY BMP receptor signaling
2.4 4.7 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 4.2 NABA_MATRISOME_ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1 3.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 27.6 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
1.1 25.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 23.3 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.2 18.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 18.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
1.0 15.7 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.5 15.6 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
1.2 14.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 13.5 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.4 12.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.4 11.6 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.3 10.9 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.4 10.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3 9.5 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.5 9.2 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 8.2 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 7.3 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.3 7.2 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 7.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.2 7.1 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis