Motif ID: Hey2

Z-value: 0.801


Transcription factors associated with Hey2:

Gene SymbolEntrez IDGene Name
Hey2 ENSMUSG00000019789.8 Hey2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hey2mm10_v2_chr10_-_30842765_30842801-0.521.2e-06Click!


Activity profile for motif Hey2.

activity profile for motif Hey2


Sorted Z-values histogram for motif Hey2

Sorted Z-values for motif Hey2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hey2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_105518736 8.891 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr4_-_107683576 6.530 ENSMUST00000131776.1
 Dmrtb1
DMRT-like family B with proline-rich C-terminal, 1
chr11_+_120721452 4.911 ENSMUST00000018156.5
 Rac3
RAS-related C3 botulinum substrate 3
chr8_+_87473116 4.881 ENSMUST00000182650.1
ENSMUST00000182758.1
ENSMUST00000181898.1
 Gm2694


predicted gene 2694


chr5_-_138996087 4.625 ENSMUST00000110897.1
 Pdgfa
platelet derived growth factor, alpha
chr11_+_120721543 4.220 ENSMUST00000142229.1
 Rac3
RAS-related C3 botulinum substrate 3
chr11_-_120348513 4.034 ENSMUST00000071555.6
 Actg1
actin, gamma, cytoplasmic 1
chr4_-_117133953 3.948 ENSMUST00000076859.5
 Plk3
polo-like kinase 3
chr8_+_87472805 3.855 ENSMUST00000180700.2
ENSMUST00000182174.1
ENSMUST00000181159.1
 Gm2694


predicted gene 2694


chr8_+_119446719 3.534 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr10_-_11080956 3.479 ENSMUST00000105560.1
 Grm1
glutamate receptor, metabotropic 1
chr13_-_68999518 3.422 ENSMUST00000022013.7
 Adcy2
adenylate cyclase 2
chr4_+_117835387 3.350 ENSMUST00000169885.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr8_+_87472838 3.328 ENSMUST00000180806.2
 Gm2694
predicted gene 2694
chr1_+_182763961 3.225 ENSMUST00000153348.1
 Susd4
sushi domain containing 4
chr2_+_140395446 2.969 ENSMUST00000110061.1
 Macrod2
MACRO domain containing 2
chr16_+_33829624 2.936 ENSMUST00000115028.3
 Itgb5
integrin beta 5
chr5_+_35757875 2.875 ENSMUST00000101280.3
ENSMUST00000054598.5
ENSMUST00000114205.1
ENSMUST00000114206.2
 Ablim2



actin-binding LIM protein 2



chr11_-_120348475 2.858 ENSMUST00000062147.7
ENSMUST00000128055.1
 Actg1

actin, gamma, cytoplasmic 1

chr19_+_22139028 2.857 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
 Trpm3


transient receptor potential cation channel, subfamily M, member 3



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 9.1 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.8 8.9 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.2 7.9 GO:0045214 sarcomere organization(GO:0045214)
0.0 6.1 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
1.5 4.6 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.3 4.4 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.4 3.9 GO:0090166 Golgi disassembly(GO:0090166) regulation of chaperone-mediated autophagy(GO:1904714)
1.2 3.5 GO:0060167 regulation of adenosine receptor signaling pathway(GO:0060167) regulation of G-protein coupled receptor internalization(GO:1904020)
0.9 3.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
1.1 3.4 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.8 3.2 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.0 3.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.4 3.1 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.7 3.0 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 3.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.2 2.9 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.9 2.8 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.2 2.8 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 2.8 GO:0007608 sensory perception of smell(GO:0007608)
0.5 2.5 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 17.1 GO:0031941 filamentous actin(GO:0031941)
0.0 5.2 GO:0098793 presynapse(GO:0098793)
0.1 4.6 GO:0005902 microvillus(GO:0005902)
0.2 4.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 4.2 GO:0005795 Golgi stack(GO:0005795)
0.3 3.5 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
1.0 2.9 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 2.9 GO:0030016 myofibril(GO:0030016)
0.9 2.8 GO:0044194 cytolytic granule(GO:0044194)
0.1 2.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.8 GO:0005903 brush border(GO:0005903)
0.1 2.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 2.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 2.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 2.5 GO:0000242 pericentriolar material(GO:0000242)
0.3 2.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 2.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 2.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.1 GO:0043209 myelin sheath(GO:0043209)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 9.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.6 8.9 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.0 7.1 GO:0003924 GTPase activity(GO:0003924)
0.3 4.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.4 4.4 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 3.9 GO:0002039 p53 binding(GO:0002039)
0.2 3.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 3.6 GO:0005178 integrin binding(GO:0005178)
1.7 3.5 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.9 3.5 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.1 3.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 3.4 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 3.0 GO:0019213 deacetylase activity(GO:0019213)
0.1 2.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 2.8 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.5 2.5 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.0 2.5 GO:0005261 cation channel activity(GO:0005261)
0.1 2.4 GO:0097602 cullin family protein binding(GO:0097602)
0.0 2.4 GO:0017048 Rho GTPase binding(GO:0017048)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.3 4.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 4.3 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 3.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 3.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 2.9 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.8 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.8 PID_P73PATHWAY p73 transcription factor network
0.1 2.5 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.1 2.1 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 1.8 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 1.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.1 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.1 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.0 PID_MTOR_4PATHWAY mTOR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.4 4.4 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 3.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.3 3.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 3.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 3.3 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 3.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.9 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.2 2.5 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 2.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 2.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 2.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 2.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.9 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.9 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.8 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.1 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling