Motif ID: Hic1

Z-value: 1.380


Transcription factors associated with Hic1:

Gene SymbolEntrez IDGene Name
Hic1 ENSMUSG00000043099.4 Hic1



Activity profile for motif Hic1.

activity profile for motif Hic1


Sorted Z-values histogram for motif Hic1

Sorted Z-values for motif Hic1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_7063423 13.335 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr5_-_146585239 11.392 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr11_-_6065538 9.950 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr8_+_70493156 9.928 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr5_+_141241490 9.597 ENSMUST00000085774.4
 Sdk1
sidekick homolog 1 (chicken)
chr13_+_109903089 9.399 ENSMUST00000120664.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr8_-_84800024 9.174 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr4_+_141368116 8.986 ENSMUST00000006380.4
 Fam131c
family with sequence similarity 131, member C
chr12_+_73997749 8.895 ENSMUST00000110451.2
 Syt16
synaptotagmin XVI
chr18_-_58209926 8.701 ENSMUST00000025497.6
 Fbn2
fibrillin 2
chr6_-_148444336 8.686 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr1_-_33907721 8.609 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr12_+_105336922 8.602 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr14_-_102982630 8.579 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr4_-_46991842 8.362 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr11_-_66525964 8.361 ENSMUST00000066679.6
 Shisa6
shisa homolog 6 (Xenopus laevis)
chr10_-_43174521 8.255 ENSMUST00000040275.7
 Sobp
sine oculis-binding protein homolog (Drosophila)
chr8_-_36249292 8.088 ENSMUST00000065297.5
 Lonrf1
LON peptidase N-terminal domain and ring finger 1
chr9_-_29412204 7.979 ENSMUST00000115237.1
 Ntm
neurotrimin
chr9_+_60712989 7.649 ENSMUST00000038407.5
 Larp6
La ribonucleoprotein domain family, member 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 483 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 21.8 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.3 20.3 GO:0050885 neuromuscular process controlling balance(GO:0050885)
2.7 18.6 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.7 17.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.0 16.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
5.2 15.7 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.9 15.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
3.1 15.6 GO:0071692 protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694)
1.1 15.0 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.2 14.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.3 14.8 GO:0034605 cellular response to heat(GO:0034605)
0.2 14.3 GO:0030032 lamellipodium assembly(GO:0030032)
0.8 14.1 GO:0006491 N-glycan processing(GO:0006491)
0.7 13.2 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
1.0 13.0 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
1.4 11.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
1.7 9.9 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 9.1 GO:0008654 phospholipid biosynthetic process(GO:0008654)
0.3 8.9 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.2 8.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 197 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 56.9 GO:0060076 excitatory synapse(GO:0060076)
0.0 45.5 GO:0016021 integral component of membrane(GO:0016021)
0.1 37.3 GO:0030425 dendrite(GO:0030425)
0.2 36.5 GO:0000139 Golgi membrane(GO:0000139)
0.4 25.0 GO:0009925 basal plasma membrane(GO:0009925)
0.5 19.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.6 17.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 17.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.9 17.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.4 15.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
4.8 14.3 GO:0098855 HCN channel complex(GO:0098855)
0.4 12.2 GO:0051233 spindle midzone(GO:0051233)
0.2 11.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 10.5 GO:0034702 ion channel complex(GO:0034702)
3.3 9.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.7 9.7 GO:0070852 cell body fiber(GO:0070852)
0.6 9.5 GO:1990635 proximal dendrite(GO:1990635)
0.2 9.2 GO:0048786 presynaptic active zone(GO:0048786)
0.0 9.2 GO:0045202 synapse(GO:0045202)
0.6 9.0 GO:0042101 T cell receptor complex(GO:0042101)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 314 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 24.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 20.6 GO:0005096 GTPase activator activity(GO:0005096)
3.1 18.7 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
4.7 18.6 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.8 18.5 GO:0043274 phospholipase binding(GO:0043274)
1.1 16.7 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.2 16.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
2.5 15.0 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
3.6 14.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
1.8 12.8 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.4 12.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
1.6 12.6 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
1.3 12.0 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.6 11.7 GO:0050811 GABA receptor binding(GO:0050811)
1.9 11.5 GO:0005042 netrin receptor activity(GO:0005042)
0.8 11.1 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.1 10.0 GO:0005516 calmodulin binding(GO:0005516)
0.3 9.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 9.3 GO:0003924 GTPase activity(GO:0003924)
0.3 9.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 20.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.5 20.3 PID_ARF6_PATHWAY Arf6 signaling events
0.8 18.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.4 15.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 14.1 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.1 13.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 10.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.2 8.8 PID_SHP2_PATHWAY SHP2 signaling
0.1 8.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 6.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 6.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 6.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 6.5 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.3 6.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 6.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 5.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 5.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
1.8 5.5 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.2 5.4 PID_ARF_3PATHWAY Arf1 pathway
0.2 5.2 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 38.3 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.7 26.2 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 20.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 18.1 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
1.4 17.2 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.6 17.2 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.5 16.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.4 15.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.7 12.7 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.5 12.5 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 12.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.4 11.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.4 11.2 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.3 10.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.4 10.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 9.6 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.3 9.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 8.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.6 8.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 8.2 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation