Motif ID: Hic2

Z-value: 1.871


Transcription factors associated with Hic2:

Gene SymbolEntrez IDGene Name
Hic2 ENSMUSG00000050240.8 Hic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hic2mm10_v2_chr16_+_17233560_17233664-0.262.2e-02Click!


Activity profile for motif Hic2.

activity profile for motif Hic2


Sorted Z-values histogram for motif Hic2

Sorted Z-values for motif Hic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_61523889 24.932 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr15_-_66831625 17.768 ENSMUST00000164163.1
 Sla
src-like adaptor
chr7_-_74554474 17.102 ENSMUST00000134539.1
ENSMUST00000026897.7
ENSMUST00000098371.2
 Slco3a1


solute carrier organic anion transporter family, member 3a1


chr11_+_104231465 14.502 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr2_-_163918683 14.391 ENSMUST00000044734.2
 Rims4
regulating synaptic membrane exocytosis 4
chr11_+_104231573 14.377 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr13_-_54055650 14.350 ENSMUST00000021932.5
 Drd1a
dopamine receptor D1A
chr10_-_109010955 14.321 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr11_+_104231515 14.302 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr11_+_75193783 14.227 ENSMUST00000102514.3
 Rtn4rl1
reticulon 4 receptor-like 1
chr1_+_74854954 14.153 ENSMUST00000160379.2
 Cdk5r2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr11_+_104231390 14.112 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr13_+_58807884 12.978 ENSMUST00000079828.5
 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr3_+_68584154 12.859 ENSMUST00000182997.1
 Schip1
schwannomin interacting protein 1
chr1_-_56969827 12.588 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr11_-_89302545 12.579 ENSMUST00000061728.3
 Nog
noggin
chr2_+_180499893 12.326 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr15_+_92051153 12.252 ENSMUST00000169825.1
 Cntn1
contactin 1
chr11_-_81968415 12.217 ENSMUST00000066197.6
 Asic2
acid-sensing (proton-gated) ion channel 2
chr1_-_56969864 11.961 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 432 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.4 57.3 GO:1900034 regulation of cellular response to heat(GO:1900034)
1.9 31.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.5 28.5 GO:0001553 luteinization(GO:0001553)
2.0 26.6 GO:0015732 prostaglandin transport(GO:0015732)
0.7 19.8 GO:0008340 determination of adult lifespan(GO:0008340)
6.5 19.6 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.6 18.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.1 16.4 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.6 15.7 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
3.5 14.2 GO:0021586 pons maturation(GO:0021586)
0.9 14.2 GO:0048681 negative regulation of axon regeneration(GO:0048681)
2.0 13.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.3 13.9 GO:0006414 translational elongation(GO:0006414)
1.9 13.4 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
1.7 13.4 GO:0005513 detection of calcium ion(GO:0005513)
1.6 12.9 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
2.1 12.7 GO:0032796 uropod organization(GO:0032796)
0.9 12.7 GO:0045161 neuronal ion channel clustering(GO:0045161)
1.8 12.4 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
3.1 12.3 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 194 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.7 57.3 GO:0045298 tubulin complex(GO:0045298)
0.5 47.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.7 41.8 GO:0009925 basal plasma membrane(GO:0009925)
0.7 33.3 GO:0048786 presynaptic active zone(GO:0048786)
1.5 30.2 GO:0098984 neuron to neuron synapse(GO:0098984)
0.2 25.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.6 24.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.6 18.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.1 17.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 15.9 GO:0044309 neuron spine(GO:0044309)
1.0 15.8 GO:0043196 varicosity(GO:0043196)
0.9 14.6 GO:0031045 dense core granule(GO:0031045)
0.5 14.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
4.7 14.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.9 14.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 13.8 GO:0043209 myelin sheath(GO:0043209)
3.1 12.3 GO:0032280 symmetric synapse(GO:0032280)
0.6 12.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
1.9 11.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.1 11.7 GO:0032426 stereocilium tip(GO:0032426)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 295 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.9 55.1 GO:0099609 microtubule lateral binding(GO:0099609)
3.9 27.6 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.7 25.9 GO:0022839 ion gated channel activity(GO:0022839)
2.8 19.6 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
1.1 17.6 GO:0045499 chemorepellent activity(GO:0045499)
0.6 17.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.7 16.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 15.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.4 15.3 GO:0030552 cAMP binding(GO:0030552)
0.7 14.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
3.6 14.3 GO:0030348 syntaxin-3 binding(GO:0030348)
1.6 14.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.5 14.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
1.0 13.8 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
2.6 13.0 GO:0005030 neurotrophin receptor activity(GO:0005030)
1.2 12.7 GO:0032036 myosin heavy chain binding(GO:0032036)
3.1 12.4 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
2.1 12.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.9 12.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.5 11.6 GO:0005044 scavenger receptor activity(GO:0005044)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 57.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 22.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 21.5 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.4 17.7 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.3 16.9 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
1.0 15.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.3 14.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.4 14.1 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.3 14.1 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.3 13.4 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.3 12.7 PID_ALK1_PATHWAY ALK1 signaling events
0.3 12.3 PID_BMP_PATHWAY BMP receptor signaling
0.4 12.1 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.4 11.5 PID_ARF_3PATHWAY Arf1 pathway
0.2 10.3 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.4 9.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 9.1 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.3 8.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.8 8.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 8.0 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 56.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
3.3 26.2 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
1.9 24.2 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
1.1 24.2 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 23.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.3 17.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 17.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.6 16.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.5 14.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
1.4 14.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.4 13.6 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.4 13.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 12.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.3 11.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.4 11.1 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.8 10.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
1.4 9.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 8.9 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.6 8.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.4 7.9 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling