Motif ID: Hif1a
Z-value: 0.911
Transcription factors associated with Hif1a:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hif1a | ENSMUSG00000021109.7 | Hif1a |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hif1a | mm10_v2_chr12_+_73907904_73907970 | -0.62 | 1.8e-09 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 11.7 | GO:0043379 | memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 2.1 | 6.2 | GO:0061762 | CAMKK-AMPK signaling cascade(GO:0061762) |
| 1.8 | 5.4 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 1.8 | 8.8 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
| 1.6 | 4.8 | GO:0071336 | white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) |
| 1.6 | 1.6 | GO:0033122 | regulation of purine nucleotide catabolic process(GO:0033121) negative regulation of purine nucleotide catabolic process(GO:0033122) |
| 1.4 | 7.1 | GO:0019659 | fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 1.4 | 9.7 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 1.3 | 4.0 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 1.3 | 10.2 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 1.3 | 3.8 | GO:1990523 | bone regeneration(GO:1990523) |
| 1.1 | 4.5 | GO:2000313 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) |
| 1.1 | 4.2 | GO:1900740 | regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740) |
| 1.0 | 3.9 | GO:0060025 | regulation of synaptic activity(GO:0060025) |
| 0.9 | 4.4 | GO:0003376 | sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520) |
| 0.8 | 2.3 | GO:0009153 | purine deoxyribonucleotide biosynthetic process(GO:0009153) |
| 0.8 | 6.1 | GO:0045541 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.7 | 8.1 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.7 | 1.4 | GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:0001844) |
| 0.6 | 3.1 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.6 | 1.8 | GO:0015886 | heme transport(GO:0015886) |
| 0.6 | 3.9 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.5 | 2.1 | GO:0006498 | N-terminal protein lipidation(GO:0006498) |
| 0.5 | 3.2 | GO:0035356 | cellular triglyceride homeostasis(GO:0035356) |
| 0.5 | 1.5 | GO:2000224 | regulation of testosterone biosynthetic process(GO:2000224) |
| 0.5 | 1.9 | GO:0018201 | peptidyl-glycine modification(GO:0018201) |
| 0.5 | 1.8 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
| 0.4 | 1.3 | GO:0006154 | adenosine catabolic process(GO:0006154) |
| 0.4 | 2.7 | GO:0070127 | tRNA aminoacylation for mitochondrial protein translation(GO:0070127) |
| 0.3 | 5.4 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.3 | 1.3 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.3 | 2.1 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.3 | 1.5 | GO:0032346 | positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) |
| 0.3 | 0.9 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
| 0.3 | 1.2 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.3 | 0.8 | GO:0033615 | mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) |
| 0.3 | 0.8 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) response to cobalt ion(GO:0032025) mitochondrial protein catabolic process(GO:0035694) |
| 0.2 | 0.5 | GO:2000017 | positive regulation of determination of dorsal identity(GO:2000017) |
| 0.2 | 2.2 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.2 | 2.2 | GO:0030388 | fructose 6-phosphate metabolic process(GO:0006002) fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.2 | 2.9 | GO:0010884 | positive regulation of lipid storage(GO:0010884) |
| 0.2 | 0.6 | GO:0071211 | protein targeting to vacuole involved in autophagy(GO:0071211) |
| 0.2 | 1.4 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.2 | 6.3 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.2 | 1.8 | GO:0070475 | rRNA base methylation(GO:0070475) |
| 0.2 | 0.9 | GO:0015871 | choline transport(GO:0015871) negative regulation of RIG-I signaling pathway(GO:0039536) |
| 0.2 | 1.0 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 0.2 | 2.8 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.2 | 1.7 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.2 | 0.8 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 0.1 | 1.5 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.1 | 13.1 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.1 | 2.3 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 3.5 | GO:0030431 | sleep(GO:0030431) |
| 0.1 | 4.3 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.1 | 4.0 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.1 | 0.9 | GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447) |
| 0.1 | 1.7 | GO:1904816 | positive regulation of protein localization to chromosome, telomeric region(GO:1904816) |
| 0.1 | 0.6 | GO:0032439 | endosome localization(GO:0032439) |
| 0.1 | 1.1 | GO:0046958 | nonassociative learning(GO:0046958) |
| 0.1 | 0.4 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.1 | 2.5 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 0.1 | 0.9 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.1 | 1.0 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.1 | 1.8 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.1 | 0.3 | GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) |
| 0.1 | 0.2 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.1 | 2.0 | GO:0014002 | astrocyte development(GO:0014002) |
| 0.1 | 2.2 | GO:0051443 | positive regulation of ubiquitin-protein transferase activity(GO:0051443) |
| 0.1 | 0.3 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 0.1 | 5.0 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.1 | 0.5 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.1 | 3.3 | GO:0009311 | oligosaccharide metabolic process(GO:0009311) |
| 0.1 | 1.0 | GO:0048240 | sperm capacitation(GO:0048240) |
| 0.1 | 1.3 | GO:0007413 | axonal fasciculation(GO:0007413) |
| 0.1 | 3.5 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.0 | 0.2 | GO:0006244 | pyrimidine nucleotide catabolic process(GO:0006244) pyrimidine deoxyribonucleotide catabolic process(GO:0009223) |
| 0.0 | 0.7 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.0 | 2.8 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154) |
| 0.0 | 0.2 | GO:0002903 | negative regulation of B cell apoptotic process(GO:0002903) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) |
| 0.0 | 0.9 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.0 | 1.1 | GO:0045471 | response to ethanol(GO:0045471) |
| 0.0 | 0.9 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.0 | 3.4 | GO:0071229 | cellular response to acid chemical(GO:0071229) |
| 0.0 | 0.2 | GO:0018126 | protein hydroxylation(GO:0018126) |
| 0.0 | 2.5 | GO:0006413 | translational initiation(GO:0006413) |
| 0.0 | 0.9 | GO:0008214 | protein demethylation(GO:0006482) protein dealkylation(GO:0008214) |
| 0.0 | 0.1 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.0 | 0.5 | GO:0009299 | mRNA transcription(GO:0009299) |
| 0.0 | 2.8 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.0 | 2.6 | GO:0001649 | osteoblast differentiation(GO:0001649) |
| 0.0 | 0.2 | GO:0070301 | cellular response to hydrogen peroxide(GO:0070301) |
| 0.0 | 5.2 | GO:0007186 | G-protein coupled receptor signaling pathway(GO:0007186) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 13.1 | GO:0097433 | dense body(GO:0097433) |
| 1.0 | 3.0 | GO:0005967 | mitochondrial pyruvate dehydrogenase complex(GO:0005967) |
| 0.6 | 9.7 | GO:0043196 | varicosity(GO:0043196) |
| 0.5 | 2.2 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.5 | 7.1 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.4 | 4.0 | GO:0005883 | neurofilament(GO:0005883) |
| 0.4 | 3.4 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.3 | 1.4 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.3 | 3.1 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.3 | 1.7 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.2 | 2.2 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
| 0.2 | 8.2 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.2 | 3.8 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 0.4 | GO:0048179 | activin receptor complex(GO:0048179) |
| 0.1 | 10.3 | GO:0005657 | replication fork(GO:0005657) |
| 0.1 | 1.4 | GO:0046930 | pore complex(GO:0046930) |
| 0.1 | 0.6 | GO:0045179 | apical cortex(GO:0045179) |
| 0.1 | 2.6 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.1 | 1.2 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 6.4 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 1.7 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 3.5 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 0.9 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 1.2 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.1 | 3.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 2.5 | GO:0005768 | endosome(GO:0005768) |
| 0.0 | 1.1 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.3 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.0 | 0.9 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 2.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.3 | GO:0034709 | methylosome(GO:0034709) |
| 0.0 | 1.0 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 1.3 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 0.9 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 6.6 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.9 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 1.0 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 4.7 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.8 | GO:0032592 | integral component of mitochondrial membrane(GO:0032592) |
| 0.0 | 4.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 1.2 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 4.8 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 0.5 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.6 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 0.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 6.3 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.4 | GO:0022833 | mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833) |
| 1.8 | 7.1 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 1.7 | 10.2 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 1.5 | 4.4 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
| 1.3 | 9.4 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 1.2 | 4.8 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 1.1 | 3.2 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
| 1.0 | 4.0 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 1.0 | 3.9 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 1.0 | 11.7 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.9 | 3.5 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.8 | 3.1 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.7 | 9.7 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.7 | 2.1 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.6 | 1.8 | GO:0009383 | rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) |
| 0.6 | 1.8 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.5 | 2.2 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.5 | 13.1 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.4 | 6.6 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.4 | 8.8 | GO:0071949 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) FAD binding(GO:0071949) |
| 0.4 | 1.5 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.4 | 3.4 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.4 | 4.6 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.3 | 2.9 | GO:0031545 | peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.3 | 1.3 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.3 | 0.3 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.3 | 4.0 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.2 | 1.7 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.2 | 2.2 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.2 | 2.3 | GO:0019206 | nucleoside kinase activity(GO:0019206) |
| 0.2 | 1.5 | GO:0005004 | GPI-linked ephrin receptor activity(GO:0005004) |
| 0.2 | 0.9 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 0.2 | 3.8 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.2 | 8.3 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.2 | 6.2 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.2 | 1.4 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 1.5 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 0.4 | GO:0016361 | activin receptor activity, type I(GO:0016361) |
| 0.1 | 1.4 | GO:0031418 | L-ascorbic acid binding(GO:0031418) |
| 0.1 | 2.5 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 0.5 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.1 | 4.0 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 0.3 | GO:0030519 | snoRNP binding(GO:0030519) |
| 0.1 | 1.3 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.1 | 2.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 3.6 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
| 0.1 | 1.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 0.2 | GO:0035605 | peptidyl-cysteine S-nitrosylase activity(GO:0035605) |
| 0.1 | 3.0 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 3.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 0.9 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.1 | 1.7 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 1.0 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.1 | 2.7 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.0 | 0.6 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.0 | 0.9 | GO:0001056 | RNA polymerase III activity(GO:0001056) |
| 0.0 | 4.3 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.0 | 0.3 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.0 | 2.8 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 3.1 | GO:0019955 | cytokine binding(GO:0019955) |
| 0.0 | 1.1 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 3.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 2.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 5.2 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.0 | 0.1 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.0 | 0.9 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.0 | 1.1 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 0.6 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.0 | 0.2 | GO:0019103 | pyrimidine nucleotide binding(GO:0019103) |
| 0.0 | 1.3 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 0.8 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.8 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.0 | 0.6 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.0 | 1.1 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.5 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.1 | GO:0000182 | rDNA binding(GO:0000182) |
| 0.0 | 0.1 | GO:0038191 | neuropilin binding(GO:0038191) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.6 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.1 | 10.1 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.1 | 6.6 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.1 | 3.8 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 5.3 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 9.2 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 5.6 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 0.5 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 1.5 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 5.8 | PID_VEGFR1_2_PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.1 | 1.5 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.1 | 0.8 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.6 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 2.7 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.1 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.7 | PID_AVB3_OPN_PATHWAY | Osteopontin-mediated events |
| 0.0 | 1.1 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 6.6 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.6 | PID_MYC_REPRESS_PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.9 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.7 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.4 | 4.8 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
| 0.3 | 7.3 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
| 0.3 | 2.6 | REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.2 | 3.1 | REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.2 | 2.9 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.2 | 5.1 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.1 | 5.8 | REACTOME_GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 2.7 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.1 | 2.2 | REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.1 | 1.8 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 1.6 | REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 3.6 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 16.0 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 1.8 | REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 1.5 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 1.0 | REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 9.7 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 3.6 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 1.2 | REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 0.9 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 1.1 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 3.2 | REACTOME_TRIGLYCERIDE_BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.0 | 3.5 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.9 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 1.9 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.7 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 0.0 | 1.2 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.4 | REACTOME_SIGNALING_BY_NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.2 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 0.9 | REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.0 | 0.2 | REACTOME_SOS_MEDIATED_SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.0 | 3.6 | REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES | Genes involved in Transmission across Chemical Synapses |
| 0.0 | 0.8 | REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 1.0 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 1.8 | REACTOME_TRANSLATION | Genes involved in Translation |
