Motif ID: Hinfp

Z-value: 1.475


Transcription factors associated with Hinfp:

Gene SymbolEntrez IDGene Name
Hinfp ENSMUSG00000032119.4 Hinfp

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hinfpmm10_v2_chr9_-_44305595_443056880.216.2e-02Click!


Activity profile for motif Hinfp.

activity profile for motif Hinfp


Sorted Z-values histogram for motif Hinfp

Sorted Z-values for motif Hinfp



Network of associatons between targets according to the STRING database.



First level regulatory network of Hinfp

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_80300866 19.751 ENSMUST00000017836.7
 Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr9_+_118478182 18.534 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 17.709 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr13_+_51645232 17.328 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr5_-_106458440 17.077 ENSMUST00000086795.6
 Barhl2
BarH-like 2 (Drosophila)
chr2_-_91931675 13.826 ENSMUST00000111309.1
 Mdk
midkine
chr17_-_35702297 13.809 ENSMUST00000135078.1
 Ddr1
discoidin domain receptor family, member 1
chr19_+_25610533 12.473 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr14_+_65806066 12.319 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr7_+_122159422 11.479 ENSMUST00000033154.6
 Plk1
polo-like kinase 1
chr5_+_108694222 10.920 ENSMUST00000013633.8
ENSMUST00000112560.3
 Fgfrl1

fibroblast growth factor receptor-like 1

chr17_-_35701937 10.790 ENSMUST00000155628.1
 Ddr1
discoidin domain receptor family, member 1
chr4_+_52439235 10.673 ENSMUST00000117280.1
ENSMUST00000102915.3
ENSMUST00000142227.1
 Smc2


structural maintenance of chromosomes 2


chr5_+_33658123 10.495 ENSMUST00000074849.6
ENSMUST00000079534.4
 Tacc3

transforming, acidic coiled-coil containing protein 3

chr1_+_139454747 10.325 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr4_+_97777606 10.301 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr14_-_8666236 9.923 ENSMUST00000102996.3
 4930452B06Rik
RIKEN cDNA 4930452B06 gene
chr3_+_69004711 9.650 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr6_+_120666388 9.372 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr2_+_124610573 9.334 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
12.1 36.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
3.6 28.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
2.0 24.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.3 20.7 GO:0006635 fatty acid beta-oxidation(GO:0006635)
1.0 17.1 GO:0030953 astral microtubule organization(GO:0030953)
0.5 17.1 GO:0001709 cell fate determination(GO:0001709)
3.1 15.7 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
4.6 13.8 GO:0030421 defecation(GO:0030421)
0.9 13.4 GO:0043249 erythrocyte maturation(GO:0043249)
0.2 13.3 GO:0001824 blastocyst development(GO:0001824)
0.9 13.0 GO:0072189 ureter development(GO:0072189)
1.1 12.5 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.3 12.3 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.2 11.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
2.9 11.5 GO:0040038 polar body extrusion after meiotic divisions(GO:0040038)
2.7 11.0 GO:0006014 D-ribose metabolic process(GO:0006014)
1.0 10.9 GO:0060539 diaphragm development(GO:0060539)
2.1 10.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.9 10.3 GO:1901250 regulation of lung goblet cell differentiation(GO:1901249) negative regulation of lung goblet cell differentiation(GO:1901250)
1.0 10.0 GO:0006610 ribosomal protein import into nucleus(GO:0006610)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.6 35.6 GO:0000796 condensin complex(GO:0000796)
6.6 19.9 GO:0036125 mitochondrial fatty acid beta-oxidation multienzyme complex(GO:0016507) fatty acid beta-oxidation multienzyme complex(GO:0036125)
0.3 19.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 16.8 GO:0005829 cytosol(GO:0005829)
0.2 15.9 GO:0005643 nuclear pore(GO:0005643)
0.1 11.8 GO:0000922 spindle pole(GO:0000922)
0.0 11.6 GO:0005615 extracellular space(GO:0005615)
2.9 11.5 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 10.9 GO:0044291 cell-cell contact zone(GO:0044291)
2.1 10.3 GO:0036449 microtubule minus-end(GO:0036449)
2.3 9.4 GO:0090537 CERF complex(GO:0090537)
0.2 9.1 GO:0016235 aggresome(GO:0016235)
1.2 8.3 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
1.4 8.2 GO:1990356 sumoylated E2 ligase complex(GO:1990356)
0.1 8.1 GO:0005871 kinesin complex(GO:0005871)
1.9 7.8 GO:0000939 nuclear MIS12/MIND complex(GO:0000818) condensed chromosome inner kinetochore(GO:0000939)
1.9 7.6 GO:0070552 BRISC complex(GO:0070552)
0.0 7.6 GO:0005667 transcription factor complex(GO:0005667)
0.0 7.5 GO:0031965 nuclear membrane(GO:0031965)
0.9 7.3 GO:0033269 internode region of axon(GO:0033269)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 38.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 28.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.3 28.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 27.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 26.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
2.7 24.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.7 20.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
5.1 20.2 GO:0016508 long-chain-enoyl-CoA hydratase activity(GO:0016508)
4.3 17.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 16.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 14.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 13.8 GO:0008083 growth factor activity(GO:0008083)
1.9 11.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.2 10.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
3.3 9.8 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.5 9.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 8.9 GO:0061650 ubiquitin-like protein conjugating enzyme activity(GO:0061650)
1.4 8.2 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.1 8.1 GO:0003777 microtubule motor activity(GO:0003777)
1.0 7.9 GO:0046790 virion binding(GO:0046790)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 37.3 PID_IL12_2PATHWAY IL12-mediated signaling events
0.5 21.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.5 20.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.7 18.9 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.5 18.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.4 15.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.4 11.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.2 11.0 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.3 10.8 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.2 10.3 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 9.0 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 7.9 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 6.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 5.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 4.3 PID_CD40_PATHWAY CD40/CD40L signaling
0.2 4.0 PID_MYC_PATHWAY C-MYC pathway
0.2 4.0 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.6 PID_HIV_NEF_PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.1 3.6 PID_RB_1PATHWAY Regulation of retinoblastoma protein

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 24.2 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
1.4 23.6 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.6 15.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 13.3 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 12.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 12.1 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.7 11.5 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.6 11.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.4 9.1 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.3 8.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.5 7.4 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3 7.1 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.4 6.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.6 6.1 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.3 6.1 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 5.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 5.2 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.2 4.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 4.3 REACTOME_ION_CHANNEL_TRANSPORT Genes involved in Ion channel transport
0.2 4.2 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Early Phase of HIV Life Cycle