Motif ID: Hivep1

Z-value: 0.841


Transcription factors associated with Hivep1:

Gene SymbolEntrez IDGene Name
Hivep1 ENSMUSG00000021366.7 Hivep1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hivep1mm10_v2_chr13_+_42052015_420520720.161.7e-01Click!


Activity profile for motif Hivep1.

activity profile for motif Hivep1


Sorted Z-values histogram for motif Hivep1

Sorted Z-values for motif Hivep1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hivep1

PNG image of the network

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Top targets:


Showing 1 to 20 of 160 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_88000350 11.774 ENSMUST00000090971.5
 Bcan
brevican
chr10_-_27616895 9.543 ENSMUST00000092639.5
 Lama2
laminin, alpha 2
chr5_-_98030727 6.602 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr3_-_107760221 6.365 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr2_-_113758638 5.988 ENSMUST00000099575.3
 Grem1
gremlin 1
chr14_+_51984857 5.806 ENSMUST00000100639.4
ENSMUST00000182909.1
ENSMUST00000182760.1
ENSMUST00000182061.1
ENSMUST00000182193.1
 Arhgef40




Rho guanine nucleotide exchange factor (GEF) 40




chr5_-_134747241 5.613 ENSMUST00000015138.9
 Eln
elastin
chr14_+_51984826 5.289 ENSMUST00000093813.5
 Arhgef40
Rho guanine nucleotide exchange factor (GEF) 40
chr1_-_156204998 4.914 ENSMUST00000015628.3
 Fam163a
family with sequence similarity 163, member A
chr14_+_80000292 4.902 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr17_-_35701937 4.892 ENSMUST00000155628.1
 Ddr1
discoidin domain receptor family, member 1
chr18_+_84088077 4.584 ENSMUST00000060223.2
 Zadh2
zinc binding alcohol dehydrogenase, domain containing 2
chr1_+_74791516 4.326 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr14_+_60732906 4.211 ENSMUST00000162945.1
 Spata13
spermatogenesis associated 13
chr17_-_34000257 3.978 ENSMUST00000087189.6
ENSMUST00000173075.1
ENSMUST00000172760.1
ENSMUST00000172912.1
ENSMUST00000025181.10
 H2-K1




histocompatibility 2, K1, K region




chr11_+_62077018 3.910 ENSMUST00000092415.5
 Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr4_-_133968611 3.657 ENSMUST00000102552.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr17_-_33890539 3.579 ENSMUST00000173386.1
 Kifc1
kinesin family member C1
chr17_+_35439155 3.514 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr7_-_102250086 3.503 ENSMUST00000106923.1
ENSMUST00000098230.4
 Rhog

ras homolog gene family, member G


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
2.5 12.4 GO:0002158 osteoclast proliferation(GO:0002158)
0.9 10.7 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.9 9.5 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.1 8.2 GO:0021766 hippocampus development(GO:0021766)
0.2 7.8 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
2.3 7.0 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
0.1 6.6 GO:1901998 toxin transport(GO:1901998)
0.2 5.8 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.8 5.3 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.1 4.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.7 4.4 GO:0097473 cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.5 4.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
1.0 4.0 GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.1 4.0 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
1.2 3.5 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 3.5 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.4 3.4 GO:1902373 negative regulation of mRNA catabolic process(GO:1902373)
0.0 3.2 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
1.3 2.7 GO:0046878 positive regulation of saliva secretion(GO:0046878)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.6 GO:0031225 anchored component of membrane(GO:0031225)
1.0 11.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 10.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.3 7.0 GO:0031616 spindle pole centrosome(GO:0031616)
2.1 6.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
1.9 5.6 GO:0071953 elastic fiber(GO:0071953)
0.4 4.9 GO:0042581 specific granule(GO:0042581)
0.0 4.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 4.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 4.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 4.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 3.9 GO:0001726 ruffle(GO:0001726)
0.2 3.6 GO:0005605 basal lamina(GO:0005605)
0.1 3.5 GO:0008180 COP9 signalosome(GO:0008180)
0.2 3.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.3 3.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.7 2.7 GO:0032127 dense core granule membrane(GO:0032127)
0.1 2.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 2.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 2.6 GO:0005901 caveola(GO:0005901)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 11.8 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.7 11.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 11.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.2 10.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.5 7.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.7 6.2 GO:0036122 BMP binding(GO:0036122)
0.1 6.2 GO:0005125 cytokine activity(GO:0005125)
0.2 5.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
1.5 4.6 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 4.4 GO:0005080 protein kinase C binding(GO:0005080)
0.1 4.3 GO:0005109 frizzled binding(GO:0005109)
0.1 4.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 3.5 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.1 3.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.3 3.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 2.7 GO:0015166 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
0.9 2.6 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.5 2.6 GO:0098821 BMP receptor activity(GO:0098821)
0.1 2.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.3 GO:0003777 microtubule motor activity(GO:0003777)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
1.2 9.5 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 7.8 PID_BMP_PATHWAY BMP receptor signaling
0.1 7.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4 6.6 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.6 6.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 5.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 4.4 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 4.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 3.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 2.6 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.1 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 2.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 1.8 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.1 1.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.3 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 1.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.1 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 1.1 PID_IL2_1PATHWAY IL2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 11.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.3 7.0 REACTOME_KINESINS Genes involved in Kinesins
0.3 4.4 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 3.9 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 3.8 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 3.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 3.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 2.7 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.6 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 2.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 2.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 2.1 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.5 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 1.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.3 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.1 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling