Motif ID: Hlf

Z-value: 0.611


Transcription factors associated with Hlf:

Gene SymbolEntrez IDGene Name
Hlf ENSMUSG00000003949.10 Hlf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlfmm10_v2_chr11_-_90390895_90390926-0.402.7e-04Click!


Activity profile for motif Hlf.

activity profile for motif Hlf


Sorted Z-values histogram for motif Hlf

Sorted Z-values for motif Hlf



Network of associatons between targets according to the STRING database.



First level regulatory network of Hlf

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_77894096 5.360 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr5_+_3343893 5.079 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr15_+_25758755 4.637 ENSMUST00000131834.1
ENSMUST00000124966.1
 Myo10

myosin X

chr5_-_124032214 4.000 ENSMUST00000040967.7
 Vps37b
vacuolar protein sorting 37B (yeast)
chr16_+_43510267 3.946 ENSMUST00000114695.2
 Zbtb20
zinc finger and BTB domain containing 20
chr7_-_46667375 3.658 ENSMUST00000107669.2
 Tph1
tryptophan hydroxylase 1
chr3_+_66219909 3.357 ENSMUST00000029421.5
 Ptx3
pentraxin related gene
chr19_-_28963863 3.353 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr2_+_25180737 3.297 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr12_+_102554966 2.956 ENSMUST00000021610.5
 Chga
chromogranin A
chr6_+_17463749 2.838 ENSMUST00000115443.1
 Met
met proto-oncogene
chr3_+_51559973 2.788 ENSMUST00000180404.1
 5031434O11Rik
RIKEN cDNA 5031434O11 gene
chr3_+_127553462 2.623 ENSMUST00000043108.4
 4930422G04Rik
RIKEN cDNA 4930422G04 gene
chr11_-_101551837 2.585 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr3_+_86070915 2.537 ENSMUST00000182666.1
 Sh3d19
SH3 domain protein D19
chr15_-_88978958 2.501 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr6_+_124808885 2.274 ENSMUST00000143040.1
ENSMUST00000052727.4
ENSMUST00000130160.1
 Spsb2


splA/ryanodine receptor domain and SOCS box containing 2


chr18_-_35498856 2.226 ENSMUST00000025215.8
 Sil1
endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)
chr19_+_60144682 2.164 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr7_+_67647405 2.074 ENSMUST00000032774.8
ENSMUST00000107471.1
 Ttc23

tetratricopeptide repeat domain 23


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 6.6 GO:0044838 cell quiescence(GO:0044838)
1.8 5.4 GO:0006553 lysine metabolic process(GO:0006553)
0.1 4.1 GO:0051489 regulation of filopodium assembly(GO:0051489)
1.3 4.0 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 3.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.5 3.7 GO:1901162 serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.7 3.4 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.3 3.3 GO:0014807 regulation of somitogenesis(GO:0014807)
0.5 3.2 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.5 3.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.0 3.0 GO:1901079 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of muscle(GO:1901079)
0.4 2.8 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1 2.7 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.9 2.6 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.3 2.5 GO:0071397 cellular response to cholesterol(GO:0071397)
0.7 2.2 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.7 2.0 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.6 1.9 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
0.2 1.9 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 1.9 GO:0045187 regulation of circadian sleep/wake cycle, sleep(GO:0045187)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 4.6 GO:0016459 myosin complex(GO:0016459)
0.5 4.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 3.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.4 2.6 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 2.6 GO:0036126 sperm flagellum(GO:0036126)
0.0 2.5 GO:0005901 caveola(GO:0005901)
0.0 2.2 GO:0000786 nucleosome(GO:0000786)
0.4 2.1 GO:0042583 chromaffin granule(GO:0042583)
0.0 1.8 GO:0043195 terminal bouton(GO:0043195)
0.3 1.5 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 1.4 GO:0000922 spindle pole(GO:0000922)
0.1 1.0 GO:0070652 HAUS complex(GO:0070652)
0.2 0.9 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
0.1 0.9 GO:0098536 deuterosome(GO:0098536)
0.1 0.9 GO:0042629 mast cell granule(GO:0042629)
0.1 0.9 GO:0032009 early phagosome(GO:0032009)
0.1 0.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 0.8 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 0.8 GO:0031143 pseudopodium(GO:0031143)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 5.4 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
1.7 5.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.1 4.8 GO:0030507 spectrin binding(GO:0030507)
1.3 3.8 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 3.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
1.2 3.7 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.5 3.4 GO:0001849 complement component C1q binding(GO:0001849)
1.1 3.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.7 2.8 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 2.5 GO:0070064 proline-rich region binding(GO:0070064)
0.7 2.2 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.7 2.0 GO:0098809 nitrite reductase activity(GO:0098809)
0.0 2.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.5 1.9 GO:0001851 complement component C3b binding(GO:0001851)
0.0 1.9 GO:0005109 frizzled binding(GO:0005109)
0.6 1.8 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182)
0.1 1.7 GO:0008301 DNA binding, bending(GO:0008301)
0.4 1.6 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 1.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.5 1.5 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 5.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 5.3 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 4.8 ST_ADRENERGIC Adrenergic Pathway
0.1 4.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.8 PID_ARF6_PATHWAY Arf6 signaling events
0.4 2.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 0.9 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 0.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.6 PID_ATM_PATHWAY ATM pathway
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.5 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.4 4.9 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.4 4.0 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 3.4 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 3.3 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 2.8 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 2.6 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 2.2 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 2.0 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.4 1.9 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.6 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.6 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.1 1.5 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.4 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 1.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac