Motif ID: Hlf
Z-value: 0.611
Transcription factors associated with Hlf:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hlf | ENSMUSG00000003949.10 | Hlf |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hlf | mm10_v2_chr11_-_90390895_90390926 | -0.40 | 2.7e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.4 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 1.3 | 4.0 | GO:1903774 | positive regulation of viral budding via host ESCRT complex(GO:1903774) |
| 1.0 | 3.0 | GO:1901079 | positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of muscle(GO:1901079) |
| 0.9 | 6.6 | GO:0044838 | cell quiescence(GO:0044838) |
| 0.9 | 2.6 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.7 | 2.2 | GO:0032918 | polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918) |
| 0.7 | 3.4 | GO:0052428 | modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428) |
| 0.7 | 2.0 | GO:0019343 | cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344) |
| 0.6 | 1.9 | GO:0046122 | purine deoxyribonucleoside metabolic process(GO:0046122) |
| 0.5 | 3.2 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.5 | 1.5 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.5 | 3.2 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.5 | 3.7 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
| 0.4 | 2.8 | GO:0070494 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.4 | 1.1 | GO:0009814 | defense response, incompatible interaction(GO:0009814) |
| 0.4 | 1.8 | GO:0015817 | glutamine transport(GO:0006868) histidine transport(GO:0015817) cellular response to potassium ion starvation(GO:0051365) |
| 0.4 | 1.4 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.3 | 0.6 | GO:0002314 | germinal center B cell differentiation(GO:0002314) |
| 0.3 | 3.3 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.3 | 0.9 | GO:1990927 | negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927) |
| 0.3 | 0.9 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.3 | 1.4 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.3 | 1.4 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
| 0.3 | 2.5 | GO:0071397 | cellular response to cholesterol(GO:0071397) |
| 0.2 | 0.7 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.2 | 1.5 | GO:0033600 | negative regulation of mammary gland epithelial cell proliferation(GO:0033600) regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 0.2 | 1.7 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.2 | 1.6 | GO:0015862 | uridine transport(GO:0015862) |
| 0.2 | 0.7 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.2 | 1.5 | GO:0042167 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.2 | 0.8 | GO:0071442 | positive regulation of histone H3-K14 acetylation(GO:0071442) |
| 0.2 | 1.9 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
| 0.2 | 1.3 | GO:0046549 | phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549) |
| 0.2 | 0.4 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.2 | 0.9 | GO:0046601 | positive regulation of centriole replication(GO:0046601) |
| 0.2 | 0.9 | GO:1904721 | regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721) |
| 0.2 | 0.5 | GO:1901069 | guanosine-containing compound catabolic process(GO:1901069) |
| 0.2 | 1.1 | GO:0006551 | leucine metabolic process(GO:0006551) |
| 0.2 | 0.6 | GO:0033326 | cerebrospinal fluid secretion(GO:0033326) |
| 0.2 | 0.5 | GO:1903722 | regulation of centriole elongation(GO:1903722) |
| 0.2 | 0.5 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
| 0.2 | 0.8 | GO:0051684 | maintenance of Golgi location(GO:0051684) |
| 0.1 | 0.4 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.1 | 1.9 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
| 0.1 | 0.9 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.1 | 0.7 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.1 | 0.5 | GO:2000319 | negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.1 | 2.7 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.1 | 1.0 | GO:0035428 | hexose transmembrane transport(GO:0035428) |
| 0.1 | 1.1 | GO:0070475 | rRNA base methylation(GO:0070475) |
| 0.1 | 0.3 | GO:0001978 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) |
| 0.1 | 3.9 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.5 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) gamma-aminobutyric acid receptor clustering(GO:0097112) |
| 0.1 | 0.4 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.1 | 0.8 | GO:0006701 | progesterone biosynthetic process(GO:0006701) |
| 0.1 | 0.6 | GO:0032049 | cardiolipin biosynthetic process(GO:0032049) |
| 0.1 | 0.2 | GO:0031554 | regulation of DNA-templated transcription, termination(GO:0031554) |
| 0.1 | 0.8 | GO:0031272 | regulation of pseudopodium assembly(GO:0031272) |
| 0.1 | 0.2 | GO:0002175 | protein localization to paranode region of axon(GO:0002175) |
| 0.1 | 0.2 | GO:2000850 | cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850) |
| 0.1 | 0.2 | GO:1900060 | negative regulation of ceramide biosynthetic process(GO:1900060) |
| 0.1 | 4.1 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.1 | 0.4 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 0.6 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.1 | 0.7 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.0 | 0.8 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.0 | 1.2 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
| 0.0 | 0.2 | GO:0090282 | trophectodermal cellular morphogenesis(GO:0001831) positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282) |
| 0.0 | 0.1 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 0.9 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.0 | 0.3 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.0 | 0.2 | GO:1900864 | mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864) |
| 0.0 | 0.7 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.1 | GO:0060023 | soft palate development(GO:0060023) |
| 0.0 | 1.5 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.0 | 0.2 | GO:0006384 | transcription initiation from RNA polymerase III promoter(GO:0006384) |
| 0.0 | 0.2 | GO:0032621 | interleukin-18 production(GO:0032621) |
| 0.0 | 0.6 | GO:0072112 | renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311) |
| 0.0 | 0.2 | GO:1902410 | mitotic cytokinetic process(GO:1902410) |
| 0.0 | 0.3 | GO:0019896 | axonal transport of mitochondrion(GO:0019896) |
| 0.0 | 0.8 | GO:0002082 | regulation of oxidative phosphorylation(GO:0002082) |
| 0.0 | 0.4 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) germ cell proliferation(GO:0036093) |
| 0.0 | 1.4 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.5 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.0 | 0.3 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.0 | 0.9 | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle(GO:0010972) |
| 0.0 | 0.1 | GO:0000393 | spliceosomal conformational changes to generate catalytic conformation(GO:0000393) |
| 0.0 | 0.3 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.0 | 0.2 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 0.1 | GO:1902037 | negative regulation of hematopoietic stem cell differentiation(GO:1902037) |
| 0.0 | 0.2 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 1.3 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.0 | 0.9 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.0 | 0.2 | GO:0060253 | negative regulation of glial cell proliferation(GO:0060253) |
| 0.0 | 1.2 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.0 | 0.6 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.0 | 0.2 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.0 | 0.6 | GO:0050819 | negative regulation of coagulation(GO:0050819) |
| 0.0 | 0.1 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.0 | 0.2 | GO:0042407 | mitochondrial protein processing(GO:0034982) cristae formation(GO:0042407) |
| 0.0 | 0.5 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.1 | GO:1903223 | positive regulation of oxidative stress-induced neuron death(GO:1903223) positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 0.0 | 0.9 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.0 | 0.4 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.1 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.0 | 0.1 | GO:0006824 | cobalt ion transport(GO:0006824) |
| 0.0 | 0.3 | GO:0007143 | female meiotic division(GO:0007143) |
| 0.0 | 0.2 | GO:0030953 | astral microtubule organization(GO:0030953) |
| 0.0 | 0.3 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.0 | 0.3 | GO:0042474 | middle ear morphogenesis(GO:0042474) |
| 0.0 | 1.0 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.0 | 0.3 | GO:0051497 | negative regulation of stress fiber assembly(GO:0051497) |
| 0.0 | 0.8 | GO:0000086 | G2/M transition of mitotic cell cycle(GO:0000086) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.4 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.4 | 2.6 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.4 | 2.1 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.3 | 1.5 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.2 | 0.9 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.1 | 0.9 | GO:0098536 | deuterosome(GO:0098536) |
| 0.1 | 1.0 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.1 | 0.8 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.1 | 0.9 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 0.9 | GO:0032009 | early phagosome(GO:0032009) |
| 0.1 | 0.2 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.1 | 4.7 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 4.6 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 0.2 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.1 | 0.8 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 0.5 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.1 | 0.4 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.1 | 0.7 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 0.8 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.5 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 0.2 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.0 | 0.7 | GO:0044232 | organelle membrane contact site(GO:0044232) |
| 0.0 | 0.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.5 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.0 | 0.6 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 0.5 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 2.2 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 2.6 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 0.7 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.0 | 2.5 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 0.1 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.0 | 3.7 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 0.1 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.0 | 0.7 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.0 | 0.5 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.8 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.6 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 1.4 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.8 | GO:0005844 | polysome(GO:0005844) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.1 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 1.3 | 5.4 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 1.3 | 3.8 | GO:0004731 | purine-nucleoside phosphorylase activity(GO:0004731) |
| 1.2 | 3.7 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 1.1 | 3.2 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.7 | 2.2 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
| 0.7 | 2.8 | GO:0005008 | hepatocyte growth factor-activated receptor activity(GO:0005008) |
| 0.7 | 2.0 | GO:0098809 | nitrite reductase activity(GO:0098809) |
| 0.6 | 1.8 | GO:0015182 | L-asparagine transmembrane transporter activity(GO:0015182) |
| 0.5 | 1.5 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.5 | 3.4 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.5 | 1.9 | GO:0001851 | complement component C3b binding(GO:0001851) |
| 0.4 | 1.6 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.4 | 1.5 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 0.3 | 1.3 | GO:0042834 | peptidoglycan binding(GO:0042834) |
| 0.3 | 1.5 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 0.2 | 1.4 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.2 | 1.1 | GO:0016434 | rRNA (cytosine) methyltransferase activity(GO:0016434) |
| 0.2 | 0.5 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.2 | 0.7 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.2 | 0.5 | GO:0044715 | 8-oxo-dGDP phosphatase activity(GO:0044715) |
| 0.1 | 1.2 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.1 | 0.9 | GO:0060698 | endoribonuclease inhibitor activity(GO:0060698) |
| 0.1 | 0.7 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.1 | 1.7 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.1 | 0.4 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.1 | 0.5 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.1 | 0.7 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.1 | 2.5 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 4.8 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 1.0 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.1 | 1.1 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.1 | 1.6 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.1 | 0.7 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.1 | 0.8 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.1 | 1.2 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.1 | 0.6 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.0 | 0.2 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.0 | 0.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 1.2 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 1.9 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.0 | 3.8 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.2 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.0 | 0.8 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
| 0.0 | 0.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.8 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.2 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 0.2 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
| 0.0 | 0.2 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.0 | 0.1 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.0 | 0.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 0.1 | GO:0097003 | adipokinetic hormone receptor activity(GO:0097003) |
| 0.0 | 0.2 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 0.9 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 2.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.6 | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups(GO:0016780) |
| 0.0 | 0.2 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.0 | 0.4 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.9 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 0.2 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.0 | 0.6 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.0 | 0.3 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.3 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 1.5 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.0 | 0.9 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.0 | 0.7 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 0.2 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.0 | 0.9 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 0.9 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.1 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.0 | 1.5 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.1 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.5 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 0.3 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.1 | GO:0015087 | cobalt ion transmembrane transporter activity(GO:0015087) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.2 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 5.3 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.1 | 5.3 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.1 | 4.0 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.1 | 4.8 | ST_ADRENERGIC | Adrenergic Pathway |
| 0.1 | 2.8 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 1.5 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.5 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.9 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 6.0 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.9 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.5 | PID_PTP1B_PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 1.0 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 0.6 | PID_ATM_PATHWAY | ATM pathway |
| 0.0 | 0.9 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 4.9 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.4 | 1.9 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
| 0.4 | 4.0 | REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.1 | 2.6 | REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 2.2 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 1.5 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 5.3 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
| 0.1 | 1.4 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 2.0 | REACTOME_SULFUR_AMINO_ACID_METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 1.0 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 1.6 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 1.1 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 2.8 | REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING | Genes involved in Sema4D in semaphorin signaling |
| 0.1 | 1.5 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 0.6 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PG | Genes involved in Acyl chain remodelling of PG |
| 0.1 | 0.7 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.1 | 1.1 | REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 1.8 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 3.3 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.6 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 1.9 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.8 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.0 | 0.5 | REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 0.5 | REACTOME_SIGNAL_ATTENUATION | Genes involved in Signal attenuation |
| 0.0 | 0.5 | REACTOME_SIGNALING_BY_PDGF | Genes involved in Signaling by PDGF |
| 0.0 | 0.5 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 0.9 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.8 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.6 | REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.0 | 3.4 | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 0.8 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.6 | REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.0 | 0.7 | REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.5 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.0 | 0.2 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.3 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.5 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.8 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.1 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
