Motif ID: Hlx

Z-value: 0.237


Transcription factors associated with Hlx:

Gene SymbolEntrez IDGene Name
Hlx ENSMUSG00000039377.6 Hlx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hlxmm10_v2_chr1_-_184732616_1847326270.309.2e-03Click!


Activity profile for motif Hlx.

activity profile for motif Hlx


Sorted Z-values histogram for motif Hlx

Sorted Z-values for motif Hlx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hlx

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_45103747 2.199 ENSMUST00000003512.7
 Fcgrt
Fc receptor, IgG, alpha chain transporter
chr15_-_8710734 1.695 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_+_54980880 1.522 ENSMUST00000093844.3
 Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr15_-_8710409 1.513 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr6_+_7555053 0.801 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr10_+_102158858 0.566 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
 Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr17_-_50094277 0.564 ENSMUST00000113195.1
 Rftn1
raftlin lipid raft linker 1
chr19_+_53944870 0.261 ENSMUST00000025932.7
 Shoc2
soc-2 (suppressor of clear) homolog (C. elegans)
chr19_-_53944621 0.254 ENSMUST00000135402.2
 Bbip1
BBSome interacting protein 1
chr1_+_180109192 0.193 ENSMUST00000143176.1
ENSMUST00000135056.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr5_-_62766153 0.180 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_-_34313531 0.077 ENSMUST00000108074.1
 4931406P16Rik
RIKEN cDNA 4931406P16 gene
chrM_+_2743 0.071 ENSMUST00000082392.1
 mt-Nd1
mitochondrially encoded NADH dehydrogenase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.2 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.3 0.8 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.2 1.5 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.6 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.1 0.3 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0034464 BBSome(GO:0034464)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 3.2 GO:0043197 dendritic spine(GO:0043197)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.4 2.2 GO:0019770 IgG receptor activity(GO:0019770)
0.2 1.5 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 0.6 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.8 GO:0071855 neuropeptide receptor binding(GO:0071855)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 3.2 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.6 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation