Motif ID: Hmbox1

Z-value: 1.389


Transcription factors associated with Hmbox1:

Gene SymbolEntrez IDGene Name
Hmbox1 ENSMUSG00000021972.8 Hmbox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmbox1mm10_v2_chr14_-_64949838_649498860.601.0e-08Click!


Activity profile for motif Hmbox1.

activity profile for motif Hmbox1


Sorted Z-values histogram for motif Hmbox1

Sorted Z-values for motif Hmbox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmbox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 137 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 46.437 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_+_100625737 27.465 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr11_+_101468164 21.365 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr3_-_100969644 14.917 ENSMUST00000076941.5
 Ttf2
transcription termination factor, RNA polymerase II
chr10_-_49783259 13.915 ENSMUST00000105484.3
ENSMUST00000105486.1
ENSMUST00000079751.2
ENSMUST00000105485.1
 Grik2



glutamate receptor, ionotropic, kainate 2 (beta 2)



chr15_+_25773985 12.994 ENSMUST00000125667.1
 Myo10
myosin X
chr8_+_45507768 12.484 ENSMUST00000067065.7
ENSMUST00000098788.3
ENSMUST00000067107.7
ENSMUST00000171337.2
ENSMUST00000138049.1
ENSMUST00000141039.1
 Sorbs2





sorbin and SH3 domain containing 2





chr2_-_172043466 12.010 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr8_+_45658666 11.845 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr8_+_45658731 11.376 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr4_-_97584612 11.275 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chrX_-_23266751 11.203 ENSMUST00000115316.2
 Klhl13
kelch-like 13
chr6_+_5390387 9.850 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chrX_-_12160355 9.722 ENSMUST00000043441.6
 Bcor
BCL6 interacting corepressor
chr11_-_64436653 9.660 ENSMUST00000177999.1
 F930015N05Rik
RIKEN cDNA F930015N05 gene
chr1_-_75278345 7.667 ENSMUST00000039534.4
 Resp18
regulated endocrine-specific protein 18
chr3_-_95217690 7.070 ENSMUST00000107209.1
 Gabpb2
GA repeat binding protein, beta 2
chr13_-_3893556 6.785 ENSMUST00000099946.4
 Net1
neuroepithelial cell transforming gene 1
chr1_+_88227005 6.560 ENSMUST00000061013.6
ENSMUST00000113130.1
 Mroh2a

maestro heat-like repeat family member 2A

chr9_-_78368167 6.356 ENSMUST00000071991.5
 Dppa5a
developmental pluripotency associated 5A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.7 46.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.8 35.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
2.7 27.5 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
1.4 21.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.7 14.9 GO:0006353 DNA-templated transcription, termination(GO:0006353)
1.3 13.9 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.1 13.0 GO:0022409 positive regulation of cell-cell adhesion(GO:0022409)
0.8 12.1 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 10.4 GO:0009306 protein secretion(GO:0009306)
0.9 9.9 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
2.4 9.7 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.1 9.3 GO:0000910 cytokinesis(GO:0000910)
0.8 9.1 GO:2000381 negative regulation of mesoderm development(GO:2000381)
1.0 8.9 GO:0035372 protein localization to microtubule(GO:0035372)
0.7 8.2 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.5 7.0 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.5 6.8 GO:0051451 myoblast migration(GO:0051451)
0.1 5.5 GO:0051310 metaphase plate congression(GO:0051310)
0.1 5.4 GO:0006821 chloride transport(GO:0006821)
0.5 5.3 GO:0006020 inositol metabolic process(GO:0006020)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 34.9 GO:0014069 postsynaptic density(GO:0014069)
0.5 27.5 GO:0045171 intercellular bridge(GO:0045171)
0.1 21.4 GO:0005769 early endosome(GO:0005769)
0.1 14.9 GO:0005681 spliceosomal complex(GO:0005681)
0.2 14.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
2.3 13.9 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.1 13.0 GO:0030175 filopodium(GO:0030175)
0.2 11.3 GO:0031985 Golgi cisterna(GO:0031985)
2.0 9.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 9.9 GO:0005815 microtubule organizing center(GO:0005815)
0.1 9.7 GO:0031519 PcG protein complex(GO:0031519)
0.1 8.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
1.5 7.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 6.0 GO:0030496 midbody(GO:0030496)
0.1 5.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 5.5 GO:0000775 chromosome, centromeric region(GO:0000775)
1.0 5.2 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.2 5.1 GO:0030992 intraciliary transport particle B(GO:0030992)
0.3 4.5 GO:0042788 polysomal ribosome(GO:0042788)
0.1 4.4 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 46.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.0 30.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 30.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 28.5 GO:0008270 zinc ion binding(GO:0008270)
0.0 23.6 GO:0019904 protein domain specific binding(GO:0019904)
0.1 20.8 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 14.6 GO:0046982 protein heterodimerization activity(GO:0046982)
2.3 13.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 13.0 GO:0030507 spectrin binding(GO:0030507)
0.4 12.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 9.1 GO:0000287 magnesium ion binding(GO:0000287)
0.1 7.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 7.0 GO:0001671 ATPase activator activity(GO:0001671)
0.3 6.8 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 5.4 GO:0005254 chloride channel activity(GO:0005254)
1.3 5.3 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.1 5.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.5 5.2 GO:0004017 adenylate kinase activity(GO:0004017)
1.7 5.1 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.1 4.4 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 11.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 9.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 6.8 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 5.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 5.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 4.3 PID_IL4_2PATHWAY IL4-mediated signaling events
0.2 3.9 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 3.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.2 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.0 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.0 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.7 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 2.7 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.6 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 1.5 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.7 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 14.4 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.8 13.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 13.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.6 8.3 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 6.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 5.2 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.4 5.1 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 3.9 REACTOME_CHROMOSOME_MAINTENANCE Genes involved in Chromosome Maintenance
0.1 3.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 3.2 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 3.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 3.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 2.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 2.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.5 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 1.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)