Motif ID: Hmga1

Z-value: 1.013


Transcription factors associated with Hmga1:

Gene SymbolEntrez IDGene Name
Hmga1 ENSMUSG00000046711.9 Hmga1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmga1mm10_v2_chr17_+_27556613_275566350.181.2e-01Click!


Activity profile for motif Hmga1.

activity profile for motif Hmga1


Sorted Z-values histogram for motif Hmga1

Sorted Z-values for motif Hmga1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmga1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 25.779 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chrX_-_103483205 7.442 ENSMUST00000127786.2
 Xist
inactive X specific transcripts
chr15_-_56694525 7.207 ENSMUST00000050544.7
 Has2
hyaluronan synthase 2
chr12_-_108003594 5.750 ENSMUST00000066060.4
 Bcl11b
B cell leukemia/lymphoma 11B
chr13_+_5861489 5.436 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr16_-_26989974 5.288 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr1_+_107511416 4.474 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr19_-_19001099 4.021 ENSMUST00000040153.8
ENSMUST00000112828.1
 Rorb

RAR-related orphan receptor beta

chr12_+_52699297 3.819 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr4_-_97584605 3.778 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_-_52490736 3.754 ENSMUST00000170269.1
 Nab1
Ngfi-A binding protein 1
chr1_-_126830632 3.720 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr13_+_83573577 3.568 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr5_-_123666682 3.476 ENSMUST00000149410.1
 Clip1
CAP-GLY domain containing linker protein 1
chr3_+_134236483 3.451 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr1_+_180101144 3.402 ENSMUST00000133890.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chr18_-_62741387 3.326 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr8_+_45658666 3.268 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr3_-_120886691 3.251 ENSMUST00000182099.1
ENSMUST00000183168.1
ENSMUST00000183276.1
ENSMUST00000182124.1
 6530403H02Rik



RIKEN cDNA 6530403H02 gene



chr8_+_45658731 3.186 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.4 26.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 9.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 8.0 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
2.5 7.6 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
2.5 7.4 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
1.8 7.2 GO:1900623 positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.2 6.3 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
1.0 5.8 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.1 5.3 GO:0006270 DNA replication initiation(GO:0006270)
0.0 5.3 GO:0010466 negative regulation of peptidase activity(GO:0010466)
1.6 4.8 GO:0007525 somatic muscle development(GO:0007525)
0.3 4.8 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 4.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.5 4.6 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.6 4.0 GO:0046549 retinal cone cell development(GO:0046549)
0.0 3.9 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
1.0 3.8 GO:2000481 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.5 3.8 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.4 3.8 GO:0071420 cellular response to histamine(GO:0071420)
1.2 3.6 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.5 GO:0042641 actomyosin(GO:0042641)
0.0 12.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.7 7.4 GO:0000805 X chromosome(GO:0000805)
0.1 6.6 GO:0044295 axonal growth cone(GO:0044295)
0.2 4.9 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 4.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 4.3 GO:0044452 nucleolar part(GO:0044452)
0.3 3.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 3.8 GO:0005640 nuclear outer membrane(GO:0005640)
0.5 3.5 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 3.3 GO:0001669 acrosomal vesicle(GO:0001669)
0.6 3.2 GO:0044316 cone cell pedicle(GO:0044316)
0.2 2.9 GO:0070852 cell body fiber(GO:0070852)
0.1 2.8 GO:0010369 chromocenter(GO:0010369)
0.0 2.6 GO:0032587 ruffle membrane(GO:0032587)
0.1 2.4 GO:0016592 mediator complex(GO:0016592)
0.5 2.3 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.2 2.3 GO:0043196 varicosity(GO:0043196)
0.1 2.3 GO:0060077 inhibitory synapse(GO:0060077)
0.4 2.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 8.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 7.8 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 7.6 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
2.4 7.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 6.8 GO:0000287 magnesium ion binding(GO:0000287)
0.1 5.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 5.5 GO:0051010 microtubule plus-end binding(GO:0051010)
1.3 4.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 3.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.6 3.8 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3 3.8 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.3 3.8 GO:0043495 protein anchor(GO:0043495)
0.2 3.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 3.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 3.7 GO:0035064 methylated histone binding(GO:0035064)
0.2 3.6 GO:0003680 AT DNA binding(GO:0003680)
0.2 3.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 3.3 GO:0017124 SH3 domain binding(GO:0017124)
0.1 3.1 GO:0008143 poly(A) binding(GO:0008143)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.7 PID_E2F_PATHWAY E2F transcription factor network
0.1 7.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 6.3 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 6.0 PID_CDC42_PATHWAY CDC42 signaling events
0.0 4.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.5 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 3.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.0 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 2.5 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.4 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 2.0 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 1.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 1.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 1.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 1.3 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 1.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.1 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.1 0.6 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 7.2 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.1 5.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 4.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.9 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.2 3.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 3.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 3.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
1.0 2.9 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.2 2.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 2.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 2.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 2.2 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.2 2.0 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.0 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 2.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 1.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 1.7 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling