Motif ID: Hmga1
Z-value: 1.013
Transcription factors associated with Hmga1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hmga1 | ENSMUSG00000046711.9 | Hmga1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hmga1 | mm10_v2_chr17_+_27556613_27556635 | 0.18 | 1.2e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 26.1 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 2.5 | 7.6 | GO:0003345 | proepicardium cell migration involved in pericardium morphogenesis(GO:0003345) |
| 2.5 | 7.4 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 1.8 | 7.2 | GO:1900623 | positive regulation of keratinocyte proliferation(GO:0010838) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 1.6 | 4.8 | GO:0007525 | somatic muscle development(GO:0007525) |
| 1.2 | 3.6 | GO:0007521 | muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111) |
| 1.0 | 3.0 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 1.0 | 5.8 | GO:0021773 | striatal medium spiny neuron differentiation(GO:0021773) |
| 1.0 | 3.8 | GO:2000481 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of cAMP-dependent protein kinase activity(GO:2000481) |
| 0.9 | 2.6 | GO:1902071 | positive regulation of cellular response to hypoxia(GO:1900039) regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071) |
| 0.9 | 3.5 | GO:0044861 | protein transport into plasma membrane raft(GO:0044861) |
| 0.7 | 2.9 | GO:0010511 | regulation of phosphatidylinositol biosynthetic process(GO:0010511) |
| 0.7 | 2.1 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.7 | 3.3 | GO:0060467 | negative regulation of fertilization(GO:0060467) |
| 0.7 | 2.6 | GO:2000182 | regulation of progesterone biosynthetic process(GO:2000182) |
| 0.6 | 4.0 | GO:0046549 | retinal cone cell development(GO:0046549) |
| 0.6 | 2.2 | GO:0006272 | DNA replication, synthesis of RNA primer(GO:0006269) leading strand elongation(GO:0006272) |
| 0.5 | 3.8 | GO:0090234 | regulation of kinetochore assembly(GO:0090234) |
| 0.5 | 2.6 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.5 | 1.5 | GO:1900127 | positive regulation of hyaluronan biosynthetic process(GO:1900127) |
| 0.5 | 2.0 | GO:0051643 | endoplasmic reticulum localization(GO:0051643) |
| 0.5 | 1.5 | GO:0045409 | negative regulation of interleukin-6 biosynthetic process(GO:0045409) |
| 0.5 | 1.5 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.5 | 4.6 | GO:0061470 | interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619) |
| 0.4 | 2.7 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.4 | 1.8 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 0.4 | 1.3 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.4 | 3.8 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.3 | 1.0 | GO:0048687 | positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) |
| 0.3 | 2.3 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.3 | 1.0 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 0.3 | 1.3 | GO:0060745 | mammary gland branching involved in pregnancy(GO:0060745) |
| 0.3 | 0.9 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203) |
| 0.3 | 1.8 | GO:0072318 | clathrin coat disassembly(GO:0072318) |
| 0.3 | 4.8 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.3 | 1.4 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.3 | 2.0 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.3 | 8.0 | GO:0007097 | nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) |
| 0.3 | 1.1 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
| 0.3 | 1.3 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) |
| 0.3 | 1.0 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) |
| 0.3 | 1.0 | GO:0044330 | canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096) |
| 0.2 | 9.4 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.2 | 0.7 | GO:0043323 | positive regulation of natural killer cell degranulation(GO:0043323) |
| 0.2 | 1.2 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.2 | 1.9 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.2 | 1.2 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.2 | 2.4 | GO:0090209 | negative regulation of triglyceride metabolic process(GO:0090209) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.2 | 0.7 | GO:1990927 | negative regulation of tumor necrosis factor secretion(GO:1904468) negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927) |
| 0.2 | 1.3 | GO:0098734 | protein depalmitoylation(GO:0002084) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) negative regulation of establishment of protein localization to plasma membrane(GO:0090005) macromolecule depalmitoylation(GO:0098734) |
| 0.2 | 1.1 | GO:0090669 | snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669) |
| 0.2 | 1.1 | GO:0015692 | vanadium ion transport(GO:0015676) lead ion transport(GO:0015692) |
| 0.2 | 1.9 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.2 | 0.6 | GO:0021972 | corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260) |
| 0.2 | 0.6 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.2 | 0.8 | GO:2001271 | negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271) |
| 0.2 | 0.7 | GO:1902774 | late endosome to lysosome transport(GO:1902774) |
| 0.2 | 1.9 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.2 | 1.5 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
| 0.2 | 1.6 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.2 | 6.3 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.2 | 0.9 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.2 | 1.4 | GO:0035887 | aortic smooth muscle cell differentiation(GO:0035887) |
| 0.1 | 0.9 | GO:0032796 | uropod organization(GO:0032796) |
| 0.1 | 2.4 | GO:0008209 | androgen metabolic process(GO:0008209) |
| 0.1 | 5.3 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 1.1 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 0.1 | 1.6 | GO:0006012 | galactose metabolic process(GO:0006012) |
| 0.1 | 0.9 | GO:0000414 | regulation of histone H3-K36 methylation(GO:0000414) |
| 0.1 | 0.5 | GO:0036216 | response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368) |
| 0.1 | 1.8 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 1.8 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.1 | 0.6 | GO:0019659 | fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 0.1 | 0.4 | GO:0002182 | cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248) |
| 0.1 | 0.4 | GO:0097401 | synaptic vesicle lumen acidification(GO:0097401) |
| 0.1 | 1.5 | GO:1900119 | positive regulation of execution phase of apoptosis(GO:1900119) |
| 0.1 | 1.0 | GO:1900364 | regulation of mRNA polyadenylation(GO:1900363) negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.1 | 0.3 | GO:0021998 | neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) positive regulation of cardiac ventricle development(GO:1904414) |
| 0.1 | 0.9 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.1 | 1.4 | GO:0034390 | smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) |
| 0.1 | 0.6 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.1 | 0.6 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 0.9 | GO:0045945 | positive regulation of transcription from RNA polymerase III promoter(GO:0045945) |
| 0.1 | 0.8 | GO:0035988 | chondrocyte proliferation(GO:0035988) |
| 0.1 | 0.4 | GO:0006706 | steroid catabolic process(GO:0006706) |
| 0.1 | 2.9 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.1 | 0.2 | GO:0072592 | oxygen metabolic process(GO:0072592) |
| 0.1 | 2.2 | GO:0007617 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
| 0.1 | 1.8 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.1 | 0.4 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.1 | 0.5 | GO:0042447 | ubiquitin homeostasis(GO:0010992) hormone catabolic process(GO:0042447) |
| 0.1 | 0.4 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.1 | 1.5 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 0.7 | GO:0000076 | DNA replication checkpoint(GO:0000076) |
| 0.1 | 0.7 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.1 | 1.1 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.1 | 4.7 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.6 | GO:0071549 | cellular response to dexamethasone stimulus(GO:0071549) |
| 0.0 | 0.7 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 0.2 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
| 0.0 | 0.5 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 0.4 | GO:0071763 | nuclear membrane organization(GO:0071763) |
| 0.0 | 1.0 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.0 | 2.8 | GO:0060349 | bone morphogenesis(GO:0060349) |
| 0.0 | 1.3 | GO:0000027 | ribosomal large subunit assembly(GO:0000027) |
| 0.0 | 0.7 | GO:0010603 | regulation of cytoplasmic mRNA processing body assembly(GO:0010603) |
| 0.0 | 1.4 | GO:0045494 | photoreceptor cell maintenance(GO:0045494) |
| 0.0 | 5.3 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.0 | 1.6 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 0.3 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.0 | 1.0 | GO:0000154 | rRNA modification(GO:0000154) |
| 0.0 | 0.7 | GO:0044342 | type B pancreatic cell proliferation(GO:0044342) |
| 0.0 | 0.5 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 0.3 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 0.8 | GO:0072348 | sulfur compound transport(GO:0072348) |
| 0.0 | 0.2 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 0.0 | 1.7 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 2.1 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.1 | GO:0051030 | snRNA transport(GO:0051030) |
| 0.0 | 0.7 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 0.3 | GO:0048194 | Golgi vesicle budding(GO:0048194) |
| 0.0 | 1.8 | GO:0001824 | blastocyst development(GO:0001824) |
| 0.0 | 2.3 | GO:0000086 | G2/M transition of mitotic cell cycle(GO:0000086) |
| 0.0 | 1.7 | GO:0030879 | mammary gland development(GO:0030879) |
| 0.0 | 0.6 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 0.1 | GO:1903441 | protein localization to ciliary membrane(GO:1903441) |
| 0.0 | 0.2 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 0.0 | 0.1 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
| 0.0 | 0.1 | GO:0046501 | protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.0 | 1.4 | GO:1903076 | regulation of protein localization to plasma membrane(GO:1903076) |
| 0.0 | 1.4 | GO:0060348 | bone development(GO:0060348) |
| 0.0 | 2.5 | GO:0001666 | response to hypoxia(GO:0001666) |
| 0.0 | 3.9 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 0.0 | 0.2 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.0 | 0.2 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 0.6 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 0.0 | 1.0 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 0.9 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 0.0 | 0.4 | GO:0051220 | cytoplasmic sequestering of protein(GO:0051220) |
| 0.0 | 0.3 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.3 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
| 0.0 | 0.4 | GO:0030500 | regulation of bone mineralization(GO:0030500) |
| 0.0 | 0.2 | GO:0043392 | negative regulation of DNA binding(GO:0043392) |
| 0.0 | 0.1 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 7.4 | GO:0000805 | X chromosome(GO:0000805) |
| 0.7 | 2.0 | GO:0042642 | actomyosin, myosin complex part(GO:0042642) |
| 0.6 | 3.2 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.5 | 2.0 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
| 0.5 | 3.5 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.5 | 2.3 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.4 | 2.2 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.4 | 1.1 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.3 | 1.0 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.3 | 1.1 | GO:0090661 | box H/ACA telomerase RNP complex(GO:0090661) |
| 0.3 | 3.8 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.2 | 2.1 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.2 | 1.8 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.2 | 2.9 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.2 | 1.5 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.2 | 4.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.2 | 1.1 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.2 | 3.8 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.2 | 1.7 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.2 | 4.9 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.2 | 2.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.2 | 0.9 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.2 | 2.3 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 1.5 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 1.0 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 2.8 | GO:0010369 | chromocenter(GO:0010369) |
| 0.1 | 1.5 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 6.6 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 0.7 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.1 | 0.6 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.1 | 12.5 | GO:0042641 | actomyosin(GO:0042641) |
| 0.1 | 0.6 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.1 | 2.3 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 1.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 0.9 | GO:0032426 | stereocilium tip(GO:0032426) |
| 0.1 | 1.4 | GO:0071564 | npBAF complex(GO:0071564) |
| 0.1 | 1.5 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 0.7 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.1 | 0.3 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.1 | 2.4 | GO:0016592 | mediator complex(GO:0016592) |
| 0.1 | 0.7 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.1 | 0.6 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 1.4 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.1 | 2.2 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 1.1 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.0 | 0.4 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.0 | 3.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 12.3 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 1.3 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.0 | 0.8 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 2.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.9 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.4 | GO:0097539 | ciliary transition fiber(GO:0097539) |
| 0.0 | 0.4 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.2 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 0.0 | 0.3 | GO:0005687 | U4 snRNP(GO:0005687) |
| 0.0 | 1.5 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.3 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 1.8 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 4.3 | GO:0044452 | nucleolar part(GO:0044452) |
| 0.0 | 0.7 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 1.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.6 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 1.3 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.5 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.4 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 0.2 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.2 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 1.3 | 4.0 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 1.0 | 2.9 | GO:0004993 | G-protein coupled serotonin receptor activity(GO:0004993) |
| 0.9 | 2.7 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 0.6 | 3.8 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.5 | 1.6 | GO:0004335 | galactokinase activity(GO:0004335) |
| 0.5 | 1.6 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.5 | 8.0 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.4 | 1.3 | GO:0031798 | type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052) |
| 0.4 | 1.8 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.3 | 2.1 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.3 | 1.6 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.3 | 5.5 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.3 | 3.8 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.3 | 3.8 | GO:0043495 | protein anchor(GO:0043495) |
| 0.3 | 2.1 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.2 | 1.0 | GO:0019808 | polyamine binding(GO:0019808) |
| 0.2 | 0.9 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.2 | 3.6 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.2 | 1.1 | GO:0015086 | cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.2 | 3.8 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.2 | 1.5 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.2 | 1.4 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.2 | 0.6 | GO:0001888 | glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0001888) |
| 0.2 | 1.3 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
| 0.2 | 3.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.2 | 2.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.2 | 0.9 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.2 | 1.1 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
| 0.1 | 0.6 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.1 | 1.0 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.1 | 2.2 | GO:0019103 | pyrimidine nucleotide binding(GO:0019103) |
| 0.1 | 3.1 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 1.9 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 2.6 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 1.3 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 2.0 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 0.1 | 5.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 0.3 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.1 | 2.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 1.5 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 2.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.1 | 1.3 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.1 | 0.9 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 0.4 | GO:0072320 | volume-sensitive chloride channel activity(GO:0072320) |
| 0.1 | 1.2 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.1 | 2.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 16.4 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 1.3 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.1 | 2.0 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.1 | 1.1 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 1.3 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.1 | 1.0 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 1.5 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.1 | 1.5 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 0.2 | GO:0004816 | asparagine-tRNA ligase activity(GO:0004816) |
| 0.1 | 2.3 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 2.2 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 0.5 | GO:0043559 | insulin binding(GO:0043559) |
| 0.1 | 1.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 2.3 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 1.5 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.1 | 1.9 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 0.4 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.1 | 0.6 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 1.0 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 3.7 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 0.9 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 7.6 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
| 0.0 | 1.8 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.3 | GO:0098821 | BMP receptor activity(GO:0098821) |
| 0.0 | 0.2 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 1.4 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.7 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 0.0 | 2.6 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.2 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.0 | 6.8 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 3.9 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 0.4 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 0.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 2.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.4 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 0.8 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.0 | 0.6 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 7.8 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 3.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.7 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 0.2 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.9 | GO:0008374 | O-acyltransferase activity(GO:0008374) |
| 0.0 | 0.7 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
| 0.0 | 0.7 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 0.1 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.6 | GO:0016278 | lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279) |
| 0.0 | 0.4 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.3 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.0 | 3.8 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 0.3 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 1.7 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.3 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.5 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 1.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.8 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 6.3 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 4.7 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 1.5 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.1 | 8.7 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.1 | 3.5 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 3.5 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 0.6 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.1 | 6.0 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.1 | 3.0 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.1 | 2.4 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.1 | 1.3 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 2.5 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 2.0 | PID_TNF_PATHWAY | TNF receptor signaling pathway |
| 0.0 | 4.8 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.1 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.6 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 1.5 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.2 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 1.6 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.5 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.5 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.8 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 2.9 | REACTOME_SEROTONIN_RECEPTORS | Genes involved in Serotonin receptors |
| 0.5 | 7.2 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.2 | 3.8 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 2.2 | REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.2 | 2.8 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.2 | 2.7 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.2 | 2.0 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 3.9 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.1 | 1.3 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 1.5 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 1.6 | REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 2.6 | REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 0.9 | REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 5.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.4 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.1 | 1.6 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 1.5 | REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING | Genes involved in SHC1 events in EGFR signaling |
| 0.1 | 2.0 | REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.1 | 1.7 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.1 | 2.6 | REACTOME_LYSOSOME_VESICLE_BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.1 | 1.8 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 4.8 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 1.4 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.1 | 1.1 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 0.5 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.1 | 8.9 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.2 | REACTOME_DEADENYLATION_OF_MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 1.1 | REACTOME_ENOS_ACTIVATION_AND_REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 4.1 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.1 | REACTOME_EXTENSION_OF_TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 0.9 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.9 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 2.0 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 3.2 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.3 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.6 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 0.6 | REACTOME_PLC_BETA_MEDIATED_EVENTS | Genes involved in PLC beta mediated events |
| 0.0 | 0.9 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.8 | REACTOME_MEIOTIC_RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.0 | 0.5 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.3 | REACTOME_SIGNALING_BY_BMP | Genes involved in Signaling by BMP |
| 0.0 | 0.2 | REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER | Genes involved in Formation of incision complex in GG-NER |
