Motif ID: Hmga2
Z-value: 1.364
Transcription factors associated with Hmga2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hmga2 | ENSMUSG00000056758.8 | Hmga2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hmga2 | mm10_v2_chr10_-_120476469_120476527 | 0.01 | 9.1e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 7.9 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) |
| 0.9 | 2.6 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.6 | 3.5 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.5 | 1.5 | GO:0016598 | protein arginylation(GO:0016598) |
| 0.5 | 2.6 | GO:0042891 | antibiotic transport(GO:0042891) dipeptide transport(GO:0042938) |
| 0.4 | 1.8 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.4 | 1.8 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
| 0.4 | 1.2 | GO:0014063 | negative regulation of serotonin secretion(GO:0014063) |
| 0.4 | 1.2 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
| 0.4 | 1.1 | GO:0045590 | negative regulation of regulatory T cell differentiation(GO:0045590) |
| 0.3 | 1.1 | GO:0035521 | monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522) histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.3 | 1.0 | GO:0072531 | pyrimidine-containing compound transmembrane transport(GO:0072531) |
| 0.2 | 0.7 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.2 | 0.7 | GO:0031554 | regulation of DNA-templated transcription, termination(GO:0031554) |
| 0.2 | 1.5 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.2 | 0.8 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.2 | 1.7 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.2 | 1.9 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 0.2 | 0.8 | GO:0010519 | negative regulation of phospholipase activity(GO:0010519) |
| 0.2 | 1.8 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.2 | 2.2 | GO:0031937 | positive regulation of chromatin silencing(GO:0031937) |
| 0.1 | 0.6 | GO:0010891 | negative regulation of sequestering of triglyceride(GO:0010891) positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.1 | 1.4 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 1.4 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 2.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 0.6 | GO:2000427 | eosinophil chemotaxis(GO:0048245) T cell extravasation(GO:0072683) positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.1 | 0.4 | GO:0010889 | regulation of sequestering of triglyceride(GO:0010889) |
| 0.1 | 1.5 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
| 0.1 | 1.3 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.1 | 2.9 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 0.4 | GO:1990414 | replication-born double-strand break repair via sister chromatid exchange(GO:1990414) |
| 0.1 | 0.7 | GO:1901162 | serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162) |
| 0.1 | 1.5 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.1 | 1.7 | GO:0031100 | organ regeneration(GO:0031100) |
| 0.1 | 2.9 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 3.7 | GO:0007606 | sensory perception of chemical stimulus(GO:0007606) |
| 0.1 | 1.4 | GO:0006693 | prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693) |
| 0.1 | 4.5 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.8 | GO:0016558 | protein import into peroxisome matrix(GO:0016558) |
| 0.0 | 0.2 | GO:0070535 | histone H2A K63-linked ubiquitination(GO:0070535) |
| 0.0 | 0.9 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 1.0 | GO:0030851 | granulocyte differentiation(GO:0030851) |
| 0.0 | 0.3 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.0 | 0.3 | GO:1900383 | regulation of synaptic plasticity by receptor localization to synapse(GO:1900383) |
| 0.0 | 0.8 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 0.4 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 0.5 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
| 0.0 | 1.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.3 | GO:0019835 | cytolysis(GO:0019835) |
| 0.0 | 0.1 | GO:1990564 | protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 7.9 | GO:0097450 | astrocyte end-foot(GO:0097450) |
| 0.7 | 2.6 | GO:0099569 | presynaptic cytoskeleton(GO:0099569) |
| 0.6 | 1.9 | GO:0036156 | inner dynein arm(GO:0036156) |
| 0.2 | 1.2 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.2 | 0.8 | GO:1990415 | Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429) |
| 0.2 | 0.8 | GO:0061702 | inflammasome complex(GO:0061702) |
| 0.2 | 0.6 | GO:0044299 | C-fiber(GO:0044299) |
| 0.2 | 0.9 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.1 | 1.1 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 0.7 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 1.7 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 1.4 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 0.6 | GO:0089701 | U2AF(GO:0089701) |
| 0.0 | 1.7 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 0.4 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.0 | 2.6 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 3.0 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 1.8 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 1.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 2.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 1.8 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.9 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.7 | GO:0045171 | intercellular bridge(GO:0045171) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0042936 | dipeptide transporter activity(GO:0042936) |
| 0.5 | 3.5 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.5 | 1.4 | GO:0036132 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
| 0.4 | 1.2 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.3 | 1.2 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.2 | 0.7 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
| 0.2 | 0.7 | GO:0001160 | transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160) |
| 0.2 | 2.6 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 0.6 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.1 | 1.9 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.1 | 1.1 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.1 | 3.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 9.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 1.5 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.1 | 1.5 | GO:0005537 | mannose binding(GO:0005537) |
| 0.1 | 2.9 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 1.8 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 1.7 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 0.7 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.1 | 1.8 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.1 | 0.7 | GO:0022842 | leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842) |
| 0.1 | 1.1 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.0 | 0.6 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.0 | 1.0 | GO:0015215 | nucleotide transmembrane transporter activity(GO:0015215) |
| 0.0 | 0.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 1.7 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.0 | 0.1 | GO:0004492 | methylmalonyl-CoA decarboxylase activity(GO:0004492) |
| 0.0 | 0.5 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 1.1 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 1.6 | GO:0004004 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 0.1 | GO:0071568 | UFM1 transferase activity(GO:0071568) |
| 0.0 | 1.1 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.8 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.8 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.6 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 3.3 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 3.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 1.8 | PID_RANBP2_PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 3.5 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.6 | PID_IL23_PATHWAY | IL23-mediated signaling events |
| 0.0 | 1.5 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.0 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 1.4 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 0.5 | NABA_COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.5 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 7.9 | REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 1.7 | REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.1 | 1.1 | REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 1.4 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.1 | 0.7 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 0.8 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 1.8 | REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 2.6 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 1.2 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 0.7 | REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 1.4 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.9 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.6 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.6 | REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.4 | REACTOME_FANCONI_ANEMIA_PATHWAY | Genes involved in Fanconi Anemia pathway |
