Motif ID: Hmx2

Z-value: 0.397


Transcription factors associated with Hmx2:

Gene SymbolEntrez IDGene Name
Hmx2 ENSMUSG00000050100.7 Hmx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx2mm10_v2_chr7_+_131548755_1315487730.103.9e-01Click!


Activity profile for motif Hmx2.

activity profile for motif Hmx2


Sorted Z-values histogram for motif Hmx2

Sorted Z-values for motif Hmx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 130 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_73237891 3.227 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr12_-_98901478 3.082 ENSMUST00000065716.6
 Eml5
echinoderm microtubule associated protein like 5
chr18_-_88894322 2.289 ENSMUST00000070116.5
ENSMUST00000125362.1
 Socs6

suppressor of cytokine signaling 6

chr7_-_37772868 2.204 ENSMUST00000176205.1
 Zfp536
zinc finger protein 536
chr5_-_28210022 2.197 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr2_+_35132194 2.123 ENSMUST00000113034.1
ENSMUST00000113037.3
ENSMUST00000113033.2
 Cep110


centrosomal protein 110


chr5_+_3343893 2.014 ENSMUST00000165117.1
 Cdk6
cyclin-dependent kinase 6
chr5_-_53707532 1.833 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr4_-_132398199 1.694 ENSMUST00000136711.1
ENSMUST00000084249.4
 Phactr4

phosphatase and actin regulator 4

chr11_-_100822525 1.649 ENSMUST00000107358.2
 Stat5b
signal transducer and activator of transcription 5B
chr8_-_123318553 1.646 ENSMUST00000118395.1
ENSMUST00000035495.8
 Fanca

Fanconi anemia, complementation group A

chr8_+_90828820 1.628 ENSMUST00000109614.2
ENSMUST00000048665.6
 Chd9

chromodomain helicase DNA binding protein 9

chr12_+_72441852 1.603 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chr12_-_90969768 1.452 ENSMUST00000181184.1
 4930544I03Rik
RIKEN cDNA 4930544I03 gene
chr13_-_59675754 1.426 ENSMUST00000022039.5
ENSMUST00000095739.2
 Golm1

golgi membrane protein 1

chr6_-_137169678 1.372 ENSMUST00000119610.1
 Rerg
RAS-like, estrogen-regulated, growth-inhibitor
chr3_+_94372794 1.357 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr18_+_50051702 1.338 ENSMUST00000134348.1
ENSMUST00000153873.2
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr19_-_58454435 1.328 ENSMUST00000169850.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr5_-_20951769 1.305 ENSMUST00000036489.5
 Rsbn1l
round spermatid basic protein 1-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 2.3 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 2.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 2.0 GO:0044838 cell quiescence(GO:0044838)
0.6 1.8 GO:0090274 positive regulation of somatostatin secretion(GO:0090274)
0.4 1.7 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.5 1.6 GO:0046544 regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819) development of secondary male sexual characteristics(GO:0046544)
0.1 1.6 GO:0045589 regulation of regulatory T cell differentiation(GO:0045589)
0.2 1.4 GO:0072615 interleukin-17 secretion(GO:0072615)
0.2 1.4 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 1.4 GO:0006997 nucleus organization(GO:0006997)
0.3 1.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 1.3 GO:0032611 interleukin-1 beta production(GO:0032611)
0.3 1.2 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.3 1.2 GO:0015889 cobalamin transport(GO:0015889)
0.3 1.2 GO:0070269 pyroptosis(GO:0070269)
0.1 1.2 GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis(GO:0003413)
0.0 1.2 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.2 1.1 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.2 1.1 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 GO:0001772 immunological synapse(GO:0001772)
0.0 2.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.8 GO:0043195 terminal bouton(GO:0043195)
0.1 1.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 1.4 GO:0097470 ribbon synapse(GO:0097470)
0.3 1.2 GO:0061702 inflammasome complex(GO:0061702)
0.1 1.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 1.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.2 GO:0002080 acrosomal membrane(GO:0002080)
0.3 1.1 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.2 1.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 1.0 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.9 GO:0043034 costamere(GO:0043034)
0.3 0.8 GO:0036156 inner dynein arm(GO:0036156)
0.1 0.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.7 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 0.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.5 GO:0097228 sperm principal piece(GO:0097228)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.1 GO:0008017 microtubule binding(GO:0008017)
0.5 3.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 2.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 2.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.7 2.0 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 1.8 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.3 1.7 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 1.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 1.4 GO:0008142 oxysterol binding(GO:0008142)
0.2 1.4 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 1.3 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 1.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.3 GO:0005178 integrin binding(GO:0005178)
0.0 1.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.2 1.2 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.2 1.2 GO:0031419 cobalamin binding(GO:0031419)
0.1 1.2 GO:0043495 protein anchor(GO:0043495)
0.0 1.2 GO:0002039 p53 binding(GO:0002039)
0.1 1.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.3 1.0 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 2.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.6 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.3 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.1 ST_INTEGRIN_SIGNALING_PATHWAY Integrin Signaling Pathway
0.0 1.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.6 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 0.6 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.3 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 2.0 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.8 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.6 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.1 1.6 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.3 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.2 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.1 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 1.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.8 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.7 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 0.6 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.1 0.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.2 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones