Motif ID: Hmx3

Z-value: 0.430


Transcription factors associated with Hmx3:

Gene SymbolEntrez IDGene Name
Hmx3 ENSMUSG00000040148.5 Hmx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx3mm10_v2_chr7_+_131542867_1315428670.056.4e-01Click!


Activity profile for motif Hmx3.

activity profile for motif Hmx3


Sorted Z-values histogram for motif Hmx3

Sorted Z-values for motif Hmx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 61 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_144893127 3.763 ENSMUST00000142808.1
Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_+_99263224 2.672 ENSMUST00000020118.4
Dusp6
dual specificity phosphatase 6
chr3_+_62419668 2.128 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr13_+_118714678 2.022 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chr13_-_92131494 1.945 ENSMUST00000099326.3
ENSMUST00000146492.1
Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr3_-_49757257 1.842 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr4_+_154960915 1.829 ENSMUST00000049621.6
Hes5
hairy and enhancer of split 5 (Drosophila)
chr11_+_103133303 1.814 ENSMUST00000107037.1
Hexim2
hexamethylene bis-acetamide inducible 2
chr12_-_83487708 1.732 ENSMUST00000177959.1
ENSMUST00000178756.1
Dpf3

D4, zinc and double PHD fingers, family 3

chr15_+_9436028 1.711 ENSMUST00000042360.3
Capsl
calcyphosine-like
chr5_-_137684665 1.385 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
Agfg2


ArfGAP with FG repeats 2


chr11_+_103133333 1.381 ENSMUST00000124928.1
ENSMUST00000062530.4
Hexim2

hexamethylene bis-acetamide inducible 2

chr9_-_123678782 1.363 ENSMUST00000170591.1
ENSMUST00000171647.1
Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr14_-_55560340 1.291 ENSMUST00000066106.3
A730061H03Rik
RIKEN cDNA A730061H03 gene
chr7_-_126897424 1.262 ENSMUST00000120007.1
Tmem219
transmembrane protein 219
chr19_-_41933276 1.145 ENSMUST00000075280.4
ENSMUST00000112123.2
Exosc1

exosome component 1

chr5_+_15516489 1.004 ENSMUST00000178227.1
Gm21847
predicted gene, 21847
chr9_-_123678873 0.988 ENSMUST00000040960.6
Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr19_+_41933464 0.930 ENSMUST00000026154.7
Zdhhc16
zinc finger, DHHC domain containing 16
chr11_+_114668524 0.920 ENSMUST00000106602.3
ENSMUST00000077915.3
ENSMUST00000106599.1
ENSMUST00000082092.4
Rpl38



ribosomal protein L38




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.8 GO:0042572 retinol metabolic process(GO:0042572)
0.1 3.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.9 2.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.2 2.4 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.1 2.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.7 2.0 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.1 1.9 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.5 1.8 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.1 1.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.2 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.9 GO:0048318 axial mesoderm development(GO:0048318)
0.0 0.9 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.9 GO:0048286 lung alveolus development(GO:0048286)
0.2 0.7 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.7 GO:0032570 response to progesterone(GO:0032570)
0.0 0.6 GO:0044144 regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.1 0.5 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 0.4 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.3 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0071565 nBAF complex(GO:0071565)
0.1 1.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 1.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.9 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.9 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 0.8 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 0.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.1 0.5 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.4 GO:0033263 CORVET complex(GO:0033263)
0.1 0.4 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 0.2 GO:0000811 GINS complex(GO:0000811)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 3.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.2 2.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 2.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 2.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.5 2.0 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 1.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 0.7 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.6 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.5 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 1.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.8 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.1 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.3 ST_P38_MAPK_PATHWAY p38 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.7 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.2 2.0 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 1.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 1.1 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.9 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ Genes involved in Cleavage of Growing Transcript in the Termination Region
0.0 0.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.4 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA