Motif ID: Hmx3

Z-value: 0.430


Transcription factors associated with Hmx3:

Gene SymbolEntrez IDGene Name
Hmx3 ENSMUSG00000040148.5 Hmx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hmx3mm10_v2_chr7_+_131542867_1315428670.056.4e-01Click!


Activity profile for motif Hmx3.

activity profile for motif Hmx3


Sorted Z-values histogram for motif Hmx3

Sorted Z-values for motif Hmx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Hmx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_144893127 3.763 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_+_99263224 2.672 ENSMUST00000020118.4
 Dusp6
dual specificity phosphatase 6
chr3_+_62419668 2.128 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr13_+_118714678 2.022 ENSMUST00000022246.8
 Fgf10
fibroblast growth factor 10
chr13_-_92131494 1.945 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr3_-_49757257 1.842 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr4_+_154960915 1.829 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr11_+_103133303 1.814 ENSMUST00000107037.1
 Hexim2
hexamethylene bis-acetamide inducible 2
chr12_-_83487708 1.732 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr15_+_9436028 1.711 ENSMUST00000042360.3
 Capsl
calcyphosine-like
chr5_-_137684665 1.385 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
 Agfg2


ArfGAP with FG repeats 2


chr11_+_103133333 1.381 ENSMUST00000124928.1
ENSMUST00000062530.4
 Hexim2

hexamethylene bis-acetamide inducible 2

chr9_-_123678782 1.363 ENSMUST00000170591.1
ENSMUST00000171647.1
 Slc6a20a

solute carrier family 6 (neurotransmitter transporter), member 20A

chr14_-_55560340 1.291 ENSMUST00000066106.3
 A730061H03Rik
RIKEN cDNA A730061H03 gene
chr7_-_126897424 1.262 ENSMUST00000120007.1
 Tmem219
transmembrane protein 219
chr19_-_41933276 1.145 ENSMUST00000075280.4
ENSMUST00000112123.2
 Exosc1

exosome component 1

chr5_+_15516489 1.004 ENSMUST00000178227.1
 Gm21847
predicted gene, 21847
chr9_-_123678873 0.988 ENSMUST00000040960.6
 Slc6a20a
solute carrier family 6 (neurotransmitter transporter), member 20A
chr19_+_41933464 0.930 ENSMUST00000026154.7
 Zdhhc16
zinc finger, DHHC domain containing 16
chr11_+_114668524 0.920 ENSMUST00000106602.3
ENSMUST00000077915.3
ENSMUST00000106599.1
ENSMUST00000082092.4
 Rpl38



ribosomal protein L38



chr2_-_153015331 0.912 ENSMUST00000028972.8
 Pdrg1
p53 and DNA damage regulated 1
chr7_+_3645267 0.902 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr7_+_25267669 0.886 ENSMUST00000169266.1
 Cic
capicua homolog (Drosophila)
chr7_-_45510400 0.777 ENSMUST00000033096.7
 Nucb1
nucleobindin 1
chr19_+_8802486 0.770 ENSMUST00000172175.1
 Zbtb3
zinc finger and BTB domain containing 3
chr10_+_106470281 0.758 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr4_-_62470868 0.738 ENSMUST00000135811.1
ENSMUST00000120095.1
ENSMUST00000030087.7
ENSMUST00000107452.1
ENSMUST00000155522.1
 Wdr31




WD repeat domain 31




chr13_+_23746734 0.723 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr14_+_54464141 0.714 ENSMUST00000022782.8
 Lrp10
low-density lipoprotein receptor-related protein 10
chr1_-_190170671 0.700 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr7_-_30559600 0.695 ENSMUST00000043975.4
ENSMUST00000156241.1
 Lin37

lin-37 homolog (C. elegans)

chr7_+_79273201 0.659 ENSMUST00000037315.6
 Abhd2
abhydrolase domain containing 2
chr2_-_130424242 0.631 ENSMUST00000089581.4
 Pced1a
PC-esterase domain containing 1A
chr19_+_11965817 0.605 ENSMUST00000025590.9
 Osbp
oxysterol binding protein
chr17_-_57247632 0.582 ENSMUST00000005975.6
 Gpr108
G protein-coupled receptor 108
chr7_+_25681158 0.579 ENSMUST00000108403.3
 B9d2
B9 protein domain 2
chr4_+_65604984 0.536 ENSMUST00000050850.7
ENSMUST00000107366.1
 Trim32

tripartite motif-containing 32

chr3_+_96629919 0.524 ENSMUST00000048915.6
 Rbm8a
RNA binding motif protein 8a
chr7_-_127208423 0.513 ENSMUST00000120705.1
 Tbc1d10b
TBC1 domain family, member 10b
chr11_+_69838514 0.498 ENSMUST00000133967.1
ENSMUST00000094065.4
 Tmem256

transmembrane protein 256

chr2_-_130424673 0.461 ENSMUST00000110277.1
 Pced1a
PC-esterase domain containing 1A
chr2_+_130424321 0.423 ENSMUST00000128994.1
ENSMUST00000028900.9
 Vps16

vacuolar protein sorting 16 (yeast)

chr7_-_30559828 0.410 ENSMUST00000108164.1
 Lin37
lin-37 homolog (C. elegans)
chrX_+_159708593 0.409 ENSMUST00000080394.6
 Sh3kbp1
SH3-domain kinase binding protein 1
chr7_-_121035096 0.407 ENSMUST00000065740.2
 Gm9905
predicted gene 9905
chr6_+_86371489 0.371 ENSMUST00000089558.5
 Snrpg
small nuclear ribonucleoprotein polypeptide G
chrM_+_9452 0.325 ENSMUST00000082411.1
 mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr5_-_87482258 0.315 ENSMUST00000079811.6
ENSMUST00000144144.1
 Ugt2a1

UDP glucuronosyltransferase 2 family, polypeptide A1

chr3_-_142169311 0.307 ENSMUST00000106230.1
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr6_+_92092369 0.292 ENSMUST00000113463.1
 Nr2c2
nuclear receptor subfamily 2, group C, member 2
chr2_-_72986716 0.282 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr3_+_109573907 0.268 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr9_+_21955747 0.265 ENSMUST00000053583.5
 Swsap1
SWIM type zinc finger 7 associated protein 1
chr2_+_3114220 0.241 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr2_-_84715160 0.231 ENSMUST00000035840.5
 Zdhhc5
zinc finger, DHHC domain containing 5
chr8_-_23237623 0.226 ENSMUST00000033950.5
 Gins4
GINS complex subunit 4 (Sld5 homolog)
chrX_+_150594420 0.204 ENSMUST00000112713.2
 Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr3_+_66985947 0.172 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr3_-_154328634 0.120 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr12_-_108179237 0.116 ENSMUST00000071095.7
 Setd3
SET domain containing 3
chr10_+_115569986 0.114 ENSMUST00000173620.1
 A930009A15Rik
RIKEN cDNA A930009A15 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.7 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.7 2.0 GO:0071336 white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.5 1.8 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.3 3.8 GO:0042572 retinol metabolic process(GO:0042572)
0.2 2.4 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.2 0.7 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.5 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 0.9 GO:0048318 axial mesoderm development(GO:0048318)
0.1 3.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 2.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 1.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.3 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 1.9 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 0.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 0.4 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.7 GO:0032570 response to progesterone(GO:0032570)
0.0 0.6 GO:0044144 regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144)
0.0 1.2 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.9 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.3 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.3 GO:0048520 positive regulation of behavior(GO:0048520)
0.0 0.9 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.1 0.9 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 0.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.9 GO:0016272 prefoldin complex(GO:0016272)
0.1 0.5 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.2 GO:0000811 GINS complex(GO:0000811)
0.1 1.7 GO:0071565 nBAF complex(GO:0071565)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.4 GO:0033263 CORVET complex(GO:0033263)
0.1 0.4 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.7 GO:0000786 nucleosome(GO:0000786)
0.0 1.1 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.5 2.0 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.4 3.2 GO:0097322 7SK snRNA binding(GO:0097322)
0.3 2.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 2.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 0.7 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 1.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.6 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 2.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.5 GO:0031369 translation initiation factor binding(GO:0031369)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 3.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.1 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 1.8 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.3 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 2.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.2 2.0 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 1.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.1 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 0.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.9 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 1.8 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.5 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ Genes involved in Cleavage of Growing Transcript in the Termination Region
0.0 0.4 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP