Motif ID: Hnf1a
Z-value: 0.558
Transcription factors associated with Hnf1a:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hnf1a | ENSMUSG00000029556.6 | Hnf1a |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.3 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 1.8 | 5.3 | GO:0061144 | alveolar secondary septum development(GO:0061144) |
| 0.9 | 3.6 | GO:0032275 | luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278) |
| 0.6 | 3.5 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.5 | 1.0 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) |
| 0.5 | 1.4 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203) |
| 0.4 | 1.3 | GO:0035482 | gastric motility(GO:0035482) gastric emptying(GO:0035483) negative regulation of gastric acid secretion(GO:0060455) |
| 0.4 | 2.2 | GO:0055118 | negative regulation of cardiac muscle contraction(GO:0055118) |
| 0.3 | 1.0 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 0.2 | 1.9 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
| 0.1 | 0.4 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) regulation of oligodendrocyte apoptotic process(GO:1900141) negative regulation of oligodendrocyte apoptotic process(GO:1900142) |
| 0.1 | 20.3 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.1 | 0.6 | GO:0007223 | Wnt signaling pathway, calcium modulating pathway(GO:0007223) |
| 0.1 | 5.7 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 0.6 | GO:0032782 | bile acid secretion(GO:0032782) |
| 0.1 | 0.8 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.1 | 1.5 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 0.1 | 0.5 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.1 | 0.3 | GO:0050748 | negative regulation of lipoprotein metabolic process(GO:0050748) |
| 0.1 | 2.0 | GO:0019432 | triglyceride biosynthetic process(GO:0019432) |
| 0.0 | 0.1 | GO:0023016 | signal transduction by trans-phosphorylation(GO:0023016) regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.0 | 0.4 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
| 0.0 | 0.2 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
| 0.0 | 1.0 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.0 | 0.4 | GO:0019369 | drug metabolic process(GO:0017144) arachidonic acid metabolic process(GO:0019369) |
| 0.0 | 0.8 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 0.0 | 1.8 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 4.4 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.0 | 0.3 | GO:0014823 | response to activity(GO:0014823) |
| 0.0 | 0.1 | GO:0051001 | negative regulation of nitric-oxide synthase activity(GO:0051001) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 7.3 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.7 | 2.2 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.3 | 3.5 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.2 | 1.4 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 1.5 | GO:0071439 | clathrin complex(GO:0071439) |
| 0.1 | 2.3 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.1 | 0.4 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.1 | 0.5 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.1 | 0.8 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 0.3 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.0 | 4.4 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.4 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 1.9 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 26.0 | GO:0097458 | neuron part(GO:0097458) |
| 0.0 | 4.5 | GO:0030133 | transport vesicle(GO:0030133) |
| 0.0 | 1.0 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.0 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.6 | 5.3 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.3 | 23.0 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.3 | 1.0 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.2 | 3.5 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 0.2 | 1.4 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.2 | 0.8 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) |
| 0.2 | 3.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.2 | 0.6 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.1 | 0.4 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.1 | 7.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 0.5 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.1 | 1.0 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 0.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.4 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 0.3 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.0 | 1.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.6 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.0 | 0.4 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 0.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 20.8 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 1.4 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 5.3 | PID_FGF_PATHWAY | FGF signaling pathway |
| 0.1 | 3.2 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.5 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 2.0 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 0.8 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.3 | REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.2 | 19.2 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 2.0 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.1 | 3.5 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 0.6 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 3.6 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.4 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.4 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.0 | 1.3 | REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.0 | 0.8 | REACTOME_GLYCOSPHINGOLIPID_METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.0 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 2.3 | REACTOME_L1CAM_INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 0.5 | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
