Motif ID: Hnf4a

Z-value: 0.834


Transcription factors associated with Hnf4a:

Gene SymbolEntrez IDGene Name
Hnf4a ENSMUSG00000017950.10 Hnf4a



Activity profile for motif Hnf4a.

activity profile for motif Hnf4a


Sorted Z-values histogram for motif Hnf4a

Sorted Z-values for motif Hnf4a



Network of associatons between targets according to the STRING database.



First level regulatory network of Hnf4a

PNG image of the network

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Top targets:


Showing 1 to 20 of 198 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_101840602 13.021 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chr14_+_101840501 11.962 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr15_+_3270767 11.668 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr9_-_77347816 9.883 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr16_-_22439719 9.087 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr9_-_77347787 7.977 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr7_+_45896941 7.883 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr2_-_131042682 6.871 ENSMUST00000028787.5
ENSMUST00000110239.1
ENSMUST00000110234.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr2_-_131043088 6.732 ENSMUST00000110240.3
ENSMUST00000066958.4
ENSMUST00000110235.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr11_-_81968415 6.703 ENSMUST00000066197.6
 Asic2
acid-sensing (proton-gated) ion channel 2
chr7_+_112225856 6.689 ENSMUST00000050149.5
ENSMUST00000106647.1
ENSMUST00000106648.1
 Mical2


microtubule associated monooxygenase, calponin and LIM domain containing 2


chr11_+_104282371 6.169 ENSMUST00000106988.1
ENSMUST00000106989.1
 Mapt

microtubule-associated protein tau

chr15_+_82252397 5.997 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chrX_-_162565514 5.681 ENSMUST00000154424.1
 Reps2
RALBP1 associated Eps domain containing protein 2
chr7_+_45897429 5.603 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr4_+_136286061 4.850 ENSMUST00000069195.4
ENSMUST00000130658.1
 Zfp46

zinc finger protein 46

chr11_+_78499087 4.787 ENSMUST00000017488.4
 Vtn
vitronectin
chr8_-_13200576 4.517 ENSMUST00000165605.2
 Grtp1
GH regulated TBC protein 1
chr8_-_113848615 4.386 ENSMUST00000093113.4
 Adamts18
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18
chr2_+_59160838 4.182 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
 Pkp4


plakophilin 4



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 17.9 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 13.6 GO:0030279 negative regulation of ossification(GO:0030279)
0.1 11.8 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
1.2 9.5 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
1.8 9.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.7 6.9 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
2.2 6.7 GO:0050915 sensory perception of sour taste(GO:0050915)
1.3 6.7 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
1.1 6.7 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.5 6.1 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.8 5.8 GO:0015862 uridine transport(GO:0015862)
0.8 5.0 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.4 4.8 GO:0097421 liver regeneration(GO:0097421)
0.1 4.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 4.2 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.3 4.1 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.0 4.0 GO:0007605 sensory perception of sound(GO:0007605)
0.1 3.9 GO:0033344 cholesterol efflux(GO:0033344)
0.3 3.6 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 3.6 GO:0007283 spermatogenesis(GO:0007283)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 25.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 16.9 GO:0016605 PML body(GO:0016605)
0.0 11.2 GO:0016324 apical plasma membrane(GO:0016324)
1.1 9.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 9.0 GO:0043197 dendritic spine(GO:0043197)
0.0 7.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 6.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.6 6.2 GO:0045298 tubulin complex(GO:0045298)
0.2 5.0 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
1.0 4.8 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.3 4.2 GO:0030057 desmosome(GO:0030057)
0.0 4.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.6 GO:0000139 Golgi membrane(GO:0000139)
0.5 3.3 GO:0070695 FHF complex(GO:0070695)
0.0 3.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 3.0 GO:0097427 microtubule bundle(GO:0097427)
0.2 2.8 GO:0031528 microvillus membrane(GO:0031528)
0.2 2.8 GO:0016460 myosin II complex(GO:0016460)
0.1 2.5 GO:0044297 cell body(GO:0044297)
0.0 2.5 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 25.0 GO:0042805 actinin binding(GO:0042805)
0.1 16.6 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
4.5 13.6 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
1.2 7.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 6.7 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.2 6.7 GO:0051059 NF-kappaB binding(GO:0051059)
0.9 6.2 GO:0099609 microtubule lateral binding(GO:0099609)
0.3 6.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 5.9 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.3 4.8 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
1.2 4.7 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.2 4.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 4.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 4.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 4.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.7 3.6 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 3.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.3 3.5 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
1.1 3.4 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 3.2 GO:0051959 dynein light intermediate chain binding(GO:0051959)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.1 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.3 6.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 6.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.3 4.8 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 4.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 3.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 3.0 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.2 2.2 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 2.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.6 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.2 PID_SHP2_PATHWAY SHP2 signaling
0.0 1.0 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.8 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.5 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.3 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.4 9.0 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 7.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.3 6.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 6.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 5.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 3.1 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 2.9 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.3 2.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 2.7 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.2 2.4 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 2.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.1 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 2.0 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 1.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.8 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 1.8 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.7 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.1 1.6 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 1.6 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation