Motif ID: Hnf4a
Z-value: 0.834
Transcription factors associated with Hnf4a:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hnf4a | ENSMUSG00000017950.10 | Hnf4a |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.7 | GO:0050915 | sensory perception of sour taste(GO:0050915) |
| 1.8 | 9.1 | GO:0048133 | germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728) |
| 1.3 | 6.7 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
| 1.2 | 9.5 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 1.1 | 6.7 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 1.0 | 3.0 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 0.9 | 3.5 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 0.8 | 5.0 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) |
| 0.8 | 5.8 | GO:0015862 | uridine transport(GO:0015862) |
| 0.8 | 2.4 | GO:0015920 | regulation of phosphatidylcholine catabolic process(GO:0010899) lipopolysaccharide transport(GO:0015920) |
| 0.7 | 2.2 | GO:2000170 | positive regulation of peptidyl-cysteine S-nitrosylation(GO:2000170) |
| 0.7 | 2.2 | GO:0044339 | canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) |
| 0.7 | 6.9 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 0.7 | 2.1 | GO:0001193 | maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193) |
| 0.6 | 3.0 | GO:1902683 | regulation of receptor localization to synapse(GO:1902683) |
| 0.6 | 1.7 | GO:0016056 | rhodopsin mediated signaling pathway(GO:0016056) |
| 0.6 | 3.4 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.5 | 1.6 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 0.5 | 1.5 | GO:0048014 | Tie signaling pathway(GO:0048014) |
| 0.5 | 1.4 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.5 | 6.1 | GO:0042761 | very long-chain fatty acid biosynthetic process(GO:0042761) |
| 0.5 | 1.8 | GO:0006558 | L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) |
| 0.5 | 1.8 | GO:0097393 | post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582) |
| 0.4 | 17.9 | GO:0010614 | negative regulation of cardiac muscle hypertrophy(GO:0010614) |
| 0.4 | 4.8 | GO:0097421 | liver regeneration(GO:0097421) |
| 0.4 | 2.0 | GO:0019659 | fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661) |
| 0.4 | 3.1 | GO:0061368 | maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.3 | 1.2 | GO:1903966 | monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966) |
| 0.3 | 4.1 | GO:0090331 | negative regulation of platelet aggregation(GO:0090331) |
| 0.3 | 3.6 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.2 | 1.2 | GO:0045347 | negative regulation of MHC class II biosynthetic process(GO:0045347) |
| 0.2 | 0.9 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.2 | 1.3 | GO:0070294 | renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294) |
| 0.2 | 1.5 | GO:0042167 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149) |
| 0.2 | 1.3 | GO:0032264 | IMP salvage(GO:0032264) |
| 0.2 | 1.1 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.2 | 3.2 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.2 | 2.4 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.2 | 13.6 | GO:0030279 | negative regulation of ossification(GO:0030279) |
| 0.1 | 1.1 | GO:0070940 | dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940) |
| 0.1 | 1.1 | GO:0032074 | negative regulation of nuclease activity(GO:0032074) |
| 0.1 | 0.4 | GO:0061762 | CAMKK-AMPK signaling cascade(GO:0061762) |
| 0.1 | 0.4 | GO:1901052 | sarcosine metabolic process(GO:1901052) sarcosine catabolic process(GO:1901053) |
| 0.1 | 0.3 | GO:1904580 | regulation of intracellular mRNA localization(GO:1904580) |
| 0.1 | 0.7 | GO:0006842 | tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746) |
| 0.1 | 4.2 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.1 | 3.9 | GO:0033344 | cholesterol efflux(GO:0033344) |
| 0.1 | 0.3 | GO:0035963 | response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963) |
| 0.1 | 1.4 | GO:0050965 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.1 | 0.2 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.1 | 0.6 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 0.9 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.1 | 1.0 | GO:0070932 | histone H3 deacetylation(GO:0070932) |
| 0.1 | 0.6 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.1 | 3.4 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.1 | 0.5 | GO:0098703 | calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035) |
| 0.1 | 3.3 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.1 | 1.5 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.1 | 4.5 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.1 | 11.8 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.1 | 2.5 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.1 | 0.3 | GO:1901668 | regulation of superoxide dismutase activity(GO:1901668) |
| 0.1 | 0.4 | GO:0042045 | epithelial fluid transport(GO:0042045) |
| 0.1 | 0.5 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.1 | 0.2 | GO:0097155 | fasciculation of sensory neuron axon(GO:0097155) |
| 0.1 | 1.6 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.1 | 0.4 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 0.1 | 2.7 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.1 | 3.2 | GO:0048286 | lung alveolus development(GO:0048286) |
| 0.1 | 0.4 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.0 | 0.7 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 1.3 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 1.0 | GO:0010039 | response to iron ion(GO:0010039) |
| 0.0 | 0.5 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.0 | 1.3 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.7 | GO:0002097 | tRNA wobble base modification(GO:0002097) |
| 0.0 | 1.8 | GO:0097006 | regulation of plasma lipoprotein particle levels(GO:0097006) |
| 0.0 | 1.3 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 0.3 | GO:0046929 | negative regulation of neurotransmitter secretion(GO:0046929) |
| 0.0 | 0.8 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 1.9 | GO:0043113 | receptor clustering(GO:0043113) |
| 0.0 | 0.2 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.0 | 4.0 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 0.0 | 3.0 | GO:0030518 | intracellular steroid hormone receptor signaling pathway(GO:0030518) |
| 0.0 | 1.3 | GO:0006414 | translational elongation(GO:0006414) |
| 0.0 | 1.8 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.0 | 0.1 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.0 | 2.2 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.0 | 0.3 | GO:2000052 | positive regulation of non-canonical Wnt signaling pathway(GO:2000052) |
| 0.0 | 0.4 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.2 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.0 | 1.8 | GO:1990830 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.0 | 3.6 | GO:0007283 | spermatogenesis(GO:0007283) |
| 0.0 | 2.7 | GO:0032259 | methylation(GO:0032259) |
| 0.0 | 0.3 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 0.6 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 0.5 | GO:0043401 | steroid hormone mediated signaling pathway(GO:0043401) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 9.5 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 1.0 | 4.8 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.6 | 6.2 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.5 | 3.3 | GO:0070695 | FHF complex(GO:0070695) |
| 0.5 | 1.8 | GO:1990421 | subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707) |
| 0.3 | 3.0 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.3 | 4.2 | GO:0030057 | desmosome(GO:0030057) |
| 0.3 | 0.9 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.3 | 1.3 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.2 | 25.8 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.2 | 2.8 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.2 | 16.9 | GO:0016605 | PML body(GO:0016605) |
| 0.2 | 5.0 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) |
| 0.2 | 2.8 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.1 | 2.0 | GO:0035686 | sperm fibrous sheath(GO:0035686) |
| 0.1 | 1.7 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 2.2 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.1 | 0.7 | GO:0031314 | extrinsic component of mitochondrial inner membrane(GO:0031314) |
| 0.1 | 0.8 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.1 | 1.9 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 0.4 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.1 | 2.1 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 0.7 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.1 | 0.6 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 1.6 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 0.3 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.1 | 2.5 | GO:0044297 | cell body(GO:0044297) |
| 0.1 | 0.5 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.0 | 2.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 11.2 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 6.5 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 1.8 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 9.0 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 2.0 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.0 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 1.4 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.4 | GO:0020003 | symbiont-containing vacuole(GO:0020003) |
| 0.0 | 4.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 2.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 3.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.3 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 7.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 1.4 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 1.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 3.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 1.1 | GO:0016591 | DNA-directed RNA polymerase II, holoenzyme(GO:0016591) |
| 0.0 | 2.4 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 0.3 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 13.6 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 1.2 | 4.7 | GO:0034041 | sterol-transporting ATPase activity(GO:0034041) |
| 1.2 | 7.0 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 1.1 | 3.4 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 0.9 | 6.2 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.8 | 2.4 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.7 | 3.6 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.7 | 25.0 | GO:0042805 | actinin binding(GO:0042805) |
| 0.6 | 2.2 | GO:0070573 | tripeptidyl-peptidase activity(GO:0008240) metallodipeptidase activity(GO:0070573) |
| 0.5 | 2.0 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.5 | 3.0 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.5 | 2.8 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
| 0.4 | 1.5 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 0.4 | 1.4 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.3 | 1.6 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.3 | 1.2 | GO:0032896 | palmitoyl-CoA 9-desaturase activity(GO:0032896) |
| 0.3 | 3.5 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.3 | 6.0 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.3 | 1.6 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.3 | 6.7 | GO:0005248 | voltage-gated sodium channel activity(GO:0005248) |
| 0.3 | 4.8 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.3 | 1.8 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.2 | 1.7 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.2 | 0.9 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.2 | 5.9 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.2 | 4.7 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.2 | 0.6 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
| 0.2 | 1.2 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.2 | 2.5 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.2 | 1.0 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.2 | 0.7 | GO:0010857 | calcium-dependent protein kinase activity(GO:0010857) |
| 0.2 | 1.3 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.2 | 2.2 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.2 | 6.7 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.1 | 0.4 | GO:0046997 | sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997) |
| 0.1 | 0.7 | GO:0015142 | citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142) |
| 0.1 | 16.6 | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191) |
| 0.1 | 0.4 | GO:0005124 | scavenger receptor binding(GO:0005124) |
| 0.1 | 1.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 3.2 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.1 | 4.4 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 3.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 0.5 | GO:0004839 | ubiquitin activating enzyme activity(GO:0004839) |
| 0.1 | 0.4 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.1 | 3.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 1.7 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
| 0.1 | 0.4 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.1 | 1.1 | GO:0019104 | DNA N-glycosylase activity(GO:0019104) |
| 0.1 | 0.5 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.1 | 0.2 | GO:0052658 | inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) |
| 0.1 | 0.8 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 1.6 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 1.3 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.1 | 0.5 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.1 | 0.7 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.1 | 0.4 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 1.7 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.1 | 1.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 1.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 0.2 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.1 | 0.8 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 4.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 2.1 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.0 | 0.1 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 0.0 | 0.2 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.0 | 2.3 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 2.3 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 1.3 | GO:0008175 | tRNA methyltransferase activity(GO:0008175) |
| 0.0 | 0.2 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) PH domain binding(GO:0042731) |
| 0.0 | 4.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 1.5 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 1.5 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.3 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 2.1 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 3.0 | GO:0008168 | methyltransferase activity(GO:0008168) |
| 0.0 | 0.5 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.3 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 1.2 | GO:0016209 | antioxidant activity(GO:0016209) |
| 0.0 | 0.3 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.0 | 2.2 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 2.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.3 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 1.4 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 2.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.5 | GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.2 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.3 | 9.1 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.3 | 4.8 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 2.2 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 3.6 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.0 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
| 0.1 | 6.1 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 2.2 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.1 | 1.6 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 2.1 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 3.0 | PID_REG_GR_PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 4.2 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.5 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.0 | PID_HIF1_TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.0 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.8 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.8 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.2 | PID_SHP2_PATHWAY | SHP2 signaling |
| 0.0 | 0.3 | PID_BETA_CATENIN_DEG_PATHWAY | Degradation of beta catenin |
| 0.0 | 0.2 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.5 | PID_CD8_TCR_PATHWAY | TCR signaling in naïve CD8+ T cells |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.0 | REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.3 | 2.8 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PS | Genes involved in Acyl chain remodelling of PS |
| 0.3 | 6.2 | REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.3 | 12.9 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.3 | 7.0 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.2 | 6.1 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 2.4 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.1 | 5.9 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 1.5 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 2.1 | REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 1.8 | REACTOME_ERKS_ARE_INACTIVATED | Genes involved in ERKs are inactivated |
| 0.1 | 1.9 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 1.4 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 1.2 | REACTOME_SYNTHESIS_OF_PE | Genes involved in Synthesis of PE |
| 0.1 | 1.8 | REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 0.7 | REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.1 | 2.0 | REACTOME_PYRUVATE_METABOLISM | Genes involved in Pyruvate metabolism |
| 0.1 | 1.6 | REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.1 | 1.3 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
| 0.1 | 1.2 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
| 0.1 | 0.8 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 1.5 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 1.7 | REACTOME_TRIGLYCERIDE_BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 0.1 | 1.6 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 3.1 | REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 0.9 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 2.2 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.8 | REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 2.9 | REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS | Genes involved in G alpha (q) signalling events |
| 0.0 | 2.7 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 0.9 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.3 | REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.0 | 0.5 | REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
