Motif ID: Homez
Z-value: 0.746
Transcription factors associated with Homez:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Homez | ENSMUSG00000057156.9 | Homez |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Homez | mm10_v2_chr14_-_54870913_54870961 | -0.19 | 1.0e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 11.3 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 1.8 | 9.1 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 1.4 | 4.2 | GO:0060060 | post-embryonic retina morphogenesis in camera-type eye(GO:0060060) |
| 1.3 | 6.5 | GO:0007089 | traversing start control point of mitotic cell cycle(GO:0007089) |
| 1.2 | 3.6 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 1.0 | 4.1 | GO:0046121 | deoxyribonucleoside catabolic process(GO:0046121) |
| 1.0 | 2.9 | GO:0050713 | negative regulation of interleukin-1 beta secretion(GO:0050713) |
| 0.9 | 5.3 | GO:0046502 | uroporphyrinogen III metabolic process(GO:0046502) |
| 0.8 | 4.9 | GO:0032196 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196) |
| 0.8 | 2.4 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.7 | 4.1 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
| 0.7 | 2.0 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 0.6 | 2.6 | GO:0070829 | heterochromatin maintenance(GO:0070829) |
| 0.6 | 3.7 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.6 | 1.8 | GO:0002865 | immune response-inhibiting signal transduction(GO:0002765) negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865) |
| 0.6 | 2.3 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.5 | 3.3 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.4 | 2.8 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.4 | 1.6 | GO:0060332 | positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335) |
| 0.4 | 1.5 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.4 | 3.3 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.3 | 1.3 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.3 | 1.0 | GO:0016598 | protein arginylation(GO:0016598) |
| 0.3 | 2.4 | GO:0035999 | folic acid-containing compound biosynthetic process(GO:0009396) tetrahydrofolate interconversion(GO:0035999) |
| 0.3 | 4.0 | GO:0046548 | retinal rod cell development(GO:0046548) |
| 0.3 | 0.8 | GO:0018094 | protein polyglycylation(GO:0018094) |
| 0.3 | 3.0 | GO:0071044 | histone mRNA catabolic process(GO:0071044) |
| 0.3 | 1.9 | GO:0017196 | N-terminal peptidyl-methionine acetylation(GO:0017196) |
| 0.3 | 0.8 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
| 0.3 | 2.4 | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA(GO:0035280) |
| 0.2 | 0.7 | GO:0048209 | regulation of vesicle targeting, to, from or within Golgi(GO:0048209) |
| 0.2 | 0.7 | GO:0002578 | negative regulation of antigen processing and presentation(GO:0002578) |
| 0.2 | 2.1 | GO:0010793 | regulation of mRNA export from nucleus(GO:0010793) |
| 0.2 | 1.9 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
| 0.2 | 0.7 | GO:0034241 | positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289) |
| 0.2 | 1.3 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.2 | 7.3 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.2 | 0.9 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 0.2 | 1.3 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 0.2 | 0.5 | GO:0090004 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.2 | 4.1 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
| 0.2 | 0.7 | GO:0071267 | amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267) |
| 0.2 | 1.5 | GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431) |
| 0.2 | 0.5 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.2 | 0.6 | GO:1902608 | regulation of large conductance calcium-activated potassium channel activity(GO:1902606) positive regulation of large conductance calcium-activated potassium channel activity(GO:1902608) |
| 0.2 | 0.5 | GO:0090118 | receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118) |
| 0.2 | 1.1 | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) |
| 0.2 | 0.9 | GO:0006741 | NADP biosynthetic process(GO:0006741) |
| 0.1 | 0.9 | GO:0048254 | snoRNA localization(GO:0048254) |
| 0.1 | 0.4 | GO:0006667 | sphinganine metabolic process(GO:0006667) |
| 0.1 | 0.4 | GO:1904719 | excitatory chemical synaptic transmission(GO:0098976) positive regulation of AMPA glutamate receptor clustering(GO:1904719) |
| 0.1 | 0.1 | GO:0009794 | regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448) |
| 0.1 | 0.8 | GO:0003431 | growth plate cartilage chondrocyte development(GO:0003431) |
| 0.1 | 7.8 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) |
| 0.1 | 1.0 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.1 | 3.9 | GO:0034508 | centromere complex assembly(GO:0034508) |
| 0.1 | 1.0 | GO:1901387 | positive regulation of voltage-gated calcium channel activity(GO:1901387) |
| 0.1 | 0.6 | GO:0034196 | acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) |
| 0.1 | 1.1 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.1 | 1.1 | GO:0070836 | caveola assembly(GO:0070836) |
| 0.1 | 0.3 | GO:0070844 | misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846) |
| 0.1 | 3.4 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.1 | 1.2 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.1 | 3.9 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
| 0.1 | 0.5 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.1 | 0.2 | GO:0006382 | adenosine to inosine editing(GO:0006382) |
| 0.1 | 0.2 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 0.1 | 1.3 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.1 | 0.3 | GO:0035720 | intraciliary anterograde transport(GO:0035720) |
| 0.1 | 1.7 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.1 | 0.6 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.1 | 0.8 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 3.3 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.1 | 0.7 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 1.9 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 0.1 | 1.5 | GO:0010960 | magnesium ion homeostasis(GO:0010960) |
| 0.1 | 0.7 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.1 | 0.5 | GO:0010256 | endomembrane system organization(GO:0010256) |
| 0.1 | 1.8 | GO:0000578 | embryonic axis specification(GO:0000578) |
| 0.1 | 1.3 | GO:0043153 | entrainment of circadian clock by photoperiod(GO:0043153) |
| 0.1 | 1.9 | GO:0001947 | heart looping(GO:0001947) |
| 0.1 | 5.1 | GO:2000177 | regulation of neural precursor cell proliferation(GO:2000177) |
| 0.1 | 2.6 | GO:0043392 | negative regulation of DNA binding(GO:0043392) |
| 0.0 | 1.1 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.9 | GO:0045653 | negative regulation of megakaryocyte differentiation(GO:0045653) |
| 0.0 | 2.0 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 1.1 | GO:0010883 | regulation of lipid storage(GO:0010883) |
| 0.0 | 1.5 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.0 | 1.1 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.3 | GO:0031118 | rRNA pseudouridine synthesis(GO:0031118) |
| 0.0 | 0.2 | GO:0006537 | glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543) |
| 0.0 | 0.0 | GO:0044837 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 0.0 | 1.1 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.0 | 0.2 | GO:0051176 | positive regulation of sulfur metabolic process(GO:0051176) |
| 0.0 | 0.1 | GO:0045065 | cytotoxic T cell differentiation(GO:0045065) |
| 0.0 | 0.6 | GO:0097113 | AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688) |
| 0.0 | 0.4 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.0 | 0.1 | GO:0006438 | valyl-tRNA aminoacylation(GO:0006438) |
| 0.0 | 0.3 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.0 | 0.9 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.9 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
| 0.0 | 0.7 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.6 | GO:0043403 | skeletal muscle tissue regeneration(GO:0043403) |
| 0.0 | 0.4 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.8 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 2.2 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.0 | 0.7 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) |
| 0.0 | 1.5 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 0.7 | GO:0014037 | Schwann cell differentiation(GO:0014037) |
| 0.0 | 0.4 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
| 0.0 | 0.4 | GO:0051984 | positive regulation of chromosome segregation(GO:0051984) |
| 0.0 | 0.3 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
| 0.0 | 0.1 | GO:0016576 | histone dephosphorylation(GO:0016576) |
| 0.0 | 0.6 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 0.2 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 0.2 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.0 | 1.5 | GO:0051225 | spindle assembly(GO:0051225) |
| 0.0 | 0.7 | GO:0007032 | endosome organization(GO:0007032) |
| 0.0 | 0.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.2 | GO:0047497 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.0 | 0.7 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.0 | 1.4 | GO:0007093 | mitotic cell cycle checkpoint(GO:0007093) |
| 0.0 | 0.7 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
| 0.0 | 0.4 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 1.1 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.0 | 0.2 | GO:0018126 | protein hydroxylation(GO:0018126) |
| 0.0 | 0.5 | GO:0010762 | regulation of fibroblast migration(GO:0010762) |
| 0.0 | 0.4 | GO:0009636 | response to toxic substance(GO:0009636) |
| 0.0 | 0.9 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.0 | 0.3 | GO:0061512 | protein localization to cilium(GO:0061512) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.6 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
| 0.9 | 2.6 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.6 | 2.3 | GO:0061702 | inflammasome complex(GO:0061702) |
| 0.5 | 2.9 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.3 | 2.8 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.3 | 2.4 | GO:0070578 | RISC-loading complex(GO:0070578) |
| 0.2 | 4.1 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.2 | 1.9 | GO:0031415 | NatA complex(GO:0031415) |
| 0.2 | 7.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.2 | 2.1 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.2 | 1.9 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.2 | 1.5 | GO:0070652 | HAUS complex(GO:0070652) |
| 0.2 | 1.1 | GO:0071817 | MMXD complex(GO:0071817) |
| 0.2 | 1.9 | GO:0000243 | commitment complex(GO:0000243) |
| 0.2 | 2.0 | GO:0005675 | holo TFIIH complex(GO:0005675) |
| 0.2 | 2.1 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 0.9 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.1 | 0.5 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.1 | 1.7 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.4 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.1 | 1.6 | GO:0044754 | autolysosome(GO:0044754) |
| 0.1 | 1.5 | GO:0042555 | MCM complex(GO:0042555) |
| 0.1 | 0.7 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
| 0.1 | 0.7 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.1 | 3.4 | GO:1990204 | oxidoreductase complex(GO:1990204) |
| 0.1 | 1.1 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.8 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 1.1 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 1.7 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.2 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.0 | 0.6 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.7 | GO:0031011 | Ino80 complex(GO:0031011) |
| 0.0 | 1.8 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.4 | GO:0097413 | Lewy body(GO:0097413) |
| 0.0 | 0.7 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 1.1 | GO:0001741 | XY body(GO:0001741) |
| 0.0 | 1.1 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 1.6 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 2.9 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 0.9 | GO:0043189 | NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562) |
| 0.0 | 5.6 | GO:0000776 | kinetochore(GO:0000776) |
| 0.0 | 0.5 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 1.0 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.3 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.0 | 2.8 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 1.1 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 0.7 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 0.6 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 0.4 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 1.7 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.0 | 0.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 2.6 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 0.1 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.0 | 1.7 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.1 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
| 0.0 | 1.5 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 3.5 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 0.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 1.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.2 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
| 0.0 | 0.3 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 0.6 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 0.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.8 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 0.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 4.9 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
| 1.1 | 3.3 | GO:0036132 | 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522) |
| 1.1 | 3.3 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.8 | 2.4 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.7 | 3.5 | GO:0004165 | dodecenoyl-CoA delta-isomerase activity(GO:0004165) |
| 0.6 | 3.9 | GO:0048101 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.5 | 1.1 | GO:0015217 | ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217) |
| 0.5 | 9.1 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.4 | 3.0 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.4 | 2.0 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 0.3 | 4.1 | GO:0016832 | aldehyde-lyase activity(GO:0016832) |
| 0.3 | 1.2 | GO:0004966 | galanin receptor activity(GO:0004966) |
| 0.3 | 1.8 | GO:0004920 | interleukin-10 receptor activity(GO:0004920) |
| 0.3 | 1.7 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.3 | 0.8 | GO:0070736 | protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) |
| 0.3 | 0.8 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
| 0.2 | 4.1 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.2 | 2.9 | GO:0050897 | cobalt ion binding(GO:0050897) |
| 0.2 | 4.2 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.2 | 2.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 1.3 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.2 | 1.0 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.2 | 1.5 | GO:0009019 | tRNA (guanine-N1-)-methyltransferase activity(GO:0009019) |
| 0.2 | 7.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.2 | 3.1 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |
| 0.2 | 1.2 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.2 | 5.3 | GO:0008198 | ferrous iron binding(GO:0008198) |
| 0.2 | 7.0 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.2 | 0.5 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
| 0.1 | 2.4 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.1 | 0.4 | GO:0004758 | serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454) |
| 0.1 | 1.2 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.1 | 0.4 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.1 | 2.4 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 1.9 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.1 | 4.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 0.7 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.1 | 1.0 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 2.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 0.5 | GO:0004445 | inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030) |
| 0.1 | 1.3 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 0.1 | 0.3 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 0.1 | 1.5 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 0.4 | GO:0000403 | Y-form DNA binding(GO:0000403) |
| 0.1 | 1.4 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.1 | 0.2 | GO:1904047 | S-adenosyl-L-methionine binding(GO:1904047) |
| 0.1 | 1.0 | GO:0001846 | opsonin binding(GO:0001846) |
| 0.1 | 0.3 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
| 0.1 | 0.6 | GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) |
| 0.1 | 1.0 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 0.1 | 3.5 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.1 | 2.8 | GO:0030170 | pyridoxal phosphate binding(GO:0030170) |
| 0.1 | 1.1 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.1 | 0.2 | GO:0030249 | guanylate cyclase regulator activity(GO:0030249) |
| 0.1 | 1.1 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.1 | 17.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 0.7 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.1 | 0.9 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.1 | 1.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 0.2 | GO:0001129 | RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132) |
| 0.1 | 2.3 | GO:0003690 | double-stranded DNA binding(GO:0003690) |
| 0.0 | 0.5 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.2 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.0 | 0.6 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.0 | 0.4 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 0.6 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
| 0.0 | 1.1 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.0 | 1.9 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 0.1 | GO:0004832 | valine-tRNA ligase activity(GO:0004832) |
| 0.0 | 0.6 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 0.6 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 0.0 | 0.5 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 23.7 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.0 | 0.6 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 0.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.5 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 1.0 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.0 | 0.3 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.0 | 0.0 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.0 | 1.7 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.0 | 1.2 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 5.3 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.0 | 0.8 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 4.0 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 9.2 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.0 | 1.8 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 2.8 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 0.2 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.4 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 0.5 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
| 0.0 | 0.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 0.9 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.9 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.3 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 9.1 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.1 | 2.9 | PID_MYC_PATHWAY | C-MYC pathway |
| 0.1 | 1.6 | PID_SMAD2_3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 0.5 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
| 0.0 | 0.8 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 2.2 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 1.3 | PID_IL2_PI3K_PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 1.7 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 0.8 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 3.2 | NABA_SECRETED_FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.5 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.7 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.1 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.3 | 3.3 | REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.3 | 1.8 | REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 5.3 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 8.1 | REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.2 | 3.5 | REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.2 | 2.3 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.1 | 2.0 | REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER | Genes involved in Formation of incision complex in GG-NER |
| 0.1 | 5.2 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 1.0 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.1 | 0.6 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 1.1 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 2.9 | REACTOME_INTERFERON_GAMMA_SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 0.8 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 0.3 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 1.7 | REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 2.2 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 2.9 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.5 | REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.6 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 1.3 | REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 2.6 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 0.6 | REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.0 | 0.4 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.5 | REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 0.6 | REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.0 | 0.1 | REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.0 | 1.2 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.8 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.5 | REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.4 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.2 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
