Motif ID: Homez

Z-value: 0.746


Transcription factors associated with Homez:

Gene SymbolEntrez IDGene Name
Homez ENSMUSG00000057156.9 Homez

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Homezmm10_v2_chr14_-_54870913_54870961-0.191.0e-01Click!


Activity profile for motif Homez.

activity profile for motif Homez


Sorted Z-values histogram for motif Homez

Sorted Z-values for motif Homez



Network of associatons between targets according to the STRING database.



First level regulatory network of Homez

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 11.327 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr4_-_117178726 9.071 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chr8_-_4779513 7.553 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr4_+_44300876 7.274 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr3_+_5218546 6.851 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr16_-_26989974 6.267 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr3_+_5218516 6.255 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr11_+_101627942 4.848 ENSMUST00000010506.3
 Rdm1
RAD52 motif 1
chr18_+_50030977 4.508 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr8_-_72305276 4.290 ENSMUST00000075602.6
 Gm10282
predicted pseudogene 10282
chr3_-_63899437 4.180 ENSMUST00000159188.1
ENSMUST00000177143.1
 Plch1

phospholipase C, eta 1

chr14_-_27508460 4.169 ENSMUST00000050480.6
 Ccdc66
coiled-coil domain containing 66
chr9_+_91368811 4.159 ENSMUST00000173054.1
 Zic4
zinc finger protein of the cerebellum 4
chr3_+_90220783 4.117 ENSMUST00000065418.6
 Rab13
RAB13, member RAS oncogene family
chr1_-_138619687 4.108 ENSMUST00000027642.2
 Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
chr6_+_137754529 4.099 ENSMUST00000087675.6
 Dera
2-deoxyribose-5-phosphate aldolase homolog (C. elegans)
chr9_+_91368970 4.096 ENSMUST00000172646.1
 Zic4
zinc finger protein of the cerebellum 4
chr6_+_85587524 3.971 ENSMUST00000072018.5
 Alms1
Alstrom syndrome 1
chr8_+_116921735 3.943 ENSMUST00000034205.4
 Cenpn
centromere protein N
chr6_-_56362356 3.868 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 11.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.8 9.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 7.8 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.2 7.3 GO:0006270 DNA replication initiation(GO:0006270)
1.3 6.5 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.9 5.3 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
0.1 5.1 GO:2000177 regulation of neural precursor cell proliferation(GO:2000177)
0.8 4.9 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
1.4 4.2 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
1.0 4.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.7 4.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.2 4.1 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.3 4.0 GO:0046548 retinal rod cell development(GO:0046548)
0.1 3.9 GO:0034508 centromere complex assembly(GO:0034508)
0.1 3.9 GO:0032611 interleukin-1 beta production(GO:0032611)
0.6 3.7 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.2 3.6 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 3.4 GO:0007608 sensory perception of smell(GO:0007608)
0.5 3.3 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.4 3.3 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 5.6 GO:0000776 kinetochore(GO:0000776)
1.2 4.6 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.2 4.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 3.5 GO:0032993 protein-DNA complex(GO:0032993)
0.1 3.4 GO:1990204 oxidoreductase complex(GO:1990204)
0.5 2.9 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 2.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.3 2.8 GO:0061574 ASAP complex(GO:0061574)
0.0 2.8 GO:0070469 respiratory chain(GO:0070469)
0.9 2.6 GO:1990423 RZZ complex(GO:1990423)
0.0 2.6 GO:0036064 ciliary basal body(GO:0036064)
0.3 2.4 GO:0070578 RISC-loading complex(GO:0070578)
0.6 2.3 GO:0061702 inflammasome complex(GO:0061702)
0.2 2.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 2.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 2.0 GO:0005675 holo TFIIH complex(GO:0005675)
0.2 1.9 GO:0031415 NatA complex(GO:0031415)
0.2 1.9 GO:0070545 PeBoW complex(GO:0070545)
0.2 1.9 GO:0000243 commitment complex(GO:0000243)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 23.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 17.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 9.2 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.5 9.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 7.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 7.0 GO:0042169 SH2 domain binding(GO:0042169)
0.2 5.3 GO:0008198 ferrous iron binding(GO:0008198)
0.0 5.3 GO:0003682 chromatin binding(GO:0003682)
1.2 4.9 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 4.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 4.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.3 4.1 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 4.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 4.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.6 3.9 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.7 3.5 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 3.5 GO:0070063 RNA polymerase binding(GO:0070063)
1.1 3.3 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
1.1 3.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.2 3.1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.4 3.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 3.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.9 PID_MYC_PATHWAY C-MYC pathway
0.0 2.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.7 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.3 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.8 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.5 PID_IL6_7_PATHWAY IL6-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.1 REACTOME_KINESINS Genes involved in Kinesins
0.2 8.1 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.2 5.3 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 5.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 3.5 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.3 3.3 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 2.9 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 2.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 2.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 2.3 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.0 2.2 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 2.0 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.3 1.8 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.7 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.5 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.3 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.2 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.1 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.0 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 0.8 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling