Motif ID: Hoxa1

Z-value: 1.189


Transcription factors associated with Hoxa1:

Gene SymbolEntrez IDGene Name
Hoxa1 ENSMUSG00000029844.9 Hoxa1



Activity profile for motif Hoxa1.

activity profile for motif Hoxa1


Sorted Z-values histogram for motif Hoxa1

Sorted Z-values for motif Hoxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_15239045 23.532 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr7_+_73391160 16.389 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr15_-_95528702 15.018 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr2_+_158375638 11.190 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr14_+_70077375 10.438 ENSMUST00000035908.1
 Egr3
early growth response 3
chr3_+_55782500 8.762 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr4_-_143299498 8.436 ENSMUST00000030317.7
 Pdpn
podoplanin
chr2_+_163225363 8.376 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr10_+_81628702 7.664 ENSMUST00000129622.1
 Ankrd24
ankyrin repeat domain 24
chr2_+_65845767 6.668 ENSMUST00000122912.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr4_-_35845204 6.631 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr5_+_27261916 6.604 ENSMUST00000101471.3
 Dpp6
dipeptidylpeptidase 6
chr2_+_90885860 6.555 ENSMUST00000111466.2
 C1qtnf4
C1q and tumor necrosis factor related protein 4
chr2_+_65845833 6.539 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr15_+_98167806 6.055 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr15_+_74516196 5.985 ENSMUST00000042035.9
 Bai1
brain-specific angiogenesis inhibitor 1
chr14_+_66344369 5.862 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
 Stmn4



stathmin-like 4



chr17_+_70522083 5.740 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr2_+_152962485 5.624 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chr14_+_66344296 5.414 ENSMUST00000152093.1
ENSMUST00000074523.6
 Stmn4

stathmin-like 4

chr10_+_26078255 5.251 ENSMUST00000041011.3
 Gm9767
predicted gene 9767
chr17_+_70522149 5.133 ENSMUST00000140728.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr10_+_79988584 4.948 ENSMUST00000004784.4
ENSMUST00000105374.1
 Cnn2

calponin 2

chr8_-_11312731 4.905 ENSMUST00000033898.9
 Col4a1
collagen, type IV, alpha 1
chr19_-_41743665 4.742 ENSMUST00000025993.3
 Slit1
slit homolog 1 (Drosophila)
chr17_+_55445375 4.680 ENSMUST00000133899.1
ENSMUST00000086878.3
 St6gal2

beta galactoside alpha 2,6 sialyltransferase 2

chr8_-_117673682 4.605 ENSMUST00000173522.1
ENSMUST00000174450.1
 Sdr42e1

short chain dehydrogenase/reductase family 42E, member 1

chr14_-_103844173 4.412 ENSMUST00000022718.3
 Ednrb
endothelin receptor type B
chr6_-_136875794 4.384 ENSMUST00000032342.1
 Mgp
matrix Gla protein
chr9_-_4796218 4.367 ENSMUST00000027020.6
ENSMUST00000063508.7
ENSMUST00000163309.1
 Gria4


glutamate receptor, ionotropic, AMPA4 (alpha 4)


chr2_-_26246707 4.325 ENSMUST00000166349.1
 C030048H21Rik
RIKEN cDNA C030048H21 gene
chr5_+_137030275 4.221 ENSMUST00000041543.8
 Vgf
VGF nerve growth factor inducible
chr3_+_68572245 4.090 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr13_+_31806627 3.969 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr7_-_30534180 3.921 ENSMUST00000044338.4
 Arhgap33
Rho GTPase activating protein 33
chr4_-_143299463 3.911 ENSMUST00000119654.1
 Pdpn
podoplanin
chr1_+_153665274 3.709 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr11_+_103774150 3.703 ENSMUST00000000127.5
 Wnt3
wingless-related MMTV integration site 3
chr4_-_106799779 3.608 ENSMUST00000145061.1
ENSMUST00000102762.3
 Acot11

acyl-CoA thioesterase 11

chr15_+_82252397 3.601 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr6_-_52012476 3.596 ENSMUST00000078214.5
 Skap2
src family associated phosphoprotein 2
chr10_+_81628570 3.571 ENSMUST00000153573.1
ENSMUST00000119336.1
 Ankrd24

ankyrin repeat domain 24

chr5_-_135573036 3.559 ENSMUST00000004936.6
 Ccl24
chemokine (C-C motif) ligand 24
chr10_+_14523062 3.551 ENSMUST00000096020.5
 Gm10335
predicted gene 10335
chr13_-_60177357 3.467 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr11_-_102296618 3.450 ENSMUST00000107132.2
ENSMUST00000073234.2
 Atxn7l3

ataxin 7-like 3

chr3_-_110143937 3.360 ENSMUST00000051253.3
 Ntng1
netrin G1
chr9_+_59589288 3.273 ENSMUST00000121266.1
ENSMUST00000118164.1
 Celf6

CUGBP, Elav-like family member 6

chr2_+_165595009 3.095 ENSMUST00000088132.6
 Eya2
eyes absent 2 homolog (Drosophila)
chr5_-_137684665 2.880 ENSMUST00000100544.4
ENSMUST00000031736.9
ENSMUST00000151839.1
 Agfg2


ArfGAP with FG repeats 2


chr7_-_16917184 2.864 ENSMUST00000173139.1
 Calm3
calmodulin 3
chr4_+_101507947 2.820 ENSMUST00000149047.1
ENSMUST00000106929.3
 Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr4_+_101507855 2.766 ENSMUST00000038207.5
 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr9_-_21312255 2.710 ENSMUST00000115433.3
ENSMUST00000003397.7
 Ap1m2

adaptor protein complex AP-1, mu 2 subunit

chr1_+_89454769 2.699 ENSMUST00000027521.8
ENSMUST00000074945.5
 Agap1

ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

chr2_-_152951688 2.564 ENSMUST00000109811.3
 Dusp15
dual specificity phosphatase-like 15
chr11_-_40755201 2.454 ENSMUST00000020576.7
 Ccng1
cyclin G1
chr5_+_88583527 2.201 ENSMUST00000031229.6
 Rufy3
RUN and FYVE domain containing 3
chr3_-_89093358 2.140 ENSMUST00000090929.5
ENSMUST00000052539.6
 Rusc1

RUN and SH3 domain containing 1

chr10_+_81628540 2.039 ENSMUST00000123896.1
 Ankrd24
ankyrin repeat domain 24
chrX_+_38600626 2.034 ENSMUST00000000365.2
 Mcts1
malignant T cell amplified sequence 1
chr18_+_56562443 1.927 ENSMUST00000130163.1
ENSMUST00000132628.1
 Phax

phosphorylated adaptor for RNA export

chr17_-_25081138 1.793 ENSMUST00000024984.6
 Tmem204
transmembrane protein 204
chr10_+_94576254 1.771 ENSMUST00000117929.1
 Tmcc3
transmembrane and coiled coil domains 3
chr10_-_63421739 1.725 ENSMUST00000054760.4
 Gm7075
predicted gene 7075
chr13_+_72628802 1.696 ENSMUST00000074372.4
 Irx2
Iroquois related homeobox 2 (Drosophila)
chr2_+_112261926 1.634 ENSMUST00000028553.3
 Nop10
NOP10 ribonucleoprotein
chr8_+_95825353 1.544 ENSMUST00000074053.4
 Gm10094
predicted gene 10094
chr16_-_18876655 1.520 ENSMUST00000023391.8
 Mrpl40
mitochondrial ribosomal protein L40
chr17_-_90455872 1.516 ENSMUST00000174337.1
ENSMUST00000172466.1
 Nrxn1

neurexin I

chr11_-_20332654 1.498 ENSMUST00000004634.6
 Slc1a4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr18_+_4994600 1.446 ENSMUST00000140448.1
 Svil
supervillin
chr4_+_119814495 1.438 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chrX_-_150812932 1.401 ENSMUST00000131241.1
ENSMUST00000147152.1
ENSMUST00000143843.1
 Maged2


melanoma antigen, family D, 2


chr11_+_24080664 1.382 ENSMUST00000118955.1
 Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr13_-_12340723 1.371 ENSMUST00000168193.1
ENSMUST00000110616.1
ENSMUST00000064204.7
 Actn2


actinin alpha 2


chr7_+_144838590 1.289 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr8_-_67515606 1.254 ENSMUST00000032981.5
 Gm9755
predicted pseudogene 9755
chr16_+_23107413 1.109 ENSMUST00000023599.6
ENSMUST00000168891.1
 Eif4a2

eukaryotic translation initiation factor 4A2

chr2_+_36230426 1.082 ENSMUST00000062069.5
 Ptgs1
prostaglandin-endoperoxide synthase 1
chr14_-_69503316 1.059 ENSMUST00000179116.2
 Gm21464
predicted gene, 21464
chrX_-_8132770 0.935 ENSMUST00000130832.1
ENSMUST00000033506.6
ENSMUST00000115623.1
ENSMUST00000153839.1
 Wdr13



WD repeat domain 13



chr16_-_18876522 0.821 ENSMUST00000119273.1
 Mrpl40
mitochondrial ribosomal protein L40
chr12_-_80260356 0.807 ENSMUST00000021554.8
 Actn1
actinin, alpha 1
chrX_-_150813637 0.578 ENSMUST00000112700.1
 Maged2
melanoma antigen, family D, 2
chr17_-_28622419 0.547 ENSMUST00000114767.1
 Srpk1
serine/arginine-rich protein specific kinase 1
chr8_-_8639363 0.504 ENSMUST00000152698.1
 Efnb2
ephrin B2
chr9_+_110344185 0.496 ENSMUST00000142100.1
 Scap
SREBF chaperone
chr6_+_91684061 0.451 ENSMUST00000032185.7
 Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr13_+_72628831 0.449 ENSMUST00000169028.1
 Irx2
Iroquois related homeobox 2 (Drosophila)
chr15_-_53346118 0.449 ENSMUST00000077273.2
 Ext1
exostoses (multiple) 1
chrX_-_134161928 0.371 ENSMUST00000033611.4
 Xkrx
X Kell blood group precursor related X linked
chr12_+_53248677 0.280 ENSMUST00000101432.2
 Npas3
neuronal PAS domain protein 3
chr2_-_131042682 0.205 ENSMUST00000028787.5
ENSMUST00000110239.1
ENSMUST00000110234.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr5_+_135369942 0.166 ENSMUST00000000940.8
 Nsun5
NOL1/NOP2/Sun domain family, member 5
chr4_-_108406676 0.143 ENSMUST00000184609.1
 Gpx7
glutathione peroxidase 7
chr6_-_88446491 0.098 ENSMUST00000165242.1
 Eefsec
eukaryotic elongation factor, selenocysteine-tRNA-specific
chr2_-_131043088 0.037 ENSMUST00000110240.3
ENSMUST00000066958.4
ENSMUST00000110235.1
 Gfra4


glial cell line derived neurotrophic factor family receptor alpha 4


chr4_-_11981265 0.016 ENSMUST00000098260.2
 Gm10604
predicted gene 10604

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 12.3 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
1.5 4.4 GO:0014826 vein smooth muscle contraction(GO:0014826)
1.4 16.4 GO:1900121 negative regulation of receptor binding(GO:1900121)
1.4 15.0 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
1.3 4.0 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
1.2 3.7 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
1.2 3.6 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.9 10.4 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643) positive regulation of thymocyte aggregation(GO:2000400)
0.9 5.6 GO:0072318 clathrin coat disassembly(GO:0072318)
0.8 10.9 GO:0070842 aggresome assembly(GO:0070842)
0.7 4.9 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.7 4.7 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.6 1.9 GO:0051030 snRNA transport(GO:0051030)
0.5 2.1 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.5 2.0 GO:0002188 translation reinitiation(GO:0002188)
0.5 4.2 GO:0043084 penile erection(GO:0043084)
0.4 1.5 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.4 1.5 GO:0015825 L-serine transport(GO:0015825)
0.4 1.1 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.3 1.4 GO:1904800 regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800)
0.3 1.4 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.3 2.0 GO:0070294 renal sodium ion absorption(GO:0070294)
0.3 1.6 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.3 3.5 GO:0042473 outer ear morphogenesis(GO:0042473)
0.3 2.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.3 3.7 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.3 4.7 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.3 4.1 GO:0001553 luteinization(GO:0001553)
0.2 1.3 GO:0030916 otic vesicle formation(GO:0030916)
0.2 11.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.2 13.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 4.9 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.2 3.3 GO:0071625 vocalization behavior(GO:0071625)
0.2 4.4 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.1 6.6 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.1 3.5 GO:0016578 histone deubiquitination(GO:0016578)
0.1 2.2 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 2.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 3.6 GO:0009409 response to cold(GO:0009409)
0.1 2.3 GO:0001945 lymph vessel development(GO:0001945)
0.1 0.4 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 6.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.9 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 4.4 GO:0030500 regulation of bone mineralization(GO:0030500)
0.1 0.8 GO:0030220 platelet formation(GO:0030220) actin filament network formation(GO:0051639)
0.1 2.6 GO:0048713 regulation of oligodendrocyte differentiation(GO:0048713)
0.0 5.1 GO:0006694 steroid biosynthetic process(GO:0006694)
0.0 2.9 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 0.3 GO:0042711 maternal behavior(GO:0042711)
0.0 1.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 1.4 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.2 GO:0070475 rRNA base methylation(GO:0070475)
0.0 3.6 GO:0002757 immune response-activating signal transduction(GO:0002757)
0.0 0.1 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.5 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 1.4 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 2.1 GO:0000209 protein polyubiquitination(GO:0000209)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 12.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
1.0 4.9 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.7 4.4 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.4 1.6 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.2 6.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 3.5 GO:0000124 SAGA complex(GO:0000124)
0.2 0.8 GO:0032127 dense core granule membrane(GO:0032127)
0.2 2.2 GO:0071437 invadopodium(GO:0071437)
0.2 16.6 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 3.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 9.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 15.0 GO:0043204 perikaryon(GO:0043204)
0.1 4.2 GO:0030667 secretory granule membrane(GO:0030667)
0.1 2.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.4 GO:0043034 costamere(GO:0043034)
0.0 1.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 4.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 15.7 GO:0014069 postsynaptic density(GO:0014069)
0.0 2.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.9 GO:0036477 somatodendritic compartment(GO:0036477)
0.0 1.5 GO:0005882 intermediate filament(GO:0005882)
0.0 1.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 4.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 19.5 GO:0005615 extracellular space(GO:0005615)
0.0 3.9 GO:0005938 cell cortex(GO:0005938)
0.0 5.6 GO:0005874 microtubule(GO:0005874)
0.0 12.3 GO:0043005 neuron projection(GO:0043005)
0.0 2.8 GO:0000139 Golgi membrane(GO:0000139)
0.0 5.3 GO:0005815 microtubule organizing center(GO:0005815)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.4 GO:0004962 endothelin receptor activity(GO:0004962)
1.3 16.4 GO:1990459 transferrin receptor binding(GO:1990459)
1.1 12.3 GO:0015250 water channel activity(GO:0015250)
0.9 4.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.8 4.6 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.7 2.9 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.6 4.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.6 4.7 GO:0048495 Roundabout binding(GO:0048495)
0.4 7.3 GO:0048018 receptor agonist activity(GO:0048018)
0.3 4.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 4.0 GO:0008301 DNA binding, bending(GO:0008301)
0.2 1.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.2 4.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 1.5 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.2 15.0 GO:0005080 protein kinase C binding(GO:0005080)
0.2 1.4 GO:0031432 thyroid hormone receptor coactivator activity(GO:0030375) titin binding(GO:0031432)
0.2 3.6 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.1 1.9 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 6.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 3.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 11.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 3.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 4.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 0.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 6.6 GO:0005125 cytokine activity(GO:0005125)
0.1 8.8 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 1.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 4.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 8.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 2.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.1 GO:0004096 catalase activity(GO:0004096)
0.0 0.5 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 9.2 GO:0015631 tubulin binding(GO:0015631)
0.0 1.1 GO:0004601 peroxidase activity(GO:0004601)
0.0 4.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 4.6 GO:0016874 ligase activity(GO:0016874)
0.0 6.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 3.6 GO:0003779 actin binding(GO:0003779)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 16.4 PID_BMP_PATHWAY BMP receptor signaling
0.2 8.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 10.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 4.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 13.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 4.4 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 2.1 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 2.5 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 4.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 0.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.4 21.1 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 3.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 8.3 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 5.7 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 1.3 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 4.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 4.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.1 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.1 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.9 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 0.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis