Motif ID: Hoxa1

Z-value: 1.189


Transcription factors associated with Hoxa1:

Gene SymbolEntrez IDGene Name
Hoxa1 ENSMUSG00000029844.9 Hoxa1



Activity profile for motif Hoxa1.

activity profile for motif Hoxa1


Sorted Z-values histogram for motif Hoxa1

Sorted Z-values for motif Hoxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_15239045 23.532 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr7_+_73391160 16.389 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr15_-_95528702 15.018 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr2_+_158375638 11.190 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr14_+_70077375 10.438 ENSMUST00000035908.1
 Egr3
early growth response 3
chr3_+_55782500 8.762 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr4_-_143299498 8.436 ENSMUST00000030317.7
 Pdpn
podoplanin
chr2_+_163225363 8.376 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr10_+_81628702 7.664 ENSMUST00000129622.1
 Ankrd24
ankyrin repeat domain 24
chr2_+_65845767 6.668 ENSMUST00000122912.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr4_-_35845204 6.631 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr5_+_27261916 6.604 ENSMUST00000101471.3
 Dpp6
dipeptidylpeptidase 6
chr2_+_90885860 6.555 ENSMUST00000111466.2
 C1qtnf4
C1q and tumor necrosis factor related protein 4
chr2_+_65845833 6.539 ENSMUST00000053910.3
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr15_+_98167806 6.055 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr15_+_74516196 5.985 ENSMUST00000042035.9
 Bai1
brain-specific angiogenesis inhibitor 1
chr14_+_66344369 5.862 ENSMUST00000118426.1
ENSMUST00000121955.1
ENSMUST00000120229.1
ENSMUST00000134440.1
 Stmn4



stathmin-like 4



chr17_+_70522083 5.740 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr2_+_152962485 5.624 ENSMUST00000099197.2
ENSMUST00000103155.3
 Ttll9

tubulin tyrosine ligase-like family, member 9

chr14_+_66344296 5.414 ENSMUST00000152093.1
ENSMUST00000074523.6
 Stmn4

stathmin-like 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 16.4 GO:1900121 negative regulation of receptor binding(GO:1900121)
1.4 15.0 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.2 13.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
2.5 12.3 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.2 11.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.8 10.9 GO:0070842 aggresome assembly(GO:0070842)
0.9 10.4 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643) positive regulation of thymocyte aggregation(GO:2000400)
0.1 6.6 GO:1901381 positive regulation of potassium ion transmembrane transport(GO:1901381)
0.1 6.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.9 5.6 GO:0072318 clathrin coat disassembly(GO:0072318)
0.0 5.1 GO:0006694 steroid biosynthetic process(GO:0006694)
0.7 4.9 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.2 4.9 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.7 4.7 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.3 4.7 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
1.5 4.4 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.2 4.4 GO:0051968 positive regulation of synaptic transmission, glutamatergic(GO:0051968)
0.1 4.4 GO:0030500 regulation of bone mineralization(GO:0030500)
0.5 4.2 GO:0043084 penile erection(GO:0043084)
0.3 4.1 GO:0001553 luteinization(GO:0001553)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.5 GO:0005615 extracellular space(GO:0005615)
0.2 16.6 GO:0031225 anchored component of membrane(GO:0031225)
0.0 15.7 GO:0014069 postsynaptic density(GO:0014069)
0.1 15.0 GO:0043204 perikaryon(GO:0043204)
1.4 12.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 12.3 GO:0043005 neuron projection(GO:0043005)
0.1 9.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 6.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 5.6 GO:0005874 microtubule(GO:0005874)
0.0 5.3 GO:0005815 microtubule organizing center(GO:0005815)
1.0 4.9 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 4.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.7 4.4 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 4.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 4.2 GO:0030667 secretory granule membrane(GO:0030667)
0.0 3.9 GO:0005938 cell cortex(GO:0005938)
0.1 3.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 3.5 GO:0000124 SAGA complex(GO:0000124)
0.0 2.8 GO:0000139 Golgi membrane(GO:0000139)
0.1 2.7 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 16.4 GO:1990459 transferrin receptor binding(GO:1990459)
0.2 15.0 GO:0005080 protein kinase C binding(GO:0005080)
1.1 12.3 GO:0015250 water channel activity(GO:0015250)
0.1 11.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 9.2 GO:0015631 tubulin binding(GO:0015631)
0.1 8.8 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 8.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.4 7.3 GO:0048018 receptor agonist activity(GO:0048018)
0.1 6.6 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 6.6 GO:0005125 cytokine activity(GO:0005125)
0.0 6.6 GO:0005096 GTPase activator activity(GO:0005096)
0.3 4.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 4.9 GO:0005516 calmodulin binding(GO:0005516)
0.9 4.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.6 4.7 GO:0048495 Roundabout binding(GO:0048495)
0.8 4.6 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 4.6 GO:0016874 ligase activity(GO:0016874)
1.5 4.4 GO:0004962 endothelin receptor activity(GO:0004962)
0.6 4.4 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 4.4 GO:0048306 calcium-dependent protein binding(GO:0048306)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 16.4 PID_BMP_PATHWAY BMP receptor signaling
0.1 13.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 10.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2 8.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 4.8 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 4.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 4.4 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 3.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.5 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 2.1 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.5 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 21.1 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 8.3 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 5.7 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 4.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 4.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 3.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.3 3.6 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.6 2.9 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 1.9 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.9 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.1 1.3 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.1 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.1 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis