Motif ID: Hoxa10

Z-value: 0.848


Transcription factors associated with Hoxa10:

Gene SymbolEntrez IDGene Name
Hoxa10 ENSMUSG00000000938.11 Hoxa10



Activity profile for motif Hoxa10.

activity profile for motif Hoxa10


Sorted Z-values histogram for motif Hoxa10

Sorted Z-values for motif Hoxa10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa10

PNG image of the network

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Top targets:


Showing 1 to 20 of 139 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_106935720 9.125 ENSMUST00000047425.3
 Sntb2
syntrophin, basic 2
chr3_+_67892189 8.447 ENSMUST00000063263.3
 Iqcj
IQ motif containing J
chrX_-_43274786 7.446 ENSMUST00000016294.7
 Tenm1
teneurin transmembrane protein 1
chr5_-_123666682 6.286 ENSMUST00000149410.1
 Clip1
CAP-GLY domain containing linker protein 1
chr9_+_53771499 6.125 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr9_-_112232449 5.328 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr2_-_79908428 4.951 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr1_+_66321708 4.749 ENSMUST00000114013.1
 Map2
microtubule-associated protein 2
chr18_-_89769479 4.746 ENSMUST00000097495.3
 Dok6
docking protein 6
chr10_-_11082287 4.632 ENSMUST00000105561.2
ENSMUST00000044306.6
 Grm1

glutamate receptor, metabotropic 1

chr13_-_99516537 4.378 ENSMUST00000064762.4
 Map1b
microtubule-associated protein 1B
chr19_+_43440404 4.335 ENSMUST00000165311.1
 Cnnm1
cyclin M1
chr8_+_58912257 4.079 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr6_+_34354119 3.904 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr2_-_79908389 3.615 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr2_-_37647199 3.506 ENSMUST00000028279.3
 Strbp
spermatid perinuclear RNA binding protein
chr11_-_42000284 3.467 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr11_-_69822144 3.383 ENSMUST00000045771.6
 Spem1
sperm maturation 1
chr6_-_99028874 3.375 ENSMUST00000154163.2
 Foxp1
forkhead box P1
chr9_-_39604124 3.240 ENSMUST00000042485.4
ENSMUST00000141370.1
 AW551984

expressed sequence AW551984


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 7.9 GO:0006869 lipid transport(GO:0006869)
0.2 7.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
1.6 6.3 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.6 6.1 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.1 5.3 GO:0034605 cellular response to heat(GO:0034605)
0.1 4.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
1.2 4.6 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.3 4.4 GO:0061339 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
1.3 3.9 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
1.3 3.9 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.2 3.7 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.4 3.5 GO:0071420 cellular response to histamine(GO:0071420)
0.1 3.5 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 3.4 GO:0030317 sperm motility(GO:0030317)
0.5 3.2 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.3 2.9 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.5 2.8 GO:0007258 JUN phosphorylation(GO:0007258)
0.5 2.3 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.2 2.3 GO:0046085 adenosine metabolic process(GO:0046085)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.0 GO:0005874 microtubule(GO:0005874)
0.9 6.3 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.5 4.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 4.6 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.3 4.4 GO:0043196 varicosity(GO:0043196)
0.2 3.5 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 3.2 GO:0072562 blood microparticle(GO:0072562)
0.0 3.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.8 GO:0043204 perikaryon(GO:0043204)
0.3 2.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 2.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 2.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 1.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.3 1.8 GO:0005955 calcineurin complex(GO:0005955)
0.4 1.7 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 1.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.5 1.4 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.5 1.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 1.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.5 GO:0005516 calmodulin binding(GO:0005516)
1.1 9.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
1.2 8.6 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 7.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.4 6.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 6.1 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 4.7 GO:0005158 insulin receptor binding(GO:0005158)
1.2 4.6 GO:0001639 PLC activating G-protein coupled glutamate receptor activity(GO:0001639) G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.8 3.9 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.7 3.9 GO:0016936 galactoside binding(GO:0016936)
0.2 3.5 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 3.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 3.1 GO:0050692 DBD domain binding(GO:0050692)
0.7 2.9 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.7 2.8 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 2.5 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.2 2.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.6 2.3 GO:0001851 complement component C3b binding(GO:0001851)
0.1 2.3 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.3 2.1 GO:0001094 TFIID-class transcription factor binding(GO:0001094)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.7 PID_LKB1_PATHWAY LKB1 signaling events
0.1 4.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 3.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 2.6 PID_ERBB1_DOWNSTREAM_PATHWAY ErbB1 downstream signaling
0.0 2.3 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 2.2 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.1 1.8 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 1.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.4 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 1.1 PID_CDC42_PATHWAY CDC42 signaling events
0.0 0.8 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 8.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 4.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 3.9 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 3.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 2.8 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 2.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.5 2.3 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.3 2.3 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 2.2 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3 1.8 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 1.8 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 1.7 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.5 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.5 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.2 1.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 1.4 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.1 1.4 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 1.3 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors