Motif ID: Hoxa11_Hoxc12

Z-value: 1.164

Transcription factors associated with Hoxa11_Hoxc12:

Gene SymbolEntrez IDGene Name
Hoxa11 ENSMUSG00000038210.9 Hoxa11
Hoxc12 ENSMUSG00000050328.2 Hoxc12



Activity profile for motif Hoxa11_Hoxc12.

activity profile for motif Hoxa11_Hoxc12


Sorted Z-values histogram for motif Hoxa11_Hoxc12

Sorted Z-values for motif Hoxa11_Hoxc12



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa11_Hoxc12

PNG image of the network

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Top targets:


Showing 1 to 20 of 136 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56978534 22.043 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr17_+_35076902 19.099 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr13_+_16014457 18.754 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr6_+_108213086 17.532 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr1_+_43730593 11.243 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr14_+_80000292 10.867 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr9_+_53771499 10.428 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr4_+_136143497 9.697 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr3_-_117360876 9.243 ENSMUST00000061071.8
 D3Bwg0562e
DNA segment, Chr 3, Brigham & Women's Genetics 0562 expressed
chr16_-_57231434 8.607 ENSMUST00000023431.6
 Tbc1d23
TBC1 domain family, member 23
chr7_-_142661858 8.566 ENSMUST00000145896.2
 Igf2
insulin-like growth factor 2
chr17_+_6270475 8.155 ENSMUST00000088940.4
 Tmem181a
transmembrane protein 181A
chr5_+_66968961 8.026 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chrX_+_73064787 6.838 ENSMUST00000060418.6
 Pnma3
paraneoplastic antigen MA3
chr15_-_101850778 6.020 ENSMUST00000023790.3
 Krt1
keratin 1
chr1_+_178529113 5.917 ENSMUST00000161017.1
 Kif26b
kinesin family member 26B
chr16_-_45408955 5.742 ENSMUST00000163230.1
 Cd200
CD200 antigen
chr1_-_189922338 5.313 ENSMUST00000027897.7
 Smyd2
SET and MYND domain containing 2
chr15_-_43869993 5.173 ENSMUST00000067469.4
 Tmem74
transmembrane protein 74
chr17_-_6477102 5.109 ENSMUST00000167717.2
 Tmem181b-ps
transmembrane protein 181B, pseudogene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 22.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.7 19.1 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
3.8 18.8 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
2.9 17.5 GO:0042045 epithelial fluid transport(GO:0042045)
4.7 14.1 GO:0030974 thiamine pyrophosphate transport(GO:0030974)
1.4 11.2 GO:0070314 G1 to G0 transition(GO:0070314)
0.2 10.9 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.4 9.7 GO:0030903 notochord development(GO:0030903)
1.1 8.6 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.4 8.2 GO:0009405 pathogenesis(GO:0009405)
0.0 8.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.2 6.7 GO:0001919 regulation of receptor recycling(GO:0001919)
0.9 6.0 GO:0001867 complement activation, lectin pathway(GO:0001867)
2.0 5.9 GO:0072092 ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093)
1.9 5.7 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.7 5.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.1 5.3 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 5.2 GO:0016236 macroautophagy(GO:0016236)
1.1 4.2 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.4 4.2 GO:0042118 endothelial cell activation(GO:0042118)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 23.7 GO:0000118 histone deacetylase complex(GO:0000118)
6.3 18.8 GO:0043512 inhibin A complex(GO:0043512)
0.6 18.4 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
5.8 17.5 GO:0031088 platelet dense granule membrane(GO:0031088)
0.7 11.2 GO:0031045 dense core granule(GO:0031045)
0.8 10.9 GO:0042581 specific granule(GO:0042581)
0.4 6.7 GO:0043083 synaptic cleft(GO:0043083)
1.2 6.0 GO:0001533 cornified envelope(GO:0001533)
0.1 5.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 5.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 4.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 3.8 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.5 3.3 GO:1990393 3M complex(GO:1990393)
0.1 3.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 3.1 GO:0031941 filamentous actin(GO:0031941)
0.0 3.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 2.6 GO:0060077 inhibitory synapse(GO:0060077)
0.8 2.5 GO:0031417 NatC complex(GO:0031417)
0.1 2.5 GO:0030673 axolemma(GO:0030673)
0.1 2.1 GO:0000930 gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.4 19.1 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
3.1 18.8 GO:0070699 type II activin receptor binding(GO:0070699)
5.8 17.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 15.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
2.4 14.1 GO:0015234 thiamine transmembrane transporter activity(GO:0015234)
0.0 12.8 GO:0003682 chromatin binding(GO:0003682)
0.2 9.7 GO:0005504 fatty acid binding(GO:0005504)
0.3 8.6 GO:0043539 insulin-like growth factor receptor binding(GO:0005159) protein serine/threonine kinase activator activity(GO:0043539)
0.6 8.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 8.0 GO:0030246 carbohydrate binding(GO:0030246)
1.0 6.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 5.9 GO:0008017 microtubule binding(GO:0008017)
0.9 5.3 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 4.6 GO:0030165 PDZ domain binding(GO:0030165)
1.1 4.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.1 4.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.8 4.0 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.3 3.8 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 3.3 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 3.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 18.8 PID_ALK1_PATHWAY ALK1 signaling events
0.5 12.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 10.6 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 8.6 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 4.9 PID_P53_REGULATION_PATHWAY p53 pathway
0.1 3.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.3 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 2.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.0 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.6 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 1.3 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 18.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.5 8.6 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 6.7 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 4.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 3.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 3.1 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 3.1 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 2.7 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 2.6 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.5 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.7 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.4 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 1.4 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.1 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 0.9 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.8 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.4 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions