Motif ID: Hoxa13

Z-value: 0.939


Transcription factors associated with Hoxa13:

Gene SymbolEntrez IDGene Name
Hoxa13 ENSMUSG00000038203.12 Hoxa13



Activity profile for motif Hoxa13.

activity profile for motif Hoxa13


Sorted Z-values histogram for motif Hoxa13

Sorted Z-values for motif Hoxa13



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa13

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_65805832 8.921 ENSMUST00000022612.3
 Pbk
PDZ binding kinase
chr14_+_65806066 8.731 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr11_-_84067063 8.709 ENSMUST00000108101.1
 Dusp14
dual specificity phosphatase 14
chr2_-_18048784 7.868 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr2_-_129297205 7.789 ENSMUST00000052708.6
 Ckap2l
cytoskeleton associated protein 2-like
chrX_+_106920618 7.464 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr4_-_133967296 7.364 ENSMUST00000105893.1
 Hmgn2
high mobility group nucleosomal binding domain 2
chr17_+_75178797 7.296 ENSMUST00000112516.1
ENSMUST00000135447.1
 Ltbp1

latent transforming growth factor beta binding protein 1

chr14_-_47411666 6.971 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr17_+_75178911 6.462 ENSMUST00000112514.1
 Ltbp1
latent transforming growth factor beta binding protein 1
chr2_+_126215100 6.432 ENSMUST00000164042.2
 Gm17555
predicted gene, 17555
chr19_-_5796924 5.971 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr8_-_4779513 5.840 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr5_+_64812336 5.835 ENSMUST00000166409.1
 Klf3
Kruppel-like factor 3 (basic)
chr1_-_45503282 5.813 ENSMUST00000086430.4
 Col5a2
collagen, type V, alpha 2
chr15_+_25773985 5.756 ENSMUST00000125667.1
 Myo10
myosin X
chr3_-_49757257 5.702 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr4_+_144893127 5.694 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr10_-_105574435 5.659 ENSMUST00000061506.8
 Tmtc2
transmembrane and tetratricopeptide repeat containing 2
chrX_-_109013389 5.636 ENSMUST00000033597.8
 Hmgn5
high-mobility group nucleosome binding domain 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 161 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.6 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.5 13.8 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.4 12.3 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.6 10.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.8 9.1 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 9.0 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.3 8.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 7.6 GO:0046847 filopodium assembly(GO:0046847)
0.3 6.9 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.3 6.1 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
1.2 6.0 GO:0035063 nuclear speck organization(GO:0035063)
1.9 5.8 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 5.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 5.4 GO:0007608 sensory perception of smell(GO:0007608)
1.0 5.2 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 5.2 GO:1900006 positive regulation of dendrite development(GO:1900006)
0.6 5.0 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.2 5.0 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 5.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.8 4.9 GO:0030913 paranodal junction assembly(GO:0030913)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.6 13.8 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 9.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 8.7 GO:0036064 ciliary basal body(GO:0036064)
0.1 8.5 GO:0016459 myosin complex(GO:0016459)
2.1 8.3 GO:0008623 CHRAC(GO:0008623)
0.4 7.3 GO:0097431 mitotic spindle pole(GO:0097431)
0.4 7.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 6.9 GO:0045177 apical part of cell(GO:0045177)
0.1 6.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 5.9 GO:0043296 apical junction complex(GO:0043296)
1.9 5.8 GO:0005588 collagen type V trimer(GO:0005588)
0.1 5.0 GO:0070469 respiratory chain(GO:0070469)
0.1 4.8 GO:0000791 euchromatin(GO:0000791)
1.2 4.6 GO:0090537 CERF complex(GO:0090537)
0.1 4.4 GO:0060077 inhibitory synapse(GO:0060077)
0.9 4.3 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.4 4.3 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 4.3 GO:0072686 mitotic spindle(GO:0072686)
0.8 4.1 GO:0070820 tertiary granule(GO:0070820)
0.3 4.1 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 125 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 13.8 GO:0050436 microfibril binding(GO:0050436)
0.0 12.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.6 8.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 8.3 GO:0051015 actin filament binding(GO:0051015)
1.1 7.5 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.4 7.0 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
1.1 6.8 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 6.2 GO:0042169 SH2 domain binding(GO:0042169)
0.3 6.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 6.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.4 5.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 5.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 5.8 GO:0030507 spectrin binding(GO:0030507)
0.8 5.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 5.7 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 5.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 5.3 GO:0017091 AU-rich element binding(GO:0017091)
0.0 5.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.7 5.2 GO:0005110 frizzled-2 binding(GO:0005110)
0.2 5.0 GO:0030215 semaphorin receptor binding(GO:0030215)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.1 NABA_COLLAGENS Genes encoding collagen proteins
0.2 7.7 PID_ATM_PATHWAY ATM pathway
0.4 7.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 6.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 6.2 PID_ARF6_PATHWAY Arf6 signaling events
0.1 5.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 5.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 3.9 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 3.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.6 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 3.2 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 3.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.7 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 2.3 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 2.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.0 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.0 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 1.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 8.0 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 7.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.7 6.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.5 4.3 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 4.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 4.1 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.2 3.9 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 3.9 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 3.6 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 3.3 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 3.2 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 3.2 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 2.9 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.3 2.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 2.8 REACTOME_INFLAMMASOMES Genes involved in Inflammasomes
0.1 2.7 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.6 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 2.0 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP